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2. Different bleeding patterns with the use of levonorgestrel intrauterine system: are they associated with changes in uterine artery blood flow?

Author

Bastianelli, Carlo, Manuela, Farris, Stefania, Rapiti, Vecchio, Bruno R., BRUNO VECCHIO, ROBERTA COSTANZA, Vecchio, R. B., and Benagiano, Giuseppe

Subjects
lng ius, Adult, medicine.medical_specialty, Article Subject, Adolescent, Population, Uterus, lcsh:Medicine, Hemorrhage, Levonorgestrel, Endometrium, General Biochemistry, Genetics and Molecular Biology, Menstruation, Young Adult, medicine.artery, medicine, Humans, Longitudinal Studies, education, Uterine artery, Menorrhagia, Gynecology, education.field_of_study, General Immunology and Microbiology, business.industry, Genitourinary system, lcsh:R, Ultrasonography, Doppler, General Medicine, Blood flow, Middle Aged, Uterine Artery, abnormal uterine bleeding, medicine.anatomical_structure, Female, business, Blood Flow Velocity, medicine.drug, Intrauterine Devices, Research Article
Abstract

Objective. Evaluate if different bleeding patterns associated with the use of the levonorgestrel intrauterine system (LNG-IUS) are associated with different uterine and endometrial vascularization patterns, as evidenced by ultrasound power Doppler analysis.Methodology. A longitudinal study, with each subject acting as its own control was conducted between January 2010 and December 2012. Healthy volunteers with a history of heavy but cyclic and regular menstrual cycles were enrolled in the study. Ultrasonographic examination was performed before and after six months of LNG-IUS placement: uterine volume, endometrial thickness, and subendometrial and myometrial Doppler blood flow patterns have been evaluated.Results. A total of 32 women were enrolled out of 186 initially screened. At six months of follow-up, all subjects showed a reduction in menstrual blood loss; for analysis, they were retrospectively divided into 3 groups: normal cycling women (Group I), amenorrheic women (Group II), and women with prolonged bleedings (Group III). Intergroup analysis documented a statistically significant difference in endometrial thickness among the three groups; in addition, mean pulsatility index (PI) and resistance index (RI) in the spiral arteries were significantly lower in Group I and Group III compared to Group II. This difference persisted also when comparing—within subjects of Group III—mean PI and RI mean values before and after insertion.Conclusions. The LNG-IUS not only altered endometrial thickness, but—in women with prolonged bleedings—also significantly changed uterine artery blood flow. Further studies are needed to confirm these results and enable gynecologists to properly counsel women, improving initial continuation rates.

Published
2014

3. Impaired uterine artery flow associated with the presence of ovarian endometrioma: preliminary results of a prospective study

Author

Porpora, Maria Grazia, Tomao, Federica, Manganaro, Lucia, YAZDANIAN MASOULEH, Deliar, Fuggetta, Eliana, Piccioni, Maria Grazia, Panici, P. B., BENEDETTI PANICI, Pierluigi, and Benagiano, Giuseppe

Subjects
Laparoscopic surgery, Infertility, Adult, medicine.medical_specialty, Time Factors, Pregnancy Rate, medicine.medical_treatment, Endometriosis, Uterine artery flow, Young Adult, Ultrasounds, Color doppler, Pregnancy, medicine.artery, Obstetrics and Gynaecology, medicine, Humans, Ovarian Diseases, Prospective Studies, Resistance Index (RI), Ultrasonography, Doppler, Color, Prospective cohort study, Uterine artery, Gynecology, ultrasounds, resistance index (ri), uterine artery flow, color doppler, infertility, endometriosis, business.industry, Research, Female infertility, Obstetrics and Gynecology, Recovery of Function, Middle Aged, medicine.disease, Uterine Artery, Fertility, Treatment Outcome, Oncology, Regional Blood Flow, Case-Control Studies, Ovarian Endometriosis, Female, Laparoscopy, Vascular Resistance, business, Infertility, Female, Blood Flow Velocity
Abstract

Background: Aim of this prospective, case–control study was to evaluate uterine arteries’ blood flow before and after laparoscopic surgery in patients with ovarian endometriosis and its possible correlation with infertility. Methods: We prospectively enrolled 110 women of reproductive age; 69 with ovarian endometriomas and scheduled for surgery, and 41 controls. At enrolment, a detailed medical, gynecologic and obstetric history was collected. Fertility and pregnancy desire were assessed. All patients underwent complete physical and gynecologic examination. Transvaginal ultrasound with Doppler color flow was performed to evaluate Resistance Index (RI) of uterine arteries during the secretory phase, at enrolment (T0) and 3 months after laparoscopic surgery (T1). Results: Among cases, 27 patients were excluded because they did not meet the inclusion criteria. At enrolment (T0) unilateral or bilateral flow alterations (RI ≥ 0.8) were found in 38 out of 42 patients with ovarian endometriosis (90%), whereas in the control group only 17 women (41%) had Doppler alterations. The difference in uterine artery RI values between cases and controls was statistically significant (P < 0.0001). A statistically significant improvement in uterine artery flow (P

