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Background: Cutaneous mixed tumors (CMTs) include benign, atypical, and malignant chondroid syringomas. This spectrum of entities is known to be a part of myoepithelial neoplasms, which display considerable genetic heterogeneity. In a previous report, a malignant chondroid syringoma (MCS) demonstrated PHF1-TFE3 gene fusion and strong TFE3 immunohistochemical (IHC) staining. The authors suggested that the MCS is genetically related to tumors with TFE3 rearrangements such as renal cell carcinoma and might have genetic heterogeneity. In this study, we aim to investigate potential TFE3 gene fusions with TFE3 IHC stain in a spectrum of CMTs. Materials: Eleven benign chondroid syringoma (BCS), one atypical chondroid syringoma (ACS), and one malignant chondroid syringoma cases were identified, stained with TFE3 IHC stain, and interpreted based on preset criteria. Results: ACS and MCS cases did not show any staining. In 7 of 11 BCS cases, weak (1+) staining was observed in less than 20% of the tumor cells and were considered negative. Additionally, in one BCS case, weak (1+) and (2+) staining was shown in approximately 15% and less than 1% of the tumor cells, respectively. Based on our positivity criteria, this case was also interpreted as negative. Conclusions: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.

Purpose: Chondroid syringoma of the skin is a rare subcutaneous tumor and localization in the eyelid and orbital region that has rarely been described. We report a case of chondroid syringoma that involved the sub-brow region and was accompanied by hair loss. Case summary: A 57-year-old women presented with a mass on the lateral side of the left sub-brow region which was observed 25 years earlier. The mass, which recurred 2 months after surgery at another hospital through a skin incision was accompanied by an itching sensation. The mass was not tender or ulcerated but was reddish with superficial blood vessels and had a smooth surface with hair loss at the site of the mass. The mass showed high signal intensity on a T2-weighted magnetic resonance image and a round echogenic nodule with an irregular hypoechoic portion was observed on ultrasonography. A full-thickness excision including the adjacent normal tissue of the sub-brow mass and direct closure were subsequently performed. The pathological diagnosis was chondroid syringoma which was revealed as numerous tubular structures with various lumens in a collagenous stroma. Mucinous and fibrous findings were also observed. No recurrence was detected during the first 2 years after surgery. Conclusions: Chondroid syringoma in the eyelid and sub-brow region is uncommon. Complete resection is required to differentiate it from a malignancy and reduce the possibility of recurrence. Incomplete resection or capsular rupture during removal of the tumor could induce recurrence or a malignant change in the tumor.

Chondroid syringoma - also known as mixed tumor of the skin - is a benign skin tumor often occurring in the head and neck region, that usually presents as a slow growing well-defined swelling in adults, with occasional commitment of the lips. The aim of this study was to report an illustrative case of chondroid syringoma in the lower lip of a 43-year-old male patient from Brazil. Physical examination revealed an asymptomatic hardened swelling of normal coloration, measuring 3.0 cm, located at the transition between the skin and semi-mucosa of the lower lip. Under the clinical hypothesis of a salivary gland tumor, an excisional biopsy was performed under local anesthesia. After histopathologic examination the final diagnosis was of chondroid syringoma of the lower lip. There is no evidence of recurrence one year after surgical procedure. Clinicians should consider chondroid syringoma when evaluating well-defined swellings of the lower lip.

Chondroid syringoma is a rare skin appendageal tumor which is most commonly encountered in the head and neck region We herein report an unusual case of a benign chondroid syringoma of the left foot in a year old female which posed as a diagnostic conundrum The approach to such a case differential diagnosis and the management of this rare entity is also presented

Siringoma condroide ou tumor misto da pele é um tipo de tumor benigno, raro e que caracteristicamente se manifesta com crescimento lento, de apresentação subcutânea, em pessoas de meia idade (predileção pelo sexo masculino). Geralmente, localiza-se em região couro cabeludo, face e nariz. Neste artigo, relata-se um caso de uma lesão na região de lobo de orelha esquerda.

