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1. List of Contributors

Author

Anthony Abdullah, Michael Abrouk, Tashmeeta Ahad, Imtiaz Ahmed, Anwar Al Hammadi, Caroline Allen, Amer Ali Almohssen, Wisam Alwan, Mahreen Ameen, Sadegh Amini, Bryan E. Anderson, Grant J. Anhalt, Donald J. Baker, Harini Rajgopal Bala, Julia Baltz, David Banach, Cedric C. Banfield, Robert Baran, Ajoy Bardhan, Melissa C. Barkham, Ysabel M. Bello, Emma Benton, Wilma F. Bergfeld, Eric Berkowitz, Brian Berman, Jeffrey D. Bernhard, Daniel Bernstein, John Berth-Jones, Chinmoy Bhate, Bhavnit K. Bhatia, Jonathan E. Blume, Nevianna Bordet, Catherine Borysiewicz, Gary J. Brauner, Robert T. Brodell, Marc D. Brown, Robert M. Burd, Anne E. Burdick, Niraj Butala, Jeffrey P. Callen, Ivan D. Camacho, Helena Camasmie, Daniel Caplivski, Mitchell S. Cappell, Genevieve A. Casey, Lawrence S. Chan, Loi-Yuen Chan, Jennifer K. Chen, Chen 'Mary' Chen, Nicole Yi Zhen Chiang, Anthony J. Chiaravalloti, Fiona J. Child, Anthony C. Chu, Timothy H. Clayton, Steven R. Cohen, Elizabeth A. Cooper, Susan M. Cooper, Nick Collier, Christina M. Correnti, Ian H. Coulson, M. Laurin Council, Shawn E. Cowper, Nicholas M. Craven, Daniel Creamer, Ponciano D. Cruz, Carrie Ann R. Cusack, Adam Daunton, Mark D.P. Davis, Robert S. Dawe, David P. D’Cruz, David de Berker, Danielle M. DeHoratius, Min Deng, Seemal R. Desai, Georgina Devlin, John J. DiGiovanna, Alexander Doctoroff, Roni P. Dodiuk-Gad, Dawn Z. Eichenfield, Lawrence F. Eichenfield, Drore Eisen, Ure Eke, Dirk M. Elston, Patrick O.M. Emanuel, Clinton W. Enos, Shaheen H. Ensanyat, Anna F. Falabella, Aaron S. Farberg, Lawrence S. Feigenbaum, Kristen Heins Fernandez, Nicole Fett, Andrew Y. Finlay, Bahar F. Firoz, Elnaz F. Firoz, James E. Fitzpatrick, Amy E. Flischel, Kelly A. Foley, Derek Freedman, Georgina A. Fremlin, Richard Fried, Philip Friedlander, Adam Friedman, Amy K. Forrestel, Brian S. Fuchs, Joanna E. Gach, Anjela Galan, Jaya Ganesh, Amit Garg, Lauren Geller, Carlo M. Gelmetti, Elizabeth Ghazi, Sneha Ghunawat, Leonard H. Goldberg, Mark J.D. Goodfield, Marsha L. Gordon, Asha Gowda, Daniel A. Grabell, Matthew Grant, Clive E.H. Grattan, Malcolm W. Greaves, Justin J. Green, Christopher E.M. Griffiths, Charles A. Gropper, Anna L. Grossberg, Aditya K. Gupta, Ali S. Hadi, Suhail M. Hadi, Iris A. Hagans, Bethany R. Hairston, Analisa Vincent Halpern, Caroline Halverstam, Natasha Harper, Matthew J. Harries, John Harris, Shannon Harrison, Michael M. Hatch, Adrian H.M. Heagerty, Adelaide A. Hebert, Stephen E. Helms, Camile L. Hexsel, Doris M. Hexsel, Warren R. Heymann, Elisabeth M. Higgins, Claire L. Higgins, Whitney A. High, Herbert Hönigsmann, Marcelo G. Horenstein, George J. Hruza, Andrea Hui, Ran Huo, Sally H. Ibbotson, Sherrif F. Ibrahim, Andrew Ilchyshyn, Dina Ismail, Stefania Jablonska, Heidi T. Jacobe, William D. James, Aysha Javed, Gregor B.E. Jemec, Graham A. Johnston, Stephen K. Jones, Jacqueline M. Junkins-Hopkins, Jessica Kaffenberger, Kelly R. Kane, Antonios Kanelleas, Ayşe Serap Karadağ, Laura Karas, Ruwani P. Katugampola, Bruce E. Katz, Roselyn Kellen, Murtaza Khan, Hooman Khorasani, Ellen J. Kim, Hee J. Kim, Brian Kirby, Joslyn S. Kirby, Rachel S. Klein, Kate Kleydman, Dimitra Koch, John J. Kohorst, John Y.M. Koo, Sandra A. Kopp, Neil J. Korman, Carrie Kovarik, Kenneth H. Kraemer, Bernice R. Krafchik, Karthik Krishnamurthy, Knut Kvernebo, Charlene Lam, Peter C. Lambert, James A.A. Langtry, Amir A. Larian, Cecilia A. Larocca, E. Frances