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Background: The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. Methods and results: We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70 years] and 18 aged-matched controls. A subset of 15 subjects (5 controls, 3 sub-elite and 7 elite athletes) also underwent cardiac magnetic resonance imaging (cMRI). Elite and sub-elite athletes had greater echocardiography-determined left ventricular myocardial mass indexed to body surface area than controls (113 +/- 22, 115.2 +/- 23.1 and 94.8 +/- 21 g/m(2), respectively, p = 0.008 for group effect), with similar results for left (50.5 +/- 4.4, 48.2 +/- 4.3 and 46.4 +/- 5.2 mm, p = 0.008) and right (38.6 +/- 3.8, 41.1 +/- 5.5 and 34.7 +/- 4.3 mm, p < 0.001) ventricular end-diastolic diameter, and cMRI-determined left atrial volume indexed to body surface area (62.7 +/- 8.1, 56.4 +/- 16.0 and 39.0 +/- 14.1 ml/m(2), p = 0.026). Two athletes showed a non-coronary pattern of small, fibrotic left ventricular patches detected by late gadolinium enhancement. No group effect was noted for biomarkers. Conclusions: Regardless of their competition level at a younger age, veteran endurance athletes showed an overall healthy, non-pathological pattern of cardiac remodeling. Nonetheless, the physiopathology of the ventricular fibrotic patches detected warrants further investigation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Service of Biochemistry, Miguel Servet UniversityHospital, Zaragoza, SpainCorresponding author: E. Serrano-Osta´riz, Section of Physical Education and Sports, University of Zaragoza, C/DomingoMiral, s/n-50009 Zaragoza, Spain. Tel: 1349 767 610 00, Fax: 1349 767 617 20, E-mail: enrise@unizar.esAccepted for publication 17 August 2009Numerous studies have observed cardiac biomarker releasewithprolongedexercise.Despitethis,weareunsureastotheconstituent aspects of any given exercise bout that maybe important in promoting cardiac biomarker release.This study examined the influence of exercise durationand intensity on the appearance of cardiac biomarkers.Twenty-one subjects ran for 45, 90 and 180min at 85%and 95% of their individual anaerobic threshold on sixdifferent days randomized. Cardiac troponin I (cTnI) andN-terminal pro-brain natiuretic peptide (NT-proBNP)were assayed from blood samples collected before,30min and 3h post-exercise. NT-proBNP was elevatedafter all exercise trials (range before: 21–32; rangepost: 38–67ng/L). Peak post-exercise concentrationsof NT-proBNP were associated with exercise duration(P50.049), but not exercise intensity (P50.451). cTnIwas elevated after all exercise trials (range before: 0.007–0.011; range post: 0.008–0.021lg/L). Peak post-exerciseconcentrations of cTnI were associated with exercise dura-tion (P50.003) and intensity (P50.037). Data suggestthat while both cTnI and NT-proBNP increased after allexercise trials, the mediating effect of duration influencedboth NT-proBNP and cTnI while intensity influenced onlycTnI.

OBJECTIVE To determine the influence of age, training status, race time, and exercise intensity on the appearance of cardiac biomarkers after a cycle-touring event. DESIGN Pre-post exercise measurements. SETTING University of Zaragoza, Zaragoza, Spain. PARTICIPANTS Ninety-one amateur cyclists. INTERVENTION The 2005 Quebrantahuesos cycle-touring event (distance: 206 km; altitude difference: 3800 m). MAIN OUTCOME MEASURES Cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were measured the day before and immediately after the race. Heart rate (HR) monitoring was performed on 55 cyclists during the race to evaluate exercise intensity. RESULTS cTnI and NT-pro-BNP were significantly elevated immediately post race, with 43% of participants exhibiting cTnI levels greater than 0.04 microg/L and 65% of the participants measuring NT-pro-BNP levels greater than 125 ng/L. The cTnI increase was significantly associated with mean exercise intensity HR (r = 0.36, P < 0.01) but was not associated with age, training status, or race time. The increase in NT-pro-BNP correlated with race time (r = 0.40, P < 0.001) and training status (r = -0.36, P < 0.001) but was not associated with age or exercise intensity HR measures. CONCLUSIONS These results suggest that, in part, exercise intensity (HR) is responsible for the cTnI increase and that race time is responsible for the increase in NT-pro-BNP. Future standardized endurance exercise trials are recommended to further elucidate the potentially differential effects of training status, exercise time, and intensity on post-exercise increases in cTnI and NT-pro-BNP.

