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Purpose [18F]-2-Fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT) is a sensitive and quantitative technic for detecting inflammatory process. Glucose uptake is correlated with an increased anaerobic glycolysis seen in activated inflammatory cells such as monocytes, lymphocytes, and granulocytes. The aim of the study was to assess the inflammatory status at the presumed peak of the inflammatory phase in non-critically ill patients requiring admission for COVID-19. Methods Patients admitted with COVID-19 were prospectively enrolled. FDG PET/CT was performed from day 6 to day 14 of the onset of symptoms. Depending on FDG PET/CT findings, patients’ profiles were classified as “inflammatory” or “low inflammatory.” FDG PET/CT data were compared with chest CT evolution and short-term clinical outcome. All inflammatory sites were reported to screen potential extra-pulmonary tropism. Results Thirteen patients were included. Maximum standardized uptake values ranged from 4.7 to 16.3 in lungs. All patients demonstrated increased mediastinal lymph nodes glucose uptake. Three patients (23%) presented mild nasopharyngeal, two patients (15%) bone marrow, and five patients (38%) splenic mild increase in glucose uptake. No patient had significant digestive focal or segmental glucose uptake. There was no significant physiological myocardial glucose uptake in all patients except one. There was no correlation between PET lung inflammatory status and chest CT evolution or short-term clinical outcome. Conclusion Inflammatory process at the presumed peak of the inflammatory phase in COVID-19 patients is obvious in FDG PET/CT scans. Glucose uptake is heterogeneous and typically focused on lungs. Trial registration NCT04441489. Registered 22 June 2020 (retrospectively registered). Electronic supplementary material The online version of this article (10.1007/s00259-020-04968-8) contains supplementary material, which is available to authorized users.

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder involving sensory processing abnormalities. Alterations to the balance between excitation and inhibition (E/I ratio) are postulated to underlie behavioral phenotypes in ASD patients and mouse models. However, in primary visual cortex (V1) of wild type mice, the E/I ratio is not a fixed value, but rather oscillates across the 24h day. Therefore, we hypothesized that the E/I oscillation, rather than the overall E/I ratio, may be disrupted in ASD mouse models. To this end, we measured the E/I ratio in Fmr1 KO and BTBR mice, models of syndromic and idiopathic ASD, respectively. We found that the E/I ratio is dysregulated in both models, but in different ways: the oscillation is flattened in Fmr1 KO and phase-shifted in BTBR mice. These phenotypes cannot be explained by altered sleep timing, which was largely normal in both lines. Furthermore, we found that E/I dysregulation occurs due to alterations in both excitatory and inhibitory synaptic transmission in both models. These findings provide a crucial perspective on the E/I ratio in ASD, suggesting that ASD phenotypes may be produced by a mismatch of E/I to the appropriate behavioral state, rather than alterations to overall E/I levels per se.

At-sea behaviour of seabirds have received significant attention in ecology over the last decades as it is a key process in the ecology and fate of these populations. It is also, through the position of top predator that these species often occupy, a relevant and integrative indicator of the dynamics of the marine ecosystems they rely on. Seabird trajectories are recorded through the deployment of GPS, and a variety of statistical approaches have been tested to infer probable behaviours from these location data. Recently, deep learning tools have shown promising results for the segmentation and classification of animal behaviour from trajectory data. Yet, these approaches have not been widely used and investigation is still needed to identify optimal network architecture and to demonstrate their generalization properties. From a database of about 300 foraging trajectories derived from GPS data deployed simultaneously with pressure sensors for the identification of dives, this work has benchmarked deep neural network architectures trained in a supervised manner for the prediction of dives from trajectory data. It first confirms that deep learning allows better dive prediction than usual methods such as Hidden Markov Models. It also demonstrates the generalization properties of the trained networks for inferring dives distribution for seabirds from other colonies and ecosystems. In particular, convolutional networks trained on Peruvian boobies from a specific colony show great ability to predict dives of boobies from other colonies and from distinct ecosystems. We further investigate accross-species generalization using a transfer learning strategy known as ‘fine-tuning’. Starting from a convolutional network pre-trained on Guanay cormorant data reduced by two the size of the dataset needed to accurately predict dives in a tropical booby from Brazil. We believe that the networks trained in this study will provide relevant starting point for future fine-tuning works for seabird trajectory segmentation. To make easier such applications, we share online the different models we trained on the considered datasets (https://github.com/AmedeeRoy/BirdDL/models).Author SummaryOver the last decades, the use of miniaturized electronic devices enabled the tracking of many wide-ranging animal species. The deployment of GPS has notably informed on migratory, habitat and foraging strategies of numerous seabird species. A key challenge in movement ecology is to identify specific behavioural patterns (e.g. travelling, resting, foraging) through the observed movement data. In this work, we address the inference of seabird diving behaviour from GPS data using deep learning methods. We demonstrate the performance of deep networks to accurately identify movement patterns from GPS data over state-of-the-art tools, and we illustrate their great accross-species generalization properties (i.e. the ability to generalize prediction from one seabird species to aother). Our results further supports the relevance of deep learning schemes as ‘ready-to-use’ tools which could be used by ecologists to segmentate animal trajectories on new (small) datasets, including when these datasets do not include groundtruthed labelled data for a supervised training.