Chondroid syringoma of the skin is a rare, benign skin adnexal tumor, usually exhibited as a slowly growing intradermal or subcutaneous nodule, typically located in the head-and-neck region. Chondroid syringoma usually appears on the face; medial canthus being a rare site of predilection. The diagnosis is usually made retrospectively based on histological features of the surgically excised mass which is usually asymptomatic. We present a rare case of a 35-year-old man who presented with a painless, subcutaneous nodule in the medial canthus of the right eye. The diagnosis of chondroid syringoma was rendered. To the best of our knowledge, only one case of chondroid syringoma of the medial canthus has been documented in the literature. Histopathological examination is mandatory for arriving at the diagnosis. It should be considered in the differential diagnosis of all the slowly growing nodular lesions in the face.

Background: Chondroid syringomas [CS] are interesting skin adnexal tumours. They have a remarkable pleomorphic-adenoma like morphology in the skin. Though the histopathology of the tumour has been described in detail in literature, cytomorphological studies are restricted to case reports and small case series. For diagnosing a CS on cytology, the index of suspicion must be high, clinical evaluation must be thorough and knowledge of variant existing morphologies is essential. Aim: This study was done with the aim of studying the common and variant cytological features of chondroid syringomas. Methods: This was a retrospective study conducted over a four-year period (2014-17) in the Department of Pathology, VMMC and Safdarjung hospital. Fine needle aspirate smears and biopsy slides were studied. Morphological details were independently reviewed in detail by two pathologists (Dr MS and Dr MA). Result and Conclusion: The conventional biphasic cell morphology of CS was seen in nearly 50% cases. Rest of the cases showed predominance of one or more variant features in few areas and thus CS was only one of the differential diagnosis in these cases. Nevertheless, FNA proved to be fast, inexpensive and a reliable method for diagnosis of chondroid syringoma. The study will be relevant and helpful in the day to day cytological reporting of CS.

Tubular apocrine adenoma is a rare benign adnexal neoplasm most commonly identified in the scalp, composed of a dermal proliferation of apocrine tubules in a background of hyalinized stroma. Tubular apocrine adenoma can be a component of various sweat gland tumors and can also morphologically overlap with other sweat gland neoplasms. Isolated tubular apocrine adenoma arising in the glands of Moll is exceedingly rare, with only 4 previously reported cases. We present a 63-year-old male with tubular apocrine adenoma of the left upper eyelid, which recurred following initial incomplete excision. Although the lesion showed focal morphologic similarity to the apocrine variant of pleomorphic adenoma (chondroid syringoma), the diagnosis of tubular apocrine adenoma was supported by fluorescence in situ hybridization studies, which demonstrated absence of PLAG1 and HMGA2 gene rearrangements seen in pleomorphic adenoma. This case illustrates the clinical, microscopic and immunohistochemical features of tubular apocrine adenoma. The recent advances in our understanding of the molecular genetics of tubular apocrine adenoma and related tumors, and how these advances shape the evolving classification of sweat gland tumors are reviewed. Keywords: Eyelid, Tubular apocrine adenoma, Chondroid syringoma, Pleomorphic adenoma, PLAG1, HMGA2

Malignant chondroid syringoma (MCS, malignant mixed tumour) is a rare neoplasm typically arising on the extremities and trunk. We are report 2 unique cases of MCS, one occurring on the scalp of a 78-year-old man and the other on the trunk of a 72-year-old woman. Both tumours harboured malignant epithelial and malignant mesenchymal components. The latter was represented by liposarcoma in the first case. The malignant components of the second tumour comprised spindle cell squamous cell carcinoma (SCC) and osteosarcoma. Origin from a pre-existing benign chondroid syringoma was clearly evident in both neoplasms. The presence of heterologous malignant mesenchymal components, however, is hitherto unreported in the context of MCS, while a spindle cell SCC component is exceptionally rare. The 2 cases presented herein highlight an expanded morphological spectrum of MCS, with resultant blurring of the boundaries between MCS and cutaneous carcinosarcoma.

Chondroid syringoma is a rare, benign, appendegeal neoplasm. It was initially termed as mixed tumor as it comprises both epithelial cells and chondromyxoid stroma. It usually presents as a slow growing, solitary, painless, subcutaneous, or intracutaneous mass, frequently in the head and neck region. Cytological features usually include the presence of both components, similar to histology but aspiration of only one component or atypical features can pose challenges in diagnosis. According to literature, only a few single case reports describing the cytological features of chondroid syringoma has been published. We report three cases of chondroid syringoma and its differential diagnosis on cytology.