Published
2013

7. Hormones and Breast Cancer

Author

THE ESHRE CAPRI WORKSHOP GROUP COLLINS, J., Crosignani, P. G., Blamey, R., Diczfalusy, E., Heinemann, L. A. J., LA VECCHIA, C., Reeves, G., Smith, I. E., Trichopoulos, D., Arisi, E., Baird, D. T., Benagiano, Giuseppe, Frigerio, G. C., Glasier, A., SCHMIDT GOLLWITZER, K., Skouby, S. O., and Volpe, A.

Published
2004

8. Infertility in the third millennium: implications for the individual, family and society: Condensed Meeting Report from the Bertarelli Foundation’s Second Global Conference

Author

REPORT PREPARED BY, B. LUNENFELD AND A. VAN STEIRTEGHEM ON BEHALF OF ALL PARTICIPANTS LERIDON H., TE VELDE, E., Adashi, E., Germond, M., DE KRETSER, D., Edwards, R., Sundby, J., Brinsden, P., VAN LOOK, P., Collins, J., Korn, A., Habbema, D., Kovacs, G., Carr, E., Wennerholm, U. B., Bonduelle, M., Squires, J., PONJAERT KRISTOFFERSEN, I., Bryan, E., Ryan, S., Dill, S., Leke, R., ZEGERS HOCHSCHILD, F., Benagiano, Giuseppe, Kuhse, H., Diedrich, K., Steinbock, B., BERTARELLI SPTH, D., Lunenfeld, B., and VAN STEIRTEGHEM, A.

Published
2004

10. Hormonal contraception without estrogens

Author

Benagiano, Giuseppe, Bygdeman, M., Diczfalusy, E., Glasier, A., Lahteenmaki, P., LA VECCHIA, C., Oettel, M., Skouby, S., and Schmidt, J. E.

Published
2003

12. Physiopathological determinants of human infertility

Author

Crosignani, THE ESHRE CAPRI WORKSHOP GROUP J. COLLINS AND P. G., Baird, WITH D. T., Benagiano, Giuseppe, Cohen, J., Evers, L. H., Fraser, L., Jacobs, H., Liebaers, I., Tarlatzis, B., Templeton, A., and VAN STEIRTEGHEM, A.

Published
2002

18. Clinical Synthesis panel on HRT

Author

SCIENTIFIC ORGANIZING COMMITTEE BOYLE, P., Benagiano, Giuseppe, Horton, H., Radda, G., Sharp, D., and Walker, A. M.

Published
1999

21. HORMONE AND CARDIOVASCULAR DISEASES: ORAL CONTRACEPTIVES AND HORMONAL REPLACEMENT THERAPY: DIFFERENTIAL EFFECTS ON CORONARY HEART DISEASE, DEEP VENOUS THROMBOSIS AND STROKE

Author

Crosignani, THE ESHRE CAPRI WORKSHOP GROUP P. G., Rubin, B. L., Collins, J., Collins, P., LA VECCHIA, C., Mannucci, P. M., Mishell, D., Paoletti, R., Stevenson, J. C., Whitehead, M., Benagiano, Giuseppe, Diczfalusy, E., Elstein, M., Farley, T., Mancuso, S., Meschia, M., Rosano, G., and Heinemann, S. O. SKOUBY L. A. J.

Published
1998

25. INFERTILITY REVISITED: THE STATE OF THE ART TODAY AND TOMORROW

Author

Crosignani, P. G., Rubin, B., Acosta, A., Baird, D. T., Benagiano, Giuseppe, Cohen, J., Collins, J., Cooke, I., Diczfalusy, E., Diederich, K., Edwards, R. G., Farley, T., Filicori, M., Glasier, A., Hargreave, T., Jager, S., Mishell, D. R., Nieschlag, E., Ragni, G., Tarlatzis, B., VAN STEIRTEGHEM, A., Walters, E., and Westrm, L.

