8 results on '"Cavallaro, Tiziana"'
Search Results
2. Relationship between clinical examination, Quality of Life, disability and depression in CMT patients: Italian Multicenter study
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Padua, L, Aprile, I, Cavallaro, Tiziana, Commodari, I, Pareyson, D, Quattrone, A, Rizzuto, Nicolo', Vita, G, Tonali, P, Schenone, A, Italian CMT QoL Study Group, Fabrizi, Gian Maria, and among study collaborators
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Adult ,Male ,Charcot-Marie-Tooth ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Neurology ,Adolescent ,Clinical examination ,Physical examination ,Dermatology ,Neuropsychological Tests ,Outcome measures ,Disability Evaluation ,Quality of life ,Charcot-Marie-Tooth Disease ,Predictive Value of Tests ,Activities of Daily Living ,medicine ,Humans ,Peripheral Nerves ,Child ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Neurologic Examination ,Depressive Disorder ,Disability ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,humanities ,nervous system diseases ,Settore MED/26 - NEUROLOGIA ,Psychiatry and Mental health ,Italy ,Multicenter study ,Sensation Disorders ,Quality of Life ,Physical therapy ,Female ,Neurology (clinical) ,Neurosurgery ,business - Abstract
To assess which are the clinical examination tests that are more related to quality of life (QoL), depression, and disability in CMT patients.Large prospective multicenter study through the use of validated clinical, disability, and QoL measurements. Correlations between clinical pattern and disability/QoL and depression were studied.Departments of Neurology.211 CMT patients (60% females, mean age 42.5 years).None.Sensory function was related to both mental and physical aspects of patient's QoL. Ability to walk on toes and heels was related to physical aspects of QoL/disability but also to bodily pain. Strength of forearm/hand intrinsic muscles was related to disability and physical aspects of QoL.Some clinical tests may be better outcome measures than others because they are related to aspects of life highly relevant to the patients. This information may be useful in clinical practice and in clinical trials to infer the patient's QoL.
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- 2008
3. Cytoskeletal pathology in ataxia-telangiectasia
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Monaco, Salvatore, Nardelli, E., Moretto, G., Cavallaro, Tiziana, and Rizzuto, Nicolo'
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Adult ,Cerebral Cortex ,Male ,neuropathology ,ataxia ,Intermediate Filaments ,Antibodies, Monoclonal ,Brain ,Cytoplasmic Granules ,Immunohistochemistry ,Ataxia Telangiectasia ,Spinal Cord ,Cerebellum ,Humans ,telangiectasia ,Cytoskeleton ,Brain Stem - Abstract
Neuropathological features of a case of ataxia-telangiectasia are reported. The main findings were the presence of Lewy bodies, cytoplasmic inclusions and axonal spheroids in the brainstem nuclei; pathological changes of spinal cord closely resembled those reported in the familial form of amyotrophic lateral sclerosis. In immunocytochemical studies, filamentous inclusions and axonal spheroids strongly reacted with monoclonal antibodies against neurofilament subunits. The results show that disorganization and accumulation of neurofilament proteins occur in ataxia-telangiectasia.
