1. Will high quality (certainty) evidence change less often than low quality evidence after new data is collected?
- Author
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Ahmed, Muhammad, Nunan, David, Hemkens, Lars, Miranda, Enderson, Riera, Rachel, Price, Amy, Djulbegovic, Benjamin, Hozo, Iztok, Koletsi, Despina, Pacheco, Rafael, de Melo, Daniela, Santos, Ana, and Nadanovsky, Paulo
- Subjects
Epidemiology ,education ,Medicine and Health Sciences ,Clinical Epidemiology ,Public Health - Abstract
The purpose of proposed research is to assess if the low quality (certainty) evidence is more often revised than high quality (certainty) evidence in subsequent studies. Answering this question is of great importance for the practice of medicine as well as for EBM. If the results based on low quality evidence are often overturned this would provide further scientific support for EBM urging practitioners to be extremely cautious in acting on very/low quality evidence as such practice would likely result in greater harm. However, if we do not observe the expected relation between quality of evidence and probability of the results being overturned, then the entire process of evidence appraisal and possibly EBM reasoning would need to be re-examined in conjunction with the current process of approval of health interventions for the use in clinical practice.
- Published
- 2022
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