1. The trans-omics landscape of COVID-19
- Author
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Wu, Peng, Chen, Dongsheng, Ding, Wencheng, Wu, Ping, Hou, Hongyan, Bai, Yong, Zhou, Yuwen, Li, Kezhen, Xiang, Shunian, Liu, Panhong, Ju, Jia, Guo, Ensong, Liu, Jia, Yang, Bin, Fan, Junpeng, He, Liang, Sun, Ziyong, Feng, Ling, Wang, Jian, Wu, Tangchun, Wang, Hao, Cheng, Jin, Xing, Hui, Meng, Yifan, Li, Yongsheng, Zhang, Yuanliang, Luo, Hongbo, Xie, Gang, Lan, Xianmei, Tao, Ye, Li, Jiafeng, Yuan, Hao, Huang, Kang, Sun, Wan, Qian, Xiaobo, Li, Zhichao, Huang, Mingxi, Ding, Peiwen, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Wang, Shiyou, Zhu, Jiacheng, Ding, Xiangning, Chai, Chaochao, Liang, Langchao, Wang, Xiaoling, Luo, Lihua, Sun, Yuzhe, Yang, Ying, Zhuang, Zhenkun, Li, Tao, Tian, Lei, Zhang, Shaoqiao, Zhu, Linnan, Chang, Ashley, Chen, Lei, Wu, Yiquan, Ma, Xiaoyan, Chen, Fang, Ren, Yan, Xu, Xun, Liu, Siqi, Yang, Huanming, Wang, Lin, Sun, Chaoyang, Ma, Ding, Jin, Xin, Chen, Gang, Bai, Yong [0000-0001-5960-8000], Li, Kezhen [0000-0001-7943-5389], Liu, Panhong [0000-0003-4568-3119], Guo, Ensong [0000-0002-7388-4324], Yang, Bin [0000-0002-6218-2773], Fan, Junpeng [0000-0002-9413-408X], Sun, Wan [0000-0002-0347-2519], Wang, Shiyou [0000-0003-1901-3920], Yang, Ying [0000-0003-4843-1689], Ren, Yan [0000-0002-4007-8625], Xu, Xun [0000-0002-5338-5173], Liu, Siqi [0000-0001-9744-3681], Sun, Chaoyang [0000-0003-2469-1638], and Apollo - University of Cambridge Repository
- Subjects
38/43 ,631/553/1833 ,631/250/255/2514 ,38/23 ,631/250/2502 ,article ,631/250/2499 ,38/91 - Abstract
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.
- Published
- 2021