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3. Supplemental figures and movie description from The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer

Author

Armen Petrosyan, Jean-Jack M. Riethoven, Carol A. Casey, Chad A. LaGrange, Cole P. Frisbie, and Sonia Manca

Abstract

S1. Determination of HDAC6 immunofluorescence in the nuclei of PCa tissues. S2. EtOH induces Golgi fragmentation in 22Rv1 cells. S3. (A) The AR W-B of the cytoplasmic and nuclear fractions isolated from LNCaP (c-19) cells. S4. Colocalization of GM130 and GSK3β in LNCaP cells. Movie S1. 3D SIM animation of the control LNCaP (c-26) cells stained with giantin (red). Movie S2. 3D SIM animation of the LNCaP (c-26) cells after EtOH treatment (35 mM for 96 h) stained with giantin (red).

Published
2023

4. Data from The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer

Author

Armen Petrosyan, Jean-Jack M. Riethoven, Carol A. Casey, Chad A. LaGrange, Cole P. Frisbie, and Sonia Manca

Abstract

Multiple epidemiologic observations and meta-analysis clearly indicate the link between alcohol abuse and the incidence and progression of prostate cancer; however, the mechanism remains enigmatic. Recently, it was found that ethanol (EtOH) induces disorganization of the Golgi complex caused by impaired function of the largest Golgi matrix protein, giantin (GOLGB1), which, in turn, alters the Golgi docking of resident Golgi proteins. Here, it is determined that in normal prostate cells, histone deacetylase 6 (HDAC6), the known regulator of androgen receptor (AR) signaling, localizes in the cytoplasm and nucleus, while its kinase, glycogen synthase kinase β (GSK3β), primarily resides in the Golgi. Progression of prostate cancer is accompanied by Golgi scattering, translocation of GSK3β from the Golgi to the cytoplasm, and the cytoplasmic shift in HDAC6 localization. Alcohol dehydrogenase–generated metabolites induces Golgi disorganization in androgen-responsive LNCaP and 22Rv1 cells, facilitates tumor growth in a mouse xenograft model and activates anchorage-independent proliferation, migration, and cell adhesion. EtOH-treated cells demonstrate reduced giantin and subsequent cytoplasmic GSK3β; this phenomenon was validated in giantin-depleted cells. Redistribution of GSK3β to the cytoplasm results in phosphorylation of HDAC6 and its retention in the cytoplasm, which, in turn, stimulates deacetylation of HSP90, AR import into the nucleus, and secretion of prostate-specific antigen (PSA). Finally, the relationship between Golgi morphology, HDAC6 cytoplasmic content, and clinicopathologic features was assessed in human prostate cancer patient specimens with and without a history of alcohol dependence.Implications:This study demonstrates the importance of alcohol-induced Golgi fragmentation in the activation of AR-mediated proliferation.

Published
2023

6. Surgical Repair of Septal Perforations: Comparison of Pedicled Anterior Ethmoid Flap vs. Temporalis Fascia Graft Techniques

Author

Megan Falls, Joseph B. Meleca, Oluwaseyi Awonusi, Jonathan L. Vincze, Jeffrey D. Johnson, Cole P. Rodman, Jonathan Y. Ting, Harold H.B. Lee, Dominic J. Vernon, and Taha Z. Shipchandler

Abstract

Background: Nasal septal perforations (NSP) cause a variety of bothersome symptoms for patients, and when medical management fails, surgical repair is indicated. Objective: This study examines the efficacy of a NSP repair method utilizing superficial or deep temporal fascia and a polydiaxonone (PDS) plate scaffold to the prior repair method of a pedicled anterior ethmoid mucosal flap. Methods: A retrospective review of patients who underwent NSP repair at a tertiary academic medical center from 2016-2021. Results: The most common etiologies for NSP were prior nasal surgery, digital trauma, and chronic epistaxis. Compared to the previous repair group with local flaps, the temporalis fascia and PDS plate group had significantly higher rates of complete closure for perforations of all sizes and a lower incidence of revision surgery. Patients also reported improved resolution of symptoms after repair with this new method. Conclusion: The use of temporalis fascia with a PDS plate is a promising surgical method for repair of NSP, regardless of size or etiology. Keywords: septal perforation, polydiaxonone, temporalis

Published
2023

7. The Effect of Diabetes Mellitus on Post-Operative Outcomes in Patients Undergoing Endoscopic Sinus Surgery

Author

Kolin E. Rubel, Cole P. Rodman, Alex Jones, Dhruv Sharma, Vince Campiti, Megan Falls, Ife Bolujo, Jonathan Y. Ting, and Elisa A. Illing

Subjects
Otorhinolaryngology, General Medicine
Abstract

Background: Diabetes Mellitus (DM) and its associated immune dysfunction are well-studied risk factors for adverse surgical outcomes. The literature regarding endoscopic sinus surgery (ESS) is less robust and there have been conflicting reports on post-operative complications and surgical results in this patient population. The purpose of this study was to analyze the impact of diabetes mellitus on outcomes after ESS via rates of post-operative medical intervention in the first 6 months after surgery. Methods: This was a retrospective cohort study of 176 subjects who underwent ESS from 2015 to 2019 at a single institution by 2 fellowship-trained rhinologists. Subjects were divided into 2 groups, those with a documented Hemoglobin A1c (HbA1c) >6.5 or diagnosis of DM and those with HbA1C Results: Out of n = 176 total patients, n = 39 (22.2%) were categorized into the DM group, which were older (46.4 vs 53.8 years, P = .004) and higher proportion of white patients (89.7% vs 68.6%, P = .008). There were no significant differences between the 2 groups in proportion of revision surgery, surgical extent, and post-operative use of antibiotics or steroids. When including all variables in binary logistic regression for use of postoperative antibiotics or steroids, the only significant variable predicting these outcomes was the extent of surgical resection including sphenoid sinus ( P = .001, OR [95% CI] = 4.02 [1.73-9.34]) or frontal sinus ( P Conclusions: Patients with DM do not appear to have worse post-operative outcomes outside of the initial 6-month postoperative period.

Published
2022

9. Measurement of Spin-Density Matrix Elements in $ρ(770)$ Production with a Linearly Polarized Photon Beam at $E_γ= 8.2\,-\,8.8\,\text{GeV}$

Author

Adhikari, S., Afzal, F., Akondi, C. S., Albrecht, M., Amaryan, M., Arroyave, V., Asaturyan, A., Austregesilo, A., Baldwin, Z., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Byer, D., Chudakov, E., Cole, P. L., Cortes, O., Crede, V., Dalton, M. M., Darulis, D., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Ebersole, D., Edo, M., Egiyan, H., Erbora, T., Eugenio, P., Fabrizi, A., Fanelli, C., Fang, S., Fegan, S., Fitches, J., Foda, A. M., Furletov, S., Gan, L., Gao, H., Gardner, A., Gasparian, A., Gleason, C., Goetzen, K., Goryachev, V. S., Grube, B., Guo, J., Guo, L., Hague, T. J., Hakobyan, H., Hernandez, J., Hoffman, N. D., Hornidge, D., Hou, G., Huber, G. M., Hurck, P., Hurley, A., Imoehl, W., Ireland, D. G., Ito, M. M., Jaegle, I., Jarvis, N. S., Jeske, T., Jones, R. T., Kakoyan, V., Kalicy, G., Khachatryan, V., Khatchatryan, M., Kourkoumelis, C., LaDuke, A., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Liu, B., Livingston, K., Lolos, G. J., Lorenti, L., Lyubovitskij, V., Ma, R., Mack, D., Mahmood, A., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mizutani, K., Neelamana, V., Ng, L., Nissen, E., Orešić, S., Ostrovidov, A. I., Papandreou, Z., Paudel, C., Pedroni, R., Pentchev, L., Peters, K. J., Prather, E., Rakshit, S., Reinhold, J., Remington, A., Ritchie, B. G., Ritman, J., Rodriguez, G., Romanov, D., Saldana, K., Salgado, C., Schadmand, S., Schertz, A. M., Scheuer, K., Schick, A., Schmidt, A., Schumacher, R. A., Schwiening, J., Sharp, P., Shen, X., Shepherd, M. R., Smith, A., Smith, E. S., Sober, D. I., Somov, S., Somov, A., Stevens, J. R., Strakovsky, I. I., Sumner, B., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Viducic, T., Whitlatch, T., Wickramaarachchi, N., Williams, M., Wunderlich, Y., Yu, B., Zarling, J., Zhang, Z., Zhao, Z., Zhou, X., Zhou, J., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

The GlueX experiment at Jefferson Lab studies photoproduction of mesons using linearly polarized $8.5\,\text{GeV}$ photons impinging on a hydrogen target which is contained within a detector with near-complete coverage for charged and neutral particles. We present measurements of spin-density matrix elements for the photoproduction of the vector meson $ρ$(770). The statistical precision achieved exceeds that of previous experiments for polarized photoproduction in this energy range by orders of magnitude. We confirm a high degree of $s$-channel helicity conservation at small squared four-momentum transfer $t$ and are able to extract the $t$-dependence of natural and unnatural-parity exchange contributions to the production process in detail. We confirm the dominance of natural-parity exchange over the full $t$ range. We also find that helicity amplitudes in which the helicity of the incident photon and the photoproduced $ρ(770)$ differ by two units are negligible for $-t, 15 pages, 11 figures

Published
2023
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10. First measurement of hard exclusive $π^- Δ^{++}$ electroproduction beam-spin asymmetries off the proton

Author

Diehl, S., Trotta, N., Joo, K., Achenbach, P., Akbar, Z., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bossu, F., Brinkmann, K. -T., Briscoe, W. J., Bulumulla, D., Burkert, V., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Djalali, C., Dupre, R., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gavalian, G., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Illari, I., Ireland, D. G., Isupov, E. L., Jo, H. S., Johnston, R., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., Camacho, C. Munoz, Naidoo, P., Neupane, K., Niccolai, S., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatie, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I., Strauch, S., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences
Abstract

The polarized cross section ratio $σ_{LT'}/σ_{0}$ from hard exclusive $π^{-} Δ^{++}$ electroproduction off an unpolarized hydrogen target has been extracted based on beam-spin asymmetry measurements using a 10.2 GeV / 10.6 GeV incident electron beam and the CLAS12 spectrometer at Jefferson Lab. The study, which provides the first observation of this channel in the deep-inelastic regime, focuses on very forward-pion kinematics in the valence regime, and photon virtualities ranging from 1.5 GeV$^{2}$ up to 7 GeV$^{2}$. The reaction provides a novel access to the $d$-quark content of the nucleon and to $p \rightarrow Δ^{++}$ transition generalized parton distributions. A comparison to existing results for hard exclusive $π^{+} n$ and $π^{0} p$ electroproduction is provided, which shows a clear impact of the excitation mechanism, encoded in transition generalized parton distributions, on the asymmetry.

Published
2023
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11. Beam Spin Asymmetry Measurements of Deeply Virtual $π^0$ Production with CLAS12

Author

Kim, A., Diehl, S., Joo, K., Kubarovsky, V., Achenbach, P., Akbar, Z., Alvarado, J. S., Armstrong, Whitney R., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Barion, L., Battaglieri, M., Bedlinskiy, I., Benkel, B., Bianconi, A., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Brinkmann, K. T., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clary, B., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., DeVita, R., Defurne, M., Deur, A., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., ElAlaoui, A., ElFassi, L., Fegan, S., Filippi, A., Fogler, C., Gavalian, G., Gilfoyle, G. P., Gosta, G., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Hung, Yu-Chun, Ilieva, Y., Ireland, D. G., Isupov, E., Jo, H. S., Johnston, R., Joosten, S., Khachatryan, M., Khanal, A., Kim, W., Klimenko, V., Kripko, A., Kuhn, S. E., Lanza, L., Leali, M., Kabir, M. L., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., McKinnon, B., Matamoros, D., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., MunozCamacho, C., Naidoo, P., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Reed, Trevor, Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhang, J., Ziegler, V., and Zurek, M.

