224 results on '"Chul-Hoon Kim"'
Search Results
2. Influence of the π-Bridge-Fused Ring and Acceptor Unit Extension in D−π–A-Structured Organic Dyes for Highly Efficient Dye-Sensitized Solar Cells
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Jung-Min Ji, Hyun Jae Lee, Haoran Zhou, Yu Kyung Eom, Chul Hoon Kim, and Hwan Kyu Kim
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General Materials Science - Abstract
Three new D-π-A-structured organic dyes, coded as
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- 2022
3. Outer-Sphere Electron-Transfer Process of Molecular Donor–Acceptor Organic Dye in the Dye-Sensitized Photocatalytic System for CO2 Reduction
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Sunghan Choi, Yun-Jae Kim, Soohwan Kim, Hyun Seok Lee, Jae Yoon Shin, Chul Hoon Kim, Ho-Jin Son, and Sang Ook Kang
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Materials Chemistry ,Electrochemistry ,Energy Engineering and Power Technology ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering - Published
- 2022
4. Accumulative Charge Separation in a Modular Quaterpyridine Bridging Ligand Platform and Multielectron Transfer Photocatalysis of π-Linked Dinuclear Ir(III)–Re(I) Complex for CO2 Reduction
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Daehan Lee, Min Su Choe, Hyung Joo Lee, Jae Yoon Shin, Chul Hoon Kim, Ho-Jin Son, and Sang Ook Kang
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Inorganic Chemistry ,Physical and Theoretical Chemistry - Published
- 2023
5. InP-Quantum Dot Surface-Modified TiO2 Catalysts for Sustainable Photochemical Carbon Dioxide Reduction
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Bumsoo Chon, Sunghan Choi, Yunjeong Seo, Hyun Seok Lee, Chul Hoon Kim, Ho-Jin Son, and Sang Ook Kang
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Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2022
6. Clinical Characteristics of Patients Diagnosed With Odontogenic Rhinosinusitis After Dental Implants
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Sangjun Kim, Eun Soo Lee, Woo Yong Bae, Chul-Hoon Kim, and Ji-Eon Yun
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Background and Objectives: With the ongoing development of intraoral surgical treatment and invasive dental treatments such as implants, odontogenic rhinosinusitis (ORS) is on the rise. ORS related to dental implants accounts for 8% to 37% of cases. The purpose of this study is to define the characteristics of patients with ORS related to dental implants.Methods: From 2015 to 2019, the medical records of 15 patients who developed maxillary sinus disease after receiving dental implants were retrospectively analyzed among patients who visited the ear nose and throat and dentistry departments. We reviewed the chief complaint, assessment, diagnosis, treatment and prognosis of these patients.Results: Of the 15 patients, all were diagnosed with ORS. One patient with a post-operative cheek cyst, 1 with fungal sinusitis, 1 with an inverted papilloma, 1 with chronic rhinosinusitis, and 1 with a radicular cyst were diagnosed after surgery. Endoscopic sinus surgery was performed in 14 patients and 2 patients underwent a combined operation. One patient improved after medical treatment. The follow-up period was about 8.6 months. No recurrence was found in any of the patients.Conclusion: If an implant problem is suspected based on history-taking and physical examination, active consultation with dentistry is needed to diagnose ORS.
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- 2022
7. Development of Non-destructive Testing System using Non-Contact Air-Coupled Ultrasonic Testing
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Jeong-Sik Shin, Chul-Hoon Kim, and Sung-Tae Kim
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- 2022
8. Serum albumin maintains Wnt water-solubility and activity
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Joo Hye Yeo, Soon Sung Kwon, Jiyeon Chae, Ines Kusen, Jaeeun Han, Ju Yeon Lim, Jae-Ho Cheong, Taeil Kim, Yang Ouk Jung, Chul Hoon Kim, and Jinu Lee
- Abstract
SummaryWnt proteins regulate adult tissue homeostasis and repair by driving stem cell self-renewal and differentiation. High-performance Wnt preparations have enormous therapeutic potential, especially alongside various stem cell technologies. Currently, most of these Wnt preparations contain FBS or the detergent CHAPS to maintain Wnt solubility and activity. Recently, afamin was identified as a serum factor that solubilizes Wnt3a in conditioned media (CM), obviating the requirement for animal sera. Here, we report serum albumin (SA) is required for afamin-mediated solubilization of Wnt3a in CM. Moreover, SA-mediated solubilization of purified Wnt3a in tubes does not require afamin. This means conventional CHAPS-Wnt3a preparations can be modified into SA-purified Wnt3a (SA-pWnt3a) preparations by exchanging CHAPS for SA through dialysis. SA-pWnt3a preparations effectively promote the growth of human stem cell organoids. These data suggest SA as a physiological factor for maintaining Wnt3a activity in therapeutic applications.
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- 2023
9. Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping
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Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Dawoon E. Jung, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, and Jun Yong Park
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Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
As genomic analysis technology has advanced, it has become possible to sub-classify intrahepatic cholangiocarcinoma (ICC) at the histological or molecular level. However, there are no truly representative models of ICC subtypes for use in studying developmental differences, carcinogenesis, and personalized drug response. Here, we sought to develop ICC organoid models that reflect the phenotypic, molecular and genetic properties of the parent tumor, and performed integrative clustering of multiple genomic data—with subtype analysis—using these models. ICC organoids from 17 patients pathologically diagnosed with cholangiocarcinoma were prepared according to a previously established organoid culture protocol. ICC patients were subclassified into small-duct (SD) type and large-duct (LD) type according to histological characteristics and S100P, N-cadherin, and CD56 expression. ICC organoids were successfully established within one month and exhibited a morphology similar to that of their matching primary cancer. LD- and SD-type organoids exhibited histologic phenotypes and staining patterns characteristic of the corresponding ICC subtypes. ICC organoids showed high concordance of somatic mutations with primary tumors. Unsupervised principal component analysis clustering effectively separated each type of ICC. Differential gene expression revealed significant enrichment on KRAS, TGFβ and ERBB2 signaling pathways in LD-type compared with SD-type ICC (P P P = 0.0105). We successfully performed prospective modeling of histological subtype specification using patient-derived ICC organoids. Moreover, gene expression profiling of ICC organoids enabled identification of type-specific targetable pathways.
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- 2023
10. Multifaceted Excited State Dynamics of Coumarin Dyes Anchored on Al
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Hyun Seok, Lee, Yun Jeong, Na, Chul Hoon, Kim, and Jae Yoon, Shin
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The co-facially stacked dyes on semiconductor films serve as an alternative model to elucidate the photo-driven exciton dynamics occurring in a molecular assembly. In this study, we report the unique emission properties of coumarin dye adsorbed on the surface of the semiconductor film, measured by ultrafast time-resolved fluorescence. When a rigid coumarin derivative, 7-hydroxycoumarin-3-carboxylic acid (OHCCA), is anchored on the Al
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- 2022
11. Sustainable Carbon Dioxide Reduction of the P3HT Polymer-Sensitized TiO
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Min Su, Choe, Sunghan, Choi, Hyun Seok, Lee, Bumsoo, Chon, Jae Yoon, Shin, Chul Hoon, Kim, Ho-Jin, Son, and Sang Ook, Kang
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In this study, a
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- 2022
12. Positional changes of the mandibular condyle in unilateral sagittal split ramus osteotomy combined with intraoral vertical ramus osteotomy for asymmetric class III malocclusion
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Jun Park, Bok-Joo Kim, Jung-Han Kim, Eun-Sup Shin, Ji-Eon Yun, Ki-Eun Hong, and Chul-Hoon Kim
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Orthodontics ,Sagittal split ramus osteotomy ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,Temporomandibular joint disorder ,medicine.disease ,Intraoral vertical ramus osteotomy ,Condyle ,Chin ,medicine.anatomical_structure ,stomatognathic system ,Oral and maxillofacial surgery ,medicine ,Temporomandibular Joint Disorder ,Original Article ,Surgery ,Displacement (orthopedic surgery) ,Oral Surgery ,Malocclusion ,business ,Facial asymmetry ,Facial symmetry - Abstract
Objectives In the present study, the effects of sagittal split ramus osteotomy (SSRO) combined with intraoral vertical ramus osteotomy (IVRO) for the treatment of asymmetric mandible in class Ⅲ malocclusion patients were assessed and the postoperative stability of the mandibular condyle and the symptoms of temporomandibular joint disorder (TMD) evaluated. Materials and Methods A total of 82 patients who underwent orthognathic surgery for the treatment of facial asymmetry or mandibular asymmetry at the Department of Oral and Maxillofacial Surgery, Dong-A University Hospital, from 2016 to 2021 were selected. The patients that underwent SSRO with IVRO were assigned to Group I (n=8) and patients that received bilateral SSRO (BSSRO) to Group II (n=10, simple random sampling). Preoperative and postoperative three-dimensional computed tomography (CT) axial images obtained for each group were superimposed. The condylar position changes and degree of rotation on the superimposed images were measured, and the changes in condyle based on the amount of chin movement for each surgical method were statistically analyzed. Results Group I showed a greater amount of postoperative chin movement. For the amount of mediolateral condylar displacement on the deviated side, Groups I and II showed an average lateral displacement of 0.07 mm and 1.62 mm, respectively, and statistically significantly correlated with the amount of chin movement (P=0.004). Most of the TMD symptoms in Group I patients who underwent SSRO with IVRO showed improvement. Conclusion When a large amount of mandibular rotation is required to match the menton to the midline of the face, IVRO on the deviated side is considered a technique to prevent condylar torque. In the present study, worsening of TMD symptoms did not occur after orthognathic surgery in any of the 18 patients.
