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Supplemental Table 1. The adipose tissue and clinical characteristics of male patients with different levels of BMI and TyG index Supplemental Table 2. The adipose tissue and clinical characteristics of female patients with different levels of BMI and TyG index Supplemental Fig. 1. ROC analyses of TyG-WC and TyG-WHR for VO (A) male patients; (B) female patients

Additional file 1: Table S1. Normality Distribution Test for Continuous Variables. Table S2. Variance Inflation Factor for the Multicollinearity Test.

Additional file 1 Figure S1. The cumulative incidence of overall mortality in patients with decompensated liver cirrhosis based on Chinese herbal medicine (CHM) usage (before matching). Figure S2. A flow diagram presenting the study participants enrollment (from the database of outpatient and inpatient). Figure S3. The cumulative incidence of overall mortality in patients with decompensated liver cirrhosis based on Chinese herbal medicine (CHM) usage (from the database of outpatient and inpatient). Table S1 Composition of the most commonly used herbal formulas and single herbs in patients with decompensated liver cirrhosis in Taiwan. Table S2 Hazard ratios (95% CI) for overall mortality of patients with decompensated liver cirrhosis (before matching). Table S3 Demographic characteristics of patients with decompensated liver cirrhosis according to CHM usage in Taiwan (from the database of outpatient and inpatient). Table S4 Hazard ratios (95% CI) for overall mortality of patients with decompensated liver cirrhosis (from the database of outpatient and inpatient). Table S5. Distribution of the cumulative period of CHM treatment of CHM users of patients with decompensated liver cirrhosis in this study in Taiwan (during study period after the index date). Table S6. Average survival time of patients with decompensated liver cirrhosis between CHM and CHM non-users. Table S7. Parameters for counting the cumulative incidence of overall mortality at Fig. 2 for CHM non-users. Table S8. Parameters for counting the cumulative incidence of overall mortality at Fig. 2 for CHM users.

Table S1. The independent correlation between IGF-1 SDS and LDL-C levels identified using multivariate piecewise linear regression analysis in groups stratified according to before and after puberty. (DOC 28 kb)

Supplemental material, Supplementary_Materials_08122019 for Integrated Chinese Herbal Medicine Therapy Improves the Survival of Patients With Ovarian Cancer by Cherry Yin-Yi Chang, Pei-Yuu Yang, Fuu-Jen Tsai, Te-Mao Li, Jian-Shiun Chiou, Chao-Jung Chen, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Bo Ban, Wen-Miin Liang and Ying-Ju Lin in Integrative Cancer Therapies

L’utilisation non controlee d’antibiotiques en elevage conduit a la selection des germes resistants, a la recrudescence des infections, l’augmentation de la mortalite et la baisse de la productivite en viande de poulet au Tchad. Cette etude a pour but de determiner la prevalence et la susceptibilite des souches de Salmonella spp. Isolees dans les carcasses de poulets au Tchad aux antibiotiques. Au total 60 echantillons de carcasses de poulets ont ete preleves dans les sites d’elevage et point de vente. Les souches de Salmonella spp. ont ete isolees suivant les methodes standard de microbiologiques et confirmees par la galerie Api 20 E. La sensibilite aux antibiotiques a ete determinee par la methode de diffusion sur milieu solide. La contamination a Salmonella spp. a ete detectee dans 68,33% des echantillons provenant des sites d’elevages et 34,15% des points de vente. Les resultats des tests de sensibilite aux antibiotiques ont montre que : 92,68% des Salmonella isolees etaient resistantes a au moins un antibiotique, 100% des souches presentaient une resistance a l’ampicilline, erythromycine et a l’imipeneme ; 87,80% a l’acide fusidique et 51,22% a la tetracycline. Un pourcentage de 34,15% de multi-resistance des souches a ete observe. Cette etude a permis d’evaluer la prevalence et d’apprecier le profil d’antibioresistance des souches de Salmonella spp. isolees. Mots cles : Poulet de chair, Salmonella spp , prevalence, antibiotique, resistance, Tchad.