Subjects
FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

The new experimental measurements of beam spin asymmetry were performed for the deeply virtual exclusive $π^0$ production in a wide kinematic region with the photon virtualities $Q^2$ up to 8 GeV$^2$ and the Bjorken scaling variable $x_B$ in the valence regime. The data were collected by the CEBAF Large Acceptance Spectrometer (CLAS12) at Jefferson Lab with longitudinally polarized 10.6 GeV electrons scattered on an unpolarized liquid-hydrogen target. Sizable asymmetry values indicate a substantial contribution from transverse virtual photon amplitudes to the polarized structure functions.The interpretation of these measurements in terms of the Generalized Parton Distributions (GPDs) demonstrates their sensitivity to the chiral-odd GPD $\bar E_T$, which contains information on quark transverse spin densities in unpolarized and polarized nucleons and provides access to the proton's transverse anomalous magnetic moment. Additionally, the data were compared to a theoretical model based on a Regge formalism that was extended to the high photon virtualities., arXiv admin note: substantial text overlap with arXiv:2210.14557

Published
2023
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12. Measurement of the J/$ψ$ photoproduction cross section over the full near-threshold kinematic region

Author

Adhikari, S., Afzal, F., Akondi, C. S., Albrecht, M., Amaryan, M., Arroyave, V., Asaturyan, A., Austregesilo, A., Baldwin, Z., Barbosa, F., Barlow, J., Barriga, E., Barsotti, R., Beattie, T. D., Berdnikov, V. V., Black, T., Boeglin, W., Briscoe, W. J., Britton, T., Brooks, W. K., Byer, D., Chudakov, E., Cole, P. L., Cortes, O., Crede, V., Dalton, M. M., Darulis, D., Deur, A., Dobbs, S., Dolgolenko, A., Dotel, R., Dugger, M., Dzhygadlo, R., Ebersole, D., Egiyan, H., Erbora, T., Eugenio, P., Fabrizi, A., Fanelli, C., Fang, S., Fegan, S., Fitches, J., Foda, A. M., Furletov, S., Gan, L., Gao, H., Gardner, A., Gasparian, A., Gleason, C., Goetzen, K., Goryachev, V. S., Grube, B., Guo, J., Guo, L., Hague, T. J., Hakobyan, H., Hernandez, J., Hoffman, N. D., Hornidge, D., Hou, G., Huber, G. M., Hurck, P., Hurley, A., Imoehl, W., Ireland, D. G., Ito, M. M., Jaegle, I., Jarvis, N. S., Jeske, T., Jones, R. T., Kakoyan, V., Kalicy, G., Khachatryan, V., Khatchatryan, M., Kourkoumelis, C., LaDuke, A., Larin, I., Lawrence, D., Lersch, D. I., Li, H., Li, W. B., Liu, B., Livingston, K., Lolos, G. J., Lorenti, L., Lyubovitskij, V., Mack, D., Mahmood, A., Martel, P. P., Marukyan, H., Matveev, V., McCaughan, M., McCracken, M., Meyer, C. A., Miskimen, R., Mitchell, R. E., Mizutani, K., Neelamana, V., Ng, L., Nissen, E., Orei, S., Ostrovidov, A. I., Papandreou, Z., Paudel, C., Pedroni, R., Pentchev, L., Peters, K. J., Prather, E., Rakshit, S., Reinhold, J., Remington, A., Ritchie, B. G., Ritman, J., Rodriguez, G., Romanov, D., Saldana, K., Salgado, C., Schadmand, S., Schertz, A. M., Scheuer, K., Schick, A., Schmidt, A., Schumacher, R. A., Schwiening, J., Sharp, P., Shen, X., Shepherd, M. R., Smith, A., Smith, E. S., Sober, D. I., Somov, S., Somov, A., Stevens, J. R., Strakovsky, I. I., Sumner, B., Suresh, K., Tarasov, V. V., Taylor, S., Teymurazyan, A., Thiel, A., Viducic, T., Whitlatch, T., Wickramaarachchi, N., Williams, M., Wunderlich, Y., Yu, B., Zarling, J., Zhang, Z., Zhao, Z., Zhou, X., Zhou, J., and Zihlmann, B.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

We report the total and differential cross sections for $J/ψ$ photoproduction with the large acceptance GlueX spectrometer for photon beam energies from the threshold at 8.2~GeV up to 11.44~GeV and over the full kinematic range of momentum transfer squared, $t$. Such coverage facilitates the extrapolation of the differential cross sections to the forward ($t = 0$) point beyond the physical region. The forward cross section is used by many theoretical models and plays an important role in understanding $J/ψ$ photoproduction and its relation to the $J/ψ-$proton interaction. These measurements of $J/ψ$ photoproduction near threshold are also crucial inputs to theoretical models that are used to study important aspects of the gluon structure of the proton, such as the gluon Generalized Parton Distribution (GPD) of the proton, the mass radius of the proton, and the trace anomaly contribution to the proton mass. We observe possible structures in the total cross section energy dependence and find evidence for contributions beyond gluon exchange in the differential cross section close to threshold, both of which are consistent with contributions from open-charm intermediate states., 15 pages 18 figures

Published
2023
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13. HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

Author

Brian A. Davies, Johanna A. Payne, Cole P. Martin, Destiny Schultz, Bennett G. Childs, Cheng Zhang, Karthik Jeganathan, Ines Sturmlechner, Thomas A. White, Alain de Bruin, Huiqin Chen, Michael A. Davies, Sarah Jachim, Nathan K. LeBrasseur, Robert C. Piper, Hu Li, Darren J. Baker, Jan van Deursen, and David J. Katzmann

Abstract

Endosomal Sorting Complexes Required for Transport (ESCRTs) drive reverse topology membrane remodeling events including the formation of intralumenal vesicles within multivesicular bodies, the budding of retroviruses from the plasma membrane, and the scission of the cytokinetic bridge. It has been difficult to study the physiological relevance of this machinery in mammals because many contributing components are essential for viability. To bypass this problem we used combinations of knockout (−), hypomorphic (H) and wildtype (+) alleles to generate a series of mice with a gradual reduction of HD-PTP (product of PTPN23), an ESCRT-associated protein known to cause embryonic lethality when fully depleted. Whereas PTPN23-/H mice died shortly after birth, PTPN23H/H mice developed into adulthood but had reduced size, lipodystrophy, and shortened lifespan. Analysis of 14-day inguinal adipose tissue indicated reduced expression of adipogenesis markers, and PTPN23 knockout preadipocytes similarly display reduced adipogenesis in vitro. Defects in insulin-stimulated signaling were apparent in differentiated PTPN23 knockout adipocytes and PTPN23H/H inguinal adipose tissue in vitro, correlating with reduced levels of insulin signaling hallmarks observed in adult PTPN23H/H inguinal adipose tissue in vivo. Whereas the ESCRT machinery have been suggested to downregulate signaling, these results indicate that HD-PTP promotes insulin-induced signaling in, as well as differentiation of, inguinal adipose tissue. These results revealed unexpected roles for HD-PTP in promoting fat accumulation in mammalian cells through supporting insulin signaling, adipogenesis, and lipid droplet formation.

Published
2022

14. Science Requirements and Detector Concepts for the Electron-Ion Collider

Author

Abdul Khalek, R., Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Ayerbe Gayoso, C., Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Dalla Torre, S., Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., Degraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., El Fassi, L., Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Gay Ducati, M. B., Gericke, M., Gil Da Silveira, G., Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Gonzalez Hernandez, J. O., Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Hiller Blin, A. N., Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., W. B., Li, Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Muñoz Camacho, C., Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Tapia Takaki, J. D., Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Torales Acosta, F., Tribedy, P., Tricoli, A., Triloki, Null, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Q. H., Xu, Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., Zurita, P., Abdul Khalek, R., Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Ayerbe Gayoso, C., Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Dalla Torre, S., Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., Degraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., El Fassi, L., Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Gay Ducati, M. B., Gericke, M., Gil Da Silveira, G., Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Gonzalez Hernandez, J. O., Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Hiller Blin, A. N., Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., Li, W. B., Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Muñoz Camacho, C., Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Tapia Takaki, J. D., Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Torales Acosta, F., Tribedy, P., Tricoli, A., Triloki, Null, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Xu, Q. H., Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., and Zurita, P.

Subjects
DIS, Nuclear and High Energy Physics, EIC, Electron-Ion Collider, Detectors, SIDIS
Abstract

This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Col- lider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nu- clei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were com- missioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimen- tal equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter.

Published
2022

16. Reported cases of multisystem inflammatory syndrome in children aged 12-20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation

Author

Anna R Yousaf, Margaret M Cortese, Allan W Taylor, Karen R Broder, Matthew E Oster, Joshua M Wong, Alice Y Guh, David W McCormick, Satoshi Kamidani, Elizabeth P Schlaudecker, Kathryn M Edwards, C Buddy Creech, Mary A Staat, Ermias D Belay, Paige Marquez, John R Su, Mark B Salzman, Deborah Thompson, Angela P Campbell, Oidda Museru, Leigh M. Howard, Monica Parise, John J. Openshaw, Chloe LeMarchand, Lauren E. Finn, Moon Kim, Kiran V. Raman, Kenneth K. Komatsu, Bryce L. Spiker, Cole P. Burkholder, Sean M. Lang, and Jonathan H. Soslow

Subjects
Male, Young Adult, COVID-19 Vaccines, Adolescent, SARS-CoV-2, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, COVID-19, Humans, Female, Child, Systemic Inflammatory Response Syndrome, United States
Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory condition associated with antecedent SARS-CoV-2 infection. In the USA, reporting of MIS-C after vaccination is required under COVID-19 vaccine emergency use authorisations. We aimed to investigate reports of individuals aged 12-20 years with MIS-C after COVID-19 vaccination reported to passive surveillance systems or through clinician outreach to the US Centers for Disease Control and Prevention (CDC).In this surveillance activity, we investigated potential cases of MIS-C after COVID-19 vaccination reported to CDC's MIS-C national surveillance system, the Vaccine Adverse Event Reporting System (co-administered by CDC and the US Food and Drug Administration), and CDC's Clinical Immunization Safety Assessment Project. A multidisciplinary team adjudicated cases by use of the CDC MIS-C definition. Any positive SARS-CoV-2 serology test satisfied case criteria; although anti-nucleocapsid antibodies indicate previous SARS-CoV-2 infection, anti-spike protein antibodies indicate either past or recent infection or COVID-19 vaccination. We describe the demographic and clinical features of cases, stratified by laboratory evidence of SARS-CoV-2 infection. To calculate the reporting rate of MIS-C, we divided the count of all individuals meeting the MIS-C case definition, and of those without evidence of SARS-CoV-2 infection, by the number of individuals aged 12-20 years in the USA who received one or more COVID-19 vaccine doses up to Aug 31, 2021, obtained from CDC national vaccine surveillance data.Using surveillance results from Dec 14, 2020, to Aug 31, 2021, we identified 21 individuals with MIS-C after COVID-19 vaccination. Of these 21 individuals, median age was 16 years (range 12-20); 13 (62%) were male and eight (38%) were female. All 21 were hospitalised: 12 (57%) were admitted to an intensive care unit and all were discharged home. 15 (71%) of 21 individuals had laboratory evidence of past or recent SARS-CoV-2 infection, and six (29%) did not. As of Aug 31, 2021, 21 335 331 individuals aged 12-20 years had received one or more doses of a COVID-19 vaccine, making the overall reporting rate for MIS-C after vaccination 1·0 case per million individuals receiving one or more doses in this age group. The reporting rate in only those without evidence of SARS-CoV-2 infection was 0·3 cases per million vaccinated individuals.Here, we describe a small number of individuals with MIS-C who had received one or more doses of a COVID-19 vaccine before illness onset; the contribution of vaccination to these illnesses is unknown. Our findings suggest that MIS-C after COVID-19 vaccination is rare. Continued reporting of potential cases and surveillance for MIS-C illnesses after COVID-19 vaccination is warranted.US Centers for Disease Control and Prevention.

