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The Drosophila adult midgut is a model epithelial tissue composed of a few major cell types with distinct regional identities. One of the limitations to its analysis is the lack of tools to manipulate gene expression based on these regional identities. To overcome this obstacle, we applied the intersectional split-GAL4 system to the adult midgut and report 653 driver combinations that label cells by region and cell type. We first identified 424 split-GAL4 drivers with midgut expression from ∼7300 drivers screened, and then evaluated the expression patterns of each of these 424 when paired with three reference drivers that report activity specifically in progenitor cells, enteroendocrine cells, or enterocytes. We also evaluated a subset of the drivers expressed in progenitor cells for expression in enteroblasts using another reference driver. We show that driver combinations can define novel cell populations by identifying a driver that marks a distinct subset of enteroendocrine cells expressing genes usually associated with progenitor cells. The regional cell type patterns associated with the entire set of driver combinations are documented in a freely available website, providing information for the design of thousands of additional driver combinations to experimentally manipulate small subsets of intestinal cells. In addition, we show that intestinal enhancers identified with the split-GAL4 system can confer equivalent expression patterns on other transgenic reporters. Altogether, the resource reported here will enable more precisely targeted gene expression for studying intestinal processes, epithelial cell functions, and diseases affecting self-renewing tissues.

WEAVE is the new wide-field spectroscopy facility for the prime focus of the William Herschel Telescope in La Palma, Spain. Its fibre positioner is essential for the accurate placement of the spectrograph's 960 fibre multiplex. We provide an overview of the recent maintenance, flexure modifications, and calibration measurements conducted at the observatory prior to the final top-end assembly. This work ensures that we have a complete understanding of the positioner's behaviour as it changes orientation during observations. All fibre systems have been inspected and repaired, and the tumbler structure contains new clamps to stiffen both the internal beam and the retractor support disk onto which the field plates attach. We present the updated metrology procedures and results that will be verified on-sky., Comment: 16 pages, 16 figures

The Hobby-Eberly Telescope (HET) Dark Energy Experiment (HETDEX) is undertaking a blind wide-field low-resolution spectroscopic survey of 540 square degrees of sky to identify and derive redshifts for a million Lyman-alpha emitting galaxies (LAEs) in the redshift range 1.9 < z < 3.5. The ultimate goal is to measure the expansion rate of the Universe at this epoch, to sharply constrain cosmological parameters and thus the nature of dark energy. A major multi-year wide field upgrade (WFU) of the HET was completed in 2016 that substantially increased the field of view to 22 arcminutes diameter and the pupil to 10 meters, by replacing the optical corrector, tracker, and prime focus instrument package and by developing a new telescope control system. The new, wide-field HET now feeds the Visible Integral-field Replicable Unit Spectrograph (VIRUS), a new low-resolution integral field spectrograph (LRS2), and the Habitable Zone Planet Finder (HPF), a precision near-infrared radial velocity spectrograph. VIRUS consists of 156 identical spectrographs fed by almost 35,000 fibers in 78 integral field units arrayed at the focus of the upgraded HET. VIRUS operates in a bandpass of 3500-5500 Angstroms with resolving power R~800. VIRUS is the first example of large scale replication applied to instrumentation in optical astronomy to achieve spectroscopic surveys of very large areas of sky. This paper presents technical details of the HET WFU and VIRUS, as flowed-down from the HETDEX science requirements, along with experience from commissioning this major telescope upgrade and the innovative instrumentation suite for HETDEX., 65 pages, 25 figures, published in the Astronomical Journal; replaced with final published version

WEAVE is a new wide-field multi-object spectroscopy (MOS) facility proposed for the prime focus of the 4.2m William Herschel Telescope. The facility comprises a new 2-degree field-of-view Prime Focus Corrector (PFC) with a 1000-multiplex fibre positioner, a small number of individually deployable integral field units, and a large single integral field unit (IFU). The IFUs and the MOS fibres can be used to feed a dual-beam spectrograph that will provide full coverage of the majority of the visible spectrum in a single exposure at a spectral resolution of ~5000 or modest wavelength coverage in both arms at a resolution ~20000. In order to compensate the field rotation, the Prime Focus Rotator (PFR) is assembled in between the WEAVE Fiber Positioner (system that positions the fibers in the focal plane) and with the Central Can (contains the Prime Focus corrector optics) on the William Herschel Telescope (WHT). The Prime Focus Rotator must provide a rotation degree of freedom for the Fibre Positioner with a high bending stiffness (causing a deflection smaller than 0.008° between interface flanges) adding the minimum mass possible to the system (less than 700kg). This is easily identified as the main design driver to be considered. The Prime Focus Rotator positions the Fibre Positioner to an accuracy of 5 arcsec when tracking and guides all the fibres and other power and control lines through a cable wrap, for which the available space is limited. IDOM proposal to comply with these coupled requirements consists of an optimized structural system with a slightly preloaded cross roller bearing providing the highest possible stiffness to weight ratio. The rotation is driven by means of a direct drive motor powered by a servo drive. For the Cable Wrap, a compact design based on a concept previously developed by IDOM for the Folded Cassegrain Sets the GTC was proposed.

