Search

Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 protects genome stability, yet its role in tumorigenesis is unknown. Here, we show that attenuated CTC1/STN1 expression is common in CRCs. We generated an inducible STN1 knockout mouse model and found that STN1 deficiency in young adult mice increased CRC incidence, tumor size, and tumor load. CRC tumors exhibited enhanced proliferation, reduced apoptosis, and elevated DNA damage and replication stress. We found that STN1 deficiency down-regulated multiple DNA glycosylases, resulting in defective base excision repair (BER) and accumulation of oxidative damage. Collectively, this study identifies STN1 deficiency as a risk factor for CRC and implicates the previously unknown STN1-BER axis in protecting colon tissues from oxidative damage, therefore providing insights into the CRC tumor–suppressing mechanism.

Colon tissues and tumors were collected at 34 weeks and embedded in paraffin, and genomic DNA was extracted and sent for WES sequencing. Results are from 3 WT and 3 STN1F/F mice, with normal and tumor tissue adjacent.

Three types of biomass of invasive plants and agrowastes, namely, the wattle bark of Acacia auriculiformis (BA), mimosa (BM), and coffee husks (BC), were converted into biochars through slow pyrolysis and investigated for their ability to remove dyes in water. The properties of the materials were characterized using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and Brunauer–Emmett–Teller (BET) analysis. The BET surface area (total pore volume) of BC was 2.62 m2/g (0.007 cm3/g), far below those of BA and BM with 393.15 cm2/g (0.195 m3/g) and 285.53 cm2/g (0.153 m3/g), respectively. The optimal adsorption doses for the removal of methylene blue (MB) were found to be 2, 5, and 5 g/L for BC, BA, and BM, respectively. The suitable pH ranges for MB removal were 6–12 for BA, 7–12 for BC, and 2–10 for BM. The majority of MB (over 83%) was removed in the initial 30 min, followed by a more quasisteady state condition after the removal rate exceeded 90%. The experimental data were fitted with the kinetic models (PFO, PSO, Bangham, IDP), indicating that physicochemical adsorption, pore diffusion process, and multiple stages are the dominant mechanisms for the MB adsorption onto biochars. Finally, BA and BM showed similar adsorption efficiencies, while BC may not be favorable for use as an adsorbent due to its low surface area and low pore volume.

This present research investigates, simulates, and models the transport ethane fluid in different phases. The applied technical, operational, and technological facilities, limitations, and economic estimation have been in various PVT thermodynamic conditions according to several states of fluid that will directly affect the transport volume. In these plans, different limitations of loading, storing, transporting, and unloading have been evaluated to transport the gaseous or liquid ethane. The simulators such as Aspen HYSY, Refprop, Aspen Capital Cost Estimator and Pipesim have been used for the assessment of processing, the thermodynamic, economical, loading, and unloading conditions. The results indicated that the mixture of fluid transport in the gaseous and compressed phase will be less costly. The best condition of transporting is almost 80 bar pressure and the temperature of 40 °C. The cost of loading, storing, transporting, and unloading has been 135 dollars/ton.

The demethanizer tower of Kavian olefin plant had a problem in more than 77% of the nominal capacity. Its performance was reduced by flooding with considering the inside pressure drop and fluctuation of the bottom liquid level increase. For this reason, a study was performed and the simulation results (with PRO II and SULCOL) were successfully implemented. Finally, troubleshooting and practical solutions were compared with simulation results. In order to tower modifications, an instruction had been issued so that all 40 trays had to be completely discharged and then the tower was refilled with 16 ton packing. According to this solution, the volume of ethylene as final product was increases about 23% and reaches the designed nominal capacity.

Sewage sludge (SS) is increasingly used as an environment functional material to reduce or control pollution and improve plant growth because of the large amounts of carbon and essential plant nutrients in it. To achieve the best application results, it is essential to comprehensively review recent progress in SS utilization. This review aims to fill the gaps in knowledge by describing the properties of SS, and its usage as adsorbents, catalysts and fertilizers, and certain application mechanisms. Although SS generates several benefits for the environment and humans, many challenges still exist to limit the application, including the risks posed by potentially toxic substances (e.g., heavy metals) in SS. Therefore, future research directions are discussed and how to make SS applications more feasible in terms of technology and economy.

