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Cowchock Wapner Kurtz syndrome is a very rare disease and lethal disorder with cervical lymphangioma obstructing the airway and causing complications, with accelerated growth resembling a teratoma. We report a 21-month-old infant with a congenital giant neck cystic hygroma, cleft palatal and deformation of the surrounded area by lymphedema and tissue swelling; started with respiratory compromise because the expansion of the malformation, requiring repetitive surgeries without remission, showing recurrence and accelerated growth of the mass. It was used sclerotherapy with Picibanil, without satisfactory response; the patient suffered a rapid deterioration and dead. This is a rare syndrome of genetic etiology currently not clarified; apparently from healthy parents, and patient’s karyotype normal, maybe can be a micro deletion that only could be detected using advanced cytogenetics.

Cutaneous syndactyly is a malformed condition in which fingers are joined together. It is one of the most common hereditary limb malformations depicting the fusion of certain fingers and/or toes, and can involve the bones or just the skin. The type affecting the feet by the fusion of two or more toes may occur as an isolated entity with nonsyndromic phenotype or a component of many genetic syndromes: principally Apert, Carpenter, and Smith-Lemli- Opitz. We present the case of a healthy 2-year-old boy with a complete cutaneous syndactyly, bilateral and near symmetrical in both feet, which appears to represent a non-syndromic phenotype that is unclassified and previously undescribed.