Developing countries in Africa are facing a great challenge related to the control of state employees. Their fragile economies do not always allow them to effectively meet the financial needs associated with the payment of salaries. A number of actions were taken in each of these countries to limit such expenses. These actions range from suspending recruitment into the public service, reducing the number of state employees and reducing salaries. Despite all these measures, these states are not always able to master their employees and the associated payroll. Actions relating to the computerization of human resource management systems within the public service have been undertaken in almost all these countries to overcome this difficulty. But at the end of the process, no tangible results have been achieved. Cameroon is one of those countries that is permanently making efforts to resolve this problem that is negatively impacting its development. To achieve this, the country is making a fourth attempt to tackle this issue by relying on information and communication technology. The aim of this paper is to understand why the actions undertaken so far have not provided a satisfactory solution. In this regard, an analysis is carried out in order to point out the reasons of these failures. A case study approach the methodology is used and the behavior human resources involved in these IT projects is analyzed. This analysis leads to the identification of the major causes that hinder the successful implementation of these ICT initiatives and also highlights some negative impacts in the use of ICT. Based on these limits, some recommendations are made to avoid failures in ICT initiative related to the mastering of state employees and the associated payroll.

An acute illness related to the scrotum is a common paediatric surgical emergency. Difficulty in ruling out testicular torsion means that scrotal exploration is often performed for other scrotal pathologies, including orchitis. The clinical course of orchitis is usually benign and long-term sequelae are rare. We describe two adolescent boys, previously vaccinated for mumps, whom had scrotal exploration for presumed testicular torsion. Both were found intraoperatively to have orchitis, and both subsequently developed testicular atrophy, within 2 months post-surgery. These cases demonstrate the rare, but potentially devastating, complication of testicular atrophy that may arise in non-mumps orchitis. The causative pathophysiology may involve some degree of testicular compartment syndrome and subsequent ischaemia. Patients must be made aware of the potential for this outcome and be advised on testicular self-examination after surgery.

Testicular atrophy (TA) is a significant complication in patients who undergo salvage procedures for testicular torsion. Studies on outcome focus on factors predicting testicular viability during scrotal exploration but few assess factors predicting TA in patients who undergo salvage procedures. We assess the incidence of TA after salvage and identify associated factors.With ethical approval, we reviewed patients who underwent salvage for testicular torsion in our institution from 2001 to 2013. Data was collected on patient demographics, duration of pain, sonographic findings, postoperative complications, and follow-up assessment of TA (defined as difference in testicular volume50% compared with the contralateral testis, based on measurement by Prader orchidometer or by ultrasound). We excluded patients with torted undescended testis, those under 1 month, and those with follow-up6 months. Chi-square or Mann-Whitney U tests were used as appropriate with significance level0.05.Of 85 patients who had scrotal exploration for testicular torsion, 53 had testicular salvage. Overall, 16 patients defaulted or had6 months follow-up, leaving 37 patients who were studied, median age 12 years (range, 0.5-16.0 years) at presentation. Median follow-up was 12.5 months (range, 6-88 months). A total of 20 patients (54%) developed TA. Median duration to TA was 12.5 months (range, 2-88 months). All had clinical evidence of atrophy by 14 months, except two who initially defaulted follow-up, but were diagnosed with TA at 35 and 88 months postoperatively when presenting with unrelated complaints. Factors associated with TA were duration of pain1 day (p = 0.004) and heterogeneous echogenicity on ultrasound (p = 0.001). Sonographic evidence of reduced vascularity was not predictive. Of 11 that had pain1 day, 10 (91%) had TA. No testes survived when pain ≥ 3 days.Half of patients with testicular torsion undergoing salvage surgery will develop testicular atrophy, even when intraoperatively assessed as viable, and should be counseled accordingly. Duration of pain1 day and sonographic heterogeneous echogenicity are predictive. Salvage rates are dismal when duration of symptoms exceeds 1 day.