The main objective of this study was to banana waste-derived activated carbon (BWAC) make a high pore surface area was prepared and composited with Fe

The CO2 methanation reaction of reduced and unreduced Ni based CeO2, Al2O3, TiO2 and Y2O3 supported catalysts was investigated. The Ni/CeO2 and Ni/Y2O3 catalysts exhibited similar CO2 conversions at all reaction temperatures. The catalysts were studied by X-ray diffraction (XRD), H2 chemisorption, H2 temperature-programmed reduction (TPR), and in situ diffuse reflection infrared Fourier transform spectroscopy (DRIFTS); the results suggested that the reducibility of both metal and support at low temperature, strong metal support interaction and small Ni particle size are important factors for low-temperature CO2 methanation. Based on the DRIFT studies, the difference in the CO2 adsorption properties and reaction pathway depending on the reduced and unreduced Ni based supported catalysts was discussed.

The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats. Thirty rats were categorized as control, diabetic control supplemented with 0, 20 mg/kg chrysoeriol and 600 μg/kg BW of glibenclamide for 45-day trial period. Our results indicated that the inclusion of chrysoeriol (20 mg/kg), showed a significant reduction in plasma glucose, hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity. Further, downregulated enzymes including glucose 6-phosphatase, fructose 1,6-bisphosphatase, and glycogen phosphorylase as well upregulated enzymes such as hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase, and hepatic glycogen content. There was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase, towards normal levels upon treatment with chrysoeriol. The histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated rats. In addition, the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase, using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide, as a standard drug. Thus, chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes.

This study examines the use of international publishing (i.e. publishing in journals/books indexed by international bibliometrics databases) within academia in Vietnam since Doi Moi (the Renovation) in 1986. Document analysis and in‐depth interviews with 20 Vietnamese scholars were undertaken to address the research objective. The findings revealed three important milestones in academic development in Vietnam: 1986–2008, 2008–2017, and 2017 to the present. Between 1986 and 2008, international publishing was almost non‐existent in actual practice in academia, except among the mathematics community. Since 2008, with the launch of the Foundation for Science and Technology Development, international publishing in Vietnam has become more visible on a broader scope (i.e. at ministerial level). Increasing awareness in the academic community of the role of international publishing contributed to a major increase in research output with an international outlook between 2008 and 2017. The third milestone was the promulgation of two new regulations, one relating to doctoral education in 2017 and another to professorship appointments in 2018, in which international publishing databases have been placed at the centre of these policy agendas. Looking ahead, policymakers and academic leaders in Vietnam are recommended to further use international publishing metrics to enhance international research outputs and quality.

The failure of the centralized water supply system forced XY community to become more dependent on uncertain and unstable water sources. The results of surveying 50 households showed that 89.18% of total households depended on water collected from rivers, which contributed 58.3% of the total water volume used for the domestic demands. The average water volume consumed was 19.5 liters/person/day (l/p/d), and 86.5% of households used more than one source; 13.5% of households collected water only from rivers, and 45.94% of families had rainwater harvesting (RWH) for their activities (domestic water demand); however, RWH only provided 9.9% of total water consumption. In this study, basic methods were applied to calculate the storage tanks necessary to balance the water deficit created by drought months. Three levels of water demand (14, 20, and 30 l/p/d) can be the best choices for RWH; for a higher demand (40 and 60 l/p/d), small roof area (30-40 m2), and many people (six to seven) per family, RWH might be impractical because of unsuitable rainfall or excessively large storage tanks.

The primary goal of the current study is thermodynamic and environmental modeling and multi-objective optimization of a new hybrid energy system. The suggested ocean-based energy conversion system consists of an organic Rankine cycle (ORC), a solar flat plate collector, a proton exchange membrane (PEM) electrolyzer boosted with thermoelectric generator (TEG) module. Exergy and exergo-environmental as two powerful tools are employed to the precise assessment of the suggested system. To achieve the best performance of the integrated system, multi-criteria optimization with different objective functions is carried out. As the results of the parametric analysis indicate, defined objective goals have an appropriate conflict with changing decision variables, which is necessary in multi-criteria optimization. Four decision variables namely solar flat plate collector area ( A p ), solar radiation intensity (I), collector temperature ( T col ), and condenser temperature ( T cond ) are chosen as decision variables. In all optimization scenarios, the net output power is common, which is based on the selected optimum points value changing between 201.02 kW and 268.17 kW. Additionally, in various optimization scenarios, the area of solar flat plate collectors tends to get a higher value in the allowable domain. The provided information in multi-objective optimization can provide good insight to engineers and system designers to select the best system configuration.