Chondroid syringoma (CS) is an uncommon, benign mixed tumor of the skin, composed of mesenchymal and sweat gland elements. In this report, we present a rare case of CS in the middle finger of a 53-year-old male patient. Excisional biopsy and skin grafting were performed. At 2 years of follow-up, the patient had no recurrence. Timely diagnosis and wide excision with a broad margin should be the preferred treatment. Pathologists and clinicians should be aware of the malignant component of CS.

Hyaline cell-rich apocrine mixed tumor is relatively rare, and it often possesses atypical cells. Despite the presence of atypical cells, other histopathological features such as well circumscription, smooth border, predominance of bland cells, and no mitotic figures lead to classify these tumors as benign. In addition, no recurrence or metastasis has been reported even when cytologic atypia is identified. Here we report a case of hyaline cell-rich apocrine mixed tumor with cytologic atypia, which did not recur for 14 months after excision.

Chondroid syringoma is also known as mixed tumour of the skin. It is a rare, biphasic cutaneous neoplasm similar to pleomorphic adenoma of salivary glands. Because of its rarity, many cases are misdiagnosed in the initial stages as cysts or other cutaneous adnexal neoplasms and are often identified only after being sent for histopathological examination.Although it usually presents in middle and older aged patients, we are presenting three younger patients with Chondroid syringoma, located over the back, nose and cheek, respectively.

Coined in 1961 by Hirsch and Helwig, the term chondroid syringoma refers to a rare mixed tumour of subcutaneous tissue. Histologically, these tumours are almost identical to pleomorphic adenomas, arising from salivary glands. With the obvious difference being the presence of sweat gland tissue (syringoma) within a matrix of cartilage (chondroid). These mixed tumours remain scarce throughout the world, with an incidence of less than 0.098%. The vast majority of cases are reported in middle-aged and older adults, where they typically present as painless swellings in the head and neck, which gradually grow in size.

Background and Objective Chondroid syringoma is a rare skin adnexal tumor, mostly involving the head and neck region. It is usually present as a skin painless nodule. We present a rare case of chondroid syringoma with extensive mature bone and cartilage formation. Methods Chondroid syringoma usually presents as a skin painless nodule. The histopathology is usually composed of a variable mixture of epithelial and myoepithelial structures on a background of chondromyxoid and fibrous stroma. It rarely shows mature bone or cartilage formation. Results To the best of our knowledge, only several cases of chondroid syringoma with bone formation and few cases of chondroid syringoma with cartilage formation have been reported in published studies to date. We report a case of chondroid syringoma with extensive mature bone and cartilage formation that is probably the first reported case showing this mixture of appearances. Conclusions Histopathologically, the presence of tumor with extensive mature bone and cartilage formation may cause diagnostic difficulties and wide differential diagnosis. Therefore, awareness of this rare entity can be helpful to avoid future diagnostic pitfalls, particularly when the appearances are unusual.

The chondroid syringoma is an extremely rare skin tumor most commonly found in the area of the head and neck region. Its rarity, potential for malignancy, and frequent misdiagnosis for other more common tumors can impart unique challenges in diagnosis and management. Diagnosis is usually revealed by excision followed by histologic examination. We report a case of a 42-year-old male with no prior medical history diagnosed with chondroid syringoma of the forehead and review the relevant literature.

Chondroid syringoma (CS) is a rare mixed tumor of sweat gland origin with a reported incidence of less than 0.1%. The tumor is mostly benign and usually seen in males. It comprises of both epithelial and mesenchymal elements. The usual presentation and clinical course of this condition makes it liable to be confused with other commoner skin conditions. We hereby present a case of facial CS in a young female patient.