Published
2022

17. A multidimensional study of the structure function ratio $σ_{LT'}/σ_{0}$ from hard exclusive $π^+$ electro-production off protons in the GPD regime

Author

Diehl, S., Kim, A., Joo, K., Achenbach, P., Akbar, Z., Amaryan, M. J., Atac, H., Avagyan, H., Gayoso, C. Ayerbe, Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossu, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bueltmann, S., Bulumulla, D., Burkert, V. D., Carman, D. S., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Grifoen, K. A., Guidal, M., Hafdi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Khachatryan, M., Khanal, A., Kim, W., Kripko, A., Kubarovsky, V., Lagerquist, V., Laget, J. -M., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I . J. D., Marchand, D., Mascagna, V., McKinnon, B., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Molina, Esteban, Montgomery, R. A., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Reed, Trevor, Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatie, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y., Shirokov, E. V., Shrestha, U., Simmerling, P., Sokhan, D., Sparveris, N., Spreafco, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhang, J., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences
Abstract

A multidimensional extraction of the structure function ratio $σ_{LT'}/σ_{0}$ from the hard exclusive $\vec{e} p \to e^\prime n π^+$ reaction above the resonance region has been performed. The study was done based on beam-spin asymmetry measurements using a 10.6 GeV incident electron beam on a liquid-hydrogen target and the CLAS12 spectrometer at Jefferson Lab. The measurements focus on the very forward regime ($t/Q^{2}$ $\ll$ 1) with a wide kinematic range of $x_{B}$ in the valence regime (0.17 $, arXiv admin note: text overlap with arXiv:2007.15677

Published
2022
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18. Evidence of a dibaryon spectrum in coherent $π^0π^0 d$ photoproduction at forward deuteron angles

Author

Jude, T. C., Alef, S., Beck, R., Braghieri, A., Cole, P. L., Elsner, D., Di Salvo, R., Fantini, A., Freyermuth, O., Frommberger, F., Ghio, F., Goertz, S, Gridnev, A., Kohl, K., Kozlenko, N., Lapik, A., Sandri, P. Levi, Lisin, V., Mandaglio, G., Moricciani, D., Nedorezov, V., Novinsky, D., Pedroni, P., Polonskiy, A., Reitz, B. -E., Romaniuk, M., Scheluchin, G., Schmieden, H., Stuglev, A., Sumachev, V., and Tarakanov, V.

Subjects
FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

The coherent reaction, $γd \rightarrow π^0π^0 d$ was studied with the BGOOD experiment at ELSA from threshold to a centre-of-mass energy of 2850\,MeV. A full kinematic reconstruction was made, with final state deuterons identified in the forward spectrometer and $π^0$ decays in the central BGO Rugby Ball. The strength of the differential cross section exceeds what can be described by models of coherent photoproduction and instead supports the three isoscalar dibaryon candidates reported by the ELPH collaboration at 2.38, 2.47 and 2.63\,GeV/c$^2$. A low mass enhancement in the $π^0π^0$ invariant mass is also observed at the $d^*(2380)$ centre-of-mass energy which is consistent with the ABC effect. At higher centre-of-mass energies, a narrow peak in the $π^0 d$ invariant mass at 2114\,MeV/c$^2$ with a width of 20\,MeV/c$^2$ supports a sequential two-dibaryon decay mechanism., 8 pages, 10 figures. Additional references (recommended by colleagues) added since the first revision

Published
2022
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19. First CLAS12 measurement of DVCS beam-spin asymmetries in the extended valence region

Author

CLAS Collaboration, Christiaens, G., Defurne, M., Sokhan, D., Achenbach, P., Akbar, Z., Amaryan, M. J., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossù, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bueltmann, S., Bulumulla, D., Burkert, V. D., Cao, T., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gates, K., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holmberg, D. E., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Kabir, M. L., Keller, D., Khachatryan, M., Khanal, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Molina, E., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Scott, M. B. C., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhang, J., Zhao, Z. W., Ziegler, V., Zurek, M., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and CLAS

Subjects
electron p: deep inelastic scattering, interference: Bethe-Heitler, generalized parton distribution, nucleon: structure, parton: distribution function, FOS: Physical sciences, Newport News CEBAF Linac, momentum transfer dependence, photon: electroproduction, x-dependence, High Energy Physics - Experiment, error: statistical, phase space, High Energy Physics - Experiment (hep-ex), deeply virtual Compton scattering, beam: scattering, CLAS, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], spectrometer, +electron+p+photon%22">electron p --> electron p photon, electron: beam, valence, spin: asymmetry, experimental results
Abstract

Deeply virtual Compton scattering (DVCS) allows one to probe Generalized Parton Distributions (GPDs) describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.6 GeV electron beam scattering from unpolarised protons. The results greatly extend the $Q^2$ and Bjorken-$x$ phase space beyond the existing data in the valence region and provide over 2000 new data points measured with unprecedented statistical uncertainty, setting new, tight constraints for future phenomenological studies., Comment: Revised Figure 4 and discussion around the number of effective ANNs after Bayesian reweighting

Published
2022
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20. First Measurement of $Λ$ Electroproduction off Nuclei in the Current and Target Fragmentation Regions

Author

Chetry, T., Fassi, L. El, Brooks, W. K., Dupré, R., Alaoui, A. El, Hafidi, K., Achenbach, P., Adhikari, K. P., Akbar, Z., Armstrong, W. R., Arratia, M., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossù, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Egiyan, H., Elouadrhiri, L., Eugenio, P., Fegan, S., Filippi, A., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Griffioen, K. A., Guidal, M., Guo, L., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jenkins, D., Jo, H. S., Kabir, M. L., Khanal, A., Khandaker, M., Kim, A., Kim, W., Klein, F. J., Kripko, A., Kubarovsky, V., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I. J. D., Marchand, D., Mascagna, V., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rosner, G., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Wei, X., Weinstein, L. B., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

We report results of $Λ$ hyperon production in semi-inclusive deep-inelastic scattering off deuterium, carbon, iron, and lead targets obtained with the CLAS detector and the Continuous Electron Beam Accelerator Facility 5.014~GeV electron beam. These results represent the first measurements of the $Λ$ multiplicity ratio and transverse momentum broadening as a function of the energy fraction~($z$) in the current and target fragmentation regions. The multiplicity ratio exhibits a strong suppression at high~$z$~and~an enhancement at~low~$z$. The measured transverse momentum broadening is an order of magnitude greater than that seen for light mesons. This indicates that the propagating entity interacts very strongly with the nuclear medium, which suggests that propagation of diquark configurations in the nuclear medium takes place at least part of the time, even at high~$z$. The trends of these results are qualitatively described by the Giessen Boltzmann-Uehling-Uhlenbeck transport model, particularly for the multiplicity ratios. These observations will potentially open a new era of studies of the structure of the nucleon as well as of strange baryons., 14 pages, 6 figures

Published
2022
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22. Improved Λp Elastic Scattering Cross Sections between 0.9 and 2.0 GeV/c as a Main Ingredient of the Neutron Star Equation of State

Author

Rowley, J., Compton, N., Djalali, C., Hicks, K., Price, J., Zachariou, N., Adhikari, K. P., Armstrong, W. R., Atac, H., Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clark, Louise, Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D’Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dupré, R., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fradi, A., Gavalian, G., Girod, F. X., Glazier, Derek I., Golubenko, A., Gothe, R. W., Griffioen, K., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, David G., Isupov, E. L., Jenkins, D., Jo, H. S., Joo, K., Keller, D., Khanal, A., Khandaker, M., Kim, A., Korover, I., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, Kenneth, MacGregor, I. J. Douglas, Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McCracken, M. E., McKinnon, Bryan, McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Neupane, K., Niccolai, S., Niculescu, G., O’Connell, T. R., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Pasyuk, E., Pogorelko, O., Prok, Y., Reed, T., Ripani, M., Ritman, J., Rizzo, A., Rosner, Guenther, Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shrestha, U., Sokhan, Daria, Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Tyson, Richard, Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D. P., Wei, K., Wei, X., Wishart, Robert, Wood, M. H., Yale, B., Yurov, M., Zhang, J., and Zhao, Z. W.

Subjects
Hyperons in neutron stars, Economica, PE2_2, PE2_1, Settore FIS/04, Nuclear Theory, Socio-culturale, Ambientale, ddc:530, Hyperons's Scattering, Nuclear Experiment, PE2_3
Abstract

Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state. Yet, compared to other elastic scattering processes, there is very little data on \ud Λ\ud −\ud N\ud scattering. This experiment utilized the CEBAF Large Acceptance Spectrometer (CLAS) detector to study the \ud Λ\ud p\ud →\ud Λ\ud p\ud elastic scattering cross section in the incident \ud Λ\ud momentum range \ud 0.9\ud –\ud 2.0\ud \ud \ud GeV\ud /\ud c\ud . These are the first data on this reaction since the 1970s. The new cross sections have significantly better accuracy and precision than the existing world data, and the techniques developed here can also be used in future experiments.

Published
2021

23. The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer

Author

Armen Petrosyan, Sonia Manca, Jean-Jack M Riethoven, Cole P. Frisbie, Chad A. LaGrange, and Carol A. Casey

Subjects
Male, 0301 basic medicine, Cancer Research, Golgi Apparatus, Mice, Nude, Histone Deacetylase 6, Article, Mice, 03 medical and health sciences, Prostate cancer, symbols.namesake, 0302 clinical medicine, GSK-3, Cell Line, Tumor, LNCaP, medicine, Animals, Humans, Secretion, Phosphorylation, Molecular Biology, Glycogen Synthase Kinase 3 beta, Ethanol, Kinase, Chemistry, Alcohol Dehydrogenase, Prostate, Prostatic Neoplasms, Golgi apparatus, medicine.disease, Rats, Androgen receptor, 030104 developmental biology, Oncology, Receptors, Androgen, Cytoplasm, 030220 oncology & carcinogenesis, Cancer research, symbols, Heterografts, Signal Transduction
Abstract

Multiple epidemiologic observations and meta-analysis clearly indicate the link between alcohol abuse and the incidence and progression of prostate cancer; however, the mechanism remains enigmatic. Recently, it was found that ethanol (EtOH) induces disorganization of the Golgi complex caused by impaired function of the largest Golgi matrix protein, giantin (GOLGB1), which, in turn, alters the Golgi docking of resident Golgi proteins. Here, it is determined that in normal prostate cells, histone deacetylase 6 (HDAC6), the known regulator of androgen receptor (AR) signaling, localizes in the cytoplasm and nucleus, while its kinase, glycogen synthase kinase β (GSK3β), primarily resides in the Golgi. Progression of prostate cancer is accompanied by Golgi scattering, translocation of GSK3β from the Golgi to the cytoplasm, and the cytoplasmic shift in HDAC6 localization. Alcohol dehydrogenase–generated metabolites induces Golgi disorganization in androgen-responsive LNCaP and 22Rv1 cells, facilitates tumor growth in a mouse xenograft model and activates anchorage-independent proliferation, migration, and cell adhesion. EtOH-treated cells demonstrate reduced giantin and subsequent cytoplasmic GSK3β; this phenomenon was validated in giantin-depleted cells. Redistribution of GSK3β to the cytoplasm results in phosphorylation of HDAC6 and its retention in the cytoplasm, which, in turn, stimulates deacetylation of HSP90, AR import into the nucleus, and secretion of prostate-specific antigen (PSA). Finally, the relationship between Golgi morphology, HDAC6 cytoplasmic content, and clinicopathologic features was assessed in human prostate cancer patient specimens with and without a history of alcohol dependence. Implications: This study demonstrates the importance of alcohol-induced Golgi fragmentation in the activation of AR-mediated proliferation.

