1. Associations between total cerebral blood flow and age related changes of the brain
- Author
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Es, A.C.G.M. van, Grond, J. van der, Dam, V.H. ten, Craen, A.J.M. de, Blauw, G.J., Westendorp, R.G.J., Admiraal-Behloul, F., Buchem, M.A. van, and PROSPER Study Grp
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Aging ,Radiology and Medical Imaging ,Medizin ,lcsh:Medicine ,Magnetic resonance angiography ,white-matter lesions internal carotid-artery contrast mr-angiography volume measurement vascular dementia elderly-people leukoaraiosis hyperintensities atrophy disease ,Atrophy ,Internal medicine ,medicine ,Humans ,lcsh:Science ,Vertebral Artery ,Aged ,Cerebral atrophy ,Tomography, Emission-Computed, Single-Photon ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Brain ,Radiology and Medical Imaging/Magnetic Resonance Imaging ,Magnetic resonance imaging ,Blood flow ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Carotid Arteries ,Cerebral blood flow ,Cerebrovascular Circulation ,Positron-Emission Tomography ,Angiography ,Cardiology ,lcsh:Q ,Female ,business ,Neuroscience/Neurobiology of Disease and Regeneration ,Perfusion ,Magnetic Resonance Angiography ,Research Article ,Neuroscience - Abstract
BACKGROUND AND PURPOSE: Although total cerebral blood flow (tCBF) is known to be related to age, less is known regarding the associations between tCBF and the morphologic changes of the brain accompanying cerebral aging. The purpose of this study was to investigate whether total cerebral blood flow (tCBF) is related to white matter hyperintensity (WMH) volume and/or cerebral atrophy. Furthermore, we investigate whether tCBF should be expressed in mL/min, as was done in all previous MR studies, or in mL/100 mL/min, which yielded good results in precious SPECT, PET and perfusion MRI studies investigating regional cerebral blood flow. MATERIALS AND METHODS: Patients were included from the nested MRI sub-study of the PROSPER study. Dual fast spin echo and FLAIR images were obtained in all patients. In addition, single slice phase contrast MR angiography was used for flow measurements in the internal carotids and vertebral arteries. tCBF was expressed in both mL/min and mL/100 mL/min. RESULTS: We found a significant correlation between tCBF in mL/min and both age (r = -.124; p = p
- Published
- 2009