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- 2021
13. Photochemical CO2-to-Formate/CO Conversion Catalyzed by Half-Metallocene Ir(III) Catalyst and Its Mechanistic Investigation
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Ho-Jin Son, Daehan Lee, Sang Ook Kang, So-Yoen Kim, Min Su Choe, S.J. Choi, Kyutai Park, and Chul Hoon Kim
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Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Organic Chemistry ,Formate ,Physical and Theoretical Chemistry ,Photochemistry ,Metallocene ,Catalysis - Published
- 2021
14. A Hybrid Ru(II)/TiO2 Catalyst for Steadfast Photocatalytic CO2 to CO/Formate Conversion Following a Molecular Catalytic Route
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Hyun Seok Lee, So-Yoen Kim, Min Su Choe, Ho-Jin Son, Daehan Lee, Sang Ook Kang, Chul Hoon Kim, S.J. Choi, and Changhyun Back
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Inorganic Chemistry ,chemistry.chemical_compound ,Monomer ,chemistry ,Polymer chemistry ,Photocatalysis ,Homogeneous catalysis ,Formate ,Electron donor ,Physical and Theoretical Chemistry ,Fourier transform infrared spectroscopy ,Catalysis - Abstract
Herein, we employed a molecular Ru(II) catalyst immobilized onto TiO2 particulates of (4,4'-Y2-bpy)RuII(CO)2Cl2 (RuP; Y = CH2PO(OH)2), as a hybrid catalyst system to secure the efficient and steady catalytic activity of a molecular bipyridyl Ru(II)-complex-based photocatalytic system for CO2 reduction. From a series of operando FTIR spectrochemical analyses, it was found that the TiO2-fixed molecular Ru(II) complex leads to efficient stabilization of the key monomeric intermediate, RuII-hydride (LRuII(H)(CO)2Cl), and suppresses the formation of polymeric Ru(II) complex (-(L(CO)2Ru-Ru(CO)2L)n-), which is a major deactivation product produced during photoreaction via the Ru-Ru dimeric route. Active promotion of the monomeric catalytic route in a hetero-binary system (IrPS + TiO2/RuP) that uses TiO2-bound Ru(II) complex as reduction catalyst led to highly increased activity as well as durability of photocatalytic behavior with respect to the homogeneous catalysis of free Ru(II) catalyst (IrPS + Ru(II) catalyst). This catalytic strategy produced maximal turnover numbers (TONs) of >4816 and >2228, respectively, for CO and HCOO- production in CO2-saturated N,N-dimethylformamide (DMF)/TEOA (16.7 vol % TEOA) solution containing a 0.1 M sacrificial electron donor.
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- 2021
15. Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia
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Song Yi Youn, Hyehyun Min, Se Rok Jeong, Jiahn Lee, Seok Jun Moon, Jinwoong Bok, and Chul Hoon Kim
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Mice, Inbred C57BL ,Stereocilia ,Cellular and Molecular Neuroscience ,Mice ,Hair Cells, Auditory, Inner ,Hearing Loss, Sensorineural ,Animals ,Humans ,Hearing Loss ,Staphylococcal Protein A ,Molecular Biology ,Microtubule-Associated Proteins ,Adaptor Proteins, Signal Transducing - Abstract
Tubby mice exhibit hearing impairment due to the loss of stereocilin from the tip regions that connect the tallest stereocilia of the outer hair cells (OHCs) to the tectorial membrane. Stereocilin is an essential stereociliary protein in the OHCs, the mutation of which in humans causes autosomal recessive non-syndromic deafness. Map1a is a modifier of tubby hearing (moth1), and its wild-type allele, rather than the moth1 allele from the C57BL/6 J strain, restores stereocilin localization to the stereocilia and rescues the hearing impairment of tubby mice. The mechanism by which MAP1A accomplishes this is unclear, partly due to ambiguity regarding whether the tubby mutation is a true null. We therefore generated Tub-null (Tub−/−) mice by deleting exon 3 and found that they exhibit hearing impairment like that of tubby mice, suggesting the tubby mutation is a loss-of-function mutation with regard to hearing. When we crossed Tub−/− mice with AKR mice that have wild-type Map1a alleles, we found that wild-type MAP1A restores stereocilin localization to the tips of stereocilia and rescues hearing impairment. These data suggest MAP1A does not require interaction with tubby protein in maintaining stereocilin at the tips of stereocilia and that OHCs use two independent molecules—MAP1A and tubby—to doubly ensure proper stereocilin localization.
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- 2022
16. Efficient Photon Extraction in Top-Emission Organic Light-Emitting Devices Based on Ampicillin Microstructures
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Dong Hyun Kim, Chang Min Lee, Amjad Islam, Dong Hyun Choi, Geon‐Woo Jeong, Tae Wook Kim, Hyun Woo Cho, Yeong Beom Kim, Syed Hamad Ullah Shah, Min Jae Park, Chul Hoon Kim, Hyun Jae Lee, Jae Woo Lee, Seain Bang, Tae‐Sung Bae, Jong Bae Park, Seung Min Yu, Yong‐Cheol Kang, Juyun Park, Myeongkee Park, Yeonsu Jeong, Sang Geul Lee, Jong Sung Jin, Kyoung‐Ho Kim, Muhammad Sujak, Surk‐Suik Moon, Sanghyuk Park, Myung kwan Song, Chang‐Su Kim, and Seung Yoon Ryu
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Abstract
The desire to enhance the efficiency of organic light-emitting devices (OLEDs) has driven to the investigation of advanced materials with fascinating properties. In this work, the efficiency of top-emission OLEDs (TEOLEDs) is enhanced by introducing ampicillin microstructures (Amp-MSs) with dual phases (α-/β-phase) that induce photoluminescence (PL) and electroluminescence (EL). Moreover, Amp-MSs can adjust the charge balance by Fermi level (E
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- 2022
17. Electron Injection Process of Porphyrin Dye into a Heterogeneous TiO2/Re(I) Photocatalyst
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Sang Ook Kang, Min Su Choe, S.J. Choi, Ho-Jin Son, Daehan Lee, Jae Yoon Shin, Chul Hoon Kim, Chyongjin Pac, and So-Yoen Kim
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Materials science ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Porphyrin ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,General Energy ,chemistry ,Electron injection ,Scientific method ,Photocatalysis ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
We now report full details of the collisional ET process at the interface between the solvated porphyrin dye (a representative molecular dye) and heterogeneous TiO2 particles (a well-defined n-type...
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- 2021
18. Relationships Between Oral-Mucosal Pressure Ulcers, Mechanical Conditions, and Individual Susceptibility in Intubated Patients Under Intensive Care: A PCR-Based Observational Study
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Hee Sam Nah, Soo-Hyun Kim, Myoung Soo Kim, Jin Bom Kim, and Chul-Hoon Kim
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Pressure Ulcer ,Staphylococcus aureus ,medicine.medical_specialty ,Saliva ,Individual susceptibility ,Critical Care ,Research and Theory ,business.industry ,Polymerase Chain Reaction ,030227 psychiatry ,Intensive Care Units ,03 medical and health sciences ,0302 clinical medicine ,Mechanical ventilator ,Intensive care ,Internal medicine ,medicine ,Humans ,Observational study ,Stage (cooking) ,Mouth mucosa ,business ,030217 neurology & neurosurgery - Abstract
Purpose: This study was performed to determine the relationship between oral-mucosal pressure ulcer (PU) stage and mechanical conditions and individual susceptibility in intubated patients. Methods: We collected 80 patient-days data from an intensive care unit of a 700-bed hospital in Korea. We analyzed oral-mucosal PUs, medical records, amount of saliva, and oral mucosal swabs. Bacterial abundance was enumerated by real-time polymerase chain reaction. The χ2 or Fisher’s exact test, t-test or Mann-Whitney U test, and Spearman’s rho correlation analysis were performed. Results: The incidence of overall oral-mucosal PUs was 31.3%, and in the maxillary and mandibular sites were 16.3% and 26.3%, respectively. There were significant correlations between the maxillary site PU stage and restraint use (r = .43, p < .001), albumin level (r = −.22, p = .046), and relative abundance of P. aeruginosa (r = .45, p < .001) and S. aureus (r = −.24, p = .033). In the mandibular sites, there were significant correlations between PU stage and restraint use (r = .30, p = .008), level of consciousness (r = .31, p = .005), and relative abundance of P. aeruginosa (r = .25, p = .028) and S. pneumoniae (r = .22, p = .046). Conclusions: Frequent monitoring and repositioning the mechanical pressure on the oral-mucosa could be an effective preventive strategy against the development and advancement of oral-mucosal PUs. Additionally, monitoring the oral microorganisms can prevent advanced stage oral-mucosal PUs in intubated patients.
