1. Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma
- Author
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Romain Lazor, Hasna Bouchaab, Daniel E. Speiser, Timothy Murray, Petra Baumgaertner, Olivier Michielin, Laurène Cagnon, Emanuela Romano, Samia Abed-Maillard, Nathalie Rufer, Carla-Marisa Costa-Nunes, Philippe O. Gannon, Natacha Bordry, and Igor Letovanec
- Subjects
Adult ,Male ,Cancer Research ,Immunology ,Autoimmunity ,Disease ,Cancer Vaccines ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Lymphocytes, Tumor-Infiltrating ,Sarcoidosis, Pulmonary ,Antigens, Neoplasm ,medicine ,Humans ,Neoplasm Metastasis ,Melanoma ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Brain Neoplasms ,Cancer ,Lymphomatoid Granulomatosis ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,3. Good health ,Vaccination ,CpG site ,030220 oncology & carcinogenesis ,Positron-Emission Tomography ,biology.protein ,medicine.symptom ,Antibody ,business ,Tomography, X-Ray Computed ,CD8 - Abstract
Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint–targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid–like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including one lesion in the brain, the patient is alive and well more than 13 years after the diagnosis of metastatic disease. The strongly activated tumor-specific CD8+ T cells showed robust long-term memory and effector functions. It is possible that long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as were present in this patient. Cancer Immunol Res; 2(12); 1148–53. ©2014 AACR.
- Published
- 2014