Search

Funder: Albert-Ludwigs-Universität Freiburg im Breisgau (1016), Background Disease burden and unsatisfactory treatment outcomes call for innovation in treatments of depression. Prospective mental imagery, i.e. future-directed voluntary imagery-based thought, about potentially-rewarding activities may offer a mechanistically-informed intervention that targets deficits in reward processing, a core clinical feature of depression. We propose that the previously described impact of prospective mental imagery on motivation for everyday activities is facilitated by affective forecasting, i.e. predictions about an individual’s emotional response to the imagined activities. Methods Participants (N = 120) self-nominated six activities to engage in over the following week and were randomized to either: (1) an affective forecasting imagery condition (n = 40); (2) a neutral process imagery condition (n = 40); or (3) a no-imagery control condition (n = 40). Results As predicted, increases in motivation ratings from pre to post experimental manipulation were significantly higher following affective forecasting imagery compared to both neutral process imagery (d = 0.62) and no-imagery (d = 0.91). Contrary to predictions, the number of activities participants engaged in did not differ between conditions. Conclusions Results provide initial evidence for a potentially important role of affective forecasting in prospective mental imagery. We discuss how these findings can inform future research aiming to harness prospective mental imagery’s potential for clinical applications.

The purpose of this study is to replicate classical temporal discounting (TD) effects, as well as effects of episodic future thinking (EFT), and exploratory, test for effects of episodic past cues on TD. Additionally, we will try to link these effects to the vividness of cue-evoked associations during the TD task, as well as exploratory, individual VVIQ2-scores.

According to the theory of reconsolidation, the contents of an original memory can be updated after reactivation with subsequent new learnings. However, there seems to be a lack of an appropriate behavioral paradigm to study the reconsolidation of explicit self-related memory, which is of great significance to further explore its cognitive neural mechanism in the future. In two separate experiments, we adapted a trial-by-trial interfering paradigm with a self-episodic simulation process and investigated (1) whether it is possible to reconsolidate negative memories under the new behavioral paradigm and (2) how the emotional valence of post-retrieval interference material affects the reconsolidation of negative memories. The results showed that the negative memories under trial-by-trial self-simulation can be degraded and updated via post-retrieval interference processes. Individuals whose original memories were reactivated by initial background cues and who were then presented with new interference situations were less able to recall original scenes and showed more memory intrusions on these scenes than those who had experienced new learning without reactivation or only reactivation without interference. Furthermore, the extent and manner of memory change/updating were greatly influenced by the characteristics of interference information. For memories with negative valences, new learning materials with the same valence produced superior interference effects in the form of lower correct recalls and more integrated false; whereas the neutral interference materials can cause more memory intrusion. Post-retrieval memory distortions of negative self-memory may underlie different functional mechanisms.

For the first time, we assess episodic simulation in a patient with visual memory deficit amnesia, following damage to visual association cortices. Compared to control participants, the patient with visual memory deficit amnesia shows severely restricted responses when asked to simulate different types of future episodic scenarios. Surprisingly, the patient’s responses are more limited in cases where the scenarios require less reliance on visual information. We explain this counterintuitive finding through discussing how the severe retrograde amnesia in visual memory deficit amnesia limits the patient’s access to episodic memories in which vision has not been a focus of their life. As a result, we argue that the deficits in visual memory deficit amnesia continue to distinguish it from amnesia after direct damage to the hippocampus.

Novel negative events are simulated in more event-specific detail than novel positive events. In the present study, we set out to assess whether this negative event detail bias is specific to simulations of personal events or whether evoking negative valence, in the context of simulations of personal and nonpersonal events, is sufficient for boosting simulated event detail. Participants simulated novel negative and positive events that might take place in their future, the future of an acquaintance, or the future of a familiar individual with whom they have not had prior contact. Across 2 experiments, we found that novel negative events were simulated in more event-specific detail than novel positive events irrespective of whether the events under consideration were personal or nonpersonal. This pattern of results also emerged when negative and positive events did not differ on a subjective measure of arousal, indicating that negative valence may play a key role in encouraging detailed elaboration of novel negative events. Implications of our findings for the role of event simulation in adaptive behavior are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Why are we willing to help others? Recent behavioral work on episodic processes (i.e. the ability to represent an event that is specific in time and place) suggests that imagining and remembering scenes of helping a person in need increases intentions to help. Here, we provide insight into the cognitive and neural mechanisms that enhance prosocial intentions via episodic simulation and memory. In Experiment 1, we scanned participants using functional neuroimaging as they imagined and remembered helping episodes, and completed non-episodic control conditions accounting for exposure to the story of need and conceptual priming of helping. Analyses revealed that activity in the medial temporal lobe (MTL) subsystem, as well as the right temporoparietal junction (RTPJ) predicted the effect of conditions on the strength of prosocial intentions. In Experiment 2, we used transcranial magnetic stimulation to disrupt activity in the RTPJ, and better isolate the contribution of MTL subsystem to prosocial intentions. The effect of conditions on willingness to help remained even when activity in the RTPJ was disrupted, suggesting that activity in the MTL subsystem may primarily support this prosocial effect. It seems our willingness to help may be guided, in part, by how easily we can construct imagined and remembered helping episodes.