The Drosophila adult midgut is a model epithelial tissue composed of a few major cell types with distinct regional identities. One of the limitations to its analysis is the lack of tools to manipulate gene expression based on these regional identities. To overcome this obstacle, we applied the intersectional split-GAL4 system to the adult midgut and report 653 driver combinations that label cells by region and cell type. We first identified 424 split-GAL4 drivers with midgut expression from over 7,300 drivers screened, and then evaluated the expression patterns of each of these 424 when paired with three reference drivers that report activity specifically in progenitor cells, enteroendocrine cells, or enterocytes. We also evaluated a subset of the drivers expressed in progenitor cells for expression in enteroblasts using another reference driver. We show that driver combinations can define novel cell populations by identifying a driver that marks a distinct subset of enteroendocrine cells expressing genes usually associated with progenitor cells. The regional cell type patterns associated with the entire set of driver combinations are documented in a freely available website, providing information for the design of thousands of additional driver combinations to experimentally manipulate small subsets of intestinal cells. In addition, we show that intestinal enhancers identified with the split-GAL4 system can confer equivalent expression patterns on other transgenic reporters. Altogether, the resource reported here will enable more precisely targeted gene expression for studying intestinal processes, epithelial cell functions, and diseases affecting self-renewing tissues.

The Drosophila adult midgut is a model epithelial tissue composed of a few major cell types with distinct regional identities. One of the limitations to its analysis is the lack of tools to manipulate gene expression based on these regional identities. To overcome this obstacle, we applied the intersectional split-GAL4 system to the adult midgut and report 653 driver combinations that label cells by region and cell type. We first identified 424 split-GAL4 drivers with midgut expression from ∼7300 drivers screened, and then evaluated the expression patterns of each of these 424 when paired with three reference drivers that report activity specifically in progenitor cells, enteroendocrine cells, or enterocytes. We also evaluated a subset of the drivers expressed in progenitor cells for expression in enteroblasts using another reference driver. We show that driver combinations can define novel cell populations by identifying a driver that marks a distinct subset of enteroendocrine cells expressing genes usually associated with progenitor cells. The regional cell type patterns associated with the entire set of driver combinations are documented in a freely available website, providing information for the design of thousands of additional driver combinations to experimentally manipulate small subsets of intestinal cells. In addition, we show that intestinal enhancers identified with the split-GAL4 system can confer equivalent expression patterns on other transgenic reporters. Altogether, the resource reported here will enable more precisely targeted gene expression for studying intestinal processes, epithelial cell functions, and diseases affecting self-renewing tissues.

The powerful combination of the cutting-edge multi-object spectrograph MOSAIC with the world largest telescope, the ELT, will allow us to probe deeper into the Universe than was possible. MOSAIC is an extremely efficient instrument in providing spectra for the numerous faint sources in the Universe, including the very first galaxies and sources of cosmic reionization. MOSAIC has a high multiplex in the NIR and in the VIS, in addition to multi-Integral Field Units (Multi-IFUs) in NIR. As such it is perfectly suited to carry out an inventory of dark matter (from rotation curves) and baryons in the cool-warm gas phases in galactic haloes at z=3-4. MOSAIC will enable detailed maps of the intergalactic medium at z=3, the evolutionary history of dwarf galaxies during a Hubble time, the chemistry directly measured from stars up to several Mpc. Finally, it will measure all faint features seen in cluster gravitational lenses or in streams surrounding nearby galactic halos, providing MOSAIC to be a powerful instrument with an extremely large space of discoveries. The preliminary design of MOSAIC is expected to begin next year, and its level of readiness is already high, given the instrumental studies made by the team., Comment: 8 pages, 4 Figures, Pre-edited version, to appear in the ESO Messenger No.182 - Quarter 1 2021 - Version identical to the Edited one

We report a tough, semicrystalline, ternary thiol–ene polymer system containing linear dithiols, cross-linking trithiols, and spiroacetal alkene units in the main chain backbone that is synthesized by “click” ultraviolet photopolymerization in a one-step, solvent-free process. We varied the cross-link density to tune crystallinity and microstructure; in turn, thermomechanical properties such as yield strength, glass transition temperature, failure strain, and stress–strain behavior could be modified and controlled. Thiol–enes containing 7.5 and 10 thiol mol % cross-linker resulted in networks that balanced crystallinity, elasticity, and cross-linking to maximize toughness. These materials demonstrate how the presence of spiro units throughout a polymer’s backbone creates semicrystalline networks of substantial toughness from traditionally weak chemistries such as thiol–enes. This system can be synthesized in a neat, one-step photopolymerization process; as such, it illustrates the power of spirochemistry ...

Thermoplastic polycarbonate urethanes (PCUs), have promise in many biomedical applications due to their low stiffness, favorable biocompatibility, and high strength. The long-term performance of PCU implants in load-bearing applications remains to be seen, and will depend in part on the material fatigue properties. Optimizing implants for success in fatigue-prone applications depends on a strong understanding of the relationship between material structure and fatigue performance, a surprisingly understudied area. In this study, we sought to develop relationships between PCU structure and mechanical properties, including fatigue, for three soft PCUs with systematically varied ratios of hard and soft segments. In addition, we compared injection molded controls to 3D printed (fused deposition modeling, FDM) varieties to examine the effects of such processing. Results indicate that increased hard segment content leads to increased stiffness, increased shear failure stress, and improvements in tensile fatigue from a stress-based standpoint despite relatively uniform tensile strength for the tested grades. Effects of hard segment content on tensile failure strain, and strain-based fatigue performance, were more complex and largely influenced by microphase organization and interaction. FDM samples matched or exceeded injection molded controls in terms of tensile failure stress and strain, compressive properties, shear strength, and tensile fatigue. The success of FDM samples is attributed in part to favorable printing parameters and the toughness of PCU which results in lower flaw sensitivity.