Published
2019

24. Observation of Beam Spin Asymmetries in the Process ep→e^{'}π^{+}π^{-}X with CLAS12

Author

Hayward, T B, Dilks, C, Vossen, A, Avakian, H, Adhikari, S, Angelini, G, Arratia, M, Atac, H, Ayerbe Gayoso, C, Baltzell, N A, Barion, L, Battaglieri, M, Bedlinskiy, I, Benmokhtar, F, Bianconi, A, Biselli, A S, Bondì, M, Bossù, F, Boiarinov, S, Briscoe, W J, Brooks, W K, Bulumulla, D, Burkert, V D, Carman, D S, Carvajal, J C, Celentano, A, Chatagnon, P, Chetry, T, Ciullo, G, Clary, B A, Cole, P L, Contalbrigo, M, Costantini, G, Crede, V, D'Angelo, A, Dashyan, N, De Vita, R, Defurne, M, Deur, A, Diehl, S, Djalali, C, Dupre, R, Dugger, M, Egiyan, H, Ehrhart, M, El Alaoui, A, El Fassi, L, Elouadrhiri, L, Fegan, S, Filippi, A, Forest, T A, Gavalian, G, Gilfoyle, G P, Girod, F X, Glazier, Derek I., Golubenko, A A, Gothe, R W, Gotra, Y, Griffioen, K A, Guidal, M, Hafidi, K, Hakobyan, H, Hattawy, M, Hauenstein, F, Hicks, K, Hobart, A, Holtrop, M, Ireland, David G., Isupov, E L, Jo, H S, Joo, K, Joosten, S, Keller, D, Khachatryan, M, Khanal, A, Kim, A, Kim, W, Kripko, A, Kubarovsky, V, Kuhn, S E, Lanza, L, Leali, M, Lee, S, Lenisa, P, Livingston, Kenneth, MacGregor, I.D. Douglas, Marchand, D, Markov, N, Marsicano, L, Mascagna, V, McKinnon, Bryan, Meziani, Z E, Mirazita, M, Mokeev, V, Movsisyan, A, Munoz Camacho, C, Nadel-Turonski, P, Naidoo, Paul, Nanda, S, Neupane, K, Niccolai, S, Niculescu, G, O'Connell, T R, Osipenko, M, Paolone, M, Pappalardo, L L, Paremuzyan, R, Pasyuk, E, Phelps, W, Pogorelko, O, Prok, Y, Raue, B A, Ripani, M, Ritman, J, Rizzo, A, Rossi, P, Rowley, J, Sabatié, F, Salgado, C, Schmidt, A, Segarra, E P, Sharabian, Y G, Shrestha, U, Sokhan, Daria, Soto, O, Sparveris, N, Stepanyan, S, Strakovsky, I I, Strauch, S, Thornton, Adam, Tyler, N, Tyson, Richard, Ungaro, M, Venturelli, L, Voskanyan, H, Voutier, E, Watts, D P, Wei, K, Wei, X, Wood, M H, Yale, B, Zachariou, N, Zhang, J, and College of William and Mary [Williamsburg] (WM)

Subjects
[PHYS]Physics [physics], Parton Distribution Functions, Physics, Settore FIS/04, Nuclear Theory, NO, PE2_2, Quantum Chomodynamics, PE2_1, Quarks and Gluons, Physics::Accelerator Physics, High Energy Physics::Experiment, ddc:530, Nuclear Experiment, PE2_3, ComputingMilieux_MISCELLANEOUS
Abstract

The observation of beam spin asymmetries in two-pion production in semi-inclusive deep inelastic scattering off an unpolarized proton target is reported. The data presented here were taken in the fall of 2018 with the CLAS12 spectrometer using a 10.6 GeV longitudinally spin-polarized electron beam delivered by CEBAF at JLab. The measured asymmetries provide the first opportunity to extract the parton distribution function e(x), which provides information about the interaction between gluons and quarks, in a collinear framework that offers cleaner access than previous measurements. The asymmetries also constitute the first ever signal sensitive to the helicity-dependent two-pion fragmentation function G_{1}^{⊥}. A clear sign change is observed around the ρ mass that appears in model calculations and is indicative of the dependence of the produced pions on the helicity of the fragmenting quark.

Published
2021

25. A Direct Detection Search for Hidden Sector New Particles in the 3-60 MeV Mass Range

Author

Ahmidouch, A., Davis, S., Gasparian, A., Hague, T. J., Mtingwa, S., Pedroni, R., Ayerbe-Gayoso, C., Bhatt, H., Devkota, B., Dunne, J., Dutta, D., Fassi, L. El, Karki, A., Mohanmurthy, P., Peng, C., Ali, S., Bai, X., Boyd, J., Dharmasena, B., Gamage, V., Gnanvo, K., Jeffas, S., Jian, S., Liyanage, N., Nguyen, H., Rathnayake, A., Khandaker, M., Byer, D., Gao, H., Howell, C., Karki, B., Khachatryan, V., Matousek, G., van Nieuwenhuizen, E., Smith, A., Yu, B., Zhao, Z., Zhou, J., Shahinyan, A., Higinbotham, D., Kubarovsky, V., Paremuzyan, R., Pasyuk, E., Stepanyan, S., Avakian, H., Battaglieri, M., De Vita, R., Bianconi, A., Constantini, G., Gosta, G., Leali, M., Migliorati, S., Venturelli, L., Mascagna, V., De Napoli, M., Larin, I., Miskimen, R., Cole, P., Xiong, W., and West, J. Rittenhouse

Subjects
Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

In our quest to understand the nature of dark matter and discover its non-gravitational interactions with ordinary matter, we propose an experiment using a \pbo ~calorimeter to search for or set new limits on the production rate of i) hidden sector particles in the $3 - 60$ MeV mass range via their $e^+e^-$ decay (or $\gamma\gamma$ decay with limited tracking), and ii) the hypothetical X17 particle, claimed in multiple recent experiments. The search for these particles is motivated by new hidden sector models and dark matter candidates introduced to account for a variety of experimental and observational puzzles: the small-scale structure puzzle in cosmological simulations, anomalies such as the 4.2$\sigma$ disagreement between experiments and the standard model prediction for the muon anomalous magnetic moment, and the excess of $e^+e^-$ pairs from the $^8$Be M1 and $^4$He nuclear transitions to their ground states observed by the ATOMKI group. In these models, the $1 - 100$ MeV mass range is particularly well-motivated and the lower part of this range still remains unexplored. Our proposed direct detection experiment will use a magnetic-spectrometer-free setup (the PRad apparatus) to detect all three final state particles in the visible decay of a hidden sector particle allowing for an effective control of the background and will cover the proposed mass range in a single setting. The use of the well-demonstrated PRad setup allows for an essentially ready-to-run and uniquely cost-effective search for hidden sector particles in the $3 - 60$ MeV mass range with a sensitivity of 8.9$\times$10$^{-8}$ - 5.8$\times$10$^{-9}$ to $\epsilon^2$, the square of the kinetic mixing interaction constant between hidden and visible sectors. This updated proposal includes our response to the PAC49 comments., Comment: 47 pages, 44 Figures. JLab PAC50 Proposal

Published
2021
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26. Beam charge asymmetries for deeply virtual Compton scattering off the proton

Author

Burkert, V., Elouadrhiri, L., Girod, F. -X., Niccolai, S., Voutier, E., Afanasev, A., Barion, L., Battaglieri, M., Bernauer, J. C., Bianconi, A., Capobianco, R., Caudron, M., Causse, L., Chatagnon, P., Chetry, T., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., Defurne, M., ~Deur, A., Diehl, S., Dupr��, R., Ehrhart, M., Fernando, I. P., Filippi, A., Forest, T., Grames, J., Gueye, P., Habet, S., Higinbotham, D., Hobart, A., Hyde, C. E., Joo, K., Kim, A., Klimenko, V., Ko, H. -S., Kubarovsky, V., Leali, M., Lenisa, P., Marchand, D., Mascagna, V., McCaughan, M., McKinnon, B., Movsisyan, A., Mu��oz~Camacho, C., Pappalardo, L., Pasyuk, E., Poelker, M., Price, K., Raue, B., Shabestari, M., Santos, R., Sergeyeva, V., Strakovsky, I., Stoler, P., Venturelli, L., Zhao, S., ~Zhao, Z. W., Collaboration, the CLAS, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CLAS, and Thomas Jefferson National Accelerator Facility (Jefferson Lab)

Subjects
Nuclear Structure and Dynamics, Proton, Hadron, polarized beam, Electron, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Economica, Positron, higher-twist, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Twist, electron: beam, Nuclear Experiment (nucl-ex), Nuclear Experiment, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], Physics, Form factor (quantum field theory), Compton scattering: form factor, 3. Good health, Polarized electron beams, Nuclear and High Energy Physics, accelerator, Socio-culturale, FOS: Physical sciences, Compton Form Factor, Bethe-Heitler, Polarized positron beams, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear physics, phase space, PE2_2, PE2_1, deeply virtual Compton scattering, CLAS, 0103 physical sciences, 010306 general physics, PE2_3, 010308 nuclear & particles physics, Compton scattering, Ambientale, Charge (physics), positron: beam, correlation, charge: asymmetry, Physics::Accelerator Physics, spectrometer
Abstract

The unpolarized and polarized Beam Char\-ge Asymmetries (BCAs) of the $\vv{e}^{\pm}p \to e^{\pm}p \gamma$ process off unpolarized hydrogen are discussed. The measurement of BCAs with the CLAS12 spectrometer at the Thomas Jefferson National Accelerator Facility, using polarized positron and electron beams at 10.6 GeV is investigated. This experimental configuration allows to measure azimuthal and $t$-dependences of the unpolarized and polarized BCAs over a large $(x_B,Q^2)$ phase space, providing a direct access to the real part of the Compton Form Factor (CFF) ${\mathcal H}$. Additionally, these measurements confront the Bethe-Heitler dominance hypothesis and eventual effects beyond leading twist. The impact of potential positron beam data on the determination of CFFs is also investigated within a local fitting approach of experimental observables. Positron data are shown to strongly reduce correlations between CFFs and consequently improve significantly the determination of $\Re {\rm e} [\mathcal{H}]$., Comment: 11 pages, 10 figures, Article part of the EPJA Topical Issue about "Positron beams and physics at Jefferson Lab". arXiv admin note: text overlap with arXiv:2007.15081

Published
2021
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27. Improved $��p$ Elastic Scattering Cross Sections Between 0.9 and 2.0 GeV/c and Connections to the Neutron Star Equation of State

Author

CLAS Collaboration, Rowley, J., Compton, N., Djalali, C., Hicks, K., Price, J., Zachariou, N., Adhikari, K. P., Armstrong, W. R., Atac, H., Baashen, L., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Bossu, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clark, L., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fradi, A., Gavalian, G., Girod, F. X., Glazier, D. I., Golubenko, A., Gothe, R. W., Griffioen, K., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jenkins, D., Jo, H. S., Joo, K., Keller, D., Khanal, A., Khandaker, M., Kim, A., Korover, I., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McCracken, M. E., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munevar, E., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T. R., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Pasyuk, E., Pogorelko, O., Prok, Y., Reed, T., Ripani, M., Ritman, J., Rizzo, A., Rosner, G., Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D., Wei, K., Wei, X., Wishart, R., Wood, M. H., Yale, B., Yurov, M., Zhang, J., and Zhao, Z. W.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Strange matter is believed to exist in the cores of neutron stars based on simple kinematics. If this is true, then hyperon-nucleon interactions will play a significant part in the neutron star equation of state (EOS). Yet, compared to other elastic scattering processes, there is very little data on $��$-$N$ scattering. This experiment utilized the CLAS detector to study the $��p \rightarrow ��p$ elastic scattering cross section in the incident $��$ momentum range 0.9-2.0 GeV/c. This is the first data on this reaction in several decades. The new cross sections have significantly better accuracy and precision than the existing world data, and the techniques developed here can also be used in future experiments., 6 pages, 5 figures