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- 1988
4. NERVE ULTRASOUND FINDINGS IN A COHORT OF PATIENTS WITH MPZ-RELATED CHARCOT-MARIE-TOOTH NEUROPATHIES
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Zanette, G., Stefano Tamburin, Cavallaro, Tiziana, Cabrini, Ilaria, Taioli, Federica, and Fabrizi, Gian Maria
5. A novel pathogenic mutation in RAB7A associated with predominantly motor CMT2B: Phenotypic and functional characterization
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Paola Saveri, Luca, Maria, Nisi, Veronica, Pisciotta, Chiara, Piscosquito, Giuseppe, Reilly, Mary, Polke, James, Cavallaro, Tiziana, Fabrizi, Gian Maria, Lombardi, Raffaella, Caravello, Francesca, Pinter, Giuseppe Lauria, Magri, Stefania, Taroni, Franco, Bucci, Cecilia, and Pareyson, Davide
6. Anxiety and depression in Charcot-Marie-Tooth disease: data from the Italian CMT national registry
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Marta, Bellofatto, Alessandro, Bertini, Irene, Tramacere, Fiore, Manganelli, Gian Maria, Fabrizi, Angelo, Schenone, Lucio, Santoro, Tiziana, Cavallaro, Marina, Grandis, Stefano C, Previtali, Isabella, Allegri, Luca, Padua, Costanza, Pazzaglia, Daniela, Calabrese, Paola, Saveri, Aldo, Quattrone, Paola, Valentino, Stefano, Tozza, Luca, Gentile, Massimo, Russo, Anna, Mazzeo, Giuseppe, Vita, Sylvie, Piacentini, Chiara, Pisciotta, Davide, Pareyson, Maria, Longo, Bellofatto, Marta, Bertini, Alessandro, Tramacere, Irene, Manganelli, Fiore, Fabrizi, Gian Maria, Schenone, Angelo, Santoro, Lucio, Cavallaro, Tiziana, Grandis, Marina, Previtali, Stefano C, Allegri, Isabella, Padua, Luca, Pazzaglia, Costanza, Calabrese, Daniela, Saveri, Paola, Quattrone, Aldo, Valentino, Paola, Tozza, Stefano, Gentile, Luca, Russo, Massimo, Mazzeo, Anna, Vita, Giuseppe, Piacentini, Sylvie, Pisciotta, Chiara, and Pareyson, Davide
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Peripheral neuropathies ,HADS ,Depression ,HMSN (Charcot-Marie-Tooth) ,Anxiety ,Antidepressive Agents ,Neurology ,Anti-Anxiety Agents ,Italy ,Charcot-Marie-Tooth Disease ,Humans ,Female ,Neurology (clinical) ,Registries - Abstract
Background There is little information about neuropsychiatric comorbidities in Charcot-Marie-Tooth disease (CMT). We assessed frequency of anxiety, depression, and general distress in CMT. Methods We administered online the Hospital Anxiety-Depression Scale (HADS) to CMT patients of the Italian registry and controls. HADS-A and HADS-D scores ≥ 11 defined the presence of anxiety/depression and HADS total score (HADS-T) ≥ 22 of general distress. We analysed correlation with disease severity and clinical characteristics, use of anxiolytics/antidepressants and analgesic/anti-inflammatory drugs. Results We collected data from 252 CMT patients (137 females) and 56 controls. CMT patient scores for anxiety (mean ± standard deviation, 6.7 ± 4.8), depression (4.5 ± 4.0), and general distress (11.5 ± 8.1) did not differ from controls and the Italian population. However, compared to controls, the percentages of subjects with depression (10% vs 2%) and general distress (14% vs 4%) were significantly higher in CMT patients. We found no association between HADS scores and disease duration or CMT type. Patients with general distress showed more severe disease and higher rate of positive sensory symptoms. Depressed patients also had more severe disease. Nineteen percent of CMT patients took antidepressants/anxiolytics (12% daily) and 70% analgesic/anti-inflammatory drugs. Patients with anxiety, depression, and distress reported higher consumption of anxiolytics/antidepressants. About 50% of patients with depression and/or general distress did not receive any specific pharmacological treatment. Conclusions An appreciable proportion of CMT patients shows general distress and depression. Both correlated with disease severity and consumption of antidepressants/anxiolytics, suggesting that the disease itself is contributing to general distress and depression.
