Search

Your search keyword '"Barbi C"' showing total 4 results
Start Over Author "Barbi C" Language undetermined
4 results on '"Barbi C"'

1. Centenariansin good health conditions

Author

Motta, M., Maugeri, D., Malaguarnera, M., Capurso, A., Colacicco, A. M., Solfrizzi, V., Bonafe', M., Barbi, C., Gaddi, A., D'Addato, S., Sangiorgi, Z., Trabucchi, M., Boffelli, S., Rozzini, R., Rapisarda, R., Tomasello, F. B., Bennati, E., Ferito, L., Frantone, A., Zoccolo, A., Perticone, F., Nardi, L., Berardelli, M., De Benedictis, G., Falcone, E., De Luca, M., Casotti, G., Monti, D., Petruzzi, E., Sorbi, S., Grassi, E., Latorraca, S., Bertolini, S., Agretti, M., Costelli, P., Nicita Mauro, V., Basile, G., Mari, D., Duca, F., Terrazzi, P., Bosi, E., Manzoni, M., Salvioli, G., Baldeli, M. V., Neri, M., Cossarizza, A., Troiano, L., Pini, G., Varricchio, M., Gambardella, A., Prolisso, G., Frada', G., Barbagallo, M., Pollina, R., Passeri, M., Sansoni, P., Lavagetto, G., Ferrari, E., Battegazzore, C., Molla, G., Senin, U., Cherubini, A., Polidori, M. C., Marigliano, V., Bauco, C., Borriello, C., Deiana, L., Carru, C., Pes, G. M., Baggio, G., Forconi, S., Boschi, S., Guerrini, M., Fabris, F., Cappa, G., and Ferrario, E.

Subjects
Aging, Health (social science), Successful aging, business.industry, Centenarians, Healthy centenarians, Data science, Text mining, Medicine, Geriatrics and Gerontology, business, Gerontology
Published
2002
Full Text
View/download PDF

2. Opposite role of changes in mitochondrial membrane potential in different apoptotic processes

Author

Salvioli, S., Barbi, C., Dobrucki, J., Moretti, L., Troiano, L., Pinti, Marcello, Pedrazzi, J., Pazienza, T. L., Bobyleva, V., Franceschi, C., and Cossarizza, Andrea

Subjects
Blotting, Western, Biophysics, Caspase 3, Apoptosis, Cytochrome c Group, Thymus Gland, Mitochondrion, Cycloheximide, apoptosis, MITOCHONDRIA, mitochondrial membrane potential, Biochemistry, Dexamethasone, Membrane Potentials, Rats, Sprague-Dawley, chemistry.chemical_compound, Valinomycin, Adenosine Triphosphate, Structural Biology, Genetics, Animals, Humans, Molecular Biology, Caspase, Cells, Cultured, Membrane potential, Microscopy, Confocal, biology, Ionophores, Tumor Necrosis Factor-alpha, Depolarization, Cell Biology, U937 Cells, Flow Cytometry, Cell biology, Mitochondria, Rats, chemistry, Caspases, biology.protein, Mitochondrial membrane potential
Abstract

We have studied the role of changes in mitochondrial membrane potential (DeltaPsi) in two widely-used models of apoptosis, such as dexamethasone-treated rat thymocytes and U937 human cells treated with tumor necrosis factor-alpha and cycloheximide. To dissipate DeltaPsi, we used low concentrations of valinomycin, unable per se to induce apoptosis, and demonstrated that the decline in DeltaPsi exerts opposite effects in the two models. Indeed, in U937 cells, depolarization of mitochondria increased apoptosis, which decreased in rat thymocytes. This leads to the suggestion that disruption of DeltaPsi plays opposite roles depending on the experimental model. In U937 cells, the drop of DeltaPsi is a possible contributory cause for the apoptotic process; in rat thymocytes, it could be a limiting factor. We propose that these opposite effects could be due to the different ATP requirement of each apoptotic pathway.

Published
2000

4. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1

Author

Stefano Salvioli, Cristiana Barbi, Gianluca Storci, Luca Tiberi, Claudio Franceschi, Matteo Rossi, Chiara Mondello, Massimiliano Bonafè, Chiara Trapassi, Daniela Monti, Francesca F. Tocco, Silvia Gravina, Salvioli S., Bonafé M., Barbi C., Storci G., Trapassi C., Tocco F., Gravina S., Rossi M., Tiberi L., Mondello C., Monti D., and Franceschi C.

Subjects
Aging, Arginine, Cell, Oligonucleotides, Apoptosis, Cell Separation, Neoplasms, 80 and over, Cytotoxic T cell, Protein Isoforms, Luciferases, Cells, Cultured, Aged, 80 and over, Microscopy, Cultured, Cell Death, Cell Cycle, Homozygote, Age Factors, Cell cycle, Flow Cytometry, medicine.anatomical_structure, medicine.drug, Propidium, Senescence, Adult, Cyclin-Dependent Kinase Inhibitor p21, Chromatin Immunoprecipitation, Proline, Cells, Antineoplastic Agents, Biology, Transfection, Fluorescence, Genetic, medicine, Humans, Polymorphism, Codon, Molecular Biology, Gene, Alleles, Aged, Polymorphism, Genetic, Bromodeoxyuridine, Fibroblasts, Microscopy, Fluorescence, Oxidative Stress, beta-Galactosidase, Cell Biology, Molecular biology, Camptothecin, Developmental Biology
Abstract

A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress. Here we report that dermal fibroblasts from Proline allele carriers (Pro+) display a higher expression of p21WAF1 gene, in both basal conditions and after treatment with doxorubicin or camptothecin. This phenomenon is accompanied by a lower susceptibility of Pro+ cells to undergo apoptosis, a lower capability to over cross G1-S transition and an increased propensity to express markers of cell senescence, with respect to fibroblasts from Arginine homozygotes (Pro-). All these phenomena are particularly evident in cells from centenarians. We conclude that the functional difference between the two p53 codon 72 alleles exerts a broad impact on the capability of cell from aged people to respond to stressors such as cytotoxic drugs.

Catalog

Books, media, physical & digital resources
See catalog results