Lawlor, Clifford M. Lawrence, Mark G. Lebwohl, Oscar Lebwohl, Julia S. Lehman, Tabi A. Leslie, Stuart R. Lessin, Jacob O. Levitt, Fiona M. Lewis, Maryam Liaqat, Kristina J. Liu, Michael P. Loosemore, Thomas A. Luger, Omar Lupi, Boris D. Lushniak, Calum C. Lyon, Andrea D. Maderal, Bassel H. Mahmoud, Slawomir Majewski, Richard B. Mallett, Steven M. Manders, Ranon Mann, Yasaman Mansouri, David J. Margolis, Orit Markowitz, Alexander Marsland, Agustin Martin-Clavijo, Daniela Martinez, Catalina Matiz, Marcus Maurer, Kevin McKerrow, Nekma Meah, Giuseppe Micali, Robert G. Micheletti, Leslie G. Millard, James E. Miller, Jillian W. Wong Millsop, Daniel Mimouni, Ginat W. Mirowski, Sultan A. Mirza, Sonja Molin, Adisbeth Morales-Burgos, Warwick L. Morison, Cato Mørk, Colin A. Morton, Richard J. Motley, Megan Mowbray, Eavan G. Muldoon, Anna E. Muncaster, George J. Murakawa, Jenny E. Murase, Michele E. Murdoch, Adam S. Nabatian, Mio Nakamura, Rajani Nalluri, Zeena Y. Nawas, Glen R. Needham, Glenn C. Newell, Julia Newton-Bishop, Adam V. Nguyen, Rosemary L. Nixon, Jack C. O’Brien, Stephanie Ogden, Suzanne M. Olbricht, Sally Jane O’Shea, Cindy E. Owen, Michael Pan, Lisa Pappas-Taffer, Jennifer L. Parish, Lawrence Charles Parish, Michael Payette, Gary L. Peck, Sandra Pena, Jarad Peranteau, Frederick A. Pereira, William Perkins, Clifford S. Perlis, Robert G. Phelps, Tania J. Phillips, Maureen B. Poh-Fitzpatrick, Miriam Keltz Pomeranz, Samantha R. Pop, Pierluigi Porcu, James B. Powell, Lori D. Prok, Tia M. Pyle, Surod Qazaz, Vikram Rajkomar, Rabia S. Rashid, Mehdi Rashighi, Ravi Ratnavel, Christie G. Regula, Michael Renzi, Jean Revuz, Rachel V. Reynolds, Elisabeth Richard, Gabriele Richard, Darrell S. Rigel, Wanda Sonia Robles, Megan Rogge, Alain H. Rook, Jamie R. Manning, Ted Rosen, Misha Rosenbach, David Rosenfeld, Christopher Rowland Payne, Adam I. Rubin, Courtney Rubin, Malcolm H.A. Rustin, Thomas Ruzicka, Sara Samimi, Lawrence A. Schachner, Noah Scheinfeld, Bethanee J. Schlosser, Rhonda E. Schnur, Robert A. Schwartz, Matthew J. Scorer, Bryan A. Selkin, Jamie Seymour, Christine M. Shaver, Christopher R. Shea, Neil H. Shear, Tang Ngee Shim, Hiroshi Shimizu, Julia Siegel, Elisha Singer, Maral Kibarian Skelsey, Chris Sladden, Michael Sladden, Janellen Smith, Joanne E. Smucker, Najwa Somani, Lacy L. Sommer, Mary Sommerlad, Christine Soon, Jennifer A. Sopkovich, Nicholas A. Soter, James M. Spencer, Richard C.D. Staughton, Jane C. Sterling, Cord Sunderkötter, Saleem M. Taibjee, Deborah Tamura, Eunice Tan, William Y-M. Tang, Lynsey Taylor, Bruce H. Thiers, Lucy J. Thomas, Cody R. Thornton, Anne-Marie Tobin, Rochelle R. Torgerson, Antonella Tosti, Fragkiski Tsatsou, Yukiko Tsuji-Abe, William F.G. Tucker, Stephen K. Tyring, Jeremy Udkoff, Robin H. Unger, Walter P. Unger, Sarah Utz, Martha C. Valbuena, Peter van de Kerkhof, Abby S. Van Voorhees, Ramya Vangipuram, David Veitch, Vanessa Venning, Sarah G. Versteeg, Martha Viera, Carmela C. Vittorio, Ruth Ann Vleugels, Gorav N. Wali, Joanna Wallengren, Joy Wan, Karolyn A. Wanat, Gabriele Weichert, Anja K. Weidmann, Jeffrey M. Weinberg, Victoria P. Werth, Lucile E. White, Adam H. Wiener, Jonathan K. Wilkin, Nathaniel K. Wilkin, Jason Williams, Niall Wilson, Karen Wiss, Joseph A. Witkowski, Lauren E. Wiznia, Henry K. Wong, Junie Li Chun Wong, Andrew L. Wright, Cooper C. Wriston, Benedict C. Wu, Adam Wulkan, Andrea L. Zaenglein, Irshad Zaki, Joshua A. Zeichner, Tian Hao Zhu, John J. Zone, Christos C. Zouboulis, and Torstein Zuberbeir