The current work is about analysis and multi-objective optimization (MOO) of weir-type solar still systems equipped with phase change material (PCM) regarding the exergetic and economic performance. To do so, the energetic and exergetic modeling of the suggested system is conducted then the substantial economic factors is applied to obtain the total cost rate of the considered SSDS. The total exergetic efficiency and total annual cost (TAC) is considered objective functions. Four parameters include mass of the PCM (mPCM), inlet brine water flow rate ( $$ {\dot{m}}_{\mathrm{f}} $$ ), gap distance (d), and insulation width (xins) is chosen as decision variables. Moreover, a genetic algorithm–based MOO was applied to find the optimum states of evaluated solar still unit. The outputs represented that increasing the brine feed water mass flow rate does not affect the TAC while decreasing distilled water production rate. The scattered distribution of optimum states infers that the optimum value of PCM mass is about 1 kg. In addition, applied MOO reveals that with optimization of the studied system, the exergy efficiency increases about 1.47% and the annual distilled water increases 4.35% compared with the non-optimized system. The suggested system is capable to produce fresh water in remote areas without any pollution as well as in a low cost rate.

This paper aims to explore the relationship between the quality of the audit and the level of stock return co-movement in the context of the Vietnamese emerging market. The empirical study is designed based on the quatitative method and deductive approach. The panel datasetincludes 256listed firmsfrom different industries,with 1115 firm-year observations on Ho Chi Minh City Stock Exchange for the period from 2014 to 2018. In the research, we built the econometric regression model, using stock return synchronicity and audit quality as the dependent and independent variable, respectively. Some control variables are also added to the econometric regression models as they are well-documented in prior research to have an effect on stock price synchronicity. To improve the accuracy of the regression coefficients, besidetheOrdinary Least Squares, we employ theRandom Effects Modeland theFixed Effects Model for better statistical analysis of panel data set. The resultsshow that the quality of the audit is positively correlated to stock price synchronicity. This finding suggests that stock returns of companies with higher quality of the audit are more synchronous with the market. Results for other control variables also support our reasoning for the main findings.

The paper examines the impact of information about cash flow from operating activities of firms listed on Vietnam’s stock market to the decision making of individual investors. Data were collected from interviews with 160 individual investors about their investment decisions based on information on profit growth and cash flow growth from operating activities. T-test was conducted to research on Vietnam’s stock market - a market considered as information that is not really public, transparent and ineffective. The research results show that: (1) investors do not care about cash flow from operating activities when making investment decisions if the company’s profits grow positively, (2) information about cash flow from operating activities only affects the decisions of individual investors once profit growth is negative, and (3) conflicting information between profit growth and cash flow growth from business activities significantly affects the confidence and comfort of investors in Vietnam’s stock market when they make investment decisions. Then, the study points out the mistake of investors when making investment decisions, and offers recommendations to investors when making investment decisions, not only concerned with profit growth, but also paying special attention to cash flow growth, especially cash flow from the company’s business operations.

Textile effluents contain triazine-substituted reactive dyes that cause health problems such as cancer, birth defects, and hormone damage. An electrochemical process was employed effectively to degrade azo reactive dye with the aim of reducing the production of carcinogenic chemicals during biodegradation. Textile dye C.I. Reactive Red 2 (RR2), a model pollutant that contains dichloro triazine ring, was subjected to the electrocoagulation process using aluminium (Al) electrodes. A maximum of 97% of colour and 72% of chemical oxygen demand (COD) removal efficiencies were achieved and 9.5 kWh/kg dye electrical energy and 0.8 kg Al/kg dye electrode consumption were observed. The dye removal mechanism was studied by analysing the results of UV-Vis spectra of RR2 and treated samples at various time intervals during electrocoagulation. Fourier transform infrared (FTIR) spectra and energy dispersive X-ray (EDX) spectral studies were used for analysing the electrocoagulated flocs. The results indicate that in this process the dye gets removed by adsorption and there is no significant carcinogenic by-product formation during the degradation of dye.

