1. Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children
- Author
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Mack, David R, Saul, Bradley, Boyle, Brendan, Griffiths, Anne, Sauer, Cary, Markowitz, James, LeLeiko, Neal, Keljo, David, Rosh, Joel R, Baker, Susan S, Steiner, Steve, Heyman, Melvin B, Patel, Ashish S, Baldassano, Robert, Noe, Joshua, Rufo, Paul, Kugathasan, Subra, Walters, Thomas, Marquis, Alison, Thomas, Sonia M, Denson, Lee, Hyams, Jeffrey, and PROTECT STUDY GROUP
- Subjects
Male ,Pediatric ,Gastroenterology & Hepatology ,Inflammatory Bowel Disease ,classification tree analysis ,Ulcerative ,Colonoscopy ,Blood Sedimentation ,Colitis ,Severity of Illness Index ,Autoimmune Disease ,Medical and Health Sciences ,Oral and gastrointestinal ,PROTECT STUDY GROUP ,Leukocyte Count ,Clinical Research ,Humans ,Female ,laboratory values ,Child ,Digestive Diseases - Abstract
ObjectivesThe aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis.MethodsA cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize predictive ability of disease attributes based on clinical disease severity using Pediatric Ulcerative Colitis Activity Index (PUCAI), severe (65+) versus not severe (
- Published
- 2020