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- 2021
19. Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus
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Jing Zhu, Soojin Park, Chul Hoon Kim, Kyoung Hoon Jeong, and Won-Joo Kim
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General Biochemistry, Genetics and Molecular Biology - Abstract
Neuroinflammation is one of the most common pathological outcomes in various neurological diseases. A growing body of evidence suggests that neuroinflammation plays a pivotal role in the pathogenesis of epileptic seizures. Eugenol is the major phytoconstituent of essential oils extracted from several plants and possesses protective and anticonvulsant properties. However, it remains unclear whether eugenol exerts an anti-inflammatory effect to protect against severe neuronal damage induced by epileptic seizures. In this study, we investigated the anti-inflammatory action of eugenol in an experimental epilepsy model of pilocarpine-induced status epilepticus (SE). To examine the protective effect of eugenol via anti-inflammatory mechanisms, eugenol (200 mg/kg) was administrated daily for three days after pilocarpine-induced SE onset. The anti-inflammatory action of eugenol was evaluated by examining the expression of reactive gliosis, pro-inflammatory cytokines, nuclear factor-κB (NF-κB), and the nucleotide-binding domain leucine-rich repeat with a pyrin-domain containing 3 (NLRP3) inflammasome. Our results showed that eugenol reduced SE-induced apoptotic neuronal cell death, mitigated the activation of astrocytes and microglia, and attenuated the expression of interleukin-1β and tumor necrosis factor α in the hippocampus after SE onset. Furthermore, eugenol inhibited NF-κB activation and the formation of the NLRP3 inflammasome in the hippocampus after SE. These results suggest that eugenol is a potential phytoconstituent that suppresses the neuroinflammatory processes induced by epileptic seizures. Therefore, these findings provide evidence that eugenol has therapeutic potential for epileptic seizures.
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- 2023
20. Rapid Exciton Migration and Amplified Funneling Effects of Multi-Porphyrin Arrays in a Re(I)/Porphyrinic MOF Hybrid for Photocatalytic CO2 Reduction
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Won-Jo Jung, S.J. Choi, Chyongjin Pac, Ho-Jin Son, Kyutai Park, Jin-Ook Baeg, Sang Ook Kang, Soyeon Kim, and Chul Hoon Kim
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Materials science ,Exciton ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,Heterogeneous catalysis ,01 natural sciences ,Porphyrin ,0104 chemical sciences ,Turnover number ,Catalysis ,chemistry.chemical_compound ,Bipyridine ,chemistry ,Photocatalysis ,General Materials Science ,Carboxylate ,0210 nano-technology - Abstract
A porphyrinic metal-organic framework (PMOF) known as PCN-222(Zn) was chemically doped with a molecular Re(I) catalyst-bearing carboxylate anchoring group to form a new type of metal-organic framework (MOF)-Re(I) hybrid photocatalyst. The porphyrinic MOF-sensitized hybrid (PMOF/Re) was prepared with an archetypical CO2 reduction catalyst, (L)ReI(CO)3Cl (Re(I); L = 4,4'-dicarboxylic-2,2'-bipyridine), in the presence of 3 vol % water produced CO with no leveling-off tendency for 59 h to give a turnover number of ≥1893 [1070 ± 80 μmol h-1 (g MOF)-1]. The high catalytic activity arises mainly from efficient exciton migration and funneling from photoexcited porphyrin linkers to the peripheral Re(I) catalytic sites, which is in accordance with the observed fast exciton (energy) migration (≈1 ps) in highly ordered porphyrin photoreceptors and the effective funneling into Re(I) catalytic centers in the Re(I)-doped PMOF sample. Enhanced catalytic performance is convincingly supported by serial photophysical measurements including decisive Stern-Volmer interpretation.
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- 2021
21. Collisional Electron Transfer Route between Homogeneous Porphyrin Dye and Catalytic TiO2/Re(I) Particles for CO2 Reduction
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Ho-Jin Son, Chul Hoon Kim, Jin-Ook Baeg, Sang Ook Kang, Chyongjin Pac, and S.J. Choi
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Quenching (fluorescence) ,Materials science ,Energy Engineering and Power Technology ,Photochemistry ,Porphyrin ,Catalysis ,Reduction (complexity) ,Electron transfer ,chemistry.chemical_compound ,chemistry ,Electron injection ,Homogeneous ,Materials Chemistry ,Electrochemistry ,Photocatalysis ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering - Abstract
Dye detachment issue in the TiO2-mediated dye-sensitized photocatalytic system engenders an electron injection route based on collisional quenching between the detached solution-phase dye and dispe...
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- 2020
22. Ancillary Ligand Effects on Heteroleptic Ir III Dye in Dye‐Sensitized Photocatalytic CO 2 Reduction: Photoaccumulation of Charges on Arylated Bipyridine Ligand and Its Control on Catalytic Performance
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Jae Yoon Shin, Ha-Yeon Cheong, Ho-Jin Son, Sang Ook Kang, Dae Won Cho, Chyongjin Pac, S.J. Choi, Ju Hyoung Jo, and Chul Hoon Kim
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010405 organic chemistry ,Chemistry ,Ligand ,Organic Chemistry ,Photodissociation ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Catalysis ,0104 chemical sciences ,Turnover number ,Bipyridine ,chemistry.chemical_compound ,Homogeneous ,Photocatalysis ,Iridium - Abstract
Herein, we report the synthesis, and photochemical and -physical properties, as well as the catalytic performance, of a series of heteroleptic IrIII photosensitizers (IrPSs), [Ir(C^N)2 (N^NAryl )]+ , possessing ancillary ligands that are varied with aryl-substituents on bipyridyl unit [C^N=(2-pyridyl)benzo[b]thiophen-3-yl (btp); N^NAryl =4,4'-Y2 -bpy (Y=-Ph or -PhSi(Ph)3 ]. We found that the π-extension of bipyridyl ligand by aryl-substitution put bipyridyl ligand in use as an electron relay unit that performed charge accumulation before delivering to the catalytic center, greatly improving the overall CO2 -to-CO conversion activities. In a typical run, the aryl-substituted IrPS (tBu IrP-PhSi )-sensitized homogeneous systems (IrPS+ReI catalyst) gave a turnover number of 1340 (ΦCO =24.2 %) at the early stage of photolysis (
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- 2020
23. Author Correction: Improved device efficiency and lifetime of perovskite light-emitting diodes by size-controlled polyvinylpyrrolidone-capped gold nanoparticles with dipole formation
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Chang Min Lee, Dong Hyun Choi, Amjad Islam, Dong Hyun Kim, Tae Wook Kim, Geon‑Woo Jeong, Hyun Woo Cho, Min Jae Park, Syed Hamad Ullah Shah, Hyung Ju Chae, Kyoung-Ho Kim, Muhammad Sujak, Jae Woo Lee, Donghyun Kim, Chul Hoon Kim, Hyun Jae Lee, Tae‑Sung Bae, Seung Min Yu, Jong Sung Jin, Yong‑Cheol Kang, Juyun Park, Myungkwan Song, Chang‑Su Kim, Sung Tae Shin, and Seung Yoon Ryu
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Multidisciplinary - Published
- 2022
24. Maladaptive Alterations of Defensive Response Following Developmental Complex Stress in Rats
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Jeong-Ho Seok, Junhyung Kim, Chiheon Lee, Chul Hoon Kim, June-Seek Choi, Jung Jin Ha, and Minkyung Park
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Freezing reaction, cataleptic ,Physiology ,Stress protocol ,Anxiety ,Foot shock ,Trauma ,Tonic (physiology) ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Animal model ,Medicine ,Juvenile ,Pharmacology (medical) ,Fear conditioning ,business.industry ,Vocalization, animal ,medicine.disease ,Personality disorders ,030227 psychiatry ,Psychiatry and Mental health ,Original Article ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Objective Despite the etiological significance of complex developmental trauma in adult personality disorders and treatment-resistant depression, neurobiological studies have been rare due to the lack of useful animal models. As a first step, we devised an animal model to investigate the effects of multiple trauma-like stress during different developmental periods. Methods Twenty-one male Sprague-Dawley rats were classified into 3 groups based on the stress protocol: fear conditioning control (FCC, n = 6), complex stress (ComS, n = 9), and control (n = 6). While the ComS experienced three types of stress (maternal separation, juvenile isolation, electric foot shock), the FCC only experienced an electric foot shock stress and the control never experienced any. We compared fear responses at postnatal day (PND) 29 and PND 56 through freezing time per episode (FTpE), total freezing time (TFT), total freezing episodes (TFE), and ultrasonic vocalization (USV). Results ComS showed the longest FTpE in the conditioned fear response test. ComS and FCC exhibited the longer TFT and these two groups only displayed USV. ComS show difference TFE between PND 29 and PND 56. Conclusion The results of this investigation show that complex stress may affect not quantity of fear response but characteristics of fear response. Longer FTpE may be associated with tonic immobility which could be considered as a failed self-protective reaction and might be analogous to a sign of inappropriate coping strategy and self-dysregulation in complex trauma patients.
