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Tisagenlecleucel demonstrated high response rates and a manageable safety profile in adults with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) in the JULIET trial. However, lack of response and chimeric antigen receptor (CAR) T-cell exhaustion were observed in patients with programmed cell death protein 1 (PD-1) overexpression. Hence, pembrolizumab, a PD-1 inhibitor, was hypothesized to improve efficacy and cellular expansion of CAR T-cells in vivo. Here, we report the final analysis of the PORTIA trial in adult patients with r/r DLBCL who had ≥2 prior lines of therapy and had an Eastern Cooperative Oncology Group performance status of ≤1. Patients received 1 tisagenlecleucel infusion on day 1. Pembrolizumab (200 mg) was given every 21 days, for up to 6 doses. Three cohorts initiated pembrolizumab on days 15 (n = 4), 8 (n = 4), or –1 (n = 4). Safety, efficacy, cellular kinetics, and biomarker analyses were included. Tisagenlecleucel plus pembrolizumab was feasible and showed a manageable safety profile, without dose-limiting toxicities. Emerging efficacy with tisagenlecleucel was observed when pembrolizumab was given the day before tisagenlecleucel; however, the limited patient sample and short follow-up do not allow for definitive conclusions. Adding pembrolizumab to tisagenlecleucel did not augment the cellular expansion of tisagenlecleucel but delayed peak expansion if given the day before tisagenlecleucel (NCT03630159).

O presente trabalho se propõe a refletir sobre a experiência da disciplina Urbanismo II, a qual foi ministrada desde 2011, ao terceiro ano do curso de Arquitetura e Urbanismo, da Universidade Estadual de Maringá. O desafio colocado pela disciplina é debater o alcance do direito à cidade no processo de planejamento urbano municipal através do exercício que perpasse a escala do plano e do projeto urbano. Desta forma o conteúdo é desenvolvido em equipe a partir de três etapas: inicia-se com debate a cerca dos marcos em direção ao direito à cidade desde o Movimento Nacional pela Reforma Urbana criado em 1985, Constituição Federal promulgada em 1988, Estatuto da Cidade (Lei 10.257/01) e a ressignificação dos Planos Diretores. Na segunda etapa é desenvolvida uma leitura-diagnóstico de um município de pequeno porte, seguida da construção da síntese da problemática levantada, elaboração de uma hipótese e estratégia para estruturação da paisagem. A terceira etapa consiste na proposta de um projeto urbano a partir do uso do instrumento Operação Urbana Consorciada, tendo como elemento obrigatório a inserção de habitação de interesse social, mobilidade urbana e sustentabilidade ambiental-urbana.

Background: Continuous oral targeted therapies (OTT) represent a major economic burden on the Canadian healthcare system, due to their high cost and administration until disease progression/toxicity. The recent introduction of venetoclax-based fixed-duration combination therapies has the potential to reduce such costs. This study aims to estimate the prevalence and the cost of CLL in Canada with the introduction of fixed OTT. Methods: A state transition Markov model was developed and included five health states: watchful waiting, first-line treatment, relapsed/refractory treatment, and death. The number of CLL patients and total cost associated with CLL management in Canada for both continuous- and fixed-treatment-duration OTT were projected from 2020 to 2025. Costs included drug acquisition, follow-up/monitoring, adverse event, and palliative care. Results: The CLL prevalence in Canada is projected to increase from 15,512 to 19,517 between 2020 and 2025. Annual costs were projected at C$880.7 and C$703.1 million in 2025, for continuous and fixed OTT scenarios, respectively. Correspondingly, fixed OTT would provide a total cost reduction of C$213.8 million (5.94%) from 2020 to 2025, compared to continuous OTT. Conclusions: Fixed OTT is expected to result in major reductions in cost burden over the 5-year projection, compared to continuous OTT.

