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To study the epidemiological-clinical profile of sickle cell patients in the health district of Bla. Method: This was a prospective and descriptive study over 1 year, from February 2021 to January 2022; relating to all patients who were screened with the TDR_Sikle Scan and/or followed up during the study period. Results: We performed the TDR in 982 patients from all the consultations (N= 2976). The mean age was 29.6 ± 3.8 years. SS and SC sickle cell disease represent 8.04% (79 cases). Children 23.52% (28 patients) and women 64.35% (51 patients). SS married couples represented (13.92%). Anemia was the most common reason for consultation (47%), followed by bone and joint pain (29%). 33% of the patients (26 cases) had a complication, of which 15 patients had had a CVO and 6 patients (23%) a worsening of the anemia. We have recorded 1 death. Conclusion: regular medical follow-up of sickle cell patients considerably improves the vital prognosis. The frequency of sickle cell traits remains high including SS and SC forms.