Published
2021
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28. Observation of Beam Spin Asymmetries in the Process $e p \rightarrow e ��^{+}��^{-}X$ with CLAS12

Author

Hayward, T. B., Dilks, C., Vossen, A., Avakian, H., Adhikari, S., Angelini, G., Arratia, M., Atac, H., Gayoso, C. Ayerbe, Baltzell, N. A., Barion, L., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bond��, M., Boss��, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clary, B. A., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Dugger, M., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Forest, T. A., Gavalian, G., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hicks, K., Hobart, A., Holtrop, M., Ireland, D. G., Isupov, E. L., Jo, H. S., Joo, K., Joosten, S., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McKinnon, B., Meziani, Z. E., Mirazita, M., Mokeev, V., Movsisyan, A, Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Nanda, S., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T. R., Osipenko, M., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Phelps, W., Pogorelko, O., Prok, Y., Raue, B. A., Ripani, M., Ritman, J., Rizzo, A., Rossi, P., Rowley, J., Sabati��, F., Salgado, C., Schmidt, A., Segarra, E. P., Sharabian, Y. G., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Thornton, A., Tyler, N., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, K., Wei, X., Wood, M. H., Yale, B., Zachariou, N., and Zhang, J.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, Physics::Accelerator Physics, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment
Abstract

The observation of beam spin asymmetries in two-pion production in semi-inclusive deep inelastic scattering off an unpolarized proton target is reported. The data presented here were taken in the fall of 2018 with the CLAS12 spectrometer using a 10.6 GeV longitudinally spin-polarized electron beam delivered by CEBAF at JLab. The measured asymmetries provide the first opportunity to extract the parton distribution function $e(x)$, which provides information about the interaction between gluons and quarks, in a collinear framework that offers cleaner access than previous measurements. The asymmetries also constitute the first ever signal sensitive to the helicity-dependent two-pion fragmentation function $G_1^\perp$. A clear sign change is observed around the $��$ mass that appears in model calculations and is indicative of the dependence of the produced pions on the helicity of the fragmenting quark., 6 pages, 5 figures

Published
2021
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29. Measurement of the $��n\rightarrow K^0��^0$ differential cross section over the $K^*$ threshold

Author

Kohl, K., Alef, S., Beck, R., Braghieri, A., Cole, P., Salvo, R. D., Fantini, A., Freyermuth, O., Frommberger, F., Ghio, F., Goertz, S., Gridnev, A., Hammann, D., Hannappel, J., Jude, T., Kozlenko, N., Lapik, A., Sandri, P. Levi, Lisin, V., Mandaglio, G., Messi, R., Moricciani, D., Nedorezov, V., Nikonov, V. A., Novinsky, D., Pedroni, P., Polonski, A., Reitz, B. -E., Romaniuk, M., Scheluchin, G., Schmieden, H., Stuglev, A., Sumachev, V., and Tarakanov, V.

Subjects
High Energy Physics::Phenomenology, Nuclear Theory, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The differential cross section for the quasi-free photoproduction reaction $��n\rightarrow K^0��^0$ was measured at BGOOD at ELSA from threshold to a center-of-mass energy of 2400 MeV. An increase in the cross section is observed at forward angles above 2000 MeV. The available statistics prevent an accurate description of this behavior, however it appears consistent with models describing a resonance of dynamically generated vector meson-baryon states, where an equivalent model predicted the $P_C$ states observed at LHCb. If proven correct, this could indicate parallels between the strange and charmed quark sectors., 6 pages, 8 figures

Published
2021
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30. Multidimensional, high precision measurements of beam single spin asymmetries in semi-inclusive $��^{+}$ electroproduction off protons in the valence region

Author

Diehl, S., Kim, A., Angelini, G., Joo, K., Adhikari, S., Amaryan, M., Arratia, M., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Baltzell, N. A., Barion, L., Bastami, S., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Bossu, F., Boiarinov, S., Brinkmann, K. -T., Briscoe, W. J., Brooks, W., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Clary, B. A., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Dilks, C., Djalali, C., Dugger, M., Dupre, R., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Forest, T., Gavalian, G., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hicks, K., Hobart, A., Holtrop, M., Hyde, C. E., Ireland, D. G., Isupov, E. L., Jo, H. S., Johnston, R., Joosten, S., Keller, D., Khachatryan, M., Khanal, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Livingston, K., Lu, Z., MacGregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McKinnon, B., Meziani, Z. E., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., Movsisyan, A., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niccolai, S., Niculescu, G., O'Connell, T. R., Osipenko, M., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Phelps, W., Pogorelko, O., Prok, Y., Prokudin, A., Raue, B. A., Ripani, M., Ritman, J., Rizzo, A., Roberts, C. D., Rossi, P., Rowley, J., Sabatie, F., Salgado, C., Schmidt, A., Segarra, E. P., Sharabian, Y. G., Shrestha, U., Simmerling, P., Sokhan, D., Soto, O., Sparveris, N., Stepanyan, S., Stoler, P., Strakovsky, I. I., Strauch, S., Tezgin, K., Thornton, A., Tyler, N., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Vossen, A., Voutier, E., Watts, D. P., Wei, K., Wei, X., Xu, S. -S., Yale, B., Zachariou, N., and Zhang, J.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment
Abstract

High precision measurements of the polarized electron beam-spin asymmetry in semi-inclusive deep inelastic scattering (SIDIS) from the proton have been performed using a 10.6~GeV incident electron beam and the CLAS12 spectrometer at Jefferson Lab. We report here a high precision multidimensional study of single $��^{+}$ SIDIS data over a large kinematic range in Bjorken x, fractional energy and transverse momentum of the hadron as well as photon virtualities $Q^{2}$ ranging from $1-7\,$GeV$^{2}$. In particular, the structure function ratio $F^{\sin��}_{LU}/F_{UU}$ has been determined, where $F^{\sin��}_{LU}$ is a twist-3 quantity that can reveal novel aspects of emergent hadron mass and quark-gluon correlations within the nucleon. The data's impact on the evolving understanding of the underlying reaction mechanisms and their kinematic variation is explored using theoretical models for the different contributing transverse momentum dependent parton distribution functions.

Published
2021
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31. Polarized Structure Function $��_{LT'}$ from $��^0 p$ Electroproduction Data in the Resonance Region at $0.4$ GeV$^2 < Q^2 < 1.0$ GeV$^2$

Author

Isupov, E. L., Burkert, V. D., Golubenko, A. A., Joo, K., Markov, N. S., Mokeev, V. I., Smith, L. C., Armstrong, W. R., Atac, H., Avakian, H., Baltzell, N. A., Barion, L., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Boss��, F., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Capobianco, R. A., Carman, D. S., Carvajal, J. C., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Clary, B. A., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Eugenio, P., Fegan, S., Filippi, A., Gavalian, G., Gilfoyle, G. P., Glazier, D. I., Gothe, R. W., Griffioen, K. A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hicks, K., Hobart, A., Holtrop, M., Illari, I., Ireland, D. G., Jenkins, D., Jo, H. S., Keller, D., Khanal, A., Khandaker, M., Kim, A., Kim, W., Klein, F. J., Klimenko, V., Kripko, A., Kubarovsky, V., Lagerquist, V., Lanza, L., Leali, M., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Marsicano, L., Mascagna, V., McKinnon, B., Meziani, Z. E., Migliorati, S., Mineeva, T., Mirazita, M., Camacho, C. Munoz, Nadel-Turonski, P., Neupane, K., Niccolai, S., O'Connell, T., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pogorelko, O., Poudel, J., Price, J. W., Prok, Y., Raue, B. A., Reed, T., Ripani, M., Ritman, J., Rowley, J., Sabati��, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sokhan, D., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D., Wei, K., Wei, X., Wood, M. H., Yale, B., Zachariou, N., Zhang, J., and Ziegler, V.

Subjects
FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The first results on the $��_{LT'}$ structure function in exclusive $��^0p$ electroproduction at invariant masses of the final state of 1.5 GeV $, 7 pages, 3 figures

Published
2021
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32. Observation of Beam Spin Asymmetries in the Process ep→e′π+π−X with CLAS12

Author

Hayward, T. B., Dilks, C., Vossen, A., Avakian, H., Adhikari, S., Angelini, G., Arratia, M., Atac, H., Ayerbe Gayoso, C., Baltzell, N. A., Barion, L., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondì, M., Bossù, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clary, B. A., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D’Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dupre, R., Dugger, M., Egiyan, H., Ehrhart, M., El Alaoui, A., El Fassi, L., Elouadrhiri, L., Fegan, S., Filippi, A., Forest, T. A., Gavalian, G., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hicks, K., Hobart, A., Holtrop, M., Ireland, D. G., Isupov, E. L., H. S., Jo, Joo, K., Joosten, S., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Livingston, K., Macgregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., Mckinnon, B., Meziani, Z. E., Mirazita, M., Mokeev, V., Movsisyan, A., Munoz Camacho, C., Nadel-Turonski, P., Naidoo, P., Nanda, S., Neupane, K., Niccolai, S., Niculescu, G., O’Connell, T. R., Osipenko, M., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Phelps, W., Pogorelko, O., Prok, Y., Raue, B. A., Ripani, M., Ritman, J., Rizzo, A., Rossi, P., Rowley, J., Sabatié, F., Salgado, C., Schmidt, A., Segarra, E. P., Sharabian, Y. G., Shrestha, U., Sokhan, D., Soto, O., Sparveris, N., Stepanyan, S., Strakovsky, I. I., Strauch, S., Thornton, A., Tyler, N., Tyson, R., Ungaro, M., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, K., Wei, X., Wood, M. H., Yale, B., Zachariou, N., and Zhang, J.

Abstract

The observation of beam spin asymmetries in two-pion production in semi-inclusive deep inelastic scattering off an unpolarized proton target is reported. The data presented here were taken in the fall of 2018 with the CLAS12 spectrometer using a 10.6 GeV longitudinally spin-polarized electron beam delivered by CEBAF at JLab. The measured asymmetries provide the first opportunity to extract the parton distribution function e(x), which provides information about the interaction between gluons and quarks, in a collinear framework that offers cleaner access than previous measurements. The asymmetries also constitute the first ever signal sensitive to the helicity-dependent two-pion fragmentation function G1⊥. A clear sign change is observed around the ρ mass that appears in model calculations and is indicative of the dependence of the produced pions on the helicity of the fragmenting quark.

Published
2021

33. A Barcode-Based Phylogenetic Characterization of Phytophthora cactorum Identifies Two Cosmopolitan Lineages with Distinct Host Affinities and the First Report of Phytophthora pseudotsugae in California

Author

Tyler B. Bourret, Sebastian N. Fajardo, Cole P. Engert, and David M. Rizzo

Subjects
Microbiology (medical), Phytophthora cactorum, Phytophthora pseudotsugae, Phytophthora hedraiandra, Phytophthora ×serendipita, Fragaria, Malus, Quercus, California, phylogeny, hybrid, Plant Science, Ecology, Evolution, Behavior and Systematics
Abstract

A collection of 30 Phytophthora cactorum and 12 P. pseudotsugae (subclade 1a) strains isolated from several recent surveys across California was phylogenetically compared to a worldwide collection of 112 conspecific strains using sequences from three barcoding loci. The surveys baited P. cactorum from soil and water across a wide variety of forested ecosystems with a geographic range of more than 1000 km. Two cosmopolitan lineages were identified within the widespread P. cactorum, one being mainly associated with strawberry production and the other more closely associated with apple orchards, oaks and ornamental trees. Two other well-sampled P. cactorum lineages, including one that dominated Californian restoration outplantings, were only found in the western United States, while a third was only found in Japan. Coastal California forest isolates of both Phytophthora species exhibited considerable diversity, suggesting both may be indigenous to the state. Many isolates with sequence accessions deposited as P. cactorum were determined to be P. hedraiandra and P. ×serendipita, with one hybrid lineage appearing relatively common across Europe and Asia. This study contains the first report of P. pseudotsugae from the state of California and one of the only reports of that species since its original description.