In this work, the surface of nano/micro-E-glass fibril (nGF) was modified with an amine silane coupling agent before applying as toughener for epoxy resin. The chemical structure and composition of...

The present study is focused on bio hydrogen (H2) and bioplastic (i.e., poly-β-hydroxybutyrate; PHB) productions utilizing various wastes under dark fermentation, photo fermentation and subsequent dark-photo fermentation. Potential bio H2 and PHB producing microbes were enriched and isolated. The effects of substrate (rice husk hydrolysate, rice straw hydrolysate, dairy industry wastewater, and rice mill wastewater) concentration (10–100%) and pH (5.5–8.0) were examined in the batch mode under the dark and photo fermentation conditions. Using 100% rice straw hydrolysate at pH 7, the maximum bio H2 (1.53 ± 0.04 mol H2/mol glucose) and PHB (9.8 ± 0.14 g/L) were produced under dark fermentation condition by Bacillus cereus. In the subsequent dark-photo fermentation, the highest amounts of bio H2 and PHB were recorded utilizing 100% rice straw hydrolysate (1.82 ± 0.01 mol H2/mol glucose and 19.15 ± 0.25 g/L PHB) at a pH of 7.0 using Bacillus cereus (KR809374) and Rhodopseudomonas rutila. The subsequent dark-photo fermentative bio H2 and PHB productions obtained using renewable biomass (i.e., rice husk hydrolysate and rice straw hydrolysate) can be considered with respect to the sustainable management of global energy sources and environmental issues.

Clean energy like hydrogen can be a promising strategy to solve problems of global warming. Photo-fermentation (PF) is an attractive technology for producing biohydrogen from various biowastes cost-effectively and environmentally friendly. However, challenges of low light conversion efficiency and small yields of biohydrogen production still limit its application. Thus, advanced strategies have been investigated to enhance photo-fermentative biohydrogen production. This review discusses advanced technologies that show positive outcomes in improving biohydrogen production by PF, including the following. Firstly, genetic engineering enhances light transfer efficiency, change the activity of enzymes, and improves the content of ATP, ammonium and antibiotic tolerance of photosynthetic bacteria. Secondly, immobilization technology is refined. Thirdly, nanotechnology makes great strides as a scientific technique and fourthly, integration of dark and photo-fermentation technology is possible. Some suggestions for further studies to achieve high levels of efficiency of photo-fermentative biohydrogen production are mentioned in this paper.

In this work, a g-C3N4/porphyrin nanocomposite was fabricated through the self-assembling of monomeric Tetrakis (4-carboxyphenyl) porphyrin (TCPP) molecules with g-C3N4 nanomaterials. The characterizing results showed a good distribution of TCPP nanofibers with a diameter of < 100 nm and several micrometers in length on the g-C3N4 nanoflakes’ surfaces. The prepared g-C3N4/porphyrin nanocomposite had two bandgap energies of 2.38 and 2.7 eV, which could harvest a wide range of photon energy in the light spectrum, particularly in visible light. The obtained C3N4/TCPP nanocomposite revealed a remarkable photodegradation efficiency toward rhodamine B dyes, with a RhB removing rate of 3.3 × 10−2 min−1. The plausible mechanism for the photocatalytic performance of the g-C3N4/porphyrin photocatalyst for the RhB dye’s degradation was also studied and discussed.

Organic-rich wastewater is a feasible feedstock for biohydrogen production. Numerous review on the performance of microorganisms and the diversity of their communities during a biohydrogen process were published. However, there is still no in-depth overview of enzymes for biohydrogen production from wastewater and their scale-up applications. This review aims at providing an insightful exploration of critical discussion in terms of: (i) the roles and applications of enzymes in wastewater-based biohydrogen fermentation; (ii) systematical introduction to the enzymatic processes of photo fermentation and dark fermentation; (iii) parameters that affect enzymatic performances and measures for enzyme activity/ability enhancement; (iv) biohydrogen production bioreactors; as well as (v) enzymatic biohydrogen production systems and their larger scales application. Furthermore, to assess the best applications of enzymes in biohydrogen production from wastewater, existing problems and feasible future studies on the development of low-cost enzyme production methods and immobilized enzymes, the construction of multiple enzyme cooperation systems, the study of biohydrogen production mechanisms, more effective bioreactor exploration, larger scales enzymatic biohydrogen production, and the enhancement of enzyme activity or ability are also addressed.