In a range of externally-directed tasks, intra-individual variability of fMRI BOLD signal has been shown to be a stronger predictor of cognitive performance than mean BOLD signal. BOLD variability's strong association with cognitive performance is hypothesised to be due to it capturing the dynamic range of neural systems. Although increased BOLD variability is also speculated to play a role in internally-directed thought, particularly when creative and flexible cognition is required, there is a relative lack of research exploring whether BOLD variability is related to internally-directed cognition. Thus, we investigated the relationship between BOLD variability and a key component of creativity - divergent thinking - in various tasks that required participants to think flexibly. We also determined whether any associations between BOLD variability and creativity overlapped with, or differed, from associations between mean BOLD signal and creativity. First, we performed task Partial Least Squares (PLS) analyses that compared BOLD signal (either mean or variability) during two future imagination conditions that differed in the amount of cognitive flexibility required: a Congruent condition in which autobiographical details (people, places, objects) comprising an imagined event belonged to the same social sphere (e.g., university) and an Incongruent condition in which details belonged to different social spheres and required greater cognitive flexibility to integrate. Results indicated that the Incongruent condition was associated with a widespread reduction in both BOLD variability and mean signal (relative to the Congruent condition), but in largely non-overlapping regions. Next, we used behavioral PLS to determine whether individual differences in performance on future simulation tasks as well as the Alternate Uses Task relates to BOLD variability and mean BOLD signal. Better performance on these tasks was predominantly associated with increases in mean BOLD signal and decreases in BOLD variability, in a range of disparate brain regions. Together, the results suggest that, unlike tasks requiring externally-directed cognition, superior performance on tasks requiring creative internal mentation is associated with less (not more) variability.

Highlights • Examined the impact of episodic simulation and motivation on children’s episodic foresight • Thirst was induced and children were asked to make future choices • 3- to 5-year-olds completed the pretzel task under 4 different experimental conditions • Children’s future predictions were most accurate in the motivation condition • A novel and motivating food item, a cupcake, helped children overcome their current state of thirst, Future simulation and motivation are two strategies that might help children improve their induced-state episodic foresight. In Study 1, 3- to 5-year-old children (N = 96) consumed pretzels (to induce thirst) and were asked what they would prefer the next day, pretzels or water. Children were randomly assigned to an experimental condition: (1) a standard thirsty condition, (2) an episodic simulation condition where they imagined being hungry the next day, (3) a motivation condition where children chose between a cupcake and water, or (4) a control condition (thirst was not induced). Future preferences did not differ by age and children were less likely to choose water (vs. a cupcake) in the motivation condition compared to the standard thirsty condition. Study 2 found that 3- to 5-year-old children (N = 22) were also less likely to choose water for right now versus a cupcake when thirst was induced.

The most striking feature of any cognitive system is its ability to keep learning cumulatively and exploit its experiences prospectively to anticipate, reason and produce goal-oriented behaviors. At the core of this intriguing capability lies our memory. Every touch, sound, sight, taste triggers our memory, enabling us to remember and flexibly connect our past experiences, with the available present to the possible future. While emerging trends in neurosciences are rapidly enriching our understanding of the functional organization of memory in the brain, a prospective memory architecture is also a central design feature necessary if robots are to truly become commonplace assistants in numerous application domains (domestic, industrial, others) and in the complexity of the environments we inhabit and create (where neither everything can be known nor can everything be experienced). Hence, with the central premise that cognition is constructive manipulation of memory, this thesis proposes a novel brain guided perspective on the design of cognitive architectures for cumulatively developing systems. Set up in the context of several experiments from animal and infant cognition reenacted on the iCub humanoid, a principled framework for cumulative learning of actions, skills, affordances and cause-effect relations through multiple streams (imitation, exploration, linguistic inputs) is proposed. How such diverse experiences of the robot learnt in past are recalled based on present context, combined with explorative actions to learn something new, creatively connected to generate novel behaviors in the context of sought goals is demonstrated through several tasks. The proposed integrated machinery provides for a shared computational basis for recalling of the past and simulation of the future in line with the emerging trends from neuroscience (like the brain’s default mode network). A notable transition further is the porting of the framework developed on iCub humanoid to real world industrial settings in tasks like assembly and manufacturing (facilitating runtime reasoning and quick switchover to novel assembly tasks). In this sense, the proposed architecture brings together the fields of Robotics, Developmental Psychology, and Neuroscience to craft cognitive and adaptable End User Applications while at the same time provides insights into the functional organization of the brain. In parallel, it lays the foundation for a new generation of cognitive architectures that are domain agnostic (i.e. support open-ended learning), partially embodiment agnostic (i.e. are configurable to new robotic platforms), partially self-driven (i.e. can generate their own internal goals) and brain guided.

