1. Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma
- Author
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François Radvanyi, Dominique Chopin, Audrey Riou, Alexandre de la Taille, Billebaud T, Eric Fontaine, Sixtina Gil Diez de Medina, Ashraf Bakkar, Y Iwatsubo, Mathilde Sibony, Claude C. Abbou, Soizick Chamming's, Yves Allory, Françoise Conso, Bernard Gattegno, Karen Leroy, Nathalie Khreich, Pascale Maillé, Vincent Ravery, Pascal Andujar, Jean-Claude Pairon, and Dimitrios Vordos
- Subjects
Oncology ,0303 health sciences ,Cancer Research ,medicine.medical_specialty ,Bladder Urothelial Carcinoma ,Pah exposure ,Biology ,Occupational safety and health ,3. Good health ,Toxicology ,03 medical and health sciences ,0302 clinical medicine ,Increased risk ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Neoplasm staging ,Occupational exposure ,Molecular Biology ,Allele frequency ,030304 developmental biology ,Urothelial carcinoma - Abstract
Occupational exposure to polycyclic aromatic hydrocarbons (PAH) is associated with an increased risk of urothelial carcinoma (UC). FGFR3 is found mutated in about 70% of Ta tumors, which represent the major group at diagnosis. The influence of PAH on FGFR3 mutations and whether it is related to the emergence or shaping of these mutations is not yet known. We investigated the influence of occupational PAH on the frequency and spectrum of FGFR3 mutations. We included on 170 primary urothelial tumors from five hospitals from France. Patients (median age, 64 yr) were interviewed to gather data on occupational exposure to PAH, revealing 104 non- and possibly PAH exposed patients, 66 probably and definitely exposed patients. Tumors were classified as follows: 75 pTa, 52 pT1, and 43 > or =pT2. Tumor grades were as follows: 6 low malignant potential neoplasms (LMPN) and 41 low-grade and 123 high-grade carcinomas. The SnaPshot method was used to screen for the following FGFR3 mutations: R248C, S249C, G372C, Y375C, A393E, K652E, K652Q, K652M, and K652T. Occupational PAH exposure was not associated with a particular stage or grade of tumors. Thirty-nine percent of the tumors harbored FGFR3 mutations. After adjustment for smoking, occupational exposure to PAH did not influence the frequency [OR, 1.10; 95% CI, 0.78-1.52], or spectrum of FGFR3 mutations. Occupational exposure to PAH influenced neither the frequency nor the spectrum of FGFR3 mutations and there was no direct relationship between these mutations and this occupational hazard.
- Published
- 2009