Search

The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediated by microvilli adhesion is demonstrated. This microvillus-mediated adhesion (MMA) has been observed using ceria and magnetite NPs with a dimension of

This paper addresses the fleet deployment problem and in particular the treatment of inventory in the maritime case. A new model based on time-continuous formulation for the combined maritime fleet deployment and inventory management problem in Roll-on Roll-off shipping is presented. Tests based on realistic data from the Ro-Ro business show that the model yields good solutions to the combined problem within reasonable time. © Springer Verlag. LOCKED until 27.9.2018 due to copyright restrictions. The final publication is available at https://link.springer.com/chapter/10.1007%2F978-3-319-68496-3_22. This is the authors' accepted and refereed manuscript to the article.