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Introduction. In the context of the pandemic of the new coronavirus and the measures taken to contain the spread of infection, including quarantine measures and transfer to remote work, there is a lack of knowledge about the effects of short- and long-term isolation on psychological well-being and cognitive performance of a person. In this situation, the closest model for studying the processes of adaptation to the conditions of isolation and crowding are isolation experiments. The study aims to research the cognitive performance and psychophysiological state of a person in conditions of isolation and crowding. Materials and methods. Scientists conducted a 14-day isolation experiment simulating a flight to the moon at the Institute of Biomedical Problems of the Russian Academy of Sciences: 6 subjects (4 men, 2 women) worked for two weeks and lived in a hermetic volume with an area of 12 sq2. With the help of situational anxiety assessment, acoustic speech analysis, cognitive and sensorimotor tests, experts obtained data on the relationship between the psychophysiological state of a person and his productivity. Results. Researchers have identified significant correlations between situational anxiety and acoustic characteristics of speech. On days when the subjects spoke at a lower volume (p