Published
2022

36. Extraction of beam-spin asymmetries from the hard exclusive $��^{+}$ channel off protons in a wide range of kinematics

Author

Diehl, S., Joo, K., Kim, A., Avakian, H., Kroll, P., Park, K., Riser, D., Semenov-Tian-Shansky, K., Tezgin, K., Adhikari, K. P., Adhikari, S., Amaryan, M. J., Angelini, G., Asryan, G., Atac, H., Barion, L., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Boss`u, F., Boiarinov, S., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Cole, P. L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Eugenio, P., Filippi, A., Forest, T. A., Ghandilyan, Y., Gilfoyle, G. P., Giovanetti, K. L., Girod, F. X., Glazier, D. I., Golovatch, E., Gothe, R. W., Griffioen, K. A., Guidal, M., Guo, L., Hakobyan, H., Harrison, N., Hattawy, M., Hayward, T. B., Heddle, D., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D. G., Ishkhanov, B. S., Isupov, E. L., Jenkins, D., Jo, H. S., Joosten, S., Keller, D., Khachatryan, M., Khanal, A., Khandaker, M., Kim, C. W., Kim, W., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Markov, N., Marsicano, L., Mascagna, V., McKinnon, B., Meziani, Z. E., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Munoz, Nadel-Turonski, P., Niculescu, G., Osipenko, M., Paolone, M., Pappalardo, L. L., Pasyuk, E., Phelps, W., Pogorelko, O., Price, J. W., Prok, Y., Raue, B. A., Ripani, M., Rizzo, A., Rossi, P., Rowley, J., Sabatie, F., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shrestha, U., Soto, O., Sparveris, N., Stepanyan, S., Stoler, P., Strakovsky, I. I., Strauch, S., Tan, J. A., Tyler, N., Ungaro, M., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wood, M. H., Zachariou, N., Zhang, J., and Zhao, Z. W.

Subjects
High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We have measured beam-spin asymmetries to extract the $\sin��$ moment $A_{LU}^{\sin��}$ from the hard exclusive $\vec{e} p \to e^\prime n ��^+$ reaction above the resonance region, for the first time with nearly full coverage from forward to backward angles in the center-of-mass. The $A_{LU}^{\sin��}$ moment has been measured up to 6.6 GeV$^{2}$ in $-t$, covering the kinematic regimes of Generalized Parton Distributions (GPD) and baryon-to-meson Transition Distribution Amplitudes (TDA) at the same time. The experimental results in very forward kinematics demonstrate the sensitivity to chiral-odd and chiral-even GPDs. In very backward kinematics where the TDA framework is applicable, we found $A_{LU}^{\sin��}$ to be negative, while a sign change was observed near 90$^\circ$ in the center-of-mass. The unique results presented in this paper will provide critical constraints to establish reaction mechanisms that can help to further develop the GPD and TDA frameworks.

Published
2020
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37. Probing the core of the strong nuclear interaction

Author

Schmidt, A, Pybus, J, Weiss, R, Segarra, E, Hrnjic, A, Denniston, A, Hen, O, Piasetzky, E, Weinstein, L, Barnea, N, Strikman, M, Larionov, A, Higinbotham, D, Adhikari, S, Amaryan, M, Angelini, G, Asryan, G, Atac, H, Avakian, H, Gayoso, C, Baashen, L, Barion, L, Bashkanov, M, Battaglieri, M, Beck, A, Bedlinskiy, I, Benmokhtar, F, Bianconi, A, Biselli, A, Bossu, F, Boiarinov, S, Brahim, M, Briscoe, W, Brooks, W, Burkert, V, Cao, F, Carman, D, Carvajal, J, Celentano, A, Chatagnon, P, Chetry, T, Ciullo, G, Clark, L, Cohen, E, Cole, P, Contalbrigo, M, Crede, V, Cruz-Torres, R, D'Angelo, A, Dashyan, N, De Vita, R, De Sanctis, E, Defurne, M, Deur, A, Diehl, S, Djalali, C, Duer, M, Dugger, M, Dupre, R, Egiyan, H, Ehrhart, M, El Alaoui, A, El Fassi, L, Eugenio, P, Filippi, A, Forest, T, Gavalian, G, Gilad, S, Gilfoyle, G, Giovanetti, K, Girod, F, Giuseppe, C, Glazier, D, Golovatch, E, Gothe, R, Griffioen, K, Guo, L, Hafidi, K, Hakobyan, H, Hanretty, C, Harrison, N, Hattawy, M, Hauenstein, F, Hayward, T, Hicks, K, Holtrop, M, Ilieva, Y, Illari, I, Ireland, D, Ishkanov, B, Isupov, E, Jenkins, D, Hs, J, Joo, K, Keller, D, Khachatryan, M, Khanal, A, Khandaker, M, Kim, C, Kim, W, Klein, F, Korover, I, Kubarovsky, V, Lanza, L, Leali, M, Lenisa, P, Macgregor, I, Marchand, D, Markov, N, Marsicano, L, Mascagna, V, Beck, S, Mckinnon, B, Mirazita, M, Mokeev, V, Camacho, C, Mustafa, B, Nadel-Turonski, P, Nanda, S, Niccolai, S, Niculescu, G, Osipenko, M, Ostrovidov, A, Paolone, M, Pappalardo, L, Paremuzyan, R, Park, K, Pasyuk, E, Patsyuk, M, Phelps, W, Pogorelko, O, Price, J, Prok, Y, Protopopescu, D, Ripani, M, Riser, D, Rizzo, A, Rosner, G, Rossi, P, Sabatie, F, Salgado, C, Schmookler, B, Schumacher, R, Sharabian, Y, Shrestha, U, Skorodumina, I, Sokhan, D, Soto, O, Sparveris, N, Stepanyan, S, Strakovsky, I, Strauch, S, Tan, J, Tyler, N, Ungaro, M, Venturelli, L, Voskanyan, H, Voutier, E, Wang, R, Watts, D, Wei, X, Wood, M, Zachariou, N, Zhang, J, Zhao, Z, Zheng, X, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CLAS, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Nuclear Theory, nucleon: pair, Socio-culturale, Nuclear Interactions, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Structure, spin: dependence, 01 natural sciences, 7. Clean energy, Nuclear physics, Nuclear Theory (nucl-th), PE2_1, CLAS, 0103 physical sciences, quantum chromodynamics, Neutron, density: high, Nuclear Models, Quarks and Gluons, Electron Scattering, Spin Dependent Cross Sections, Nuclear Experiment (nucl-ex), 010306 general physics, neutron star, Nuclear Experiment, PE2_3, nucleus: interaction, Physics, Quantum chromodynamics, Multidisciplinary, 010308 nuclear & particles physics, Settore FIS/04, Nuclear matter, Fundamental interaction, quark gluon: interaction, Neutron star, electron: scattering, kinematics, nuclear matter, Atomic nucleus, Quark–gluon plasma, Nucleon, experimental results
Abstract

The strong nuclear interaction between nucleons (protons and neutrons) is the effective force that holds the atomic nucleus together. This force stems from fundamental interactions between quarks and gluons (the constituents of nucleons) that are described by the equations of Quantum Chromodynamics (QCD). However, as these equations cannot be solved directly, physicists resort to describing nuclear interactions using effective models that are well constrained at typical inter-nucleon distances in nuclei but not at shorter distances. This limits our ability to describe high-density nuclear matter such as in the cores of neutron stars. Here we use high-energy electron scattering measurements that isolate nucleon pairs in short-distance, high-momentum configurations thereby accessing a kinematical regime that has not been previously explored by experiments, corresponding to relative momenta above 400 MeV/c. As the relative momentum between two nucleons increases and their separation thereby decreases, we observe a transition from a spin-dependent tensor-force to a predominantly spin-independent scalar-force. These results demonstrate the power of using such measurements to study the nuclear interaction at short-distances and also support the use of point-like nucleons with two- and three-body effective interactions to describe nuclear systems up to densities several times higher than the central density of atomic nuclei., Comment: Total 26 pages, 13 figures. Main text: 8 pages, 3 figures. Methods section: 6 pages. Extended Data: 8 figures, 1 table. Supplementary Materials: 8 pages, 2 figures

Published
2020
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38. $K^+��$ photoproduction at forward angles and low momentum transfer

Author

Alef, S., Bauer, P., Bayadilov, D., Beck, R., Bella, A., Bieling, J., Braghieri, A., Cole, P. L., Elsner, D., Di Salvo, R., Fantini, A., Freyermuth, O., Frommberger, F., Ghio, F., Goertz, S., Gridnev, A., Hammann, D., Hannappel, J., Jude, T. C., Kohl, K., Kozlenko, N., Sandri, A. Lapik P. Levi, Lisin, V., Mandaglio, G., Messi, F., Messi, R., Moricciani, D., Nedorezov, V., Nikonov, V. A, Novinskiy, D., Pedroni, P., Polonskiy, A., Reitz, B. -E., Romaniuk, M., Sarantsev, A. V, Scheluchin, G., Schmieden, H., Stuglev, A., Sumachev, V., Vegna, V., Tarakanov, V., and Zimmermann, T.

Subjects
FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

$��p \rightarrow K^+ ��$ differential cross sections and recoil polarisation data from threshold for extremely forward angles are presented. The measurements were performed at the BGOOD experiment at ELSA, utilising the high angular and momentum resolution forward spectrometer for charged particle identification. The data discriminates between conflicting results in the world data set and enable extraction of the cross section as the minimum momentum transfer to the recoiling hyperon is approached., 12 pages (including a 2 page appendix), 14 figures

Published
2020
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39. Observation of a cusp-like structure in the $��p \rightarrow K^+��^0$ cross section at forward angles and low momentum transfer

Author

Jude, T. C., Alef, S., Bauer, P., Bayadilov, D., Beck, R., Bella, A., Bieling, J., Braghieri, A., Cole, P. L., Elsner, D., Di Salvo, R., Fantini, A., Freyermuth, O., Frommberger, F., Ghio, F., Goertz, S., Gridnev, A., Hammann, D., Hannappel, J., Kohl, K., Kozlenko, N., Sandri, A. Lapik P. Levi, Lisin, V., Mandaglio, G., Messi, F., Messi, R., Moricciani, D., Nedorezov, V., Nikonov, V. A, Novinskiy, D., Pedroni, P., Polonskiy, A., Reitz, B. -E., Romaniuk, M., Sarantsev, A. V, Scheluchin, G., Schmieden, H., Stugelev, A., Sumachev, V., Vegna, V., Tarakanov, V., and Zimmermann, T.