Published
2018
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3. DFPE, PARTIALLY FLUORINATED ETHER

Author

Nigel Simpson, Janet R. Sparrow, Rodrigo A. V. Santos, Stanley Chang, Brian S. Fuchs, Marcos Pereira de Ávila, Brian J. Song, and David J. Keegan

Subjects
Male, genetic structures, Endotamponade, Cataract, Retina, chemistry.chemical_compound, Retinal Diseases, Vitrectomy, Lens, Crystalline, Electroretinography, Animals, Silicone Oils, Medicine, Outer nuclear layer, medicine.diagnostic_test, business.industry, Retinal, General Medicine, Intravitreal tamponade, eye diseases, Vitreous Body, Drug Combinations, Ophthalmology, medicine.anatomical_structure, chemistry, Anesthesia, Intravitreal Injections, Fluorinated ether, Rabbits, sense organs, Tamponade, Posterior subcapsular cataract, business, Ethers
Abstract

To evaluate decafluoro-di-n-pentyl ether (DFPE) as a vitreous tamponade by examining ocular tolerance in rabbits' eyes.Thirteen rabbits were divided into 4 groups after mechanical vitrectomy and were followed up to 12 months. The tamponade remained in the eye for 6 months in group 1 (DFPE) and Group 3 (DFPE and silicone oil) and for 12 months in group 2 (DFPE). Group 4 served as control.In groups 1, 2, and 3, dispersion of the fluid appeared 2 weeks postoperatively. Posterior subcapsular cataracts appeared in rabbits' eyes with large fills of DFPE (50%). Histologic findings in groups 1 and 2 showed no detectable change in outer nuclear layer thickness. Except for some vacuolations, the inner retina was well preserved in all injected rabbits' eyes. On the electroretinography of injected rabbits' eyes, there was no effect on the a wave amplitude and b wave implicit time, but the b wave amplitude was elevated with statistical significance (P0.001) at 1, 3, and 6 months postoperatively but with no statistical significance (P0.05) after that period when compared with group 4 and unoperated fellow rabbits' eyes of each group.Decafluoro-di-n-pentyl ether demonstrated minimum adverse effects in retinal rabbits; further studies are needed before clinical use as short-term tamponade.

