1. Prevalence of human papillomavirus genotypes in high‐grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States
- Author
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Brenda Y. Hernandez, Troy D. Querec, Trevor D. Thompson, Jacqueline M. Mix, Edward S. Peters, Marc T. Goodman, Glenn Copeland, Elizabeth R. Unger, Mona Saraiya, Thomas C. Tucker, April Greek, and Charles F. Lynch more...
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Oncology ,Cancer Research ,medicine.medical_specialty ,Invasive cervical cancer ,Genotype ,Cervical precancer ,Population ,Uterine Cervical Neoplasms ,Article ,Internal medicine ,Prevalence ,Humans ,Medicine ,Papillomavirus Vaccines ,Registries ,Human papillomavirus ,education ,Cervical cancer ,Human papillomavirus 16 ,education.field_of_study ,business.industry ,Papillomavirus Infections ,virus diseases ,Cancer ,medicine.disease ,Vaccine introduction ,United States ,female genital diseases and pregnancy complications ,Female ,business - Abstract
Background US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability. Methods Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. HPV testing was performed using L1 consensus polymerase chain reaction analysis. HPV-type-specific prevalence was examined grouped by hierarchical attribution to vaccine types: HPV 16, 18, HPV 31, 33, 45, 52, 58, other oncogenic HPV types, and other types/HPV negative. Generalized logit models were used to compare HPV prevalence in the prevaccine study to the postvaccine study by patient age, adjusting for sampling factors. Results A total of 676 precancers (328 prevaccine and 348 postvaccine) and 1140 invasive cervical cancers (777 prevaccine and 363 postvaccine) were typed. No differences were observed in HPV-type prevalence by patient age between the 2 studies among precancers or invasive cancers. Conclusions The lack of reduction in vaccine-type prevalence between the 2 studies is likely explained by the low number of cases and low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies will continue to be important in evaluating the impact of the HPV vaccine. more...
- Published
- 2021
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