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- 2022
7. Clinical and pathological findings in neurolymphomatosis: Preliminary association with gene expression profiles in sural nerves
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Federica Cerri, Francesco Gentile, Ferdinando Clarelli, Silvia Santoro, Yuri Matteo Falzone, Giorgia Dina, Alessandro Romano, Teuta Domi, Laura Pozzi, Raffaella Fazio, Paola Podini, Melissa Sorosina, Paola Carrera, Federica Esposito, Nilo Riva, Chiara Briani, Tiziana Cavallaro, Massimo Filippi, Angelo Quattrini, Cerri, Federica, Gentile, Francesco, Clarelli, Ferdinando, Santoro, Silvia, Falzone, Yuri Matteo, Dina, Giorgia, Romano, Alessandro, Domi, Teuta, Pozzi, Laura, Fazio, Raffaella, Podini, Paola, Sorosina, Melissa, Carrera, Paola, Esposito, Federica, Riva, Nilo, Briani, Chiara, Cavallaro, Tiziana, Filippi, Massimo, and Quattrini, Angelo
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Cancer Research ,Oncology - Abstract
Although inflammation appears to play a role in neurolymphomatosis (NL), the mechanisms leading to degeneration in the peripheral nervous system are poorly understood. The purpose of this exploratory study was to identify molecular pathways underlying NL pathogenesis, combining clinical and neuropathological investigation with gene expression (GE) studies. We characterized the clinical and pathological features of eight patients with NL. We further analysed GE changes in sural nerve biopsies obtained from a subgroup of NL patients (n=3) and thirteen patients with inflammatory neuropathies as neuropathic controls. Based on the neuropathic symptoms and signs, NL patients were classified into three forms of neuropathy: chronic symmetrical sensorimotor polyneuropathy (SMPN, n=3), multiple mononeuropathy (MN, n=4) and acute motor-sensory axonal neuropathy (AMSAN, n=1). Predominantly diffuse malignant cells infiltration of epineurium was present in chronic SMPN, whereas endoneurial perivascular cells invasion was observed in MN. In contrast, diffuse endoneurium malignant cells localization occurred in AMSAN. We identified alterations in the expression of 1266 genes, with 115 up-regulated and 1151 down-regulated genes, which were mainly associated with ribosomal proteins (RP) and olfactory receptors (OR) signaling pathways, respectively. Among the top up-regulated genes were actin alpha 1 skeletal muscle (ACTA1) and desmin (DES). Similarly, in NL nerves ACTA1, DES and several RPs were highly expressed, associated with endothelial cells and pericytes abnormalities. Peripheral nerve involvement may be due to conversion towards a more aggressive phenotype, potentially explaining the poor prognosis. The candidate genes reported in this study may be a source of clinical biomarkers for NL.
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- 2022
8. Huffer’s neuropathy: A case of acute-onset tetraparesis mimicking Guillain-Barré syndrome
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Paolo Manganotti, Valentina Tommasini, Marta Cheli, Mauro Catalan, Giulia Mazzon, Mariana Ridolfi, Massimo Bovenzi, Tiziana Cavallaro, Salvatore Monaco, Lucia Antonutti, Tommasini, Valentina, Catalan, Mauro, Antonutti, Lucia, Mazzon, Giulia, Cheli, Marta, Ridolfi, Mariana, Cavallaro, Tiziana, Monaco, Salvatore, Bovenzi, Massimo, and Manganotti, Paolo
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Pediatrics ,medicine.medical_specialty ,solvents ,GBS ,nerve biopsy ,Guillain-Barre syndrome ,business.industry ,Tetraparesis ,medicine.disease ,solvent ,Acute onset ,Neurology ,Huffer ,medicine ,Neurology (clinical) ,business - Abstract
We herein report an unusual case of a 40-year-old woman presenting to the emergency department with acute-onset tetraparesis due to inhalation of chemical solvents containing n-hexane. The clinical picture, a mild albumin-cytologic dissociation and the demyelinating features on nerve conduction study initially mimicked the presentation of Guillain-Barré syndrome (GBS), but the patient failed to respond to intravenous immunoglobulin treatment and plasma exchange. Diagnosis of hexane-induced neuropathy was then confirmed by means of sural nerve biopsy, showing axonal enlargement with secondary retraction and thinning of the myelin sheath.
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- 2021
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