Network on Chip (NoC) is growing technology whereby multiprocessor state interconnect patterns are formed. NoC technology is adapted to support a variety of multiprocessor requirements. The existing designs do not support the growth requirements of user applications. Because of the complex routing connections, several problems exist about traffic congestion and Power consumption contributing to a network's low efficiency. Traffic Congestion, Power consumption, and latency are a significant concern in Network on Chip architectures because of various dynamic routing connections. The existing models do not consider all the above-mentioned factors and struggle to achieve higher performance. The previous methods do not trigger the circuits according to the traffic condition and maximum power consumption. For this, the proposed High-Speed Virtual Logic Network on Chip router architecture is utilized for controlling the traffic congestion and deadlock issues, reduce the latency by selecting the minimal interval paths. In this research work, an architecture containing a Virtual router is introduced which yields low power consumption resulting in improving the performance of a network by performing the routing in a diagonal direction along with the other directions. Also, the method selects an optimal path according to various conditions that neglect the unnecessary triggering of chips which reduces the power consumption. The proposed model considers the dynamic congestion and route available to perform routing with the least power consumption. By comparing both the architectures, VC Router outperformed 15% of low power consumption for the 8-bit system, 10% of low power consumption for the 16-bit system, and 22% of low power consumption for the 32-bit system.

The NS-Pten knockout (KO) mouse exhibits hyperactivity of the mammalian target of rapamycin (mTOR) and is a model of autism spectrum disorder (ASD). ASD presents with marked deficits in communication which can be elucidated by investigating their counterpart in mice, ultrasonic vocalizations (USVs). While USVs have been found to be altered in NS-Pten KO pups, no study has assessed whether this communication deficit persists into adulthood. In the present study, we investigate female urine-induced USVs, scent marking behavior, and open field activity in NS-Pten KO and wildtype (WT) adult male mice. Results showed that there was no difference in the quantity of vocalizations produced between groups, however, there were extensive alterations in the spectral properties of USVs. KO mice emitted vocalizations of a lower peak frequency, shorter duration, and higher peak amplitude compared to WT mice. KO animals also emitted a significantly different distribution of call-types relative to controls, displaying increased complex and short calls, but fewer upward, chevron, frequency steps, and composite calls. No significant differences between groups were observed for scent marking behavior and there was no difference between groups in the amount of time spent near the female urine. Overall, this study demonstrated that mTOR hyperactivity contributes to communication deficits in adult mice.

We present the consolidated scientific case for multi-object spectroscopy with the MOSAIC concept on the European ELT. The cases span the full range of ELT science and require either 'high multiplex' or 'high definition' observations to best exploit the excellent sensitivity and wide field-of-view of the telescope. Following scientific prioritisation by the Science Team during the recent Phase A study of the MOSAIC concept, we highlight four key surveys designed for the instrument using detailed simulations of its scientific performance. We discuss future ways to optimise the conceptual design of MOSAIC in Phase B, and illustrate its competitiveness and unique capabilities by comparison with other facilities that will be available in the 2020s., Comment: Paper presented at SPIE 2018 - Ground-based and Airbone Instrumentation for Astronomy VII

This chapter highlights the material selection process for shape-memory polymers (SMPs). When selecting SMPs, additional properties need to be considered, so two case studies are given as examples. Current SMPs are grouped based on their polymer structure or physical structure (composite, foam, fiber) to accelerate the material selection process for SMPs. The thermomechanical properties and shape-memory properties have been tabulated for acrylics, polyurethanes, epoxies, and other SMPs. For each type of SMP, their chemical structure, synthesis, properties, and performance are discussed. The properties of commercially available SMPs are also presented and discussed.

Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382–3387, 2013.

The Australian Astronomical Observatory's 'tilting spine' fibre positioning technology has been redeveloped to provide superior performance in a smaller package. The new design offers demonstrated closed-loop positioning errors of 2.8 ��m RMS in only five moves (~10 s excluding metrology overheads) and an improved capacity for open-loop tracking during observations. Tilt-induced throughput losses have been halved by lengthening spines while maintaining excellent accuracy. New low-voltage multilayer piezo actuator technology has reduced a spine's peak drive amplitude from ~150 V to, 12 pages, 15 figures, Proc. SPIE 9912 (2016)

The workhorse instruments of the 8-10m class observatories have become their multi-object spectrographs (MOS), providing comprehensive follow-up to both ground-based and space-borne imaging. With the advent of deeper imaging surveys from, e.g., the HST and VISTA, there are a plethora of spectroscopic targets which are already beyond the sensitivity limits of current facilities. This wealth of targets will grow even more rapidly in the coming years, e.g., after the completion of ALMA, the launch of the JWST and Euclid, and the advent of the LSST. Thus, one of the key requirements underlying plans for the next generation of ground-based telescopes, the Extremely Large Telescopes (ELTs), is for even greater sensitivity for optical and infrared spectroscopy. Here we revisit the scientific motivation for a MOS capability on the European ELT, combining updated elements of science cases advanced from the Phase A instrument studies with new science cases which draw on the latest results and discoveries. These science cases address key questions related to galaxy evolution over cosmic time, from studies of resolved stellar populations in nearby galaxies out to observations of the most distant galaxies, and are used to identify the top-level requirements on an 'E-ELT/MOS'. We argue that several of the most compelling ELT science cases demand MOS observations, in highly competitive areas of modern astronomy. Recent technical studies have demonstrated that important issues related to e.g. sky subtraction and multi-object AO can be solved, making fast- track development of a MOS instrument feasible. To ensure that ESO retains world leadership in exploring the most distant objects in the Universe, galaxy evolution and stellar populations, we are convinced that a MOS should have high priority in the instrumentation plan for the E-ELT.

