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Background Despite the causal relationship between obesity and colon cancer being firmly established, the effect of obesity on the course of cancer calls for further elucidation. The objective was to assess differences in clinical-pathological and psychosocial variables between obese and nonobese individuals with colon cancer. Materials and Methods This was a prospective, multicentric, observational study conducted from 2015-2018. The sample comprised patients with stage II-III, resected colon cancer about to initiate adjuvant chemotherapy with fluoropyrimidine in monotherapy or associated with oxaliplatin and grouped into nonobese (body mass index = 30 kg/m(2)). Subjects completed questionnaires appraising quality of life (European Organization for Research and Treatment of Cancer Quality of Life Core questionnaire), coping (Mini-Mental Adjustment to Cancer), psychological distress (Brief Symptom Inventory 18), perceived social support (Multidimensional Scale of Perceived Social Support), personality (Big Five Inventory 10), and pain (Brief Pain Inventory). Toxicity, chemotherapy compliance, 12-month recurrence, and mortality rate data were recorded. Results Seventy-nine of the 402 individuals recruited (19.7%) were obese. Obese subjects exhibited more comorbidities (>= 2 comorbidities, 46.8% vs. 30.3%, p = .001) and expressed feeling slightly more postoperative pain (small size-effect). There was more depression, greater helplessness, less perceived social support from friends, and greater extraversion among the obese versus nonobese subjects (all p < .04). The nonobese group treated with fluoropyrimidine and oxaliplatin suffered more grade 3-4 hematological toxicity (p = .035), whereas the obese had higher rates of treatment withdrawal (17.7% vs. 7.7%, p = .033) and more recurrences (10.1% vs. 3.7%, p = .025). No differences in sociodemographic, quality of life, or 12-month survival variables were detected. Conclusion Obesity appears to affect how people confront cancer, as well as their tolerance to oncological treatment and relapse. Implications for Practice Obesity is a causal factor and affects prognosis in colorectal cancer. Obese patients displayed more comorbidities, more pain after cancer surgery, worse coping, and more depression and perceived less social support than nonobese patients. Severe hematological toxicity was more frequent among nonobese patients, whereas rates of withdrawal from adjuvant chemotherapy were higher in the obese cohort, and during follow-up, obese patients presented greater 12-month recurrence rates. With the growing and maintained increase of obesity and he cancers associated with it, including colorectal cancer, the approach to these more fragile cases that have a worse prognosis must be adapted to improve outcomes.

[ES] La Formación Escucha, situada en la Rama Oriental de la Cordillera Ibérica, constituye la unica unidad litoestratigráfica terrígena dentro de la sedimentación carbonatada de finales del Cretácico inferior Esta unidad se depositó en un sistema de deltaestuario que evoluciona verticalmente a un sistema deltaico dominado por el medio fluvial. Desde el punto de vista palinológico la llanura deltaica inferior se caracteriza por la abundancia de Classopollis y una pequeña proporción de cistes de Dinoficeas. En la llanura deltaica superior el predominio corresponde a las Esporas, los Classopollis han reducido su porcentaje y las Dinoficeas han prácticamente desaparecido. El dominio de las esporas Pteridofitas y la abundancia de Schizaeaccae indicaría un clima húmedo, de cálido a subtropical, con pequeños enclaves más áridos en los que sc desarrollaban las Cheirolepidiaceae. El análisis palinológico de 11 muestras procedentes de las Cubetas de Utrillas y Olíete, ha proporcionado un conjunto de 113 taxones, siendo de destacar la presencia de Angiospermas tricolpadas. La comparación con otras áreas del Maestrazgo, anteriormente estudiadas, así como la baja proporción de Angiospermas tricolpadas confirman una edad Albiense inferior-medio para la Formación Escucha., [EN] The Escucha Fm., situated in the eastern branch of the Iberian Range, constitutes the only terrigenous lithostratigraphic unit in the carbonate sedimentation at the end of the Early Cretaceous. This unit was formed in a delta-estuary system, which evolved vertically to a fluvial dominated delta system. From the palynological view point, the lower delta plain is characterized by the abundance of Cíassopollis and a small quantity of Dinoflagellate cysts. In the upper delta plain the spores predominate, the Ciassopollis baving decreased in number and the Dinoflagellate cyst having practically disappeared. The predominance of the Pteridopbytae spores and abundanee of Schizaeaceae suggest a humid climate, warm to subtropical, with small areas that are more arid where thc Cheirolepidiaceae developed. The palynological analysis of the 11 samples produced 113 taxons with the notable presence of tricolpate Angiospermae. Comparison with other arcas of the Maestrat Basin, studied previously, and the low number of tricolpate Angiospermae confirm a lower-middle Albian age for the Escucha Fm.