A 31-year-old male with no known medical illness presented with painless left eye protrusion for the past 2 years. Radiographic features were of an extraconal superior orbital mass with no invasion of adjacent structures. The patient underwent an excisional biopsy of the left superior extraconal mass a week later. The histopathological examination revealed a well-circumscribed lobulated mass with chondroid and myxoid stroma enveloping benign bland-appearing epithelial and myoepithelial cells. These pathological features were consistent with benign chondroid syringoma of the orbit. The patient had an uneventful recovery with no active ocular complaint post-operatively.Despite chondroid syringoma of the orbit being a rare tumour, it should be considered in the differential diagnosis of periorbital masses. Excision of the tumour remains the treatment of choice with histopathological examination as the gold standard of diagnosis. Regular follow-up is warranted in view of possible local recurrence or metastasis.

Chondroid syringoma is a benign mixed tumor characterized by sweat gland elements in a cartilaginous stroma. A 34-year-old male patient presented with a slow growing mass since 2 yrs. A complete surgical excision was done for the same under local anesthesia which showed a significant improvement. Our report aims to raise awareness about this rare benign tumour of the eyelids and to study the histopathological aspects of it.

Chondroid syringoma (CS) is a rare benign adnexal tumor of the skin with a resemblance to pleomorphic adenoma of salivary gland, most commonly involving the head and neck region. In the present literature, reports of the cytologic appearance of CS are scarce as it is rarely encountered by fine needle aspiration (FNA). A 67-year-old woman presented with a 1 year history of a 1 cm subcutaneous nodule in the right axilla. FNA biopsy was performed revealing an epithelial-mesenchymal biphasic neoplasm suggesting CS. Surgical excision confirmed the diagnosis and demonstrated extensive ossification, an extremely rare feature, with only seven reported cases, all located on the head. CS is a rare benign adnexal tumor of the skin, often overlooked due to its unremarkable clinical presentation. FNA is a reliable tool for the diagnosis of CS and helps guide optimal surgical management.

Chondroid syringomas are uncommon cutaneous neoplasms of sweat gland origin which are slow-growing, nontender, subcutaneous or intracutaneous in location and often occurring in the head and neck region. Chondroid syringoma should be considered in the differential diagnosis of any subcutaneous nodule over the face. The clinician may miss the diagnosis of this lesion and if it is suspected, tumour should be excised with a margin of normal tissue and regular follow up should be done.

Chondroid syringoma (CS) is a rare benign appendageal tumour of the skin, with histological similarities to pleomorphic adenoma of salivary glands. It typically presents as a slow growing nodular mass generally less than 3 cm, arising from the skin, predominantly in the head and neck region. We report a case of a 61-year-old male with a massive nasal mass attained over a period of 2 years. A fine needle aspiration of the lesion was suggestive of CS. It was excised completely under general anaesthesia. The postoperative histopathology was also consistent with CS. The patient was followed up on a regular basis and was rendered disease free till his last follow up at 4 months. Our purpose of reporting this case is to highlight the rarity of the disease entity, as well as the occasion of it acquiring a large size yet, maintaining its benign nature.

Resume Introduction Le syringome chondroide est une tumeur cutanee rare caracterisee par une double composante epitheliale et mesenchymateuse. Le diagnostic histologique morphologique peut etre oriente par l’immuno-histochimie. Nous presentons 10 cas et leurs caracteristiques clinico-pathologiques. Materiel et methode Dix cas de syringomes chondroides ont ete inclus, entre janvier 2000 et aout 2013, sur les CHU Louis-Mourier et de Fort-de-France. Ils ont tous ete relus par un expert en pathologie cutanee et des complements d’immuno-histochimie ont ete realises. Les donnees cliniques et histologiques ont ete colligees. Resultats Les lesions etaient surtout localisees au visage (3/10) et aux extremites (3/10). La taille variait de 1,2 a 5,2 cm. Tous les cas ont ete traites chirurgicalement, aucun cas de malignite n’a ete diagnostique. L’histologie montrait un aspect de tumeur dermique limitee, avec une double differenciation syringo-chondroide, et des cavites revetues d’une a deux assises cellulaires evoquant une tumeur annexielle de type apocrine (5/10) ou eccrine (4/10). L’etude immuno-histochimique montrait une positivite de l’EMA, l’ACE et de la CK7 sur les cellules bordant les lumieres, et une positivite de la PS100 et de la vimentine sur les cellules de la bordure externe. Discussion Le syringome chondroide est caracterise par une double composante epitheliale et mesenchymateuse au sein d’un stroma myxoide ou chondroide. Notre serie a des particularites cliniques et histologiques (localisation aux extremites, raccordement epidermique…). Les principaux diagnostics differentiels sont les autres lesions annexielles, dont l’immuno-histochimie ne serait pas caracteristique de celle des syringomes chondroides : les cellules bordant les lumieres expriment les marqueurs epitheliaux (EMA, cytokeratines et ACE), les cellules de la bordure externe les marqueurs mesenchymateux (PS100, vimentine). Le traitement est chirurgical. Conclusion L’aspect histologique du syringome chondroide est evocateur mais en cas de doute la realisation d’une etude immuno-histochimique montrant une double composante cellulaire peut en faciliter le diagnostic.