© 2015. The American Astronomical Society. All rights reserved.We try to constrain the gas inflow and outflow rate of star-forming galaxies at z ∼ 1.4 by employing a simple analytic model for the chemical evolution of galaxies. The sample is constructed based on a large near-infrared spectroscopic sample observed with Subaru/FMOS. The gas-phase metallicity is measured from the [N II] λ6584/Hα emission line ratio and the gas mass is derived from the extinction corrected Hα luminosity by assuming the Kennicutt-Schmidt law. We constrain the inflow and outflow rate from the least-χ 2 fittings of the observed gasmass fraction, stellar mass, and metallicity with the analytic model. The joint χ 2 fitting shows that the best-fit inflow rate is ∼1.8 and the outflow rate is ∼0.6 in units of star-formation rate. By applying the same analysis to the previous studies at z ∼ 0 and z ∼ 2.2, it is shown that both the inflow and outflow rates decrease with decreasing redshift, which implies the higher activity of gas flow process at higher redshift. The decreasing trend of the inflow rate from z ∼ 2.2 to z ∼ 0 agrees with that seen in previous observational works with different methods, though the absolute value is generally larger than in previous works. The outflow rate and its evolution from z ∼ 2.2 to z ∼ 0 obtained in this work agree well with the independent estimations in previous observational works.

This paper defines the UKIRT Infrared Deep Sky Survey (UKIDSS) Early Data Release (EDR). UKIDSS is a set of five large near-infra-red surveys defined by Lawrence et al. (2006), being undertaken with the UK Infra-red Telescope (UKIRT) Wide Field Camera (WFCAM). The programme began in May 2005 and has an expected duration of seven years. Each survey uses some or all of the broadband filter complement ZYJHK. The EDR is the first public release of data to the European Southern Observatory (ESO) community. All worldwide releases occur after a delay of 18 months from the ESO release. The EDR provides a small sample dataset, ~50 sq.deg (about 1% of the whole of UKIDSS), that is a lower limit to the expected quality of future survey data releases. In addition, an EDR+ dataset contains all EDR data plus extra data of similar quality, but for areas not observed in all of the required filters (amounting to ~220 sq.deg). The first large data release, DR1, will occur in mid-2006. We provide details of the observational implementation, the data reduction, the astrometric and photometric calibration, and the quality control procedures. We summarise the data coverage and quality (seeing, ellipticity, photometricity, depth) for each survey and give a brief guide to accessing the images and catalogues from the WFCAM Science Archive., Accepted by MNRAS. 30 pages, 15 figures (some at reduced resolution due to upload restrictions - full res version at http://surveys.roe.ac.uk/wsa/pubs.html)

Two new hybrid compounds, [Co(4,4′-bpy)2(H2O)4][(4,4′-bpyH2]2[CoW12O40]·8H2O (1) and [Fe(2,2′-bpy)3]3[H2W12O40]·6H2O (2), (4,4′-bpy = 4,4′-bipyridine, 2,2′-bpy = 2,2′-bipyridine) have been hydrothermally synthesized. These solids were characterized by elemental analysis, thermogravimetric analysis, UV–Vis spectroscopy and X-ray diffraction. The hydrogen-bonding interactions in 1 lead to the formation of a three dimensional network consisting of [CoW12O40]6− anionic clusters, [Co(4,4′-bpy)2(H2O)4]2+ cations and lattice water molecules, while the discrete Keggin ion [H2W12O40]6− in compound 2 is surrounded by 14 [Fe(2,2′-bpy)3]2+ complexes through CH⋯O interactions (2.24–2.56 A).

Obesity and asthma have reached epidemic proportions in the United States. The reasons for these epidemics are complex, and the solutions to address them are many. This article explores the epidemics, their causes and consequences, associations and relationships, an expansion of the definition of the environment, and current national initiatives that address the components of the built and social environments that promote obesity and precipitate asthma.

We have calculated the two-point correlation functions in redshift space, xi(sigma,pi), for galaxies of different spectral types in the 2dF Galaxy Redshift Survey. Using these correlation functions we are able to estimate values of the linear redshift-space distortion parameter, beta = Omega_m^0.6/b, the pairwise velocity dispersion, a, and the real-space correlation function, xi(r), for galaxies with both relatively low star-formation rates (for which the present rate of star formation is less than 10% of its past averaged value) and galaxies with higher current star-formation activity. At small separations, the real-space clustering of passive galaxies is very much stronger than that of the more actively star-forming galaxies; the correlation-function slopes are respectively 1.93 and 1.50, and the relative bias between the two classes is a declining function of radius. On scales larger than 10 h^-1 Mpc there is evidence that the relative bias tends to a constant, b(passive)/b(active) ~ 1. This result is consistent with the similar degrees of redshift-space distortions seen in the correlation functions of the two classes -- the contours of xi(sigma,pi) require beta(active)=0.49+/-0.13, and beta(passive)=0.48+/-0.14. The pairwise velocity dispersion is highly correlated with beta. However, despite this a significant difference is seen between the two classes. Over the range 8-20 h^-1 Mpc, the pairwise velocity dispersion has mean values 416+/-76 km/s and 612+/-92 km/s for the active and passive galaxy samples respectively. This is consistent with the expectation from morphological segregation, in which passively evolving galaxies preferentially inhabit the cores of high-mass virialised regions., Comment: 10 pages, 7 figures. Submitted to MNRAS

