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Your search keyword '"Di Filippo P"' showing total 31 results
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31 results on '"Di Filippo P"'

6. Correlazione fra tossicità delle frazioni granulometriche del PM e loro composizione

Author

Achilli M., Balducci C., Campanella L., Canepari S., Cardarelli E., Catrambone M., Cattani G., Cecinato A., Di Filippo P., Ghighi S., Inglessis M., Marconi A., Perrino C., Pietrodangelo A., Pomata D., Riccardi C., and Spicaglia S.

Subjects
biosensori, frazionamento dimensionale, materiale particellare sospeso, tossicità
Published
2006

10. Correlazione tra tossicità delle frazioni granulometriche del PM e loro composizione

Author

Achilli M., Balducci C., Campanella L., Canepari S., Cardarelli E., Catrambone M., Cattani G., Cecinato A., Di Filippo P., Ghini S., Inglessis M., Marconi A., Perrino C., Pietrodangelo A., Pomata D., Riccardi C., and Spicaglia S.

Subjects
airborne particulates, atmospheric pollution, chemical analysis, toxicity tests, toxic compounds
Published
2006

30. A randomised, double-blind, placebo-controlled trial of dermatan sulphate for prevention of deep vein thrombosis in hip fracture

Author

Agnelli, Giancarlo, Cosmi, B, Di Filippo, P, Ranucci, V, Veschi, F, Longetti, M, Renga, C, Barzi, F, Gianese, F, and Lupattelli, Luciano

Subjects
Male, Double-Blind Method, Hip Fractures, Risk Factors, Dermatan Sulfate, Humans, Female, Drug Monitoring, Middle Aged, Thrombophlebitis, Aged
Abstract

Dermatan sulphate (MF 701) is a natural glycosaminoglycan that catalyses thrombin inhibition by heparin cofactor II. The aim of the study was to evaluate the efficacy and safety of MF 701 for prevention of deep vein thrombosis (DVT) in patients with hip fracture. A randomised, double-blind, placebo-controlled design was used to assess two dose regimens of MF 701 in two consecutive study phases. Treatment was started within 48 h from the trauma and continued for 14 days for non-operated patients or until the 10th postoperative day. Bilateral mandatory venography was used to assess the end-point. Eighty patients were included in the first phase (40 MF 701, 40 placebo). MF 701, 100 mg IM b.i.d., did not reduce incidence of DVT from that on placebo and did not induce any bleeding. In the second phase 126 patients were included, with a randomisation ratio of 2:1 (84 MF 701, 300 mg IM b.i.d., 42 placebo). Bilateral venography was obtained for 110 patients. The incidence of DVT was 64% (23/36) in the placebo group and 38% (28/74) in the MF 701 group (p = 0.01; odds ratio [OR] = 0.34, 95% confidence limits [CL] = 0.15-0.80p; proximal DVTs were 42% (15/36) and 20% (15/74), respectively (p = 0.02; OR = 0.36, CL = 0.15-0.89). No significant differences were found in haemorrhagic complications (2.4% in each group), blood loss from drains, blood transfusions, haemoglobin and haematocrit values. This study is the first demonstration that dermatan sulphate is a clinically effective antithrombotic agent without bleeding effects. It also provides evidence of the biological role of heparin cofactor II.

Published
1992

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