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- 2020
25. Multiplex Protein Imaging with Secondary Ion Mass Spectrometry Using Metal Oxide Nanoparticle-Conjugated Antibodies
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Minseok Kim, Eunjoo Kim, Dae Won Moon, Dong Kwon Lim, Heejin Lim, Yebin Jung, Sungjee Kim, Chul Hoon Kim, Su Hwa Kwak, Sun Young Lee, Hyunmin Kim, Su-Il In, Young Ho Park, and Hyang Sook Hoe
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0301 basic medicine ,Materials science ,Ion beam ,Metal Nanoparticles ,Spectrometry, Mass, Secondary Ion ,Nanoparticle ,Mice, Transgenic ,Conjugated system ,Antibodies ,Mass spectrometry imaging ,Ion ,Mice ,03 medical and health sciences ,Alzheimer Disease ,Animals ,General Materials Science ,Multiplex ,Particle Size ,CA1 Region, Hippocampal ,030102 biochemistry & molecular biology ,Proteins ,Oxides ,Mice, Inbred C57BL ,Secondary ion mass spectrometry ,Disease Models, Animal ,030104 developmental biology ,Membrane ,Biophysics ,Antibodies, Immobilized - Abstract
In spite of recent developments in mass spectrometry imaging techniques, high-resolution multiplex protein bioimaging techniques are required to unveil the complex inter- and intracellular biomolecular interactions for accurate understanding of life phenomena and disease mechanisms. Herein, we report multiplex protein imaging with secondary ion mass spectrometry (SIMS) using metal oxide nanoparticle (MONP)-conjugated antibodies with
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- 2020
26. Non-Born–Oppenheimer Molecular Dynamics Observed by Coherent Nuclear Wave Packets
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Matthias F. Kling, Christian Burger, Taiha Joo, Myeongkee Park, JunWoo Kim, Dong Eon Kim, and Chul Hoon Kim
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Physics ,Wave packet ,Strong interaction ,Diabatic ,Born–Oppenheimer approximation ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Molecular physics ,0104 chemical sciences ,Molecular dynamics ,symbols.namesake ,Reaction dynamics ,Molecular vibration ,symbols ,General Materials Science ,Density functional theory ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
The reaction dynamics of a photochemical reaction is typically described by reaction coordinates based on the Born-Oppenheimer (BO) approximation. A strong interaction between electrons and nuclei, conventionally occurring at conical intersections, however, breaks the BO approximation and has major consequences for the efficiency of a photochemical reaction. Despite its importance, related studies into the non-BO dynamics are scarce. Here, we investigate the non-BO dynamics of excited-state intramolecular proton transfer (ESIPT) occurring in 10-hydroxybenzo[h]quinoline (HBQ). Two coherent vibrational modes at 237 and 794 cm-1 representing molecular dynamics on a diabatic surface in HBQ are identified by a wave packet analysis based on a transient absorption measurement with a time resolution of 11 fs and with a density functional theory-based model calculation. It is also revealed that the strong Coulomb field effect in HBQ leads to the completion of ESIPT within about two cycles of the OH stretching mode. The work paves the way for time-domain studies of molecular dynamics beyond the BO approximation in other photochemical reactions.
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- 2020
27. Immediate reconstruction of mandibular defect after treatment of medication-related osteonecrosis of the jaw (MRONJ) with rhBMP-2/ACS and miniplate: Review of 3 cases
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Kyung-Jin Kim, Bok-Joo Kim, Chul-Hoon Kim, Mu-seong Kim, and Jung-Han Kim
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musculoskeletal diseases ,medicine.medical_specialty ,Radiography ,medicine.medical_treatment ,Miniplate ,Article ,Collagen sponge ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Medical history ,Stage (cooking) ,Case series ,business.industry ,Mandible ,food and beverages ,Bisphosphonate ,medicine.disease ,Medication-related osteonecrosis of the jaws ,Surgery ,Sequestrectomy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Bone morphogenic protein ,business ,Osteonecrosis of the jaw - Abstract
Highlights • The pathogenesis of MRONJ is related to repression of osteoclast mediated bone remodeling. • rhBMP-2 can stimulate not only osteoblasts but also osteoclasts and induce new bone formation. • ACS has been proved to be a good carrier of rhBMP-2 with maximal efficacy. • Application of rhBMP-2/ACS can be a new approach to surgical treatment for MRONJ patients., Introduction The purpose of this study was to pursue, and to report the results of, mandibular reconstruction and rehabilitation of medication-related osteonecrosis of the jaw (MRONJ) patients having large critical-sized defects of the mandible using a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and absorbable collagen sponge (ACS) with surgical miniplate without any grafting materials. Case presentation Three (3) patients aged 67 and 86 (2 patients) presented due to discomfort on the mandible. They all had a medical history of bisphosphonate and steroids treatment orally or intravenously, and all had been diagnosed as MRONJ stage 3. Sequestrectomy and saucerization were performed, and then a surgical miniplate (Hansolmedical, Korea) was adapted and fixed on the sound portion of the mandible. rhBMP-2 was loaded onto an ACS at a dose of 1.5 mg/cc. Several rhBMP-2 (Cowellmedi, Korea)/ACS (Ateloplug, TRMkorea, Korea) were placed into the bony defect with a surgical miniplate. All 3 patients recovered without complications. They all exhibited radiographic evidence of bone formation by 3 months postoperatively in every case. Conclusions All 3 patients were treated successfully with rhBMP-2/ACS and miniplate without any complications. This protocol reported herein represents a new approach to the surgical treatment of maxillofacial bone defects and deficiencies, especially in MRONJ patients.
- Published
- 2020
28. Dynamics of accelerated excimer formation of coumarin dyes anchored on semiconductor films
- Author
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Yun Jeong Na, Hyun Seok Lee, Chul Hoon Kim, and Jae Yoon Shin
- Subjects
General Physics and Astronomy ,Physical and Theoretical Chemistry - Published
- 2023
29. Is distal segment ostectomy essential for stabilization of the condylar position in patients with facial asymmetry?
- Author
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Jung Han Kim, Bok Joo Kim, Jun Park, Eun Sup Shin, Ji Eon Yun, Ki Eun Hong, and Chul-Hoon Kim
- Subjects
Orthodontics ,BSSRO ,medicine.medical_specialty ,RD1-811 ,business.industry ,Research ,medicine.medical_treatment ,RK1-715 ,Distal segment ostectomy ,Condyle position ,Mandibular prognathism ,Condyle ,Temporomandibular joint ,Plastic surgery ,medicine.anatomical_structure ,stomatognathic system ,Dentistry ,Oral and maxillofacial surgery ,medicine ,Surgery ,In patient ,Displacement (orthopedic surgery) ,Ostectomy ,business ,Facial symmetry - Abstract
Background The purpose of this retrospective study was to evaluate the postoperative change in the position and stability of the mandibular condyle after bilateral sagittal split ramus osteotomy (BSSRO) and BSSRO with distal segmental ostectomy (DSO) in patients with facial asymmetry using 3D computed tomography. Methods The condyles of the patient diagnosed with facial asymmetry were divided into the deviated side (DS) and the non-deviated side (NDS). Group I, which was treated with BSSRO only, and Group II, which additionally received DSO along with BSSRO, were superimposed on the condyle using the pre-and postoperative 3D CT. The amount of condylar change in anteroposterior displacement, mediolateral displacement, and rotation was measured. The clinical symptoms of temporomandibular joint were also evaluated before and after surgery for each patient. Results Between Groups I and II, there was no statistically significant difference in the anteroposterior condylar position on both DS and NDS. And also, there was no statistical difference between the two groups in the mediolateral change on DS but, statistically significant difference on NDS. The change in the rotation of the condyle was observed to rotate inward from both condylar heads of Groups I and II, and a statistically significant difference was observed between the two groups on both DS and NDS. Moreover, no difference in clinical temporomandibular joint symptoms was observed after surgery in each DS and NDS condyle of the two groups. Conclusions As a result of analyzing the condylar position change of the group treated with BSSRO alone and the group treated with BSSRO and DSO in patients with facial asymmetry, there were statistically significant differences in the mediolateral displacement of NDS and the condyle rotation of NDS and DS. However, the anteroposterior condylar position did not show any difference in the bilateral condyles. In addition, since worsening clinical symptoms of bilateral temporomandibular joint were not observed before and after surgery in both groups, it is concluded that it is not necessary to accompany DSO in patients with facial asymmetry (minimum 3 mm, maximum 7 mm).