Published
1996

34. Salute to a giant ... Robert Geoffrey Edwards

Author

Ahuja, Kamal, Bennett, Fiona, Cohen, Jacques, Edwards, Ruth, Pritchard, Huw, Silver, Ann, Sirlin, Julio, Slee, John, Abse, Dannie, Ashwood-Smith, M. J., Bavister, Barry, Bedford, J. Michael, Beier, Henning M., Bronson, Richard, Cattanach, Bruce, Daniel, Joseph C., Dawes, Edwin A., Ferguson-Smith, Malcolm, Gardner, Richard, Griffin, Dave, Hunter, R. H. F., Johnson, Martin, Jones, Howard, Lunenfeld, Bruno, Mittwoch, Ursula, Moor, Robert, Rankin, Barbara, Schally, Andrew V., Sharpe, David J., Simpson, David, Yanagimachi, Ryuzo Yana, Alexandre, Henri, Bhargava, Pushpa M., Dexter, Alan, Diedrich, Klaus, Emperaire, Jean-Claude, Findlay, Alan, Fishel, Simon, Fox, Norma Lynn, Goddard, Hester, Gomel, Victor, Gore-Langton, Robert E., Gosden, Roger, Iritani, A., Koskimies, Aarne I., Macdonald, Grace, Menezo, Yves, Mettler, Liselotte, Monk, Marilyn, Mori, Takahide, Mortimer, David, Papaioannou, Virginia E., Racowsky, Catherine, Surani, Azim, Trounson, Alan, Blerkom, Jonathan, Vincent, Paul, Walters, Eurof, Webster, John, Williams, Peter, Aboulghar, M., Barri, Pedro N., Benagiano, Giuseppe, Blackwell, Caroline, Bolton, Virginia N., Brinsden, Peter R., Bustillo, Maria, Coulam, Carolyn, Chaouat, Gerard, Crosignani, Piergiorgio, Gardner, David, Gianaroli, Luca, Hamberger, Lars, Hartshorne, Geraldine, Hollands, Peter, Howles, Colin, Illmensee, Karl, Jauniaux, Eric, Kini, Dee, Lee, Sammy, Lees, Martin, Leese, Henry, Mathews, Thomas, Moate, Elaine, Nygren, Karl, Colin Ockleford, Palermo, Gianpiero D., Pandiyan, N., Rizk, Botros, Rosenwaks, Zev, Sallam, Hassan, Sathananthan, A. Henry, Saunders, Douglas M., Simpson, Joe Leigh, Sunde, Arne, Tan, Seang Lin, Ulloa-Aguirre, Alfredo, Gosden, Lucinda Veeck, Veiga, Anna, Albertini, David F., Alikani, Mina, Balaban, Basak, Thornhill, Alan, Beard, Helen K., Ben-Shlomo, Izhar, Borini, Andrea, Carrell, Douglas, Jonge, Christopher, Eichenlaub-Ritter, Ursula, Fleming, Steven, Geber, Selmo, Gerris, Jan, Golombok, Susan, Leather, Dame Suzi, Nagy, Zsolt Peter, Nielsen, H. Ingolf, Oehninger, Sergio, Olivennes, Francois, Patrizio, Pasquale, Paulson, Richard J., Polak Fried, Ester, Pool, Thomas B., Risquez, Francisco, Sauer, Mark V., Sciarra, John J., Basuray, Rita, Boiso, Irene, Bose, Chinmoy K., Cryan, Bob, Falconer, Anthony, Hansis, Christoph, Kahraman, Semra, Ko, Minoru S. H., Korsak, Vladislav, Loeffler, Frank, Ludwig, Michael, Magli, M. Cristina, Robertson, John A., Roche, Lady Alexandra, Thornhill, A., Wallberg-Henriksson, Harriet, Woo, George, and Ivf, Canada