A recent meta-analysis by Iskandar et al. (1) nicely showed that endurance athletes have larger left atrial (LA) diameters compared with control subjects. Yet only 9 of 54 studies included in their analysis reported LA volume values corrected for body surface area (BSA). In fact, few studies have determined LA volume in young athletes, and, to the best of our knowledge, no study has reported this variable in older athletes. This is an important question given the growing debate about the potential deleterious effects of long-term strenuous endurance exercise on the human heart, notably the higher risk of atrial fibrillation (AF), a condition for which both atrial dilation and the normal aging process are thought to be potential causative mechanisms (2). Thus, we aimed to assess the long-term consequences of endurance exercise on LA volume in athletes who were highly competitive at younger ages and are still active. To this end, we compared BSA-corrected LA volumes determined with late gadolinium enhancement magnetic resonance imaging (LGE-MRI) in former elite endurance athletes and sedentary control subjects. Sin financiación 10.189 JCR (2016) Q1, 1/127 Radiology, Nuclear Medicine and Medical Imaging, 6/126 Cardiac and Cardiovascular Systems 5.038 SJR (2016) Q1, 7/375 Cardiology and Cardiovascular Medicine No data IDR 2016 UEM

a Faculty of Medicine, Department of Physiology, University of Valencia, Valencia, Spain b Fundacion de Investigacion del Hospital Clinico Universitario Valencia (FIHCUV-INCLIVA), Valencia, Spain c Faculty of Health and Sport Science, University of Zaragoza, Huesca, Spain d Hospital Universitario 12 de Octubre, Research Institute (i + 12), Madrid, Spain e HospitalUniversitario Miguel Servet, Zaragoza, Spain f Cardiology Service, Hospital Universitario Miguel Servet, Zaragoza, Spain g European University of Madrid, Madrid, Spain h Faculty of Medicine, Physical Education and Sports Section, University of Zaragoza, Zaragoza, Spain

Here, we compared the maximal lactate steady state velocity (vMLSS) estimated from a single-visit protocol (v5 × 2000) to the traditional multi-day protocol (vMLSS). Furthermore, we determined whether there was a lactate steady state during the time limits (Tlim) at vMLSS or v5 × 2000. Eight runners completed a half marathon (HM), the traditional protocol to determine the vMLSS and the 5 × 2000 m test in a randomised order, and a Tlim at vMLSS and at v5 × 2000 in a randomised order. The vMLSS (13.56 ± 0.90 km·h − 1 ) was higher than the v5 × 2000 (12.93 ± 0.90 km·h − 1 , p = 0.001) and comparable to the vHM (13.34 ± 0.75 km·h − 1 ). The vMLSS (r = 0.83) and the v5 × 2000 (r = 0.91) were associated with the vHM but were not indicative of the competition pace. The Tlim at vMLSS (64 ± 15 min) was lower than the Tlim at v5 × 2000 (94 ± 21 min) and the HM time (95 ± 5 min). In both Tlim, lactate was lower at 45 min than upon fi nishing the eff ort and was predictive of its duration (p < 0.05). Our results indicate that the 5 × 2000 m test can be equally useful to assess runners as the traditional MLSS protocol and that there is no lactate steady state during the Tlim at vMLSS or at v5 × 2000