- Published
- 2021
30. Immediate implant placement following tooth extraction with simultaneous lateral sinus augmentation: a retrospective clinical study after at least 1 year of loading
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Bok-Joo Kim, Jung-Han Kim, and Chul-Hoon Kim
- Subjects
Survival rate ,Dental implant ,medicine.medical_treatment ,Sinus Floor Augmentation ,Dentistry ,Osseointegration ,Statistical significance ,Maxilla ,medicine ,Humans ,Stage (cooking) ,Retrospective Studies ,Transverse Sinuses ,Sinus augmentation ,business.industry ,Research ,Immediate placement ,RK1-715 ,Lateral sinus ,Immediate implant ,Implant stability quotient ,Tooth Extraction ,Medicine ,business - Abstract
Background Lateral sinus augmentation is necessary when the residual bone height is insufficient in the posterior maxilla. Immediate implant placement following tooth extraction with lateral sinus augmentation will shorten the number of operations and treatment time. Purpose To evaluate radiologic and clinical results for at least 1 year after loading in patients who underwent tooth extraction, implant placement, and lateral sinus augmentation at the same time. Materials and methods We retrospectively evaluated 35 implants placed in 25 patients. Preoperative and postoperative CBCT were compared and analyzed for residual bone height (RBH) and increased bone height (IBH), the initial torque value (ITV), and the implant stability quotient (ISQ). A comparative evaluation was performed between a 1-stage (non-submerged) group and a 2-stage (submerged) group. After loading for at least 1 year, clinical and radiological evaluations were performed to evaluate the survival rate. Results One of the 35 implants failed in osseointegration, and the remaining 34 showed successful results. The failure-free survival rate at 1 year was 97.06% (95% CI, 91.38-100.0%). The RBH ranged from 3.1 to 9.6 mm (mean, 5.62 ± 1.68 mm), and the IBH ranged from 3 to 15.3 mm (mean, 8.87 ± 2.74 mm). Among the RBH, ITV, ISQ, treatment period, final bone height, and failure evaluation by stage of implant placement, only ISQ showed statistical significance between the groups (p < .001). A comparison of RBH, ITV, and ISQ, regardless of group, showed that each value tended to increase, but there were no statistically significant differences. Conclusions Immediate implant placement following tooth extraction with simultaneous lateral sinus augmentation is considered reliable even though the procedures had been performed at the same time.
- Published
- 2021
31. Efficient Photon Extraction in Top‐Emission Organic Light‐Emitting Devices Based on Ampicillin Microstructures (Adv. Mater. 32/2022)
- Author
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Dong Hyun Kim, Chang Min Lee, Amjad Islam, Dong Hyun Choi, Geon‐Woo Jeong, Tae Wook Kim, Hyun Woo Cho, Yeong Beom Kim, Syed Hamad Ullah Shah, Min Jae Park, Chul Hoon Kim, Hyun Jae Lee, Jae Woo Lee, Seain Bang, Tae‐Sung Bae, Jong Bae Park, Seung Min Yu, Yong‐Cheol Kang, Juyun Park, Myeongkee Park, Yeonsu Jeong, Sang Geul Lee, Jong Sung Jin, Kyoung‐Ho Kim, Muhammad Sujak, Surk‐Suik Moon, Sanghyuk Park, Myung kwan Song, Chang‐Su Kim, and Seung Yoon Ryu
- Subjects
Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2022
32. A Hybrid Ru(II)/TiO
- Author
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Min Su, Choe, Sunghan, Choi, So-Yoen, Kim, Changhyun, Back, Daehan, Lee, Hyun Seok, Lee, Chul Hoon, Kim, Ho-Jin, Son, and Sang Ook, Kang
- Abstract
Herein, we employed a molecular Ru(II) catalyst immobilized onto TiO
- Published
- 2021
33. Organometallic Iridium(III) Complex Sensitized Ternary Hybrid Photocatalyst for CO 2 to CO Conversion
- Author
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Pil Soo Kim, Wooyul Kim, Sang Ook Kang, Yoon Seo Lee, Chyongjin Pac, Chul Hoon Kim, So-Yoen Kim, S.J. Choi, B. Kim, Ho-Jin Son, Ju Hyoung Jo, and Wonyong Choi
- Subjects
Ternary numeral system ,Quenching (fluorescence) ,010405 organic chemistry ,Organic Chemistry ,chemistry.chemical_element ,General Chemistry ,Rhenium ,010402 general chemistry ,Heterogeneous catalysis ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Turnover number ,chemistry ,Polymer chemistry ,Iridium ,Ternary operation - Abstract
A series of heteroleptic iridium(III) complexes functionalized with two phosphonic acid (-PO3 H2 ) groups (dfppy IrP, ppy IrP, btp IrP, and piq IrP) were prepared and anchored onto rhenium(I) catalyst (ReP)-loaded TiO2 particles (TiO2 /ReP) to build up a new IrP-sensitized TiO2 photocatalyst system (IrP/TiO2 /ReP). The photosensitizing behavior of the IrP series was examined within the IrP/TiO2 /ReP platform for the photocatalytic conversion of CO2 into CO. The four IrP-based ternary hybrids showed increased conversion activity and durability than that of the corresponding homo- (IrP+ReP) and heterogeneous (IrP+TiO2 /ReP) mixed systems. Among the four IrP/TiO2 /ReP photocatalysts, the low-energy-light (>500 nm) activated piq IrP immobilized ternary system (piq IrP/TiO2 /ReP) exhibited the most durable conversion activity, giving a turnover number of ≥730 for 170 h. A similar kinetic feature observed through time-resolved photoluminescence measurements of both btp IrP/TiO2 and TiO2 -free btp IrP films suggests that the net electron flow in the ternary hybrid proceeds dominantly through a reductive quenching mechanism, unlike the oxidative quenching route of typical dye/TiO2 -based photolysis.
- Published
- 2019
34. Utility of Squaraine Dyes for Dye-Sensitized Photocatalysis on Water or Carbon Dioxide Reduction
- Author
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So-Yoen Kim, Sang Ook Kang, Pil Soo Kim, Chyongjin Pac, Minji Jo, S.J. Choi, Chul Hoon Kim, Ju Hyoung Jo, and Ho-Jin Son
- Subjects
Chemistry ,General Chemical Engineering ,Photocatalysis ,General Chemistry ,QD1-999 ,Article ,Catalysis ,Nuclear chemistry ,Electrochemical reduction of carbon dioxide - Abstract
Red light-sensitized squaraine (SQ) dyes were developed and incorporated into dye-sensitized catalysts (DSCs) with the formula of SQ/TiO2/Cat, and their efficacies were evaluated in terms of performance on either water or carbon dioxide reduction. Pt nanoparticles or fac-[Re(4,4′-bis-(diethoxyphosphorylmethyl)-2,2′-bipyridine)(CO)3Cl] were used as each catalytic center within the DSC frame of SQ/TiO2/Pt (Type I) or SQ/TiO2/Re(I) (Type II). In order to convey the potential utility of SQ in low energy sensitization, the following catalytic reductions were carried out under selective lower energy irradiation (>500 nm). Type I and II showed different catalytic performances, primarily due to the choice of solvent for each catalytic condition: hydrogenation was carried out in H2O, but CO2 reduction in dimethylformamide (DMF), and SQ was more stable in aqueous acid conditions for hydrogen generation than CO2 reduction in DMF. A suspension of Type I in 3 mL water containing 0.1 M ascorbic acid (pH = 2.66) resulted in efficient photocatalytic hydrogen evolution, producing 37 μmol of H2 for 4 h. However, in photocatalysis of Type II (SQ/TiO2/Re(I)) in 3 mL DMF containing 0.1 M 1,3-dimethyl-2-phenyl-1,3-dihydrobenzimidazole, the TiO2-bound SQ dyes were not capable of working as a low energy sensitizer because SQ was susceptible to dye decomposition in nucleophilic DMF conditions, resulting in DSC deactivation for the CO2 reduction. Even with the limitation of solvent, the DSC conditions for the utility of SQ have been established: the anchoring group effect of SQ with either phosphonic acid or carboxylic acid onto the TiO2 surface; energy alignment of SQ with the flat band potentials (Efb) of TiO2 semiconductors and the reduction power of electron donors; and the wavelength range of the light source used, particularly when >500 nm.
