1. Irregular menses predicts ovarian cancer: Prospective evidence from the Child Health and Development Studies
- Author
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Cirillo, PM, Wang, ET, Cedars, MI, Chen, L-M, and Cohn, BA
- Subjects
Adult ,Aging ,Oncology and Carcinogenesis ,and over ,Kaplan-Meier Estimate ,polycycstic ovarian syndrome ,California ,Young Adult ,Rare Diseases ,Risk Factors ,Clinical Research ,80 and over ,cohort study ,Humans ,Oncology & Carcinogenesis ,Menstruation Disturbances ,Menstrual Cycle ,Aged ,Cancer ,Ovarian Neoplasms ,Incidence ,Prevention ,Middle Aged ,prospective ,Ovarian Cancer ,Female ,Follow-Up Studies ,irregular menstrual cycles - Abstract
We tested the hypothesis that irregular menstruation predicts lower risk for ovarian cancer, possibly due to less frequent ovulation. We conducted a 50-year prospective study of 15,528 mothers in the Child Health and Development Studies cohort recruited from the Kaiser Foundation Health Plan from 1959 to 1966. Irregular menstruation was classified via medical record and self-report at age 26. We identified 116 cases and 84 deaths due to ovarian cancer through 2011 via linkage to the California Cancer Registry and Vital Statistics. Contrary to expectation, women with irregular menstrual cycles had a higher risk of ovarian cancer incidence and mortality over the 50-year follow-up. Associations increased with age (p
- Published
- 2016
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