1. Measles seroprevalence in Chiradzulu district, Malawi: Implications for evaluating vaccine coverage
- Author
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Jonathan A. Polonsky, Northan Hurtado, Aitana Juan-Giner, Charlie Masiku, Matthew Kagoli, and Rebecca F. Grais
- Subjects
Adult ,Male ,Malawi ,medicine.medical_specialty ,Adolescent ,Measles Vaccine ,Measles ,Odds ,Young Adult ,Seroepidemiologic Studies ,Immunology and Microbiology(all) ,Epidemiology ,medicine ,Humans ,Seroprevalence ,Child ,Aged ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Vaccination ,Public Health, Environmental and Occupational Health ,HIV ,Infant ,Odds ratio ,Middle Aged ,medicine.disease ,veterinary(all) ,Drug Utilization ,Confidence interval ,Infectious Diseases ,Immunization ,Child, Preschool ,Immunology ,Molecular Medicine ,Female ,business ,Demography - Abstract
IntroductionSelf-reported measles vaccination coverage is frequently used to inform vaccination strategies in resource-poor settings. However, little is known to what extent this is a reliable indicator of underlying seroprotection, information that could provide guidance ensuring the success of measles control and elimination strategies.MethodsAs part of a study exploring HIV infection and measles susceptibility, we conveniently sampled consenting HIV-uninfected patients presenting at the HIV voluntary counselling and testing centre, and HIV-infected patients presenting for regular care, in Chiradzulu district hospital, Malawi, between January and September 2012.ResultsA total of 2106 participants were recruited between January and September 2012, three quarters of whom were HIV positive. Vaccination cards were available for just 7 participants (0.36%). 91.9% of participants were measles seropositive.Older age (OR=1.11 per year increase in age; 95%CI: 1.09–1.14) and being female (OR=1.90; 95%CI: 1.26–2.87) were both associated with significantly increased odds for seroprotection. Prior vaccination history was associated with lower odds (Odds Ratio (OR)=0.44; 95% confidence interval (CI): 0.22–0.85) for confirmed seropositivity. Previous measles infection was not significantly associated with seroprotection (OR=1.31; 95%CI: 0.49–3.51).Protection by history and serological status were concordant for 64.3% of participants
- Published
- 2015