The impact of intermittent exercise on cardiac biomarker release has not been clearly established. In experienced athletes, we examined the acute effect of a heavy resistance training session (n=18 males) and an indoor soccer match (n=21, 11 males, 10 females) on the release of cTnI, cTnT, and NT-proBNP. Biomarkers were assayed from blood samples collected at rest, immediately post- and at 1, 3, 6, 12, and 24 h post-exercise. The heavy resistance training session resulted in an increase in NT-proBNP (pre: 15 ± 17, peak post: 41 ± 56 ng L (-1); p=0.001) but not in cTnI (pre: 0.024 ± 0.009, peak post: 0.025 ± 0.011 μg L (-1), p=0.809) or cTnT (undetectable in all samples). The indoor soccer match led to an increase in the release of NT-proBNP (pre: 28 ± 32, peak post: 66 ± 56 ng L (-1); p=0.000) and cTnI (pre: 0.026 ± 0.047, peak post: 0.033 ± 0.051 μg L (-1); p=0.008) in both males and females but not cTnT (detectable in only one subject). The current data suggest that intermittent bouts of exercise result in only modest perturbations of cardiac biomarkers with very limited evidence of myocyte injury/insult.

We sought to determine the influence of exercise intensity on the release of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in amateur marathon runners. Fourteen runners completed three exercise trials of the same duration but at exercise intensities corresponding to: (a) a competitive marathon [mean ± SD: heart rate 159 ± 7 beat min(-1), finish time 202 ± 14 min]; (b) 95% of individual anaerobic threshold [heart rate 144 ± 6 beat min(-1)] and; (c) 85% of individual anaerobic threshold [heart rate 129 ± 5 beat min(-1)]. cTnI and NT-proBNP were assayed from blood samples collected before, 30 min and 3 h post-exercise for each trial. cTnI and NT-proBNP were not different at baseline before each trial. After exercise at 85% of individual anaerobic threshold cTnI was not significantly elevated. Conversely, cTnI was elevated after exercise at 95% of individual anaerobic threshold (0.016 μg L(-1)) and to an even greater extent after exercise at competition intensity (0.054 μg L(-1)). Peak post-exercise values of NT-proBNP were elevated to a similar extent after all exercise trials (P0.05). The upper reference limit for cTnI (0.04 μg L(-1)) was exceeded in six subjects at competition intensity. No data for NT-proBNP surpassed its upper reference limit. Peak post-exercise values for cTnI and NT-proBNP were correlated with their respective baseline values. These data suggest exercise intensity influences the release of cTnI, but not NT-proBNP, and that competitive marathon running intensity is required for cTnI to be elevated over its upper reference limit.

This study describes the results of a survey of the resistance training practices of the following Spanish sports teams: soccer and basketball professional leagues, and top-division leagues for handball, volleyball, indoor soccer, and field hockey. The response rate was 81.8% (77 of 94). This survey examines (a) strength and conditioning (SC) coach profiles, (b) resistance training exercises, (c) resistance training load, (d) repetition velocity, and (e) training leading to muscle failure. The results indicate that 80.5% of coaches held a university degree, with 22% holding a master's degrees, 40% held National Federation certification, and none held Strength and Conditioning Specialist certification. Respondents relied on nonscientific sources of information to develop their conditioning programs. Fifty-eight percent of the SC coaches were hired full time, with 18% performing the duties of a first trainer. Many SC coaches did not use weightlifting (54%), full squat (51%), load squat jump (35%), or bench press throw (100%) exercises. Thirty-eight percent of respondents did not control the load intensity or did not use a load of 50-90% of 1 repetition maximum. For these load intensities, 70% did not perform the combination of maximum repetition velocity and nonmuscular failure. More significant deficiencies in the fundamental principles of resistance training were observed in indoor soccer, soccer, field hockey, and among lower performing handball and basketball teams. These results indicate that the profile of the SC coaches in the Spanish teams is insufficient for an optimal application of resistance training. Spanish SC coaches should therefore take advantage of advances made through scientific research in the area of strength and conditioning by acquiring master's degrees and specific certificates and consulting peer-reviewer journals.