1. Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands
- Author
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Battilocchio, Claudio, Claudio, Baumann, Marcus, Baxendale, Ian, R., Biava, Mariangela, Kitching, Matthew O., Ley, Steven V., Martin, Rainer E., Ohnmacht, Stephan A., and Tappin, Nicholas D. C.
- Subjects
Chelidonic acid ,chemistry.chemical_compound ,Flow (mathematics) ,Chemistry ,Ligand ,Organic Chemistry ,Enantioselective synthesis ,Flow chemistry ,Combinatorial chemistry ,Catalysis ,Amine derivatives - Abstract
A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for immobilization through microencapsulation technologies. © Georg Thieme Verlag Stuttgart · New York.
- Published
- 2012
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