The present paper is the protocol of a review we are planning to write on the use in research of the Verona Coding Definitions of Emotional Sequences (VR-CoDES), a coding system developed to analyze emotional communication in provider-patient encounters. Since VR-CoDES publication (Del Piccolo et al., 2011, Zimmermann et al., 2011) a variety of papers have been published, but not systematically collected and analyzed, therefore the aim of the review is to gather and summarize the empirical research which has applied the system since its inception. To accomplish this aim we will: 1. report summaries of the frequencies of cues, concerns and responses, and investigate to which extent these frequencies differ across settings, type of health care provider and type of recording device; 2. examine the associations between expressions of cues and concerns and other variables, such as age, gender and psychological traits and states of patient and clinician, socioeconomic status and other variables; 3. evaluate the potential clinical relevance of the study of cues and concerns and related responses.