- Published
- 2019
35. Triplet Energy Transfer between a Sacrificial PMP and Blue TPF2 Iridium Dopants Leading to Enhancement of OLED Device Performance
- Author
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Sang Ook Kang, Chul Hoon Kim, Ho-Jin Son, Seungjun Yi, Mi Rang Son, Jin-Hyoung Kim, and So-Yoen Kim
- Subjects
Materials science ,Dopant ,Intermolecular force ,Doping ,chemistry.chemical_element ,Excimer ,Photochemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,General Energy ,chemistry ,Picosecond ,OLED ,Iridium ,Physical and Theoretical Chemistry ,Luminescence - Abstract
In this study, we prepared phenylimidazole-based C^N-cyclometalated Ir(III) complexes (DMP, TPF2) and a C^C-cyclometalated Ir(III) complex (PMP), and investigated the energy transfer process by examining the intermolecular interactions between the two cyclometalated Ir(III) complexes. In films doped with 3% Ir(C^C)3 complex (PMP) and 15% Ir(C^N)3 complex (DMP or TPF2), the PMP effectively induced energy transfer to the DMP or TPF2. This intermolecular energy transfer process was investigated using a picosecond time-resolved emission spectroscopic method. In the case of mixing PMP with DMP, where two types of luminescence were observed at 470 and 580 nm, the emission at 470 nm was due to DMP, while the emission at 580 nm can be assigned as the intermolecular exciplex emission. By contrast, in the case of mixing PMP with TPF2, the emission at 465 nm corresponding to the PMP emission region decreased for 18.5 ns, while the emission at 530 nm corresponding to TPF2 increased. This emission can be attributed to...
- Published
- 2019
36. Phenothiazine Functionalized Multifunctional A−π–D−π–D−π–A-Type Hole-Transporting Materials via Sequential C–H Arylation Approach for Efficient and Stable Perovskite Solar Cells
- Author
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Hwan Kyu Kim, Chunyuan Lu, Chul Hoon Kim, Kyutai Park, and Mahalingavelar Paramasivam
- Subjects
Materials science ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Acceptor ,Small molecule ,0104 chemical sciences ,chemistry.chemical_compound ,Crystallography ,chemistry ,Phenothiazine ,General Materials Science ,Lewis acids and bases ,0210 nano-technology ,Perovskite (structure) - Abstract
Three phenothiazine-based A-π-D-π-D-π-A-type small molecules containing various terminal acceptor units, which act as Lewis base blocks, have been synthesized via an efficient and step-economical, direct C-H arylation strategy in the aim toward the development of hole-transporting materials (HTMs) with multifunctional features (such as efficient hole extraction layer, trap passivation layer, and hydrophobic protective layer) for perovskite solar cells (PrSCs). Optical-electrochemical correlation and density functional theory studies reveal that dicyanovinylene acceptor in SGT-421 downshifted the highest occupied molecular orbital (HOMO) level (-5.41 eV), which is more proximal to the valence band (-5.43 eV) of the perovskite, whereas N-methyl rhodanine in SGT-420 and 1,3-indanedione (IND) in SGT-422 destabilized the HOMO, leading to an increased interfacial energy-level offset. SGT-421 exhibits superior properties in terms of a sufficiently low-lying HOMO level and favorable energy-level alignment, intrinsic hole mobility, interfacial hole transfer, hydrophobicity, and trap passivation ability over spiro-OMeTAD as a benchmark small-molecule HTM. As envisaged in the design concept, SGT-421-based PrSC not only yields a comparable efficiency of 17.3% to the state-of-art of spiro-OMeTAD (18%), but also demonstrates the enhanced long-term stability compared to the spiro-OMeTAD because of its multifunctional features. More importantly, the synthetic cost of SGT-421 is estimated to be 2.15 times lower than that of spiro-OMeTAD. The proposed design strategy and the study of acceptor-property relationship of HTMs would provide valuable insights into and guidelines for the development of new low-cost and efficient multifunctional HTMs toward the realization of efficient and long-term stable PrSCs.
- Published
- 2019
37. Harvesting near- and far-field plasmonic enhancements from large size gold nanoparticles for improved performance in organic bulk heterojunction solar cells
- Author
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Yong-Cheol Kang, Juuyn Park, Kwun-Bum Chung, Hassan Hafeez, Chang Su Kim, Dong Hyun Kim, Tae-Sung Bae, P. Justin Jeusraj, Won-Ho Lee, Jongmoon Shin, Jong Chan Lee, Chul Hoon Kim, Aeran Song, Hong Gyu Park, Seung Yoon Ryu, Dae Keun Choi, Seung Min Yu, Kyoung-Ho Kim, and Myungkwan Song
- Subjects
Materials science ,Organic solar cell ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Polymer solar cell ,law.invention ,Biomaterials ,PEDOT:PSS ,law ,Solar cell ,Materials Chemistry ,Electrical and Electronic Engineering ,Surface plasmon resonance ,Plasmon ,business.industry ,Energy conversion efficiency ,General Chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Optoelectronics ,0210 nano-technology ,business ,Luminescence - Abstract
The high stability and strong coupling nature of gold nanoparticles (Au-NPs) than other metal counter parts have attracted the solar cell industry to pursue enhanced performances. Herein, we report on the improved performance of polymer bulk hetero-junction (BHJ) solar cells by the incorporation of large-size Au-NPs in the hole transport layer of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS). To examine the reproducibility of the enhancement parameters, two different donor photoactive materials have been adapted and the role of larger-size (>70 nm, i.e. 71, 80, 87, 103 nm) Au-NPs in BHJ solar cells have been studied extensively. Significantly, when employing Au-NPs smaller than 80 nm, near-field coupling (localized surface plasmon resonance; LSPR) was prevalent, while the infusion of Au-NPs with sizes greater than 87 nm resulted in far-field scattering enhancement as the dominant effect, which was clearly determined using time resolved photo luminescence studies. The superior power conversion efficiency of 5.35% and 8.58% was achieved with PBDTTT-C: PC61BM and PTB7: PC71BM BHJs respectively, by employing 87 nm Au-NPs due to the balanced contribution of near- and far-field plasmonic effects, improved vertical coverage and better interfacial properties. This study illustrates that 87 nm Au-NPs is the maximum size to attain the improved efficiency, above which the rate of enhancement reduces dramatically.
- Published
- 2019
38. Ring Closure Reaction Pathway of a Diarylethene in Solution Using Femtosecond Time‐resolved Fluorescence Spectra
- Author
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Chul Hoon Kim, Taiha Joo, Kiho Seo, Intae Eom, and Sangdeok Shim
- Subjects
chemistry.chemical_compound ,Materials science ,Diarylethene ,chemistry ,Femtosecond ,Closure (topology) ,General Chemistry ,Time-resolved spectroscopy ,Ring (chemistry) ,Photochemistry ,Spectral line - Published
- 2019
39. Oral mucosa pressure ulcers in intensive care unit patients: A preliminary observational study of incidence and risk factors
- Author
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Nam Jung Park, Chul-Hoon Kim, Myung Ja Kang, Hyun Kyeong Jung, Hyun Hee Kim, and Myoung Soo Kim
- Subjects
Male ,medicine.medical_specialty ,Dermatology ,Pathology and Forensic Medicine ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,law ,Internal medicine ,Intensive care ,Republic of Korea ,Intubation, Intratracheal ,Humans ,Vasoconstrictor Agents ,Medicine ,Prospective Studies ,Oral mucosa ,Stage (cooking) ,Aged ,Retrospective Studies ,Pressure Ulcer ,030504 nursing ,business.industry ,Incidence ,Incidence (epidemiology) ,Medical record ,Mouth Mucosa ,Middle Aged ,Respiration, Artificial ,Intensive care unit ,Intensive Care Units ,medicine.anatomical_structure ,Female ,Observational study ,0305 other medical science ,Airway ,business - Abstract
Purpose: This study examined the incidence of oral mucosa pressure ulcers (PUs) in intensive care unit (ICU) patients and the relationship between biomechanical and physiological variables in onset of PUs. Methods: A prospective observational descriptive study design was used. We recruited patients over 18 years of age with endotracheal tube (ETT) insertion in three ICUs in a tertiary hospital in Korea. We analysed 113 patient-days of data. Patient assessments and medical record reviews were conducted to gather biomechanical and physiological data. Fisher's exact tests and χ2 test and Spearman's rank correlations were used to compare data. Results: The highest incidence of oral mucosa PUs occurred in lower oral mucosa (36.3%). There was a significant relationship between lower oral mucosa PU stage and bite-block or airway use (r = .20, p = .036), commercial ETT holder use (r = 0.19, p = .048), sedative use (r = −0.22, p = .022), and plasma protein (r = 0.20, p = .033). Upper oral mucosa PU stage was related to commercial ETT holder use (r = 0.19, p = .044), haemoglobin(r = 0.24, p = .011), haematocrit (r = 0.27, p = .004), and serum albumin (r = −0.24, p = .012). Stage was related to commercial ETT holder use in both sites (r = 0.28, p = .003), haematocrit (r = 0.19, p = .039), and serum albumin (r = −0.23, p = .015). Conclusion: Oral mucosa PUs developed more frequently and healed more quickly than general skin PUs. Taken together, these data indicate that biomechanical and haematological variables are risk factors associated with PU incidence should be considered in intensive care patients.