This research explores the possibilities of a dual-chamber microbial fuel cell as a biosensor to measure Bisphenol A (BPA) in wastewater. BPA is an organic compound and is considered to be an endocrine disruptor, affecting exposed organisms, the environment, and human health. The performance of the microbial fuel cells (MFCs) was first controlled with specific operational conditions (pH, temperature, fuel feeding rate, and organic loading rate) to obtain the best accuracy of the sensor signal. After that, BPA concentrations varying from 50 to 1000 μg L

Immobilization of enzymes has many advantages for their application in biotechnological processes. In particular, the cross-linked enzyme aggregates (CLEAs) allow the production of solid biocatalysts with a high enzymatic loading and the advantage of obtaining derivatives with high stability at low cost. The purpose of this study was to produce cross-linked enzymatic aggregates (CLEAs) of LipMatCCR11, a 43 kDa recombinant solvent-tolerant thermoalkaliphilic lipase from Geobacillus thermoleovorans CCR11. LipMatCCR11-CLEAs were prepared using (NH4)2SO4 (40% w/v) as precipitant agent and glutaraldehyde (40 mM) as cross-linker, at pH 9, 20 °C. A U10(56) uniform design was used to optimize CLEA production, varying protein concentration, ammonium sulfate %, pH, glutaraldehyde concentration, temperature, and incubation time. The synthesized CLEAs were also analyzed using scanning electron microscopy (SEM) that showed individual particles of

Wastewater contains a significant amount of recoverable nitrogen. Hence, the recovery of nitrogen from wastewater can provide an option for generating some revenue by applying the captured nitrogen to producing bio-products, in order to minimize dangerous or environmental pollution consequences. The circular bio-economy can achieve greater environmental and economic sustainability through game-changing technological developments that will improve municipal wastewater management, where simultaneous nitrogen and energy recovery are required. Over the last decade, substantial efforts were undertaken concerning the recovery of nitrogen from wastewater. For example, bio-membrane integrated system (BMIS) which integrates biological process and membrane technology, has attracted considerable attention for recovering nitrogen from wastewater. In this review, current research on nitrogen recovery using the BMIS are compiled whilst the technologies are compared regarding their energy requirement, efficiencies, advantages and disadvantages. Moreover, the bio-products achieved in the nitrogen recovery system processes are summarized in this paper, and the directions for future research are suggested. Future research should consider the quality of recovered nitrogenous products, long-term performance of BMIS and economic feasibility of large-scale reactors. Nitrogen recovery should be addressed under the framework of a circular bio-economy.

The prominent characteristics of the biochar, high porosity, sorption capacity with low density improve the aeration, making it a desirable amendment material for composting process. The composting efficiency was analysed by the impact of rice husk biochar amendment (0, 2, 4, 6, 8 and 10%) in the presence of salts for the co-composting of food waste and swine manure, in composting reactors for 50 days. Results revealed that biochar amendment had improved the degradation rates by microbial activities in comparison with control. The final compost quality was improved by reducing the bulk density (29 - 53%), C/N ratio (29 - 57%), gaseous emissions (CO2, CH4, and NH3) and microbial pathogens (Escherichia coli and Salmonella sp.). However, 6% biochar amendment had significant improvement in compost quality, degradation rates and nutritional value which is recommended as the ideal ratio for obtaining mature compost from the feedstock, food waste and swine manure.