This paper presents a comprehensive framework for the cooperative guidance of a fleet of autonomous vehicles, relying on Model Predictive Control (MPC). Solutions are provided for many common problems in cooperative control, namely collision and obstacle avoidance, formation flying and area exploration. Cost functions of the MPC strategy are defined to ensure a safe collaboration between the vehicles for these missions. An efficient way to select the optimal cost with limited computation time is also provided. The performance of the proposed approach is illustrated by simulation results., AerospaceLab Journal, Issue 8, December 2014; ISSN: 2107-6596

A fermionic supersymmetric extension is established for the Gauss-Weingarten and Gauss-Codazzi equations describing conformally parametrized surfaces immersed in a Grassmann superspace. An analysis of this extension is performed using a superspace-superfield formalism together with a supersymmetric version of a moving frame on a surface. In contrast with the bosonic supersymmetric extension, the equations of the fermionic supersymmetric Gauss-Codazzi model resemble the form of the classical equations. Next, a superalgebra of Lie point symmetries of these equations is determined and a classification of the one-dimensional subalgebras of this superalgebra into conjugacy classes is presented. The symmetry reduction method is used to obtain group-invariants, orbits and reduced systems for three chosen one-dimensional subalgebras. The explicit solutions of these reduced systems correspond to different surfaces immersed in a Grassmann superspace. Within this framework for the supersymmetric version of the Gauss-Codazzi equations a geometrical interpretation of the results is dicussed.

The Aegys Mi 600 Fourier transform-infrared milk analyzer was evaluated for performance in 8 independent laboratories in Europe, the United States, and Australia. This instrument, equipped with a mid-infrared source, a temperature-controlled transmission flow cell or cuvette, and detection device, uses interferometry for wavelength generation; multilinear regression was used to create calibration equations for measurement of fat, protein, lactose, and solids nonfat. Each instrument was tested independently for various performance criteria including but not limited to accuracy in calibration and validation, repeatability, and purge efficiency. Mean difference for accuracy and standard deviation of differences for accuracy observed in each laboratory were well within AOAC requirements (

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The creation of a paediatric surgical unit requires autoevaluation in order to: assess the quality of the results with respect to recognised international standards, answer the family's questions about the results obtained and adhere to criteria of accreditation Between January 2003 and December 2004, 201 consecutive patients, children (N= 164) or operated for adult congenital heart disease (N= 37) were treated. No patient was excluded. The RACHS-1 risk score, the ARISTOTLE scores of complexity and performance and the CUSUM and VLAD graphic analyses were applied to the study of hospital mortality. An original "variable performance-adjusted display" (VPAD) graphic analysis was performed to show up any possible variations of performance. Paediatric hospital survival was 97.56% (95% CI: 93.9 - 99.1). The paediatric complexity and performance scores were 6.79 +/- 0.22 and 6.62 respectively. In the absence of statistical significance in this field of autoevaluation, graphic analyses indicated the performance of our unit with no "learning" curves. Graphic scores and analyses allow assessment of the function of a paediatric cardiac surgical unit and the variations of complexity with respect to time, before the appearance of statistical significance. The ARISTOTLE complexity and performance scores and their adaptation in VPAD seem to be more reliable and discriminating than the RACHS-1 score.

We investigated an increase of human cases of Salmonella Enteritidis occurring from August until November 2010 in Belgium, Luxembourg and Germany involving an estimated three hundred laboratory confirmed cases. Molecular typing indicated that the increase in Luxembourg and Belgium was due a particular strain having phage type 14b, MLVA pattern 4-7-3-13-10-2-2 and fully susceptible to the Enternet panel of antibiotics. MLVA and phage typing were found to have similar discriminatory power on a collection of 40 Belgian and Luxembourg strains isolated during 2010. Epidemiological investigations in Luxembourg suggested eggs as a possible source for some cases, although supermarket eggs tested were negative. No other EU countries observed a substantial increase of cases, although three smaller outbreaks in Germany were also due to a strain with the same phage type and MLVA pattern. In 2010 the EU directive banning battery cages came into force in Germany followed by a dioxin food scare incident. Given that the EU Laying Hens Directive will come into force across all Member States in 2012, a closer monitoring of Salmonella contamination of imported eggs at retail and wholesale level is recommended.

Acetylcholine (ACh) has been recognized for a long time as a major neurotransmitter in the retina, however, little is known about the contribution of acetylcholine receptors in synaptic processing. Moreover, even less information is available concerning their role during development. To address this question further, we examined the physiological and pharmacological properties of neuronal nicotinic acetylcholine receptors (nAChRs) in retinal ganglion cells from embryonic (E) 12-18-day-old Leghorn chicks. Patch-clamp recordings in whole-cell configuration revealed that at E12 approximately 21% of the ganglion cells responded to acetylcholine pulses with inward currents. The number of responsive cells progressively increased to 57% at E15 to reach up to 15 positive cells out of 15 cells tested at E18. Acetylcholine-evoked responses could be subdivided, according to their time course, into fast and slowly desensitizing. Taking advantage of the selectivity of the frog toxin epibatidine (Epi), that preferentially activates heteromeric neuronal nicotinic acetylcholine receptors, we compared the currents evoked by this toxin vs. the effects of acetylcholine. A further characterization of the receptor diversity during development was to assess their sensitivity to the alpha-conotoxin MII (alpha-CTX-MII), which has been shown to preferentially block alpha6- and alpha3beta2-containing receptors. These data demonstrate that ganglion cells of the chick retina express multiple receptor subtypes that progressively develop as a function of retina maturation.