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Frontiers in psychiatry 13, 920665 (2022). doi:10.3389/fpsyt.2022.920665, Published by Frontiers Research Foundation, Lausanne

Additional file 1: Figure S 1. Composition of workshop participants as per field of expertise. The organizing team mainly consists of meta-researchers with a clinical or preclinical background. Other refers to e.g., stakeholders from funding agencies that also attended the workshop. Methods S1. Multi-stakeholder workshop method-Workshop design. Glossary. Glossary of terms.

Additional file 1: Supplementary table 1. Variables included in the propensity score with their ORs from coefficients of multiple logistic regression model with outcome renal improvement. Fitted values of this logistic model were used to calculate the propensity score for each patient. Supplementary table 2. Multiple Cox model of two-year survival after TAVI. Supplementary table 3. Sensitivity analyses using different definitions of RI, based on improvement thresholds of serum creatinine or eGFR.

We aimed to compare the clinical data at first presentation to inpatient treatment of children (&lt, 14 years) vs. adolescents (&ge, 14 years) with anorexia nervosa (AN), focusing on duration of illness before hospital admission and body mass index (BMI) at admission and discharge, proven predictors of the outcomes of adolescent AN. Clinical data at first admission and at discharge in 289 inpatients with AN (children: n = 72, adolescents: n = 217) from a German multicenter, web-based registry for consecutively enrolled patients with childhood and adolescent AN were analyzed. Inclusion criteria were a maximum age of 18 years, first inpatient treatment due to AN, and a BMI &lt, 10th BMI percentile at admission. Compared to adolescents, children with AN had a shorter duration of illness before admission (median: 6.0 months vs. 8.0 months, p = 0.004) and higher BMI percentiles at admission (median: 0.7 vs. 0.2, p = 0.004) as well as at discharge (median: 19.3 vs. 15.1, p = 0.011). Thus, in our study, children with AN exhibited clinical characteristics that have been associated with better outcomes, including higher admission and discharge BMI percentile. Future studies should examine whether these factors are actually associated with positive long-term outcomes in children.

Pesticide exposure is associated with increased risk of Parkinson's disease (PD). We investigated in Egypt whether common variants in genes involved in pesticide detoxification or transport might modify the risk of PD evoked by pesticide exposure. We recruited 416 PD patients and 445 controls. Information on environmental factors was collected by questionnaire-based structured interviews. Candidate single-nucleotide polymorphisms (SNPs) in 15 pesticide-related genes were genotyped. We analyzed the influence of environmental factors and SNPs as well as the interaction of pesticide exposure and SNPs on the risk of PD. The risk of PD was reduced by coffee consumption [OR = 0.63, 95% CI: 0.43-0.90, P = 0.013] and increased by pesticide exposure [OR = 7.09, 95% CI: 1.12-44.01, P = 0.036]. The SNP rs1126680 in the butyrylcholinesterase gene BCHE reduced the risk of PD irrespective of pesticide exposure [OR = 0.38, 95% CI: 0.20-0.70, P = 0.002]. The SNP rs1803274, defining K-variant BCHE, interacted significantly with pesticide exposure (P = 0.007) and increased the risk of PD only in pesticide-exposed individuals [OR = 2.49, 95% CI: 1.50-4.19, P = 0.0005]. The K-variant BCHE reduces serum activity of butyrylcholinesterase, a known bioscavenger for pesticides. Individuals with K-variant BCHE appear to have an increased risk for PD when exposed to pesticides.

Table S1. Primers, PCR conditions, fragment sizes and screening methods for LEP, MC4R, MRAP2 and BDNF mutation screening [59â 61]. Table S2. PCR-fragments and primers for BDNF expression analysis. Table S3. Association analyses. Table S4: Phenotype data of the index patients and available family members with infrequent variants in BDNF and MC4R. Figure S1. Amino acid sequence conservation in MC4R and BDNF among different species (including primates, rodents, laurasiatheria, placental mammals, sauropsia and fish). Text S1. Functional in vitro analyses for p.Met215Ile MC4R [62]. (DOCX 62 kb)

Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation of genes in this pathway are hypothesized to affect this common condition. Methods We analyzed the coding regions of LEP, MC4R, MRAP2 and BDNF in 185 children with SNS (height

Additional file 1.

Additional file 1.