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8 results on '"Dayane B. Tada"'

1. Niobium Pentachloride as a Stoichiometric Reagent in the Sequential Transesterification-Esterification Reactions for the Synthesis of Methyl Salicylate and the Study of Its Antimicrobial Activity

Author

Sandro Luiz Barbosa, DAVID LEE NELSON, Milton de Freitas Souza, Lucas Paconio Silva, Wallans TORRES PIO DOS SANTOS, ALEXANDRE PEREIRA WENTZ, Erenilda F. de Macedo, Rafaela C. Queiroz, Dayane B. Tada, Carolina R. Hurtado, Katia Conceição, Gabriela R. Hurtado, Fernando L. P. Pessoa, Gabriel de P. Bueno, and Giuliano C. Clososki

Abstract

Methyl Salicylate (MS), the principal constituent of Wintergreen oil (WO) was obtained from acetyl salicylic acid (ASA) by sequential transesterification-esterification reaction promoted by NbCl5for the first time. The reagents were added simultaneously, and the reaction process involved the transesterification and esterification reactions, which were accompanied by thin layer chromatography and gas chromatography. The conversion rate via GC was 100%, and the MS yield was 94%. A cytotoxicity of 50% and 64% for cultured S. aureus and metastatic melanoma cells, respectively, was observed for a concentration of 0.6 mg/mL, whereas no cytotoxicity for non-tumor cells was observed for this concentration, and it is considered to be the optimum concentration.

Published
2023

2. Contributors

Author

Kenneth K. Agwu, Ishaq Ahmad, Victor Sunday Aigbodion, Samson O. Aisida, Yuksel Akinay, A. Ayeshaamriam, Lucas Barbosa, Debosreeta Bose, Katia Conceição, Erenilda F. de Macedo, Shoroshi Dey, Calister N. Eze, Blessing N. Ezealigo, Fabian Ezema, Sabastine C. Ezike, Sabastine Ezugwu, D. Gopi, Midhun Harilal, Carolina R. Hurtado, Innocent Sunday Ike, Patrick O. Ike, Chinedu Iroegbu, Anejo Itodo, David C. Iwueke, Priyanka Jagadish, A.R. Mohamed Jahangir, L. Kavitha, K. Kaviyarasu, Syam G. Krishnan, M. Maaza, Jayanta Mukhopadhyay, Madhumita Mukhopadhyay, Agnes C. Nkele, Paul S. Nnamchi, Paul Sunday Nnamchi, Hope E. Nsude, Kingsley U. Nsude, Assumpta C. Nwanya, O.A. Nwoke, Camillus S. Obayi, Camillus Sunday Obayi, Bridget Chizobam N. Obitte, Nicholas Chinedu Obitte, Raphael M. Obodo, Izunna S. Okeke, Luciane D. Oliveira, Rodrigo L.M.S. Oliveira, A.D. Omah, Edwin U Onah, Martina P. Orji, N. Punithavelan, Lucas de P. Ramos, S. Ramya, M. Ramzan, D. Saravanakkumar, M.I. Shahzad, Abhijit Das Sharma, E. Shinyjoy, S. Sutha, Dayane B. Tada, Eliandra de S. Trichês, Mrumun David Tyona, Anyaegbunam A. Ubachukwu, Paulinus E. Ugwuoke, Chika Oliver Ujah, U.O. Uyor, and G.M. Whyte

Published
2023

4. Co-Functionalization of Gold Nanoparticles with C7H2 and HuAL1 Peptides: Enhanced Antimicrobial and Antitumoral Activities

Author

Daniela M. D. Formaggio, Jéssica A. Magalhães, Vitor M. Andrade, Katia Conceição, Juliana M. Anastácio, Gabrielli S. Santiago, Denise C. Arruda, and Dayane B. Tada

Subjects
Pharmaceutical Science, gold nanoparticles, therapeutic peptides, HuaL1, C7H2, CDR peptides, tumor targeting, metastatic melanoma
Abstract

The functionalization of nanoparticles with therapeutic peptides has been pointed out as a promising strategy to improve the applications of these molecules in the field of health sciences. Peptides are highly bioactive but face several limitations such as low bioavailability due to the difficulty of overcoming the physiological barriers in the body and their degradation by enzymes. In this work, gold nanoparticles (AuNPs) were co-functionalized with two therapeutic peptides simultaneously. The peptides from the complementary determining region of monoclonal antibodies, composed of the amino acid sequences YISCYNGATSYNQKFK (C7H2) and RASQSVSSYLA (HuAL1) were chosen for having exhibited antitumor and antimicrobial activity before. The peptides-conjugated AuNPs were characterized regarding size, morphology, and metal concentration by using TEM, dynamic light scattering, and ICP-OES techniques. Then, peptides-conjugated AuNPs were evaluated regarding the antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. The antitumoral activity was evaluated in vitro by cell viability assays with metastatic melanoma cell line (B16F10-Nex2) and the cytotoxicity was evaluated against human foreskin fibroblast (Hs68) cell line. Finally, in vivo assays were performed by using a syngeneic animal model of metastatic melanoma. Our findings have highlighted the potential application of the dual-peptide AuNPs in order to enhance the antitumor and antimicrobial activity of peptides.

Published
2022

8. PHBV-TiO

Author

Natália F, Braga, Daniel A, Vital, Lilia M, Guerrini, Ana P, Lemes, Daniela M D, Formaggio, Dayane B, Tada, Tatiane M, Arantes, and Fernando H, Cristovan

Subjects
Titanium, Tissue Engineering, Tissue Scaffolds, Cell Survival, Polyesters, Biocompatible Materials, Electrochemical Techniques, Fibroblasts, Cell Line, Nanocomposites, Mice, Tensile Strength, Materials Testing, Animals, Humans, Nanoparticles, Crystallization, Cell Proliferation
Abstract

One of the most important challenges in tissue engineering research is the development of biomimetic materials. In this present study, we have investigated the effect of the titanium dioxide (TiO

Published
2017

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