We constrain flat cosmological models with a joint likelihood analysis of a new compilation of data from the cosmic microwave background (CMB) and from the 2dF Galaxy Redshift Survey (2dFGRS). Fitting the CMB alone yields a known degeneracy between the Hubble constant h and the matter density Ωm, which arises mainly from preserving the location of the peaks in the angular power spectrum. This 'horizon-angle degeneracy' is considered in some detail and is shown to follow the simple relation Ωm h3.4 = constant. Adding the 2dF-GRS power spectrum constrains Ωm h and breaks the degeneracy. If tensor anisotropies are assumed to be negligible, we obtain values for the Hubble constant of h = 0.665±0.047, the matter density Ωm = 0.313±0.055, and the physical cold dark matter and baryon densities Ωm h2 = 0.115±0.009, Ωm h2 = 0.022±0.002 (standard rms errors). Including a possible tensor component causes very little change to these figures; we set an upper limit to the tensor-to-scalar ratio of r < 0.7 at a 95 per cent confidence level. We then show how these data can be used to constrain the equation of state of the vacuum, and find w < -0.52 at 95 per cent confidence. The preferred cosmological model is thus very well specified, and we discuss the precision with which future CMB data can be predicted, given the model assumptions. The 2dFGRS power-spectrum data and covariance matrix, and the CMB data compilation used here, are available from http://www.roe.ac.uk/~wjp/.

Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p0.02). The linear correlation between experimental and predicted MTM values is R(2) = 0.75.

The EAGLE and EVE Phase A studies for instruments for the European Extremely Large Telescope (E-ELT) originated from related top-level scientific questions, but employed different (yet complementary) methods to deliver the required observations. We re-examine the motivations for a multi-object spectrograph (MOS) on the E-ELT and present a unified set of requirements for a versatile instrument. Such a MOS would exploit the excellent spatial resolution in the near-infrared envisaged for EAGLE, combined with aspects of the spectral coverage and large multiplex of EVE. We briefly discuss the top-level systems which could satisfy these requirements in a single instrument at one of the Nasmyth foci of the E-ELT., 14 pages, to be published in Proc SPIE 8446: Ground-based & Airborne Instrumentation for Astronomy IV

This paper analyzes the role of threshold limit values (TLVs) in national air pollution policy during the 1980s, a period in which the Environmental Protection Agency (EPA) sought to delegate to individual states the authority to evaluate and regulate airborne toxic substances. We focus on 20 carcinogens and 11 substances with non-genotoxic health effects that were regulated by local air toxics programs using TLVs. Data from EPA's National Air Toxics Information Clearinghouse indicate that maximum TLV-based Ambient Air Level guidelines (AALs) frequently exceed minimum TLV-based AALs by a factor of greater than 1,000. Cancer potency data from EPA's Integrated Risk Information System suggest significant risks remain at TLV-based AALs. Cancer risks at the median TLV-based AAL exceed 1,000 cases per million exposed persons for cadmium (1,040), nickel and its compounds (1,420), propylene oxide (1,550), coke oven emissions (1,860), benzene (2,500), arsenic and its compounds (7,300), N-nitrosodimethylamine (21,000), asbestos (21,500), and ethylene dibromide (55,000). We also summarize published studies that report non-genotoxic health effects in workers exposed at levels near the TLV for 11 substances whose AALs were based on TLVs. Contrary to the assumption frequently made by state air toxics program, TLVs cannot be taken to represent no observed effect levels (NOELs) for regulatory purposes.

New results are presented, as part of the Hi-z Emission Line Survey (HiZELS), from the largest area survey to date (1.4 sq.deg) for Lyman-alpha emitters (LAEs) at z~9. The survey, which is primarily targeting H-alpha emitters at z7 by Galactic brown dwarf stars is also examined, leading to the conclusion that such contamination may well be significant for searches at 7.7, Comment: 5 pages, 3 figures. Accepted for publication in MNRAS Letters

