1. X-ray phase-contrast micro tomography of soft tissues using a compact laboratory system with two-directional sensitivity
- Author
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Navarrete-Leon, Carlos, Doherty, Adam, Savvidis, Savvas, Gerli, Mattia F. M., Piredda, Giovanni, Astolfo, Alberto, Cipiccia, Silvia, Bate, David, Hagen, Charlotte K., Olivo, Alessandro, and Endrizzi, Marco
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Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) - Abstract
X-ray micro tomography is a non-destructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology and medical research. Phase-contrast imaging extends the domain of application of X-ray micro tomography to classes of samples that exhibit weak attenuation, thus appear with poor contrast in standard X-ray imaging. Notable examples are low-atomic-number materials, like carbon-fibre composites, soft matter and biological soft tissues. We report on a compact and cost effective system for X-ray phase-contrast micro tomography. The system features high sensitivity to phase gradients and high resolution, requires a low-power sealed X-ray tube, a single optical element, and fits in a small footprint. It is compatible with standard X-ray detector technologies: single-photon-counting offers higher sensitivity whereas flat-panels are preferred for a larger field of view. The system is benchmarked against known-material phantoms and its potential for soft-tissue three-dimensional imaging is demonstrated on small-animal organs: a piglet oesophagus and a rat heart.
- Published
- 2022
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