1. Serum growth differentiation factor-15 (GDF-15) level in behcet's disease patients: Relation to clinical characteristics, musculoskeletal ultrasound findings and disease activity
- Author
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Hanan M. El-Saadany, Elham M. Elbarky, Nagat M. El-Gazzar, Mervat I. Hussien, and Maaly M. Mabrouk
- Subjects
medicine.medical_specialty ,Visual analogue scale ,Growth differentiation factor-15 ,Arthritis ,Behcet's disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Behcet's Disease ,Internal medicine ,Ultrasound ,medicine ,030212 general & internal medicine ,Subclinical infection ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,Soft tissue ,RC581-607 ,medicine.disease ,Erythrocyte sedimentation rate ,GDF15 ,Immunologic diseases. Allergy ,business - Abstract
Aim of the work: This study was conducted to assess serum level of growth differentiation factor-15(GDF-15) in Behcet’s disease (BD) patients and its relationship with clinical characteristics, ultrasound findings and disease activity. Patients and methods: Study included 30 BD patients and 20 matched healthy controls. Visual analog scale (VAS)-pain of affected joints and Behcet’s disease current activity form (BDCAF) were assessed. The most affected joints and surrounding soft tissues were assessed by musculoskeletal ultrasound (MSUS).Serum GDF-15 level was measured. Results: Patients were 23 males and 7 females (M:F 3.3:1) with a mean age of 34.6 ± 8.6 years and mean disease duration of 6.6 ± 4.5 years. 18(60%) had arthritis and arthralgia. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were 26.2 ± 21.2 mm/1sthr and 50.4 ± 37 mg/dl respectively. There was significant increase of GDF-15 levels in patients with articular affection (3492.3 ± 4618.8 ng/ml) compared to those without (338.9 ± 90.3 ng/ml) and controls (322 ± 78.8 ng/ml) (p
- Published
- 2021
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