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5. Indanylacetic acids as PPAR-delta activator insulin sensitizers

Author

Manami Tsutsumi, Rico C. Lavoie, James N. Livingston, Frederick Ehrgott, Laurel Sweet, Herbert Ogutu, Steve Magnuson, Tatiana E. Shelekhin, Philip Wickens, Jeff Shapiro, Qian Zhao, Robert Schoenleber, Louis-David Cantin, Bullock William H, John Amatruda, Sidney X. Liang, Fernando Dela Cruz, Ellalahewage Kumarasinghe, David Ladner, Thomas H. Claus, Miao Dai, Christopher Town, Chengzhi Zhang, Derek B. Lowe, Martin F. Hentemann, Michael Burns, Sarah Heald, Jeffrey Johnson, Gretchen Mannelly, Susan Pleasic-Williams, Mugge Ingo A, Chih-Yuan Chuang, Dongping Fan, David P. Dickson, Xin Ma, and Christiana Iwuagwu

Subjects
Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Indane, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Biochemistry, Chemical synthesis, Acetic acid, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Fluorescence Resonance Energy Transfer, PPAR delta, Molecular Biology, chemistry.chemical_classification, Activator (genetics), Ligand, Insulin, Organic Chemistry, chemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Insulin Resistance
Abstract

A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.

Published
2007

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