35. Salute to a giant ... Robert Geoffrey Edwards

Author

Ahuja, Kamal, Bennett, Fiona, Cohen, Jacques, Edwards, Ruth, Pritchard, Huw, Silver, Ann, Sirlin, Julio, Slee, John, Abse, Dannie, Ashwood-Smith, M. J., Bavister, Barry, Bedford, J. Michael, Beier, Henning M., Bronson, Richard, Cattanach, Bruce, Daniel, Joseph C., Dawes, Edwin A., Ferguson-Smith, Malcolm, Gardner, Richard, Griffin, Dave, Hunter, R. H. F., Johnson, Martin, Jones, Howard, Lunenfeld, Bruno, Mittwoch, Ursula, Moor, Robert, Rankin, Barbara, Schally, Andrew V., Sharpe, David J., Simpson, David, Yanagimachi, Ryuzo Yana, Alexandre, Henri, Bhargava, Pushpa M., Dexter, Alan, Diedrich, Klaus, Emperaire, Jean-Claude, Findlay, Alan, Fishel, Simon, Fox, Norma Lynn, Goddard, Hester, Gomel, Victor, Gore-Langton, Robert E., Gosden, Roger, Iritani, A., Koskimies, Aarne I., Macdonald, Grace, Menezo, Yves, Mettler, Liselotte, Monk, Marilyn, Mori, Takahide, Mortimer, David, Papaioannou, Virginia E., Racowsky, Catherine, Surani, Azim, Trounson, Alan, Blerkom, Jonathan, Vincent, Paul, Walters, Eurof, Webster, John, Williams, Peter, Aboulghar, M., Barri, Pedro N., Benagiano, Giuseppe, Blackwell, Caroline, Bolton, Virginia N., Brinsden, Peter R., Bustillo, Maria, Coulam, Carolyn, Chaouat, Gerard, Crosignani, Piergiorgio, Gardner, David, Gianaroli, Luca, Hamberger, Lars, Hartshorne, Geraldine, Hollands, Peter, Howles, Colin, Illmensee, Karl, Jauniaux, Eric, Kini, Dee, Lee, Sammy, Lees, Martin, Leese, Henry, Mathews, Thomas, Moate, Elaine, Nygren, Karl, Ockleford, Colin, Palermo, Gianpiero D., Pandiyan, N., Rizk, Botros, Rosenwaks, Zev, Hossam El-Din Sallam, Sathananthan, A. Henry, Saunders, Douglas M., Simpson, Joe Leigh, Sunde, Arne, Tan, Seang Lin, Ulloa-Aguirre, Alfredo, Gosden, Lucinda Veeck, Veiga, Anna, Albertini, David F., Alikani, Mina, Balaban, Basak, Thornhill, Alan, Beard, Helen K., Ben-Shlomo, Izhar, Borini, Andrea, Carrell, Douglas, Jonge, Christopher, Eichenlaub-Ritter, Ursula, Fleming, Steven, Geber, Selmo, Gerris, Jan, Golombok, Susan, Leather, Dame Suzi, Nagy, Zsolt Peter, Nielsen, H. Ingolf, Oehninger, Sergio, Olivennes, Francois, Patrizio, Pasquale, Paulson, Richard J., Polak Fried, Ester, Pool, Thomas B., Risquez, Francisco, Sauer, Mark V., Sciarra, John J., Basuray, Rita, Boiso, Irene, Bose, Chinmoy K., Cryan, Bob, Falconer, Anthony, Hansis, Christoph, Kahraman, Semra, Ko, Minoru S. H., Korsak, Vladislav, Loeffler, Frank, Ludwig, Michael, Magli, M. Cristina, Robertson, John A., Roche, Lady Alexandra, Thornhill, A., Wallberg-Henriksson, Harriet, and Woo, George

37. An observational study of adherence to combined oral contraceptive regimens

Author

Carlo Bastianelli, Roberta Costanza Bruno Vecchio, Elena Rosato, Giuseppe Benagiano, Manuela Farris, Maurizio Guida, Bastianelli, Carlo, Farris, Manuela, Bruno Vecchio Roberta, Costanza, Rosato, Elena, Guida, Maurizio, and Benagiano, Giuseppe

Subjects
Adult, medicine.medical_specialty, Evening, Adolescent, Endocrinology, Diabetes and Metabolism, Research methodology, Population, adherence, contraception, missed pills, oral contraceptives, patient compliance, Medication Adherence, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, oral contraceptive, Internal medicine, medicine, Humans, 030212 general & internal medicine, education, Gynecology, education.field_of_study, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics and Gynecology, Middle Aged, Regimen, Contraceptives, Oral, Combined, Family planning, Pill, missed pill, Observational study, Female, business, Developed country, Follow-Up Studies
Abstract

To analyze adherence to an oral contraceptive (OC) regimen and correlate results to participants' socio-demographic and behavioral characteristics.Women were prospectively enrolled and followed for 6 months. At enrollment, subjects were given a card for recording daily pill intake; its completion was checked at 6 months when women completed a self-administered questionnaire.Out of 755 eligible subjects, 704 agreed to participate; 402 women completed 6 months of recording of use of an OC and properly filled the questionnaire. Good adherence was reported by 64% of participants; 20.9% missed one pill and 14.9% missed more than one pill. Mean number of missed pills per subject was 0.59 and mean number of pills delayed for less than 24 h was 1.18. Best adherence to a COC regimen was associated with evening time intake (p = 0.0019). No statistically significant associations of adherence with socio-demographic characteristics were found. Age was only marginally associated with having missed at least one pill.In the present study, a lower number of missed pills were observed than previously reported, but the proportion of missed pills was similar. No association with specific subject characteristics that could serve as markers of increased risk of nonadherence was found.

Published
2016

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