Subjects
FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The $��p \rightarrow K^+��^0$ differential cross section at extremely forward angles was measured at the BGOOD experiment. A three-quarter drop in strength over a narrow range in energy and a strong dependence on the polar angle of the $K^+$ in the centre-of-mass of the reaction is observed at a centre-of-mass energy of 1900\,MeV. Residing close to multiple open and hidden strangeness thresholds, the structure appears consistent with meson-baryon threshold effects which may contribute to the reaction mechanism., 9 pages (including a 2 page appendix of tabulated data), 10 figures

Published
2020
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40. Sassafras

Author

Cole P, Rodman

Subjects
Cancer Research, Narration, Students, Medical, Oncology, Neoplasms, Humans
Published
2020

41. NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

Author

Jason Gertz, Paul M Rindler, Elizabeth A. Leibold, Maria C Ferreira dos Santos, Malini Rajan, Cole P. Anderson, and Steven J. Romney

Subjects
Mutant, Receptors, Cytoplasmic and Nuclear, SMF-3, 0302 clinical medicine, Sense (molecular biology), Biology (General), PQM-1, innate immunity, Disease Resistance, 0303 health sciences, General Neuroscience, General Medicine, Cell biology, DNA-Binding Proteins, Pseudomonas aeruginosa, C. elegans, Medicine, Research Article, Signal Transduction, animal structures, QH301-705.5, Science, Iron, Biology, NHR-14, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Animals, Pseudomonas Infections, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Gene, Transcription factor, Loss function, 030304 developmental biology, Innate immune system, General Immunology and Microbiology, iron uptake, Genetics and Genomics, Biological Transport, Transporter, Cell Biology, Immunity, Innate, Trace Elements, Nuclear receptor, Trans-Activators, 030217 neurology & neurosurgery, pathogen, Transcription Factors
Abstract

Iron is essential for survival of most organisms. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In C. elegans, iron uptake and sequestration are regulated by HIF-1. We previously showed that hif-1 mutants are developmentally delayed when grown under iron limitation. Here we identify nhr-14, encoding a nuclear receptor, in a screen conducted for mutations that rescue the developmental delay of hif-1 mutants under iron limitation. nhr-14 loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants. nhr-14 mutants display increased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to Pseudomonas aeruginosa. These responses are dependent on the transcription factor PQM-1, which localizes to intestinal cell nuclei in nhr-14 mutants. Our data reveal how C. elegans utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron sequestration as a component of the innate immune response.

Published
2019

43. Exclusive $\bm{��^{0}p}$ electroproduction off protons in the resonance region at photon virtualities 0.4~GeV$\bm{^{2}}$ $\bm{\leq~ Q^{2} \leq~1}$~GeV$\bm{^{2}}$

Author

Markov, N., Joo, K., Burkert, V. D., Mokeev, V. I., Smith, L. C., Ungaro, M., Adhikari, S., ~Amaryan, M. J., Angelini, G., ~Atac, H., ~Avakian, H., Gayoso, C. Ayerbe, ~Baltzell, N. A., Barion, L., ~Battaglieri, M., ~Bedlinskiy, I., Benmokhtar, F., ~Biselli, A. S., ~Boss��, F., ~Boiarinov, S., ~Briscoe, W. J., ~Brooks, W. K., ~Carman, D. S., ~Carvajal, J. C., ~Celentano, A., ~Chatagnon, P., Chetry, T., ~Cole, P. L., ~Contalbrigo, M., ~Crede, V., Ciullo, G., ~D'Angelo, A., ~Dashyan, N., ~De~Vita, R., ~De~Sanctis, E., Defurne, M., ~Deur, A., Diehl, S., ~Djalali, C., ~Dupre, R., ~Ehrhart, M., ~El~Alaoui, A., ~El~Fassi, L., ~Eugenio, P., ~Evans, C., ~Filippi, A., ~Ghandilyan, Y., ~Girod, F. X., ~Golovatch, E., ~Gothe, R. W., ~Griffioen, K. A., ~Guidal, M., ~Hafidi, K., ~Hakobyan, H., ~Hattawy, M., ~Hayward, T. B., ~Hicks, K., ~Holtrop, M., ~Ilieva, Y., ~Ireland, D. G., ~Ishkhanov, B. S., ~Isupov, E. L., ~Jenkins, D., ~Jo, H. S., ~Keller, D., ~Khachatryan, M., ~Khanal, A., ~Khandaker, M., ~Kim, A., ~Kim, C. W., ~Kim, W., ~Klein, F. J., ~Kubarovsky, V., Lanza, L., ~Leali, M., ~Livingston, K., ~MacGregor, I . J . D., ~Marchand, D., ~Mascagna, V., ~McKinnon, B., ~Mineeva, T., ~Mirazita, M., ~Nadel-Turonski, P., ~Nanda, S., ~Niccolai, S., ~Niculescu, G., ~Osipenko, M., ~Paolone, M., ~Pappalardo, L. L., ~Paremuzyan, R., ~Park, K., ~Pasyuk, E., ~Phelps, W., ~Pogorelko, O., ~Price, J. W., ~Prok, Y., ~Protopopescu, D., ~Ripani, M., Riser, D., ~Rizzo, A., ~Rowley, J., ~Sabati��, F., ~Salgado, C., ~Schumacher, R. A., ~Sharabian, Y. G., ~Shrestha, U., ~Sokhan, D., ~Soto, O., ~Sparveris, N., ~Stepanyan, S., ~Stoler, P., ~Strakovsky, I. I., ~Strauch, S., ~Taiuti, M., ~Tan, J. A., ~Tyler, N., ~Venturelli, L., ~Voskanyan, H., ~Voutier, E., Wang, R., ~Wei, X., ~Wood, M. H., and ~Zachariou, N.

Subjects
FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The exclusive electroproduction process $ep \rightarrow e'p'��^{0}$ was measured in the range of photon virtualities $Q^{2} = 0.4 - 1.0$~GeV$^{2}$ and the invariant mass range of the $p��^{0}$ system of $W = 1.1 - 1.8$~GeV. These kinematics are covered in exclusive $��^{0}$ electroproduction off the proton with nearly complete angular coverage in the $p��^{0}$ center-of-mass system and with high statistical accuracy. Nearly 36000 cross section points were measured, and the structure functions $��_T+����_L$, $��_{LT}$, and $��_{TT}$, were extracted via fitting the $��_{��^{0}}$ dependence of the cross section. A Legendre polynomial expansion analysis demonstrates the sensitivity of our data to high-lying $N^*$ and $��^{*}$ resonances with $M~>~1.6$ GeV. As part of a broad effort to determine the electrocouplings of the $N^{*}$ and $��^{*}$ resonances using both single- and double-pion electroproduction, this dataset is crucial for the reliable extraction of the high-lying resonance electrocouplings from the combined isospin analysis of the $N ��$ and $��^{+}��^{-} p$ channels., 21 pages, 24 figures

Published
2019
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44. Lipid droplet membrane proteome remodeling parallels ethanol-induced hepatic steatosis and its resolution

Author

Michael J. Naldrett, Cole P. Frisbie, Carol A. Casey, Vikas Kumar, Terrence M. Donohue, Nicholas T. Woods, Mark A. McNiven, Paul G. Thomes, and Jacy L. Kubik

Subjects
0301 basic medicine, lipid droplet, 030204 cardiovascular system & hematology, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Lipid droplet, steatosis, ACSM5, acyl-coenzyme A synthetase 5, HSD17β7, hydroxysteroid 17β-dehydrogenase 7, TFEB, transcription factor EB, PLIN, perilipin, LAL, lysosomal acid lipase, perilipins, Cell biology, mitochondria, TE, Tris/EDTA, WB, Western blot, ACSM1, acyl-coenzyme A synthetase 1, immunohistochemistry, G0s2, G0/G1 switch protein 2, Proteome, Research Article, FDR, false discovery rate, LD, lipid droplet, fasting, CIDEB, cell death–inducing DFFA-like effector B, Phospholipid, LAMP, lysosome-associated membrane protein, QD415-436, pATGL, phosphorylated adipocyte TG lipase, liver, DHCR7, 7-dehydrocholesterol reductase, 03 medical and health sciences, proteomics, HSC70, heat shock cognate protein 70, Lipid biosynthesis, COXIV, cytochrome c oxidase subunit IV, medicine, LSS, lanosterol synthase, HSD17β11, hydroxysteroid 17β-dehydrogenase 11, ATP6V0A1, ATPase 116 kDa subunit a isoform 1, Ethanol, HSD17β13, hydroxysteroid 17β-dehydrogenase 13, PCA, principal component analyses, Lipid metabolism, Lipid Droplets, MS, Cell Biology, IPA, ingenuity pathway analysis, medicine.disease, pHSL, phosphorylated hormone-sensitive lipase, 030104 developmental biology, TM7SF2, delta (14)-sterol reductase, chemistry, Membrane protein, Perilipin, Steatosis
Abstract

Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD functions. Despite the crucial role of LDs in lipid metabolism, remodeling of LD protein composition in disease contexts, such as steatosis, remains poorly understood. We hypothesized that chronic ethanol consumption, subsequent abstinence from ethanol, or fasting differentially affects the LD membrane proteome content and that these changes influence how LDs interact with other intracellular organelles. Here, male Wistar rats were pair-fed liquid control or ethanol diets for 6 weeks, and then, randomly chosen animals from both groups were either refed a control diet for 7 days or fasted for 48 h before euthanizing. From all groups, LD membrane proteins from purified liver LDs were analyzed immunochemically and by MS proteomics. Liver LD numbers and sizes were greater in ethanol-fed rats than in pair-fed control, 7-day refed, or fasted rats. Compared with control rats, ethanol feeding markedly altered the LD membrane proteome, enriching LD structural perilipins and proteins involved in lipid biosynthesis, while lowering LD lipase levels. Ethanol feeding also lowered LD-associated mitochondrial and lysosomal proteins. In 7-day refed (i.e., ethanol-abstained) or fasted-ethanol-fed rats, we detected distinct remodeling of the LD proteome, as judged by lower levels of lipid biosynthetic proteins, and enhanced LD interaction with mitochondria and lysosomes. Our study reveals evidence of significant remodeling of the LD membrane proteome that regulates ethanol-induced steatosis, its resolution after withdrawal and abstinence, and changes in LD interactions with other intracellular organelles.

Published
2021

45. Iron in infection and immunity in C. elegans

Author

Malini Rajan, Cole P Anderson, Steven Joshua Romney, Maria Carolina Ferreira Dos Santos, Jason Gertz, and Elizabeth A Leibold

Subjects
Immunology, Immunology and Allergy
Abstract

Iron is essential for survival of most organisms, but is toxic in excess. All organisms have thus developed mechanisms to sense, acquire and sequester iron. In C. elegans, iron uptake and sequestration are regulated by HIF-1. We previously showed that hif-1 loss of function mutants are developmentally delayed when grown under iron limitation. Here we identify nhr-14, encoding a nuclear receptor homologous to vertebrate HNF4, in a genetic screen conducted for mutations that rescue the developmental delay of hif-1 mutants under iron limitation. NHR-14 is highly expressed in intestinal cell nuclei and in cells in the head, and its subcellular localization and expression are not regulated by iron. Loss of nhr-14 leads to the upregulation of the intestinal metal transporter SMF-3 that increases iron uptake in hif-1 mutants, rescuing the low iron-dependent developmental delay. Loss of nhr-14 also promotes the nuclear localization of the zinc-finger transcription factor PQM-1, which activates smf-3 through the interaction with GATA-like DAF-16-associated elements (DAEs) in the smf-3 promoter. In addition to smf-3, RNA-seq analysis revealed upregulation of innate immune response genes as well as DAF-16/FoxO-suppressed Class 2 genes. Consistent with the RNA-seq results, nhr-14 mutants showed enhanced resistance to the human pathogen Pseudomonas aeruginosa that depends in part on iron uptake as well as the upregulation of innate immune response genes. Our data provide insight into how C. elegans utilizes nuclear receptors to regulate innate immunity and iron availability, and show iron sequestration as an important component of the innate immune response.