lu c ea OSHA's Four Inconsistent Carcinogen Policies Background No issue has proven more conten- tious in occupational health policy than the control of chemical carcinogens. The Occupational Safety and Health Admin- istration (OSHA) has focused much of its efforts on cancer risks, both through sub- stance-specific regulations and through broader efforts to establish generic poli- cies and work practices. The 1980 Generic Carcinogen Policy was conceptualized as the centerpiece of OSHA's shift from sub- stance-specific to generic regulations cov- ering hundreds if not thousands of sub- stances. Despite adverse judicial rulings and a generally anti-regulatory political climate, OSHA continued to pursue a ge- neric approach to occupational health hazards during the 1980s, particularly through its 1983 Hazard Communication Standard and 1989 Air Contaminants Standard. The legal and political wran- gling have left deep scars on OSHA's strategy, however. While consistency and comprehensiveness were once the princi- ples underlying OSHA's efforts to control carcinogens, the current collection of pol- icies and regulations is remarkable for the inconsistent and incomplete way in which suspect chemicals are treated. In this paper, we analyze OSHA's four carcinogen strategies, as embodied in the Generic Carcinogen Policy, the sub- stance-specific carcinogen regulations, the Hazard Communication Standard, and the Air Contaminants Standard. Two issues are of particular interest. Given the inherent methodological limitations to epidemiological data on oc- cupational and environmental cancer, a June 1991, Vol. 81, No. 6 an e avv major scientific and policy debate has de- veloped over the appropriate use in hu- man risk assessment of laboratory evi- dence on chemical carcinogenesis in animals. The four OSHA policies exhibit quite different positions on this debate. 0 The choice between direct regula- tion and indirect labor market pressure, and the stringency of those exposure lim- its that are imposed, reflect different atti- tudes toward the appropriate balance of economic costs and health benefits for oc- cupational health regulations. OSHA's four policies reflect dramatically different balancing efforts. We begin with the Generic Carcino- gen Policy, which remains OSHA's for- mal policy on the issue but which has been blocked by administrative stays and never incorporated into risk management pro- grams. The substance-specific cancer standards are then analyzed in terms of their comprehensive treatment of a few public health hazards and neglect of many others. While partially an attempt to pre- empt stronger state and local regulations, the Hazard Communication Standard is in many ways both comprehensive and in- novative, covering a wide range of chem- icals and imposing duties on employers that could potentially lead to substitution of alternative products and processes. Given its current prominence as the cen- terpiece of OSHA's regulatory program, the Air Contaminants Standard receives the greatest emphasis. Containing its own internal inconsistencies, the Air Contam- inants Standard embodies the best and the worst of OSHA's new regulatory philos- ophy and its strategy for controlling chem- ical carcinogens in the workplace. T7e GenericCarcinogen Poly OSHA's Generic Carcinogen Policy1 was a response to two complementary concerns that emerged over the course of the 1970s and came to dominate the agen- cy's agenda. OSHA had devoted a sub- stantial portion of its resources to the reg- ulation of individual carcinogens but had achieved only meagre results. The agency leadership faced growing demand for an accelerated regulatory timetable from Congress, organized labor, and environ- mental groups. Of equal significance, per- haps, was the competition among several federal agencies for leadership in formu- lating governmental policies with respect to chemical carcinogens. Proposed in 1977 and promulgated in 1980, OSHA's Ge- neric Carcinogen Policy embodied a highly protective approach to chemical carcinogenesis. Based on the most con- servative set of assumptions concerning methods of cancer induction and the most stringent set of requirements for exposure controls, the 1980 policy represents the high water mark of governmental enthu- siasm for regulating occupational and en- vironmental carcinogens. OSHA devoted much of its energies during the 1970s to developing standards regulating exposure to occupational car- cinogens, including asbestos2 in 1972, vi- nyl chloride3 and a group of 14 chemicals4 in 1974, coke oven emissions5 in 1976, plus benzene,6 dibromochloropropane (DBCP),7 inorganic arsenic,8 and acry- From the Center for Occupational and Envi- ronmental Health, University of California, Berkeley. Address reprint requests to James C. Robinson, PhD, Center for Occupational and Environmental Health, School of Public Health, University of California, Berkeley, CA 94720. This paper, submitted to the Journal June 20, 1990, was revised and accepted for publication January 30, 1991. George J. Annas, JD, MPH, Chair, Health Law Department, Boston University, Schools of Public Health and Medicine, 80 East Concord Street, Boston, MA 02118, is editor of the Public Health and the Law column. American Journal of Public Health 775

This paper evaluates the decision by the Occupational Safety and Health Administration (OSHA) to base its Air Contaminants Standard on the threshold limit values (TLVs) of the American Conference of Governmental Industrial Hygienists. Contrary to the claim made by OSHA in promulgating the standard, the TLV list was not the sole available basis for a generic standard covering toxic air contaminants. The National Institute for Occupational Safety and Health (NIOSH) presented data indicating that the TLVs were insufficiently protective for 98 substances. NIOSH Recommended Exposure Limits (RELs) were available for 59 of these substances. The ratio of PEL to REL ranged up to 1,000, with a median of 2.5 and a mean of 71.4. OSHA excluded 42 substances from the standard altogether despite the availability of NIOSH RELs, solely because no TLV had been established.

We present a novel design of a fibre-fed high-resolution spectrograph (HRS hereafter) for WFMOS. WFMOS HRS is a multi-object spectrograph for studying the formation and evolution history of our Galaxy by measuring spectra of Galactic stars. In a 8m-class telescope, it aims to measure 1,500 stellar spectra simultaneously with spectral resolution between 25,000 and 40,000 in optical wavebands de.ned within 4000Å and 9000Å. For the HRS optical design, we have explored three disperser options : Volume Phase Holographic Grating (VPHGs), prism-immersed VPHG, and Echelle grating. Two camera designs have also been studied for the spectrograph camera optics, one tranmissive design and the other a Schmidt design. We also investigated a conjugate collimator design that allows two spectrographs to share a single grating so as to work as a single spectrograph.

