1. Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth
- Author
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Tarca, Adi L, Pataki, Bálint Ármin, Romero, Roberto, Sirota, Marina, Guan, Yuanfang, Kutum, Rintu, Gomez-Lopez, Nardhy, Done, Bogdan, Bhatti, Gaurav, Yu, Thomas, Andreoletti, Gaia, Chaiworapongsa, Tinnakorn, DREAM Preterm Birth Prediction Challenge Consortium, Hassan, Sonia S, Hsu, Chaur-Dong, Aghaeepour, Nima, Stolovitzky, Gustavo, Csabai, Istvan, Costello, James C, Bhatti, Gaurav [0000-0002-8557-3347], and Apollo - University of Cambridge Repository
- Subjects
Proteomics ,Adult ,aptamers ,Gestational Age ,Reproductive health and childbirth ,Low Birth Weight and Health of the Newborn ,Pre-Eclampsia ,Pregnancy ,Clinical Research ,Preterm ,Infant Mortality ,Humans ,spontaneous preterm birth ,Longitudinal Studies ,DREAM Preterm Birth Prediction Challenge Consortium ,Pediatric ,screening and diagnosis ,plasma proteomics ,Contraception/Reproduction ,Infant, Newborn ,Infant ,whole blood transcriptomics ,Blood Proteins ,Perinatal Period - Conditions Originating in Perinatal Period ,Newborn ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,machine learning ,Good Health and Well Being ,ROC Curve ,collaborative competition ,preterm labor and delivery ,Asymptomatic Diseases ,Premature Birth ,Crowdsourcing ,Female ,Transcriptome ,human transcriptome arrays ,Cell-Free Nucleic Acids ,predictive modeling ,Biomarkers - Abstract
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to develop predictive models of PTB. The findings indicate that whole-blood gene expression predicts ultrasound-based gestational ages in normal and complicated pregnancies (r= 0.83) and, using data collected before 37weeks of gestation, also predicts the delivery date in both normal pregnancies (r=0.86) and those with spontaneous preterm birth (r= 0.75). Based on samples collected before 33weeks in asymptomatic women, our analysis suggests that expression changes preceding preterm prelabor rupture of the membranes are consistent across time points and cohorts and involve leukocyte-mediated immunity. Models built from plasma proteomic data predict spontaneous preterm delivery with intact membranes with higher accuracy and earlier in pregnancy than transcriptomic models (AUROC= 0.76 versus AUROC= 0.6 at 27-33weeks of gestation).
- Published
- 2021