Published
2013
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4. Clinical Documentation

Author

Amanda Focht, Brian S. Fuchs, and Gloria J. Rodriguez

Subjects
Documentation, medicine, Medical emergency, Psychology, medicine.disease
Published
2016
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5. Use of High-Frequency, High-Resolution Ultrasound Before Mohs Surgery

Author

Giselle Singer, Eric Z. Berkowitz, Brian S. Fuchs, Jane Y. Yoo, and Ellen S. Marmur

Subjects
Male, medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, High resolution, Dermatology, Cohort Studies, Predictive Value of Tests, Mohs surgery, medicine, Humans, Neoplasm Staging, Ultrasonography, business.industry, Ultrasound, Reproducibility of Results, High resolution ultrasound, General Medicine, Mohs Surgery, Surgery, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Ultrasound imaging, Female, Neoplasm staging, Radiology, business
Abstract

Although ultrasound imaging is employed ubiquitously today, its use to examine and assess the skin is a relatively new technology. We explored the clinical application and use of high-frequency, high-resolution ultrasound in Mohs micrographic surgery.To evaluate the ability of ultrasound to accurately determine lesion length and width of tumor borders in order to reduce the number of surgical stages.This was an institutional review board-approved single-center study of 26 Mohs surgery patients. Ultrasound images were taken to record lesion dimensions, and then the investigator documented clinical estimation of the first stage. Extirpation of the tumor and histological analysis were performed thereafter.The results of 20 patients were included in the analysis. A paired-samples t-test revealed no significant difference between clinical and ultrasound widths (t=-1.324, p=.20). Similarly, there was no significant difference between the lengths found from clinical assessment and ultrasound (t=-1.093, p=.29). For different tumor types, there was no significant difference between clinical and ultrasound widths or lengths for basal cell carcinoma (t=-1.307, p=.23; t=-1.389, p=.20) or squamous cell cancer (t=-0.342, p=.73; t=0.427, p=.68). CONCLUSION There is a diagnostic role for high-resolution ultrasound in Mohs surgery regarding the delineation of surgical margins, but its limitations preclude its practical adoption at this time.

Published
2010
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6. Non-vascular vision loss in pseudoxanthoma elasticum

Author

Chai Lin Chou, Stanley Chang, Irena Tsui, Stephen H. Tsang, and Brian S. Fuchs

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, Eye disease, Vision Disorders, Visual Acuity, Article, Vision disorder, Physiology (medical), Ophthalmology, Electroretinography, medicine, Humans, Fluorescein Angiography, Pseudoxanthoma Elasticum, Pigment Epithelium of Eye, Aged, Retinal pigment epithelium, medicine.diagnostic_test, business.industry, Pseudoxanthoma elasticum, medicine.disease, Fluorescein angiography, eye diseases, Sensory Systems, Angioid streaks, medicine.anatomical_structure, Maculopathy, Angioid Streaks, Female, sense organs, Atrophy, medicine.symptom, business
Abstract

Pseudoxanthoma elasticum patients with angioid streaks are well-known to have acute vision loss due to choroidal bleeding. However, chronic vision loss due to macular atrophy is less well characterized. We describe a patient with sub-acute vision loss in one eye due to loss of macular retinal pigment epithelium function. Autofluorescence and pattern electroretinogram were useful adjuncts to help diagnose the source of her vision loss.