We compare the information used by the Occupational Safety and Health Administration (OSHA) to regulate carcinogens under its 1989 Air Contaminants Standard to publicly available information on substances with potential carcinogenic activity. Carcinogenicity evaluations were obtained from the National Institute for Occupational Safety and Health (NIOSH), the American Conference of Governmental Industrial Hygienists (ACGIH), the National Toxicology Program (NTP), the Environmental Protection Agency (EPA), and the International Agency for Research on Cancer (IARC). We focus on three sets of substances: those which were regulated as carcinogens by OSHA in the Standard, those which were included in the Standard but whose exposure limits are based on noncarcinogenic effects, and those substances designated as potential carcinogens by NIOSH, ACGIH, and/or NTP but which were excluded from the Standard. The data indicate that OSHA relied almost exclusively upon the recommendations of the nongovernmental ACGIH to the exclusion of IARC and the three governmental bodies. Given their statutory authority to evaluate chemical carcinogenicity for regulatory agencies such as OSHA, the exclusion of NIOSH and NTP is particularly striking.

X. Zhao and co-workers develop on page 4035 a new biocompatible hydrogel system that is extremely tough and stretchable and can be 3D printed into complex structures, such as the multilayer mesh shown. Cells encapsulated in the tough and printable hydrogel maintain high viability. 3D-printed structures of the tough hydrogel can sustain high mechanical loads and deformations.

The 2dFGRS Percolation-Inferred Galaxy Group (2PIGG) catalogue of ~29000 objects is used to study the luminous content of galaxy systems of various sizes. Mock galaxy catalogues constructed from cosmological simulations are used to gauge the accuracy with which intrinsic group properties can be recovered. A Schechter function is found to be a reasonable fit to the galaxy luminosity functions in groups of different mass in the real data. The characteristic luminosity L* is larger for more massive groups. However, the mock data show that the shape of the recovered luminosity function is expected to differ from the true shape, and this must be allowed for when interpreting the data. The variation of halo mass-to-light ratio with group size is studied in both these wavebands. A robust trend of increasing M/L with increasing group luminosity is found in the 2PIGG data. From groups with L_bj=10^{10}Lsol to those 100 times more luminous, the typical bj-band M/L increases by a factor of 5, whereas the rf-band M/L grows by a factor of 3.5. These trends agree well with the simulations, which also predict a minimum M/L on a scale corresponding to the Local Group. Our data indicate that if such a minimum exists, then it must occur at L, Comment: Same as before

We present a detailed analysis of the two-point correlation function, from the 2dF Galaxy Redshift Survey (2dFGRS). We estimate the redshift-space correlation function, xi(s), from which we measure the redshift-space clustering length, s_0=6.82+/-0.28 Mpc/h. We also estimate the projected correlation function, Xi(sigma), and the real-space correlation function, xi(r), which can be fit by a power-law, with r_0=5.05+/-0.26Mpc/h, gamma_r=1.67+/-0.03. For r>20Mpc/h, xi drops below a power-law as is expected in the popular LCDM model. The ratio of amplitudes of the real and redshift-space correlation functions on scales of 8-30Mpc/h gives an estimate of the redshift-space distortion parameter beta. The quadrupole moment of xi on scales 30-40Mpc/h provides another estimate of beta. We also estimate the distribution function of pairwise peculiar velocities, f(v), including rigorously the effect of infall velocities, and find that it is well fit by an exponential. The accuracy of our xi measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of xi(r) and the two redshift-space distortion effects parameterized by beta and velocity dispersion, a. We find beta=0.49+/-0.09 and a=506+/-52km/s, though the best fit values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(sigma), and find that the shape is consistent with models and simulations. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that beta(L=L*,z=0)=0.47+/-0.08, and that the present day matter density of the Universe is 0.3, consistent with other 2dFGRS estimates and independent analyses., 19 pages, revised following referee's report, and accepted by MNRAS. Higher resolution Figures, an animated version of Figure 12 and a colour version of Figure 22 are available from http://www.nottingham.ac.uk/~ppxeh/

The BTC40 Survey for high-redshift quasars is a multicolor search using images obtained with the Big Throughput Camera (BTC) on the CTIO 4-m telescope in V, I, and z filters to search for quasars at redshifts of 4.8 < z < 6. The survey covers 40 sq. deg. in B, V, & I and 36 sq. deg. in z. Limiting magnitudes (3 sigma) reach to V = 24.6, I = 22.9 and z = 22.9. We used the (V-I) vs. (I-z) two-color diagram to select high-redshift quasar candidates from the objects classified as point sources in the imaging data. Follow-up spectroscopy with the AAT and CTIO 4-m telescopes of candidates having I < 21.5 has yielded two quasars with redshifts of z = 4.6 and z = 4.8 as well as four emission line galaxies with z = 0.6. Fainter candidates have been identified down to I = 22 for future spectroscopy on 8-m class telescopes., 27 pages, 8 figures; Accepted for publication in the Astronomical Journal

The 2dF Galaxy Redshift Survey is the first to observe more than 100,000 redshifts. This allows precise measurements of many of the key statistics of galaxy clustering, in particular redshift-space distortions and the large-scale power spectrum. This paper presents the current 2dFGRS results in these areas. Redshift-space distortions are detected with a high degree of significance, confirming the detailed Kaiser distortion from large-scale infall velocities, and measuring the distortion parameter beta equiv Omega_m^{0.6}/b = 0.43 +- 0.07. The power spectrum is measured to < 10% accuracy for k > 0.02 h Mpc^{-1}, and is well fitted by a CDM model with Omega_m h = 0.20 +- 0.03 and a baryon fraction of 0.15 +- 0.07. A joint analysis with CMB data requires Omega_m = 0.29 +- 0.05, assuming scalar fluctuations, but no priors on other parameters. Two methods are used to determine the large-scale bias parameter: an internal bispectrum analysis yields b = 1.04 +- 0.11, in very good agreement with the b = 1.10 +- 0.08 obtained from a joint 2dFGRS+CMB analysis, again assuming scalar fluctuations. These figures refer to galaxies of approximate luminosity 2L^*; luminosity dependence of clustering is detected at high significance, and is well described by b/b^* = 0.85 + 0.15(L/L^*)., 20 Pages. To appear in "A New Era in Cosmology" (ASP Conference Proceedings), eds T. Shanks and N. Metcalfe. Replaced with minor corrections to match revised 2dFGRS bias paper