- Published
- 2019
40. Highly Selective and Durable Photochemical CO2 Reduction by Molecular Mn(I) Catalyst Fixed on a Particular Dye-Sensitized TiO2 Platform
- Author
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Chul Hoon Kim, S.J. Choi, Ho-Jin Son, Ju Hyoung Jo, Sung-Jun Woo, Chyongjin Pac, So-Yoen Kim, Pil Soo Kim, and Sang Ook Kang
- Subjects
Reduction (complexity) ,010405 organic chemistry ,Chemistry ,Photocatalysis ,General Chemistry ,010402 general chemistry ,Photochemistry ,Heterogeneous catalysis ,Highly selective ,01 natural sciences ,Catalysis ,0104 chemical sciences - Abstract
A Mn(I)-based hybrid system (OrgD-|TiO2|-MnP) for photocatalytic CO2 reduction is designed to be a coassembly of Mn(4,4′-Y2-bpy)(CO)3Br (MnP; Y = CH2PO(OH)2) and (E)-3-[5-(4-(diphenylamino)phenyl)-...
- Published
- 2019
41. Molecular design and synthesis of D–π–A structured porphyrin dyes with various acceptor units for dye-sensitized solar cells
- Author
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Haoran Zhou, Min Su Kim, Chul Hoon Kim, Sung Ho Kang, Jung-Min Ji, Hyun Seok Lee, and Hwan Kyu Kim
- Subjects
Materials science ,Photovoltaic system ,Energy conversion efficiency ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,Photochemistry ,01 natural sciences ,Acceptor ,Porphyrin ,0104 chemical sciences ,Dye-sensitized solar cell ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,0210 nano-technology ,Absorption (electromagnetic radiation) ,HOMO/LUMO - Abstract
Two porphyrin sensitizers, SGT-023 and SGT-025, were synthesized through acceptor structural engineering. SGT-023 was designed by replacing the commonly used benzothiadiazole (BTD) unit in the well-known platform of D-porphyrin-triple bond-BTD-acceptor sensitizers (e.g., SM315 and SGT-021) with a pyridothiadiazole unit as a stronger electron-withdrawing group. As for SGT-025, an additional ethynylene bridge was inserted into the acceptor part of the well-known skeleton of D-porphyrin-triple bond-BTD-acceptor sensitizers. The impact of the auxiliary acceptors on the optical, electrochemical, and photovoltaic properties was investigated and compared with a benchmark dye, SGT-021, developed by our group. Consequently, both porphyrin sensitizers could red-shift the absorption range and downshift the lowest unoccupied molecular orbital (LUMO) energy level, which was supposed to achieve higher light harvest efficiency (LHE). Under standard global AM 1.5G solar light conditions, SGT-025 attained a relatively high maximum power conversion efficiency (PCE) of 11.0%, which was slightly lower than that of the reference dye SGT-021 (12.6%), and a moderate PCE of 5.6% was obtained by SGT-023. The main reason is the lower charge collection efficiency, which can be attributed to the tilted dye adsorption mode on TiO2. This may allow for faster charge recombination which eventually leads to lower Jsc, Voc and PCE.
- Published
- 2019
42. Patient-derived hepatocellular carcinoma organoids as predictors of Treatment Response
- Author
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Jun Yong Park, Kyung Joo Cho, Hye Won Lee, Hye Jung Park, Sang Hoon Ahn, Hee Seung Lee, and Chul Hoon Kim
- Subjects
Hepatology - Published
- 2022
43. Integrative clustering of multiple genomic data using organoid model with application to subtype analysis in intrahepatic cholangiocarcinoma
- Author
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Hee Seung Lee, Dai Hoon Han, Kyung Joo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, and Jun Yong Park
- Subjects
Hepatology - Published
- 2022
44. Targeted Temperature Management at 33°C or 36°C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke
- Author
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Chul Hoon Kim, Yong Eun Chung, Je Sung You, Sung Phil Chung, Incheol Park, Jisoo Lim, and Jung Ho Lee
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Resuscitation ,medicine.medical_treatment ,Fluorescent Antibody Technique ,Infarction ,Brain damage ,Targeted temperature management ,Real-Time Polymerase Chain Reaction ,Critical Care and Intensive Care Medicine ,Neuroprotection ,03 medical and health sciences ,0302 clinical medicine ,Hypothermia, Induced ,Internal medicine ,medicine ,Animals ,business.industry ,Standard treatment ,Temperature ,Infarction, Middle Cerebral Artery ,Sudden cardiac arrest ,Hypothermia ,medicine.disease ,Rats ,Stroke ,Disease Models, Animal ,030104 developmental biology ,Emergency Medicine ,Cardiology ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Targeted temperature management (TTM, 32°C to 36°C) is one of the most successful achievements in modern resuscitation medicine. It has become standard treatment for survivors of sudden cardiac arrest to minimize secondary brain damage. TTM at 36°C is just as effective as TTM at 33°C and is actually preferred because it reduces adverse TTM-associated effects. TTM also likely has direct neuroprotective effects in ischemic brains in danger of stroke. It remains unclear, however, whether higher temperature TTM is equally effective in protecting the brain from the effects of stroke. Here, we asked whether TTM at 36°C is as effective as TTM at 33°C in improving outcomes in a middle cerebral artery occlusion (MCAO) model of ischemic stroke. After dividing rats randomly into MCAO, MCAO+33°C TTM, MCAO+36°C TTM, and sham groups, we subjected all of them except for the sham group to MCAO for 3 h (for the behavioral tests) or 4 h (for all other biochemical analyses). We found TTM protocols at both 33°C and 36°C to produce comparable reductions of infarct volumes in the MCAO territory and equally attenuate the extracellular release of high mobility group box 1 in postischemic brains. Both the TTM conditions prevent the mRNA induction of a major pro-inflammatory cytokine, tissue necrosis factor-α, in the ischemic penumbra region. Finally, both the TTM protocols produce similar improvements in neurological outcomes in rats, as measured by a battery of behavior tests 21 h after the start of reperfusion. These data acquired in a rat MCAO model suggest TTM at 36°C has excellent therapeutic potential for improving clinical outcomes for patients with acute ischemic stroke.
- Published
- 2018
45. Rapid Exciton Migration and Amplified Funneling Effects of Multi-Porphyrin Arrays in a Re(I)/Porphyrinic MOF Hybrid for Photocatalytic CO
- Author
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Sunghan, Choi, Won-Jo, Jung, Kyutai, Park, So-Yeon, Kim, Jin-Ook, Baeg, Chul Hoon, Kim, Ho-Jin, Son, Chyongjin, Pac, and Sang Ook, Kang
- Abstract
A porphyrinic metal-organic framework (
- Published
- 2021
46. Neuronal defects in a human cellular model of 22q11.2 deletion syndrome
- Author
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Jonathan A. Bernstein, Julia M. Schaepe, Themasap Khan, Yishan Sun, Anna K. Krawisz, Judith L. Rapoport, Neal D. Amin, Masayuki Yazawa, Yuan Tian, Min-Yin Li, Carrie E. Bearden, Matthew H. Porteus, Seiji Nishino, Ruth O'Hara, Aaron Gordon, Sergiu P. Paşca, John R. Huguenard, Ricardo E. Dolmetsch, Omer Revah, Leila Kushan, Noriaki Sakai, Daniel H. Geschwind, Se-Jin Yoon, Chul Hoon Kim, Joachim Hallmayer, Carleton Goold, and Kazuya Ikeda
- Subjects
0301 basic medicine ,Adult ,Male ,Cellular differentiation ,Induced Pluripotent Stem Cells ,Immunology ,chemistry.chemical_element ,Calcium ,Biology ,Medical and Health Sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Young Adult ,Congenital ,0302 clinical medicine ,Stem Cell Research - Nonembryonic - Human ,DiGeorge Syndrome ,Genetics ,Premovement neuronal activity ,Humans ,2.1 Biological and endogenous factors ,Calcium Signaling ,Aetiology ,Induced pluripotent stem cell ,Calcium signaling ,Cerebral Cortex ,Neurons ,Pediatric ,Voltage-dependent calcium channel ,Stem Cell Research - Induced Pluripotent Stem Cell - Human ,Stem Cell Research - Induced Pluripotent Stem Cell ,Neurosciences ,Cell Differentiation ,General Medicine ,Stem Cell Research ,Cell biology ,Organoids ,030104 developmental biology ,Mental Health ,chemistry ,030220 oncology & carcinogenesis ,Neurological ,Female ,Stem cell ,Cellular model - Abstract
22q11.2 deletion syndrome (22q11DS) is a highly penetrant and common genetic cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from 15 individuals with 22q11DS and 15 control individuals and differentiated them into three-dimensional (3D) cerebral cortical organoids. Transcriptional profiling across 100 days showed high reliability of differentiation and revealed changes in neuronal excitability-related genes. Using electrophysiology and live imaging, we identified defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived cortical neurons. The calcium deficit was related to resting membrane potential changes that led to abnormal inactivation of voltage-gated calcium channels. Heterozygous loss of DGCR8 recapitulated the excitability and calcium phenotypes and its overexpression rescued these defects. Moreover, the 22q11DS calcium abnormality could also be restored by application of antipsychotics. Taken together, our study illustrates how stem cell derived models can be used to uncover and rescue cellular phenotypes associated with genetic forms of neuropsychiatric disease. A human stem cell–derived model helps to uncover neuronal phenotypes associated with genetic forms of neuropsychiatric disease.