Chondroid syringoma is a cutaneous sweat gland tumor. Despite its relative rarity, a benign and malignant variant have been described. We present a case report of chondroid syringoma of the foot in a healthy patient. Definitive diagnosis required histopathologic examination, while treatment included wide resection. Surgeons who are presented with a painless, solid nodule in the lower extremities should be cognizant of this neoplasm.Levels of Evidence: Therapeutic, Level IV: Case report

Chondroid syringoma, also known as benign mixed tumour of the skin, is a rare benign adnexal tumour. It is a biphasic tumour, composed of both epithelial and mesenchymal components and constitutes

Mixed tumor of skin (chondroid syringoma) is a rare skin tumor. We report on the rare occasion of an atypical mixed tumor of skin (chondroid syringoma) in a 71-year old Caucasian male patient. The tumor presented as a firm subcutaneous nodule on his flank. Histopathologic investigations revealed a focally increased proliferative activity and satellites in the adipose tissue. This is in accordance with the diagnosis of an atypical chondroid syringoma. The differential diagnosis to malignant chondroid syringoma is discussed. The tumor was removed by delayed Mohs surgery. Atypical chondroid syringoma is a very rare subtype of mixed tumor of skin. It is an important differential diagnosis to malignant chondroid syringoma of skin.

Chondroid syringoma or mixed skin tumour is a rare, benign skin adnexal tumour which typically occurs in the head and neck region of middle-aged patients. Due to their rarity, they are often clinically misdiagnosed and with the diagnosis only confirmed on histological examination. They typically comprise sweat gland elements within a prominent ‘cartilage-like' stroma. Treatment involves total excision with clear surgical margins. Where excision is incomplete, routine follow up is required due to risk of recurrence or malignant transformation, though the latter is extremely rare. Herein we describe a classical case with review of the current literature.

Chondroid syringoma (CS) is an uncommon cutaneous tumor in the head and neck, with reported incidence rate from 0.01% to 0.1%. The CS of skin is a rare type of soft tissue tumor originating from the sweat glands. We report a documented case of CS occurring in the nasal dorsum in a 58-year-old man, which developed during the course of 1 year. The clinical, gross pathologic, and histologic findings of the tumor are described. The lesion was totally excised via transcutaneous approach and showed no evidence of recurrence after excision.

Chondroid syringoma is an unusual, benign skin appendageal tumor originating from the eccrine and apocrine sweat glands resembling mixed tumors of the salivary glands. It develops as a slow-enlarging, small, cutaneous nodule or mass. The lesions are usually seen in older men on head and neck. This is a clinical report of a 46-year-old lady who presented with a slowly growing nodular protruding mass in a cheek. The clinical and histologic findings of the tumor are demonstrated. The clinician and the pathologist should take into account the tumor among differential diagnosis not to overlook the lesion. Total surgical excision is needed with a long-term follow-up.

Chondroid syringoma, or mixed tumour of the skin, is an uncommon benign sweat gland tumour. It is the cutaneous counterpart of pleomorphic adenoma of the salivary glands. The clinical presentation of chondroid syringoma is non-specific and its histological diagnosis can prove difficult. Characteristically, it is composed of a proliferation of epithelial cells set in a chondromyxoid matrix. We report a case of chondroid syringoma arising from a polyp in the external auditory canal in a 25 year old male who presented with a sensation of blockage of the ear and impaired hearing. The aim of this report is to help both the clinician and the pathologist recognize this uncommon benign neoplasm. © 2010 SEAP y SEC. Published by Elsevier Espana, S.L. All rights reserved.