Published
2007
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7. Diagnostic Dilemma: Crusted Scabies Superimposed on Psoriatic Erythroderma in a Patient With Acquired Immunodeficiency Syndrome

Author

Allen N. Sapadin, Donald Rudikoff, Robert G. Phelps, and Brian S. Fuchs

Subjects
Male, Insecticides, medicine.medical_specialty, Erythema, Administration, Oral, Erythroderma, Sarcoptes scabiei, Administration, Cutaneous, Acitretin, Diagnosis, Differential, Scabies, Keratolytic Agents, Ivermectin, Antiretroviral Therapy, Highly Active, medicine, Animals, Humans, Permethrin, Psoriatic erythroderma, Acquired Immunodeficiency Syndrome, Scalp, biology, business.industry, Extremities, General Medicine, Middle Aged, biology.organism_classification, medicine.disease, Trunk, Dermatology, Surgery, medicine.anatomical_structure, Nails, Face, medicine.symptom, business, Dermatitis, Exfoliative, medicine.drug
Abstract

A 45-year-old man with AIDS presented with extensive erythema and scaling involving the face, trunk, and upper and lower extremities, and mild nail dystrophy. The patient had been diagnosed with psoriasis 2 years previously, and at the time of presentation was using emollients and topical corticosteroid creams with little improvement. He was receiving zidovudine, lamivudine, trimethoprim/sulfamethoxazole, acyclovir, rifabutin, and hydroxyzine. Pertinent laboratory data included CD4 lymphocytes (10 cells/mm(3)), viral load (32,000 copies per mL) white blood cell count (3.4 x 10(3)/microL), hemoglobin (13.5 g/dL), and platelets (204 x 10(3)/microL). Because of the extensive eruption and lack of response to topical agents, the patient was started on acitretin 25 mg daily. The patient had shown no signs of improvement 4 weeks later and was noted to have brownish gray crusted plaques involving the beard area, neck, upper part of the back, arms, trunk, genitals, and thighs in addition to his erythroderma (Figure 1 and Figure 2). Microscopic examination of scales from the upper part of the back revealed numerous scabies mites and eggs. He was then treated with lindane shampoo on the scalp and beard area and permethrin 5% cream to the body. The patient returned 2 weeks later with some improvement after thrice-weekly applications of this regimen; however, scrapings from the trunk once again revealed live scabies mites. Microscopic examination of scales that had fallen on the examination table revealed multiple mites and eggs. The patient was then given permethrin 5% cream, which he applied 3 times a week for 2 weeks, and 1 dose of oral ivermectin, 200 micro/kg. This resulted in a marked decrease in crusting and scaling. With resolution of the scabies lesions, the patient displayed marked erythema and scaling of the trunk and extremities consistent with generalized psoriasis (Figure 3). Treatment with acitretin resulted in gradual resolution of the erythroderma. A few months later, the patient presented with nodules on the upper part of the back, which on biopsy revealed a scabies mite (Figure 4).

Published
2007
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9. Use of etanercept in the treatment of psoriasis and psoriatic arthritis

Author

Suhail Hadi and Brian S. Fuchs

Subjects
musculoskeletal diseases, medicine.medical_specialty, Injections, Subcutaneous, Recombinant Fusion Proteins, Receptors, Tumor Necrosis Factor, Proinflammatory cytokine, Etanercept, Psoriatic arthritis, Psoriasis, medicine, Humans, skin and connective tissue diseases, Randomized Controlled Trials as Topic, Pharmacology, Ankylosing spondylitis, business.industry, Tumor Necrosis Factor-alpha, Arthritis, Psoriatic, General Medicine, medicine.disease, Dermatology, Treatment Outcome, Rheumatoid arthritis, Immunoglobulin G, Tumor necrosis factor alpha, business, Juvenile rheumatoid arthritis, medicine.drug
Abstract

Psoriasis and psoriatic arthritis are debilitating inflammatory immunemediated diseases which are chronic in nature and often require lifelong attention. Traditional therapies used to combat these diseases lack sufficient long-term efficacy and are associated with a number of toxicities. Failing to adequately satisfy both patients and physicians, traditional therapies have proven insufficient and have left few options. Etanercept is a tumor necrosis factor (TNF) antagonist that reduces elevated TNF levels by competitively binding to both TNF-alpha and TNF-beta and inhibiting the proinflammatory cascade. Providing a valuable treatment option alone, etanercept can also be effectively administered in conjunction with traditional treatments. Etanercept is self administered by subcutaneous (SC) injection, making treatment less of a burden for patients by eliminating the need for frequent office visits and laboratory testing. Etanercept is approved in the US for the treatment of psoriasis, psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, and ankylosing spondylitis.

Published
2008

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