1. Ionic liquid catalyzed solvent-free synthesis of chalcone and its derivatives under mild conditions
- Author
-
Fei Xu, Fuxia Liao, Gang Wang, Cao Yijun, Qiu Zhao, Yifan Sha, Zengxi Li, and Chunshan Li
- Subjects
Chalcone ,Reaction mechanism ,Environmental Engineering ,Solvent free ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Biochemistry ,Medicinal chemistry ,Catalysis ,chemistry.chemical_compound ,020401 chemical engineering ,chemistry ,Aldol reaction ,Yield (chemistry) ,Ionic liquid ,0204 chemical engineering ,0210 nano-technology ,Selectivity - Abstract
An ionic liquid (IL) catalyzed solvent-free process was developed for the direct synthesis of chalcone and its derivatives by using substituted acetophenones and benzaldehydes via aldol reaction under mild conditions. A series of acidic and basic ILs were selected and screened. The influences of cations and reaction conditions on product yield and selectivity were systematically investigated. The [Bmim]OH was identified as the optimal IL, with the highest yield and selectivity reaching up to 96.7% and 100%, respectively. A reaction mechanism-based kinetic model was established and regressed with experimental data, revealing the β-Hydroxylketone dehydrolysis with activation barrier of 37.8 kJ·mol−1 was observed as the rate-controlling step.
- Published
- 2021