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This project deals with the realization of Mathematical Modeling and simulation in MATLAB of Differential Protection in Two-Winding Power Transformers, the same one that will be part of the Salesian Polytechnic University, Guayaquil headquarters; will have the objective of simulating the operating conditions of the protection equipment (SEL 587) found in a Substation, obtaining the equation that governs the differential protection operations of said relay, by theoretically analyzing the system conditions, both under normal conditions and for any fault event (external fault, internal fault) on the primary and / or secondary side of the transformer, facilitating students who are in the last cycles of the Electrical Engineering career, learning the concepts and principles of operation of System protections Electric Power. Este proyecto trata sobre la realización del Modelado Matemático y simulación en MATLAB de Protección Diferencial en Transformadores de Potencia de Dos Devanados, el mismo que formará parte de la Universidad Politécnica Salesiana, sede Guayaquil; tendrá como objetivo simular las condiciones de operación de los equipos de protección (SEL 587) que se encuentran en una Subestación, obteniendo la ecuación que rige las operaciones de protección diferencial de dicho relé, mediante el análisis teórico de las condiciones del sistema, tanto en condiciones normales como ante cualquier falla. evento (falla externa, falla interna) en el lado primario y/o secundario del transformador, facilitando a los estudiantes que se encuentran en los últimos ciclos de la carrera de Ingeniería Eléctrica, el aprendizaje de los conceptos y principios de funcionamiento de las protecciones del Sistema de Energía Eléctrica.

Supplementary_File-AD-5-17-18 for The strategic value of advertising expenditures in the tourism and hospitality industry by Rui Qi, David A Cárdenas, Xichen Mou, and Simon Hudson in Tourism Economics

19 p.-6 fig. In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline and induce transgenerational epigenetic disorders. The anti-androgenic compound vinclozolin represents a paradigmatic example of molecule causing transgenerational effects on germ cells. We performed prenatal exposure to vinclozolin in mice and analyzed the phenotypic and molecular changes in three successive generations. A reduction in the number of embryonic PGCs and increased rate of apoptotic cells along with decrease of fertility rate in adult males were observed in F1 to F3 generations. Blimp1 is a crucial regulator of PGC differentiation. We show that prenatal exposure to vinclozolin deregulates specific microRNAs in PGCs, such as miR-23b and miR-21, inducing disequilibrium in the Lin28/let-7/Blimp1 pathway in three successive generations of males. As determined by global maps of cytosine methylation, we found no evidence for prominent changes in DNA methylation in PGCs or mature sperm. Our data suggest that embryonic exposure to environmental endocrine disruptors induces transgenerational epigenetic deregulation of expression of microRNAs affecting key regulatory pathways of germ cells differentiation. We thank M. Quesada, O. Barcón and M. Moreno for caring for the animals. We also acknowledged the support from "EpiGeneSys European Network of Excellence".