1. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
- Author
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Dehn, Jason, Spellman, Stephen, Hurley, Carolyn K, Shaw, Bronwen E, Barker, Juliet N, Burns, Linda J, Confer, Dennis L, Eapen, Mary, Fernandez-Vina, Marcelo, Hartzman, Robert, Maiers, Martin, Marino, Susana R, Mueller, Carlheinz, Perales, Miguel-Angel, Rajalingam, Raja, and Pidala, Joseph
- Subjects
Adult ,Clinical Sciences ,Immunology ,Graft vs Host Disease ,Cardiorespiratory Medicine and Haematology ,Regenerative Medicine ,Donor Selection ,Paediatrics and Reproductive Medicine ,5.4 Surgery ,Humans ,Registries ,Transplantation ,5.2 Cellular and gene therapies ,Histocompatibility Testing ,Prevention ,Inflammatory and immune system ,Hematopoietic Stem Cell Transplantation ,Infant ,Hematology ,Fetal Blood ,Newborn ,Stem Cell Research ,surgical procedures, operative ,Cord Blood Stem Cell Transplantation ,Development of treatments and therapeutic interventions ,Unrelated Donors - Abstract
Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution donor-recipient HLA match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatibility Advisory Group, provide evidence-based guidelines for optimal selection of unrelated donors and cord blood units.
- Published
- 2019