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Introduction: For neonates, early-onset sepsis is still a prevalent and deadly disease. In adult studies, the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been shown to have relevant relationships with inflammatory markers and the severity of various disorders. Aim: The purpose of this study was to see how useful the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are as diagnostic adjunct tests for term infants with neonatal early-onset sepsis (EOS). Methodology: A case-control study, comprised 150 newborns (100 newborns with neonatal sepsis who were admitted to NICU (Menoufia University Hospital, from December 2019 to February 2021) within the first three postnatal days as a case group and 50 healthy newborns as a control group). History taking, full clinical examination, complete blood picture, C-reactive protein and blood culture, neutrophil to lymphocyte ratio(NLR) and platelet to lymphocyte ratio (PLR) were done for all newborns. Results: There were no significant differences between patient and control groups as regard gestational age, gender, mode of delivery, gestational age and birth weight. Respiratory distress and tachycardia were the most common clinical sign so fearly onset sepsis (EOS). As regard the vital data patient group had higher respiratory rate and heart rate of SPO2 neutrophil there was significant difference between patient and control groups as regard immature to total ratio. Patient group had higher neutrophil count, NLR and PLR ratios and CRP ratio than control group. As regard blood culture, Klebsiella, Pseudomonas and Staphaureus were the most common organism. Additionally, the sensitivity of NLR and PLR to diagnose sepsis were100%, 83.3%, respectively. Specificity was 100% and 100%, respectively, at cutoff value of ≥6.79 and >27.24, with accuracy of96%,85.6%, respectively. Conclusion: As diagnostic indicators for early-onset newborn sepsis, the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), I/T ratio, and serum CRP levels demonstrated good sensitivity a