1. 3D bioengineered tissues: From advancements in in vitro safety to new horizons in disease modeling
- Author
-
Deborah G. Nguyen, Chad Viergever, Alice E. Chen, and Rhiannon N. Hardwick
- Subjects
0301 basic medicine ,Pharmacology ,Engineering ,New horizons ,Tissue Engineering ,business.industry ,Nanotechnology ,Disease ,Disease Models, Animal ,03 medical and health sciences ,Imaging, Three-Dimensional ,030104 developmental biology ,0302 clinical medicine ,Human disease ,Chemical safety ,030220 oncology & carcinogenesis ,Animals ,Humans ,Pharmacology (medical) ,Biochemical engineering ,business ,Physiological Phenomena ,Physiological Phenomenon - Abstract
Research aimed at more fully emulating human biology in vitro has rapidly progressed in recent years with advancements in 3D tissue engineering and microphysiological systems. The initial target of such systems has been directed towards drug and chemical safety assessment, with the goal of improving sensitivity and predictive capabilities. Here we discuss recent developments of in vitro organ culture systems, and their future applications in modeling human disease.
- Published
- 2017