The 2dF Galaxy Redshift Survey (2dFGRS) is designed to measure redshifts for approximately 250000 galaxies. This paper describes the survey design, the spectroscopic observations, the redshift measurements and the survey database. The 2dFGRS uses the 2dF multi-fibre spectrograph on the Anglo-Australian Telescope, which is capable of observing 400 objects simultaneously over a 2-degree diameter field. The source catalogue for the survey is a revised and extended version of the APM galaxy catalogue, and the targets are galaxies with extinction-corrected magnitudes brighter than b_J=19.45. The main survey regions are two declination strips, one in the southern Galactic hemisphere spanning 80deg x 15deg around the SGP, and the other in the northern Galactic hemisphere spanning 75deg x 10deg along the celestial equator; in addition, there are 99 fields spread over the southern Galactic cap. The survey covers 2000 sq.deg and has a median depth of z=0.11. Adaptive tiling is used to give a highly uniform sampling rate of 93% over the whole survey region. Redshifts are measured from spectra covering 3600A-8000A at a two-pixel resolution of 9.0A and a median S/N of 13 per pixel. All redshift identifications are visually checked and assigned a quality parameter Q in the range 1-5; Q>=3 redshifts are 98.4% reliable and have an rms uncertainty of 85 km/s. The overall redshift completeness for Q>=3 redshifts is 91.8%, but this varies with magnitude from 99% for the brightest galaxies to 90% for objects at the survey limit. The 2dFGRS database is available on the WWW at http://www.mso.anu.edu.au/2dFGRS, accepted by MNRAS; version with high-resolution figures at http://www.mso.anu.edu.au/2dFGRS/Public/Publications; accompanies the 2dFGRS 100k Release, now available at http://www.mso.anu.edu.au/2dFGRS

We describe the construction of catalogues of galaxy clusters from the APM Galaxy survey using an automated algorithm based on Abell-like selection criteria. We investigate the effects of varying several parameters in our selection algorithm, including the magnitude range and radius from the cluster centre used to estimate the cluster richnesses. We quantify the accuracy of the photometric distance estimates by comparing them with measured redshifts, and we investigate the stability and completeness of the resulting catalogues. We find that the angular correlation functions for different cluster catalogues are in good agreement with one another, and are also consistent with the observed amplitude of the spatial correlation function of rich clusters. © 1997 RAS.

In 1989, after almost two decades of substance-by-substance standard setting, the Occupational Safety and Health Administration (OSHA) promulgated its Air Contaminants Standard, imposing new exposure limits for 376 toxic substances encountered in U.S. industry. In marked contrast to earlier regulations, the Air Contaminants Standard has generated relatively little industry opposition. This paper analyzes the standard in the context of the twenty-year debate over the appropriate role for technological feasibility and economic compliance costs in occupational health policy. The political feasibility of the new standard is traced to OSHA's abandonment of “technology forcing” in favor of reliance on “off-the-shelf” technologies already in use in major firms. While important as an embodiment of OSHA's new “generic” approach to regulation, the Air Contaminants Standard cannot serve as a model for future occupational health policy, due to its reliance on informal, closed-door mechanisms for establishing regulatory priorities and permissible exposure limits.

A review of the data cited by OSHA in its final standard for exposure to benzene provides no clear scientific basis for a short-term-exposure limit (STEL). While leukemia and bone marrow toxicity were related to cumulative exposures of benzene received by workers, no evidence was presented that the rate of exposure at a given cumulative exposure contributed to the effects. Likewise, animal experiments suggested that exposures of several hours duration at a given level of benzene induced more bone-marrow toxicity when administered 3 rather than 5 days/week but did not indicate that the rate of exposure over shorter time scales played any role. The toxicokinetics of benzene in humans were also studied to determine whether nonlinear dose-rate effects would be likely to result from peak exposures associated with an exposure dose of 8 ppm-hr, which is allowed under the permissible exposure limit. This led to three conclusions. First, the concentration of benzene in the bone marrow should be sufficiently damped that the impact of a peak exposure should be minimal. Second, the peak concentration of benzene in the liver should be within the capacity of the cytochrome P450 system to maintain first-order metabolism. And finally, the maximum blood concentration of metabolites should be well below levels which have been shown to induce toxic effects in vitro. Taken together, the toxicokinetic relationships and the absence of clear experimental dose-rate effects suggest that the current STEL for benzene is unwarranted, assuming that 8-hr average exposures are kept below 1 ppm. While the argument can be made, on the basis of health considerations, that the existing 8-hr limit for benzene is too high, the rate of exposure during short periods appears to be irrelevant. Thus, we recommend that health professionals focus upon long-term exposures to benzene received by large numbers of workers rather than devote scarce resources to evaluate transient air levels.