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2 results on '"Favre, Claudio"'

1. 'β3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells

Author

Calvani, Maura, Cavallini, Lorenzo, Annalisa, Tondo, Spinelli, Valentina, Luisa, Ricci, Pasha, Amada, Bruno, Gennaro, Buonvicino, Daniela, Bigagli, Elisabetta, Vignoli, Marina, Bianchini, Francesca, Sartiani, Laura, Lodovici, Maura, Semeraro, Roberto, Fontani, Filippo, De Logu, Francesco, Dal Monte, Massimo, Chiarugi, Paola, Favre, Claudio, and and Luca Filippi

Subjects
Beta3-adrenoreceptors, melanoma, enbryonic stem cells
Published
2018

2. The prognostic value of biological markers in paediatric Hodgkin lymphoma

Author

Gaetano Bottigliero, Maurizio Mascarin, Roberta Caruso, Simone Cesaro, Grazia Iaria, Marco Zecca, Ada Zaccaron, Paolo Pierani, Giuseppe Puccio, Claudio Favre, Giulio Murgia, Massimo Provenzi, Franco Locatelli, Fulvio Porta, Eva Passone, Carlo Cosmi, Nadia Mirra, Giulio Andrea Zanazzo, Monica Cellini, Roberta Pericoli, Roberta Burnelli, Raffaela De Santis, Antonella Sau, Fausto Fedeli, Marta Pillon, Alberto Garaventa, Salvatore D'Amico, Katia Perruccio, Alessandra Todesco, Maurizio Caniglia, Caterina Consarino, Domenico Sperlì, Luigi Nespoli, Piero Farruggia, Andrea Pession, Tommaso Casini, Nicola Santoro, Maurizio Bianchi, P Bertolini, Adele Civino, Alessandra Sala, Paolo D'Angelo, Mauro Caini, Giovanni Scarzello, Angela Trizzino, Salvatore Buffardi, Roberto Rondelli, Farruggia, Piero, Puccio, Giuseppe, Sala, Alessandra, Todesco, Alessandra, Buffardi, Salvatore, Garaventa, Alberto, Bottigliero, Gaetano, Bianchi, Maurizio, Zecca, Marco, Locatelli, Franco, Pession, Andrea, Pillon, Marta, Favre, Claudio, D'Amico, Salvatore, Provenzi, Massimo, Trizzino, Angela, Zanazzo, Giulio Andrea, Sau, Antonella, Santoro, Nicola, Murgia, Giulio, Casini, Tommaso, Mascarin, Maurizio, and Burnelli, Roberta

Subjects
Male, Oncology, Cancer Research, Pathology, Time Factors, Databases, Factual, medicine.medical_treatment, hodgkin lymphoma, paediatric, prognostic factor, Hodgkin lymphoma, Paediatric, Prognostic factor, Adolescent, Age Factors, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Child, Child, Preschool, Disease Progression, Disease-Free Survival, Female, Ferritins, Hodgkin Disease, Humans, Infant, Infant, Newborn, Italy, Kaplan-Meier Estimate, Leukocyte Count, Multivariate Analysis, Neoplasm Staging, Platelet Count, Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk Factors, Treatment Outcome, Blood Platelets, Eosinophils, Procarbazine, chemistry.chemical_compound, 0302 clinical medicine, Prednisone, Tumor, Vinblastine, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, 030220 oncology & carcinogenesis, medicine.drug, medicine.medical_specialty, Vincristine, Dacarbazine, Bleomycin, Databases, 03 medical and health sciences, Internal medicine, medicine, Preschool, Factual, Chemotherapy, business.industry, Newborn, chemistry, ABVD, business, Biomarkers, 030215 immunology
Abstract

Background Many biological and inflammatory markers have been proposed as having a prognostic value at diagnosis of Hodgkin lymphoma (HL), but very few have been validated in paediatric patients. We explored the significance of these markers in a large population of 769 affected children. Patients and methods By using the database of patients enrolled in A.I.E.O.P. (Associazione Italiana di Emato-Oncologia Pediatrica) trial LH2004 for paediatric HL, we identified 769 consecutive patients treated with curative intent from 1st June 2004 to 1st April 2014 with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), or hybrid COPP/ABV (cyclophosphamide, vincristine, prednisone, procarbazine, doxorubicin, bleomycin and vinblastine) regimens. Results On multivariate analysis with categorical forms, the 5-year freedom from progression survival was significantly lower in patients with stage IV or elevated value of platelets, eosinophils and ferritin at diagnosis. Furthermore, stage IV and eosinophils seem to maintain their predictive value independently of interim (after IV cycles of chemotherapy) positron emission tomography. Conclusion Using the combination of four simple markers such as stage IV and elevated levels of platelets, ferritin and eosinophils, it is possible to classify the patients into subgroups with very different outcomes.

Published
2016

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