Planning social tasks are essential jobs of every organization, business, and government. With increasing challenges of society, the organization and effective implementation depend on optimizing the plans of the organization and efficient operations of the professional teams in order, time, and specific requirements. In the context of the impact of the COVID-19 pandemic on social activities, developing strategies for the organization and operation of working teams in implementing disease prevention, control, and elimination are research issues that should be raised. This paper model the plan to organize and operate the social-mission working group problem with a multi-objective approach. The problem includes organizing and planning the health workforce to perform tasks in epidemic prevention and implementing guidelines of the Ministry of Health under the administration of the government. These pose a requirement to balance resources, medical equipment, and ancillary equipment to perform tasks according to different priority levels: disease prevention; vaccination; sterilization, isolation, treatment by different locations, and time to ensure effectiveness. The problem is modeled by approaching the multi-objective optimization with three objectives: makespan, performance efficiency, and rate of human resource usage. We also propose a guidance technique to improve the surrogate-assisted multi-objective optimization algorithms on analyzing the factors that influence finding solutions and maintain a balance between local exploration and global exploitation. The enhanced algorithms confirm the proposed model for social tasks against the COVID-19 pandemic.

Zero-valent iron (ZVI) has been widely studied and utilized as a highly reductive agent for environmental remediation. In this study, a ZVI nanoflake-decorated graphene composite was successfully fabricated via the reduction of Fe2+ ions in ethanol solution. The new ZVI nanoflake-decorated graphene composite (GNPs@fZVI) (here GNPs are graphene nanoplates) was thoroughly characterized using scanning electron microscopy, energy dispersive spectroscopy mapping, X-ray diffraction, Fourier-transform infrared spectroscopy, and magnetic measurements. The obtained GNP@fZVI composite consisted of hierarchical ZVI nanoflakes decorated on the surface of the GNPs. The hierarchical ZVI nanosheets presented a top layer of structural flake-like ZVI clusters with an average diameter of 1 μm and a bottom layer of uniform petal-like nanosheets with less than 10 nm thickness. The rhodamine B (RhB) removal performance of the resultant GNP@fZVI composite from aqueous solutions and the factors affecting the RhB removal efficiency of the composites were investigated. The results indicated that the as-prepared GNP@fZVI composite exhibited high RhB removal performance, and its removal efficiency was 100% after only 2.5 h of treatment using 3 g L−1 GNP@fZVI composite. Lastly, the probable simultaneous adsorption and reduction mechanism of the RhB dye using the GNP@fZVI composites was also discussed.

Adsorption technologies are considered to be cost-effective solutions for the removal of toxic residues. In the present study, two types of sulfated TiO2 adsorbents, sulfated–TiO2(A) and sulfated–TiO2(B), were prepared by the wetness impregnation method, and tested for how effectively they could bind to, and hence, remove arsenic. These adsorbents were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR). The interaction of the arsenic with the sulfate group at the surface of the adsorbent can be deduced by the reduction in the peak intensity of the S O bond at 1219 cm−1, corresponding to the SO42− group. In particular, the number of Lewis and Bronsted acid sites was enhanced in the sulfated–Ti(OH)4 adsorbents, which modulated the surface acidity of titania by controlling the electron density and facilitated the adsorption of arsenic. Our results confirmed that sulfated–TiO2(B) is 20% more efficient at removing arsenic, as compared to TiO2 (60%) and Ti(OH)4 (64%).

We prepared epoxidized soybean oil (ESO) grafted with carboxyl-terminated poly(acrylonitrile-co-butadiene) (CTBN) (ESO-g-CTBN) by a ring-opening reaction between the epoxide group and the carboxyl group. The structural features of the resulting product were determined using modern analytical techniques, such as Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, and gel permeation chromatography (GPC). The ESO-g-CTBN was applied as a toughener for an epoxy resin-based composite that was fabricated by blending the epoxy resin with diethylenetriamine (DETA) as the curing agent. The main aim of this procedure is to simultaneously improve the mechanical properties and fracture toughness of a bisphenol A-based epoxy resin. When 15 phr of ESO-g-CTBN was added to the EP/DETA mixture, the resin fracture toughness (KIC) and tensile strength increased from 0.65 to 1.09 MPa m1/2 and from 34.42 to 42.55 MPa, respectively. The ESO-g-CTBN existed in the EP matrix as a separate phase and induced an increase in the KIC via stopping crack growth or changing the crack direction. The epoxydized soybean oil grafted with CTBN (ESO-g-CTBN) was synthesized from ring opening reaction between epoxide group and carboxyl group. The ESO-g-CTBN help to improve the fracture toughness of epoxy resin by the mechanism as shown in the figure.