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Supplemental material, sj-docx-1-acr-10.1177_02841851231187065 for Left atrium volume and ventricular volume ratio algorithm as indication of pulmonary hypertension etiology by Yoav Granot, Tomer Ziv-Baran, Shlomo Berliner, Yan Topilsky and Galit Aviram in Acta Radiologica

Additional file 1. Tables S1���S6.

Supplemental material, sj-pdf-1-lup-10.1177_0961203320947805 for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage by Ehud Chorin, Aviram Hochstadt, Uri Arad, Eihab Ghantous, Smadar Gertel, David Levartovsky, Irena Litinsky, Ofir Elaluof, Ari Polachek, Ilana Kaufman, Valerie Aloush, Sara Borok, Irena Wigler, Jonathan Wollman, Dan Caspi, Michal Laufer-Perl, Sevan Letourneau-Shesaf, Shlomo Berliner, Ori Elkayam, Yan Topilsky and Daphna Paran in Lupus

Supplemental material, sj-pdf-1-lup-10.1177_0961203320947805 for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage by Ehud Chorin, Aviram Hochstadt, Uri Arad, Eihab Ghantous, Smadar Gertel, David Levartovsky, Irena Litinsky, Ofir Elaluof, Ari Polachek, Ilana Kaufman, Valerie Aloush, Sara Borok, Irena Wigler, Jonathan Wollman, Dan Caspi, Michal Laufer-Perl, Sevan Letourneau-Shesaf, Shlomo Berliner, Ori Elkayam, Yan Topilsky and Daphna Paran in Lupus

Supplemental material, sj-pdf-2-lup-10.1177_0961203320947805 for Soluble ST2 and CXCL-10 may serve as biomarkers of subclinical diastolic dysfunction in SLE and correlate with disease activity and damage by Ehud Chorin, Aviram Hochstadt, Uri Arad, Eihab Ghantous, Smadar Gertel, David Levartovsky, Irena Litinsky, Ofir Elaluof, Ari Polachek, Ilana Kaufman, Valerie Aloush, Sara Borok, Irena Wigler, Jonathan Wollman, Dan Caspi, Michal Laufer-Perl, Sevan Letourneau-Shesaf, Shlomo Berliner, Ori Elkayam, Yan Topilsky and Daphna Paran in Lupus

Table S1. Multivariate Regression to Predict hs-cTnT Detection Status (>â 5â ng/L) in Men and Women. (DOCX 19 kb)

Background specific heart rate parameters notably associate with variable risks of cardiovascular disease and mortality, however, to date there are no readily available blood tests associated with these parameters. Because of the established parasympathetic contributions towards cardiac regulation, we challenged the working hypothesis that serum acetylcholinesterase (AChE) activity is involved. Methods A total of 403 Healthy men and women were included in the study and underwent treadmill exercise testing. Prior to exercise testing the subject’s serum AChE activity levels were assessed by measuring rates of acetylthiocholine hydrolysis. Results In male subjects AChE activity was positively correlated to resting heart rate (r = 0.210, p = 0.001). Complementing this observation, AChE activity was negatively correlated to the exercise-induced heart rate increase (r = –0.181, p = 0.005) and to heart rate recovery at 1, 2 and 5 minutes following cessation of exercise (r = –0.150, p = 0.022; r = –0.157, p = 0.016; r = –0.176, p = 0.008 respectively). This indicated that lower than average AChE activities, which presumably reflect increased peripheral ACh levels, might be correlated to favorable heart rate parameters. Similar observations were made in female subjects, except for lack of correlation to their resting heart rate. Additionally, we observed that we were able to stratify subjects into two groups of significantly different AChE activity (p = 0.001) based on a cut point of heart rate recovery below 20 beats one minute after cessation of exercise. Conclusion In asymptomatic individuals lower than average AChE activity is associated with favorable indices of exercise-inducible heart rate increase as well as heart rate recovery. Future studies will be needed to evaluate the added prognostic significance gained by implementing this marker into routine practice.

Supplementary material, approximately 80 KB.