Published
2020

46. Direct Numerical Simulation of Acoustic Disturbances in the Rectangular Test Section of a Hypersonic Wind Tunnel

Author

Lian Duan, Meelan M. Choudhari, and Cole P. Deegan

Subjects
Physics, Turbulence, Nozzle, Mechanics, 01 natural sciences, 010305 fluids & plasmas, Physics::Fluid Dynamics, symbols.namesake, Boundary layer, Mach number, Inviscid flow, 0103 physical sciences, symbols, Hypersonic wind tunnel, 010306 general physics, Reynolds-averaged Navier–Stokes equations, Freestream
Abstract

Direct numerical simulations (DNS) of the full-scale rectangular nozzle of a hypersonic wind tunnel are conducted to study the acoustic freestream fluctuations radiating from turbulent boundary layers (TBLs) along the nozzle walls. The nozzle geometry and the flow conditions of the DNS match those of the NASA 20-Inch Mach 6 Tunnel, and the DNS has been completed for a domain without spanwise sidewall boundary conditions. The turbulent boundary layer parameters based on the DNS compare well with those derived from Reynolds Averaged Navier-Stokes (RANS) calculations as well as with the predictions based on Pate’s correlation. A similarly good comparison is observed for both the Mach number distribution and the Reynold’s stresses obtained from the DNS and RANS calculations, respectively. Various characteristics of the acoustic pressure fluctuations within the inviscid core of the nozzle flow are compared with those associated with a single flat plate at a similar freestream Mach number. The frequency spectrum and bulk propagation speeds match well between the nozzle and the flat plate, but the rms pressure fluctuation is higher for the nozzle configuration, likely due to the combined effect of acoustic radiation from the top and bottom walls. Spatial contours of the two-point correlation coefficient display elliptical tails with approximately equal but opposite angles corresponding to the preferred directionality of acoustic structures radiated from both walls. Future work will focus on DNS of the full nozzle configuration, including the effects of the nozzle side walls.

Published
2018

47. First Measurements of the Double-Polarization Observables $F$, $P$, and $H$ in $��$ Photoproduction off Transversely Polarized Protons in the $N^\ast$ Resonance Region

Author

Roy, P., Park, S., Crede, V., Anisovich, A. V., Klempt, E., Nikonov, V. A., Sarantsev, A. V., Wei, N. C., Huang, F., Nakayama, K., Adhikari, K. P., Adhikari, S., Angelini, G., Avakian, H., Barion, L., Battaglieri, M., Bedlinskiy, I., Biselli, A. S., Boiarinov, S., Briscoe, W. J., Brock, J., Brooks, W. K., Burkert, V. D., Cao, F., Carlin, C., Carman, D. S., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Cole, P. L., Contalbrigo, M., Cortes, O., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Deur, A., Diehl, S., Djalali, C., Dugger, M., Dupre, R., Duran, B., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Eugenio, P., Fegan, S., Filippi, A., Fradi, A., Gilfoyle, G. P., Girod, F. X., Golovatch, E., Gothe, R. W., Griffioen, K. A., Guidal, M., Guo, L., Hafidi, K., Hanretty, C., Harrison, N., Hattawy, M., Hayward, T. B., Heddle, D., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D. G., Ishkhanov, B. S., Isupov, E. L., Jenkins, D., Jo, H. S., Johnston, S., Joosten, S., Kabir, M. L., Keith, C. D., Keller, D., Khachatryan, G., Khachatryan, M., Khanal, A., Khandaker, M., Kim, A., Kim, W., Klein, F. J., Kubarovsky, V., Kuleshov, S. V., Kunkel, M. C., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., McKinnon, B., Meekins, D. G., Meyer, C. A., Mineeva, T., Mokeev, V., Montgomery, R. A., Movsisyan, A, Camacho, C. Munoz, Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A. I., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Payette, D., Phelps, W., Pierce, J., Pogorelko, O., Prok, Y., Protopopescu, D., Raue, B. A., Ripani, M., Riser, D., Ritchie, B. G., Rizzo, A., Rosner, G., Sabatie, F., Salgado, C., Schumacher, R. A., Seely, M. L., Sharabian, Y. G., Shrestha, U., Skorodumina, Iu., Sokhan, D., Soto, O., Sparveris, N., Strakovsky, I. I., Strauch, S., Taiuti, M., Tan, J. A., Torayev, B., Tyler, N., Ungaro, M., Voskanyan, H., Voutier, E., Walford, N. K., Wang, R., Watts, D. P., Wei, X., Wood, M. H., Zachariou, N., Zhang, J., and Zhao, Z. W.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, Physics::Accelerator Physics, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

First measurements of double-polarization observables in $��$ photoproduction off the proton are presented using transverse target polarization and data from the CEBAF Large Acceptance Spectrometer (CLAS) FROST experiment at Jefferson Lab. The beam-target asymmetry $F$ has been measured using circularly polarized, tagged photons in the energy range 1200 - 2700 MeV, and the beam-target asymmetries $H$ and $P$ have been measured using linearly polarized tagged photons in the energy range 1200 - 2000 MeV. These measurements significantly increase the database on polarization observables. The results are included in two partial-wave analyses and reveal significant contributions from several nucleon ($N^\ast$) resonances. In particular, contributions from new $N^\ast$ resonances listed in the Review of Particle Properties are observed, which aid in reaching the goal of mapping out the nucleon resonance spectrum., Two authors added, figures updated

Published
2018
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48. First results on nucleon resonance photocouplings from the $��p \to ��^+��^-p$ reaction

Author

CLAS Collaboration, Golovatch, E., Burkert, V. D., Carman, D. S., Gothe, R. W., Hicks, K., Ishkhanov, B. S., Mokeev, V. I., Pasyuk, E., Adhikari, S., Akbar, Z., Amaryan, M. J., Avakian, H., Ball, J., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Biselli, A. S., Boiarinov, S., Briscoe, W. J., Cao, F., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Clark, L., Clary, B. A., Cole, P. L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Defurne, M., Deur, A., Diehl, S., Djalali, C., Dugger, M., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Eugenio, P., Fedotov, G., Fersch, R., Filippi, A., Ghandilyan, Y., Gilfoyle, G. P., Giovanetti, K. L., Girod, F. X., Glazier, D. I., Griffioen, K. A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Harrison, N., Hattawy, M., Heddle, D., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jenkins, D., Jo, H. S., Johnston, S., Joo, K., Kabir, M. L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, W., Klein, A., Klein, F. J., Kubarovsky, V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Markov, N., McKinnon, B., Meyer, C. A., Montgomery, R. A., Movsisyan, A., Camacho, C. Munoz, Nadel-Turonski, P., Niccolai, S., Niculescu, G., Osipenko, M., Ostrovidov, A. I., Paolone, M., Paremuzyan, R., Park, K., Pogorelko, O., Price, J. W., Prok, Y., Protopopescu, D., Ripani, M., Riser, D., Rizzo, A., Rosner, G., Sabati��, F., Salgado, C., Schumacher, R. A., Sharabian, Y. G., Skorodumina, Iu., Smith, G. D., Sober, D. I., Sokhan, D., Sparveris, N., Strakovsky, I. I., Strauch, S., Taiuti, M., Tan, J. A., Tyler, N., Ungaro, M., Voskanyan, H., Voutier, E., Wang, R., Wei, X., Wood, M. H., Zachariou, N., Zhang, J., and Zhao, Z. W.

Subjects
FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report the first experimental measurements of the nine 1-fold differential cross sections for the $��p \to ��^+��^-p$ reaction, obtained with the CLAS detector at Jefferson Laboratory. The measurements cover the invariant mass range of the final state hadrons from 1.6~GeV~$

Published
2018
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49. Beam-Target Helicity Asymmetry $E$ in $K^{0}��$ and $K^{0}��^0$ Photoproduction on the Neutron

Author

CLAS Collaboration, Ho, D. H., Schumacher, R. A., D'Angelo, A., Deur, A., Fleming, J., Hanretty, C., Kageya, T., Klein, F. J., Klempt, E., Lowry, M. M., Lu, H., Nikonov, V. A., Peng, P., Sandorfi, A. M., Sarantsev, A. V., Strakovsky, I. I., Walford, N. K., Wei, X., Workman, R. L., Adhikari, K. P., Adhikari, S., Adikaram, D., Akbar, Z., Ball, J., Barion, L., Bashkanov, M., Bass, C. D., Battaglieri, M., Bedlinskiy, I., Biselli, A. S., Briscoe, W. J., Boiarinov, S., Burkert, V. D., Cao, F., Carman, D. S., Celentano, A., Chandavar, S., Charles, G., Chatagnon, P., Chetry, T., Ciullo, G., Clary, B. A., Cole, P., Contalbrigo, M., Crede, V., De Vita, R., Defurne, M., Diehl, S., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fradi, A., Ghandilyan, Y., Giovanetti, K. L., Girod, F. X., Gohn, W., Golovatch, E., Gothe, R. W., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Harrison, N., Hattawy, M., Heddle, D., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D. G., Ishkhanov, B. S., Isupov, E. L., Jenkins, D., Jo, H. S., Johnston, S., Kabir, M. L., Keller, D., Khachatryan, G., Khachatryan, M., Khandaker, M., Kim, A., Kim, W., Klein, A., Kubarovsky, V., Laine, V., Lanza, L., Lenisa, P., Livingston, K., MacGregor, I . J . D., Marchand, D., Markov, N., Mayer, M., McKinnon, B., Meyer, C. A., Mirazita, M., Mokeev, V., Montgomery, R. A., Movsisyan, A, Camacho, C. Munoz, Nadel-Turonski, P., Niccolai, S., Niculescu, G., O'Connell, T., Osipenko, M., Ostrovidov, A. I., Paolone, M., Paremuzyan, R., Park, K., Pasyuk, E., Pogorelko, O., Price, J. W., Prok, Y., Protopopescu, D., Rehfuss, M., Ripani, M., Riser, D., Rizzo, A., Rosner, G., Sabati��, F., Salgado, C., Sharabian, Y. G., Skorodumina, Iu., Smith, G. D., Sober, D. I., Sokhan, D., Sparveris, N., Strauch, S., Taiuti, M., Tan, J. A., Ungaro, M., Voskanyan, H., Voutier, E., Wang, R., Watts, D. P., Weinstein, L. B., Whisnant, C. S., Wood, M. H., Zachariou, N., Zhang, J., Zhao, Z. W., and Zonta, I.

Subjects
Nuclear Theory, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

We report the first measurements of the $E$ beam-target helicity asymmetry for the $\vec�� \vec{n} \to K^{0}��$, and $K^{0}��^{0}$ channels in the energy range 1.70$\leq W\leq$2.34 GeV. The CLAS system at Jefferson Lab uses a circularly polarized photon beam and a target consisting of longitudinally polarized solid molecular hydrogen deuteride with low background contamination for the measurements. The multivariate analysis method boosted decision trees was used to isolate the reactions of interest. Comparisons with predictions from the KaonMAID, SAID, and Bonn-Gatchina models are presented. These results will help separate the isospin $I=0$ and $I=1$ photo-coupling transition amplitudes in pseudoscalar meson photoproduction., 14 pages, 9 figures; Revised to match published version

Published
2018
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50. Informed consent for biobanking: consensus-based guidelines for adequate comprehension

Author

Laura M. Beskow, Carrie B. Dombeck, Kevin P. Weinfurt, J. Kemp Watson-Ormond, and Cole P. Thompson

Subjects
Adult, Male, Biomedical Research, research ethics, Best practice, Genetic Information Nondiscrimination Act, Delphi method, Context (language use), Article, biobanking, Informed consent, Humans, Medicine, Genetics (clinical), Aged, Biological Specimen Banks, Medical education, Research ethics, Informed Consent, business.industry, Middle Aged, Biobank, Comprehension, Practice Guidelines as Topic, Delphi process, Female, business
Abstract

Purpose Federal regulations and best practice guidelines identify categories of information that should be communicated to prospective biobank participants during the informed consent process. However, uncertainty remains about which of this information participants must understand to provide valid consent. Methods We conducted a Delphi process to define “adequate comprehension” in the context of biobanking consent. The process involved an iterative series of 3 online surveys of a diverse panel of 51 experts, including genome scientists, biobank managers, ethics and policy experts, and community and participant representatives. We sought consensus (greater than 70% agreement) concerning what specific details participants should know about 16 biobank consent topics. Results Consensus was achieved for 15 of the 16 consent topics. The exception was the comprehension needed regarding the Genetic Information Nondiscrimination Act. Conclusions Our Delphi process was successful in identifying a concise set of key points that prospective participants must grasp to provide valid consent for biobanking. Specifying the level of knowledge sufficient for individuals to make an informed choice provides a basis for improving consent forms and processes, as well as an absolute metric for assessing the effectiveness of other interventions to improve comprehension.

Published
2015

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