Uncontrolled use of antibiotics in the treatment of calves suffering from gastroenteritis and dairy cows suffering from mastitis, created in pathogenic staphylococci enterotoxin producers some resistance to these drugs. These pathogens enterotoxin producers are often excreted with milk from cows with mastitis. That is why the specific and topical issue remains the isolation and identification of strains producing staphylococcal enterotoxin from cow milk and faeces of calves suffering from enteritis. Given all this, we have set a goal to get staphylococcal enterotoxin type D for use as mastitis diagnostic kit and enteritis and antigen for obtaining the antiserum. To obtain the staphylococcal enterotoxin type D we used strain S. aureus No. 494 (ATSS23235) courtesy offered by Dr. FC Fluer from Institute of Experimental Medicine, NF Gamaley, Medical Academy (USSR). Verification of the specificity of the enterotoxin) was performed using 5 strains of S.aureus producing different enterotoxins (enterotoxin- A; enterotoxin-B; enterotoxin C-1; C-2 and enterotoxin - E) as well as non-enterotoxigenic staphylococcal strain (S. aureus Wood 46). In addition to the staphylococcal strains, five strains of Escherichia coli, producing thermostable and thermolabile enterotoxins were also used in the experiment. The method of purification of enterotoxin-D by precipitation twice chromatography on km - cellulose and gel filtration on Sephadex G-75 allows to obtain pure enterotoxin-D having the biological properties, immunological and antigenic characteristics. Immunization of rabbits with purified enterotoxin-D associated with incomplete Freund's adjuvant provides antiserum very active and specific.

African swine fever (ASF) is an acute, highly contagious animal disease, affecting pigs and wild boars, warthogs, bush pigs and ticks (Ornithodoros), who are the likely vector. Its agent is a large double-stranded DNA virus of the genus Asfarvirus, the only representative of Asfarviridae family. Described for the first time in 1921 in East Africa (Kenya) by Montgomery, ASF has settled in the Iberian Peninsula. Since 1960, ASF has spread considerably in sub-Saharan Africa where it is endemic. ASF has emerged in Chad for the first time in October 2010 in the city of Bongor, capital of the region of Mayo-Kebbi-East, which is located about 250 km from Ndjamena. The city borders with northern Cameroon where the disease was reported in May 2010. The disease was introduced into the country from the far north in the Department of Mayo Danaye, Cameroon. Since 2010-2011, suspicions have become rare or no observed. The purpose of this study is to demonstrate the presence or absence of ASF virus circulation in Chad in order to clarify the epidemiological situation of the disease in the country. To do this, a serological survey was conducted on different sites. The choice of these sites was based on the history of the disease in the country, where there has actually outbreaks of disease and on stamping out importance achieved during ASF episode of 2010-2011. A total of 275 Sera and 17 bloods on filter papers were collected and analyzed by indirect ELISA for antibodies directed to ASF virus. Out of 275 sera analyzed, 13 (4.72%) have had antibodies directed to ASF virus. No sample taken from filter papers was positive vis-a-vis ASF virus. The study identified 4.72% animals carrying ASF virus. Given these results, we can say that ASF virus still circulates in some areas of the country. The areas where sera were positive should be admitted to the extent control of ASF by implementing the strategy of stamping out.It would also be preferable to undertake another large-scale serological study coupled with active surveillance to show that indeed there is no circulation of ASF virus in the country.

Peste des petits ruminants (PPR) is an acute febrile viral disease of goats and sheep characterized by mucopurulent nasal and ocular discharge, erosive and necrotizing stomatitis, enteritis and pneumonia. It is widespread, virulent and devastating causing significant impacts to the economy, food security and livelihoods of poor marginalized farmers. This study focused on clinical observations of 233 suspected cases of PPR and provided detailed information on the prevalence of antibodies against the PPR virus in sera from 986 small ruminants and 31 from camels. Most of specimens for this study were obtained from the slaughterhouse in N'Djamena. Sera for the detection of antibodies against the PPR virus were not necessarily representative of the target population, even if they were from a larger number of regions. According to information provided by the epidemiological surveillance field agents, the foci of the disease were more severe in goats than in sheep and the outbreaks frequency was higher during the Cold dry season (December to June) than during the other months of the year. Analysis of 1017 sera collected in small ruminants and camels revealed that the prevalence of antibodies against the PPR virus was 34.48%. The prevalence of antibodies against the PPR virus varied by species (goats, 15.21%, sheep, 19.25% and camels, 0%), age groups and geographic areas. The rate of infection by the PPR virus was higher in the sheep population (34. 67%) than in goats (27.37%). The study showed seroprevalence higher in sheep than in goats. In contrast, no serum from camels revealed positive vis-a-vis the PPR virus. Another serological survey would need to be undertaken in the population of camels in order to clarify their role in the epidemiology of PPR.