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An anti-CD30 antibody-drug conjugate incorporating the antimitotic agent DM1 and a stable SMCC linker, anti-CD30-MCC-DM1, was generated as a new antitumor drug candidate for CD30-positive hematological malignancies. Here, the in vitro and in vivo pharmacologic activities of anti-CD30-MCC-DM1 (also known as F0002-ADC) were evaluated and compared with ADCETRIS (brentuximab vedotin). Pharmacokinetics (PK) and the safety profiles in cynomolgus monkeys were assessed. Anti-CD30-MCC-DM1 was effective in in vitro cell death assays using CD30-positive lymphoma cell lines. We studied the properties of anti-CD30-MCC-DM1, including binding, internalization, drug release and actions. Unlike ADCETRIS, anti-CD30-MCC-DM1 did not cause a bystander effect in this study. In vivo, anti-CD30-MCC-DM1 was found to be capable of inducing tumor regression in subcutaneous inoculation of Karpas 299 (anaplastic large cell lymphoma), HH (cutaneous T-cell lymphoma) and L428 (Hodgkin’s disease) cell models. The half-lives of 4 mg/kg and 12 mg/kg anti-CD30-MCC-DM1 were about 5 days in cynomolgus monkeys, and the tolerated dose was 30 mg/kg in non-human primates, supporting the tolerance of anti-CD30-MCC-DM1 in humans. These results suggest that anti-CD30-MCC-DM1 presents efficacy, safety and PK profiles that support its use as a valuable treatment for CD30-positive hematological malignancies.

To observe the therapeutic effects of acupuncture and cupping for hiccup in cases of cerebrovascular accident.80 cases of hiccup due to cerebrovascular accident were randomly divided into the treatment group of 40 cases treated by acupuncture and cupping and the control group of 40 cases treated with Ritaline.In the treatment group, 24 cases were cured, 8 cases markedly effective, 5 cases improved, and 3 cases failed, with a total effective rate of 92.5%. In the control group, 9 cases were cured, 12 cases markedly effective, 8 cases improved, and 11 cases failed, with a total effective rate of 72.5%. There was a statistically significant difference in the therapeutic effects between the two groups (mu = 3.3259, P = 0.0009).The effect of acupuncture and cupping for hiccup due to cerebrovascular accident was noticeably superior to Ritaline.

Thirty-six cases of cholelithiasis were treated by acupuncture at the Back-Shu and Front-Mu points plus oral decoction. The total effective rate was 97.2%, and the cured plus markedly effective rate was 83.3%, which were much better than those of 83.3% and 52.8% in the control group of 36 cases treated with oral decoction alone. The statistical differences between the two groups were respectively P0.05 and P0.01.

A bench-scale anaerobic–anoxic–oxic (A2O) bioreactor with steady denitrifying phosphorus removal performance was tested to determine the influence of influent C/N ratio (SCOD/TN) and C/P ratio (SCOD/TP) on biological nutrient removal for treating synthetic brewage wastewater; meanwhile, the spatial profiles of DO, pH and ORP sensors in such systems were investigated. The results showed that influent C/N ratio had significant effect on the TN, TP removal efficiencies and the ratio of anoxic to aerobic P uptake amount. The maximal TN and TP removal efficiencies could be achieved when influent C/N ratio was kept at about 7.1 and 5, respectively. Besides, the ratio of anoxic to aerobic P uptake amount was found to be linearly dependent on the influent C/N ratio with coefficient R2 of 0.685 when total recirculation ratio was constant at 3.5. Influent C/P ratio had an important effect on the TP removal efficiency, while it hardly affected TN removal efficiency. In addition, the TP removal efficiency reached the maximum for influent C/P ratio of 42. On the other hand, it was also found that the typical profiles of DO, pH and ORP sensors could be observed, and they have similar trends at the different influent C/N ratio and C/P ratio. It was suggested that the operational state could be well known according to the changes of simple on-line sensors.

Transmission errors and contact pattern have determinative effects on the meshing performances of a gear drive,so a new approach for designing pinion surface of spiral bevel gears is proposed,based on a predesigned parabolic function of transmission errors with limited magnitude of maximal transmission errors and a predesigned linear function of contact path.This approach is based on three meshing points.By controlling their magnitudes of transmission errors and the positions on the tooth surface,the whole process control of engagement quality is realized.In addition,in order to meet different manufacturing reguirements,the value of work offset,one of the pinion machine tool settings,can also be assigned in advance with little influence on transmission performance.The developed approach is illustrated with numerical example.The proposed ideas are proven by the manufacturing and test of a pair of spiral bevel gears.

Transmission errors and contact pattern have de- terminative effects on the gearing performances of a gear drive, so a new approach for design of spiral bevel gears is proposed, based on a predesigned parabolic function of transmission er- rors with limited magnitude of maximal transmission errors and a predesigned linear function of contact path.This approach is based on three meshing points.By controlling their magnitudes of transmission errors and the positions on the tooth surface,the allover control of engagement quality is realized.The advan- tages of the function-oriented active tooth surface design are the reduction of level of noise and the obtaining of favorable shape and dimensions of contact pattern,and moreover,the gearing performance in whole tooth contact could be controlled directly in design.The goals are achieved by application of local syn- thesis algorithm,local conjugate theory and machining princi- ple of spiral bevel gears.Function-oriented active tooth surface design provides an innovative desiring approach for the spiral bevel gears and is quite important for the gears in high speed, heavy duty or with special requirements.