Introduction Major depressive disorder (MDD) and trauma-related disorders are associated with deficits in remembering the past and imagining the future (i.e., episodic simulation). We examined parental bonding and neuropsychological performance in relation to episodic simulation in trauma-exposed patients with recurrent MDD. Methods Trauma-exposed patients with MDD (n = 21) and matched controls (n = 20) completed a future-oriented Autobiographical Interview, the Parental Bonding Instrument, and a standardized neuropsychological battery. Results Patients with major depressive disorder generated fewer episodic details for future neutral events compared to controls. Although higher reported levels of maternal care were associated with increased specificity of negative future events among the patient group, higher maternal overprotection was related to decreased specificity of negative and positive future events. Higher levels of performance on measures of intelligence, verbal memory, executive functioning, and sustained attention were associated with increased specificity of future events. Conclusions Maternal relations during childhood and neuropsychological performance are related to the specificity of episodic simulation in adult patients with MDD. Childhood experience continues to influence memory performance into adulthood.

One of the key goals of memory research is to develop a basic understanding of the nature and characteristics of memory processes and systems. Another important goal is to develop useful applications of basic research to everyday life. This editorial considers two lines of work that illustrate some of the prospects for applying memory research to everyday life: interpolated quizzing to enhance learning in educational settings, and specificity training to enhance memory and associated functions in individuals who have difficulties remembering details of their past experiences.

Functional neuroimaging studies have noted that brain regions supporting theory of mind (ToM) overlap remarkably with those underlying episodic memory, suggesting a link between the two processes. The present study shows that memory for others’ past experiences modulates significantly our appraisal of, and reaction to, what is happening to them currently. Participants read the life story of two characters; one had experienced a long series of love-related failures, the other a long series of work-related failures. In a later faux pas recognition task, participants reported more empathy for the character unlucky in love in love-related faux pas scenarios, and for the character unlucky at work in work-related faux pas scenarios. The memory-based modulation of empathy correlated with the number of details remembered from the characters’ life story. These results suggest that individuals use memory for other people’s past experiences to simulate how they feel in similar situations they are currently facing. The integration of ToM and memory processes allows adjusting mental state inferences to fit unique social targets, constructing an individualized ToM (iToM).

Studies on memory, imagination, and empathy have largely progressed in isolation. Consequently, humans' empathic tendencies to care about and help other people are considered independent of our ability to remember and imagine events. Despite this theoretical autonomy, work from across psychology, and neuroscience suggests that these cognitive abilities may be linked. In the present paper, I tentatively propose that humans' ability to vividly imagine specific events (as supported by constructive memory) may facilitate prosocial intentions and behavior. Evidence of a relationship between memory, imagination, and empathy comes from research that shows imagination influences the perceived and actual likelihood an event occurs, improves intergroup relations, and shares a neural basis with memory and empathy. Although many questions remain, this paper outlines a new direction for research that investigates the role of imagination in promoting empathy and prosocial behavior.

Human memory is not a literal reproduction of the past, but instead relies on constructive processes that are sometimes prone to error and distortion. Understanding of constructive memory has accelerated during recent years as a result of research that has linked together its cognitive and neural bases. This article focuses on three aspects of constructive memory that have been the target of recent research: (i) the idea that certain kinds of memory distortions reflect the operation of adaptive cognitive processes that contribute to the efficient functioning of memory; (ii) the role of a constructive memory system in imagining or simulating possible future events; and (iii) differences between true and false memories that have been revealed by functional neuroimaging techniques. The article delineates the theoretical implications of relevant research, and also considers some clinical and applied implications.