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- 2020
47. Highly efficient, heat dissipating, stretchable organic light-emitting diodes based on a MoO
- Author
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Muhammad Sujak, Tae-Sung Bae, Yong-Cheol Kang, Hyung Ju Chae, Seunghyup Yoo, Geon-Woo Jeong, Changmin Lee, Hassan Hafeez, Boo Soo Ma, Subrata Sarker, Seung Yoon Ryu, Dong-Hyun Kim, Jae Woo Lee, Kyoung-Ho Kim, Dae Keun Choi, Hyun Jae Lee, Dong Hyun Kim, Chul Hoon Kim, Chang Su Kim, Jinouk Song, Juyun Park, Jun Su Yang, Taek-Soo Kim, Dong Hyun Choi, Myungkwan Song, Seung Min Yu, and Tae Wook Kim
- Subjects
Materials science ,Science ,General Physics and Astronomy ,Nanoparticle ,02 engineering and technology ,Substrate (electronics) ,010402 general chemistry ,Elastomer ,01 natural sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,Displays ,OLED ,Organic LEDs ,Author Correction ,Diode ,Multidisciplinary ,business.industry ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Electrode ,Optoelectronics ,Quantum efficiency ,Adhesive ,0210 nano-technology ,business - Abstract
Stretchable organic light-emitting diodes are ubiquitous in the rapidly developing wearable display technology. However, low efficiency and poor mechanical stability inhibit their commercial applications owing to the restrictions generated by strain. Here, we demonstrate the exceptional performance of a transparent (molybdenum-trioxide/gold/molybdenum-trioxide) electrode for buckled, twistable, and geometrically stretchable organic light-emitting diodes under 2-dimensional random area strain with invariant color coordinates. The devices are fabricated on a thin optical-adhesive/elastomer with a small mechanical bending strain and water-proofed by optical-adhesive encapsulation in a sandwiched structure. The heat dissipation mechanism of the thin optical-adhesive substrate, thin elastomer-based devices or silicon dioxide nanoparticles reduces triplet-triplet annihilation, providing consistent performance at high exciton density, compared with thick elastomer and a glass substrate. The performance is enhanced by the nanoparticles in the optical-adhesive for light out-coupling and improved heat dissipation. A high current efficiency of ~82.4 cd/A and an external quantum efficiency of ~22.3% are achieved with minimum efficiency roll-off., A transparent twistable and stretchable MoO3/Au/MoO3 electrode is demonstrated by Choi et al. for organic light-emitting diodes. The device fabricated on thin elastomer shows enhanced EQE with minimum efficiency roll-off owing to the improved charge injection and heat dissipation from the substrate.
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- 2020
48. Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells
- Author
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Joon Seong Park, Jae-Il Choi, Chul Hoon Kim, Jong-Baeck Lim, Sung Ill Jang, Jaehyun Hong, and Soon Sung Kwon
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0301 basic medicine ,Cancer Research ,endocrine system diseases ,Cell Line ,03 medical and health sciences ,Paracrine signalling ,0302 clinical medicine ,Cancer stem cell ,Organoid ,Human Umbilical Vein Endothelial Cells ,Tumor Microenvironment ,Humans ,Wnt Signaling Pathway ,Tumor microenvironment ,biology ,Receptors, Notch ,Chemistry ,Stem Cells ,CD44 ,Wnt signaling pathway ,Pancreatic Ducts ,CD24 Antigen ,Endothelial Cells ,Epithelial Cell Adhesion Molecule ,digestive system diseases ,Organoids ,Pancreatic Neoplasms ,030104 developmental biology ,HEK293 Cells ,Hyaluronan Receptors ,Oncology ,030220 oncology & carcinogenesis ,Cancer cell ,Cancer research ,biology.protein ,Stem cell ,Carcinoma, Pancreatic Ductal ,Signal Transduction - Abstract
Pancreatic ductal adenocarcinoma (PDAC) shows poor prognosis and high malignancy due to the presence of cancer-initiating cells (CICs) and characteristics of the tumor microenvironment (TME). Organoids are useful for studying PDAC, and establishing organoids is dependent on stem cell growth factors, including Wnt signaling. Herein, using a conventional organoid culture system, we demonstrated that CD44(+)CD24(+) and CD44(+)CD24(+)EpCAM(+) CICs were enriched >65% in a PDAC patient-derived organoid. CICs expressing CD44 formed lumen structures by gathering into circles. Additionally, organoid-derived CD44(-) cancer cells were capable of organoid re-formation and could be re-programed as CD44-expressing CICs in the organoid culture system. To mimic a TME absent artificial stem cell growth factors, a PDAC organoid with vascular niche was established. CICs in the PDAC tumor organoid were maintained by paracrine effects and direct interactions with endothelial cells. Interestingly, CD44(+) cells in PDAC tumor tissue were detected primarily in the vascular niche. Inhibiting both Wnt and Notch signaling in endothelial cells suppressed organoid formation and the maintenance of CD24(+)CD44(+) CICs. Collectively, our results suggest that PDAC patient-derived organoids maintain CICs by interacting with endothelial cells via Wnt and Notch pathways.
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- 2020
49. Clozapine generates obsessive compulsive disorder-like behavior in mice
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Se Joo Kim, Chul Hoon Kim, Soo Hyeon Bae, Yong-Seok Kim, Kyung Sue Hong, Hogun Lew, Jong-Cheol Rah, Jisoo Lim, Hyun Jong Noh, and Shinwon Kang
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0301 basic medicine ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Neurology ,Nerve Tissue Proteins ,behavioral disciplines and activities ,lcsh:RC346-429 ,Micro Report ,Mice ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Gene interaction ,Obsessive compulsive ,Continuous release ,Internal medicine ,mental disorders ,medicine ,Animals ,Clozapine ,Molecular Biology ,lcsh:Neurology. Diseases of the nervous system ,Mice, Knockout ,Fluoxetine ,Behavior, Animal ,business.industry ,medicine.disease ,Grooming ,030104 developmental biology ,Endocrinology ,Schizophrenia ,Psychopharmacology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear whether clozapine can generate OCS de novo. Thus, it has been difficult to establish a causal link between clozapine and OCS in human studies. To address this question, we asked whether chronic treatment with clozapine can induce obsessive compulsive disorder (OCD)-like behavior in mice. We injected mice with long-term continuous release pellets embedded with clozapine four times at 60-day intervals and then monitored the mice for signs of OCD-like behavior up to 40 wk. of age. We found clozapine increases grooming behavior as early as 30 wk. of age. We also investigated the effect clozapine on grooming behavior in Sapap3 knockout (KO) mice, which are a well-known animal model of OCD. In Sapap3 heterozygous KO mice, clozapine increases grooming behavior much earlier than in wild-type mice, suggesting a clozapine-OCD gene interaction. Fluoxetine, which is often used in the treatment of OCS and OCD, reduced the grooming behavior induced by clozapine. These data demonstrate that chronic clozapine treatment can generate OCD-like behavior in mice and support the hypothesis that clozapine produces de novo OCS regardless of schizophrenia status.
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- 2020
50. Ancillary Ligand Effects on Heteroleptic Ir
- Author
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Ju Hyoung, Jo, Sunghan, Choi, Ha-Yeon, Cheong, Jae Yoon, Shin, Chul Hoon, Kim, Dae Won, Cho, Ho-Jin, Son, Chyongjin, Pac, and Sang Ook, Kang
- Abstract
Herein, we report the synthesis, and photochemical and -physical properties, as well as the catalytic performance, of a series of heteroleptic Ir
- Published
- 2020
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