Background: Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding. Methods: Fifty subacute stroke patients (7±3days poststroke) underwent diffusion-weighted magnetic resonance imaging and a battery of clinical tests of motor and cognitive functions. We defined indices of impairment in strength, dexterity, and attention. We also computed imaging-based probabilistic tractography and whole-brain connectomes. To efficiently integrate inputs from different sources, brain networks rely on a rich-club of a few hub nodes. Lesions harm efficiency, particularly when they target the rich-club. Overlaying individual lesion masks onto the tractograms enabled us to split the connectomes into their affected and unaffected parts and associate them to impairment. Results: We computed efficiency of the unaffected connectome and found it was more strongly correlated to impairment in strength, dexterity, and attention than efficiency of the total connectome. The magnitude of the correlation between efficiency and impairment followed the order attention>dexterity ≈ strength (strength: | r |=.03, P =0.02, dexterity: | r |=.30, P =0.05, attention: | r |=.55, P Conclusions: Attentional impairment is more sensitive to disruption of coordinated networks between brain regions than motor impairment, which is sensitive to disruption of localized networks. Providing more accurate reflections of actually functioning parts of the network enables the incorporation of information about the impact of brain lesions on connectomics contributing to a better understanding of underlying stroke mechanisms.

Introdução: A obesidade é uma doença de etiologia multifatorial, se apresentando como uma das mais prevalentes síndromes do mundo. Tal condição pode ser definida como excesso de gordura corporal, mensurada pelo IMC. A moléstia pode apresentar diversas repercussões negativas no bem-estar do indivíduo, como doenças metabólicas e cardiovasculares, além de prejuízos sociais e psicológicos. Objetivo: O presente estudo teve como objetivo realizar uma revisão narrativa acerca das principais consequências da obesidade a longo prazo. Método: Trata-se de uma revisão narrativa com buscas na Scielo, Pubmed e Lilacs, no período de 2012 a 2022, utilizando os termos chave: “obesidade”, “consequências”, “evolução médica”, “obesity” e “consequences”. Resultados: Foram selecionados 10 artigos no total, sendo 4 na Scielo, 4 no Pubmed e 2 na Lilacs, por corresponderem ao objetivo do trabalho. Discussão: A principal consequência da obesidade se apresenta nos distúrbios metabólicos, com destaque para a Diabetes tipo 2, devido ao aumento da inflamação e, portanto, da resistência à insulina. Outros impactos repercutem na osteoartrite, diversos tipos de câncer, doença renal crônica e condições que podem levar a pessoa acometida a óbito. Indivíduos obesos estão vulneráveis a questões sociais, como isolamento e discriminação e podem, portanto, desenvolver doenças psicológicas. Conclusão: Conclui-se que a obesidade deve ser tratada de forma multidisciplinar, sugerindo novos estudos relacionados aos prejuízos laborais sofridos pelos trabalhadores obesos.

A abordagem agroecológica promove a autonomia, devido valorizar os produtos locais, promover o diálogo e a troca de saberes por meio do reconhecimento dos métodos tradicionais de manejo produtivo. A construção de Unidades de Aprendizagem (UA) se deu com o diálogo entre o conhecimento das famílias agricultoras e o formal dos técnicos, para a inclusão socioprodutiva das famílias beneficiárias da Política Pública (PBSM), de território rural Sergipano. A metodologia foi de pesquisa-ação-participativa, envolvendo 120 famílias. As UAs geraram conhecimentos adaptados à realidade das famílias, permitindo a construção de um novo conhecimento sobre a realidade local promovendo soluções que geraram maior autonomia com a utilização de insumos locais. É incontestável o papel das políticas públicas para promoção da autonomía e segurança alimentar e nutricional das famílias

Phosphorus (P) deficiency impairs productivity of ruminants and is the most expensive mineral used in supplements for cattle and buffalo under Brazilian grazing conditions. There is a need for the rational use of P, particularly under extensive grazing conditions, as this mineral resource is expensive and the world’s supplies are exhaustible. The diagnosis of P deficiency must start with careful and detailed history taking, followed by clinical examination of the herd and the use of ancillary tests. The latter are complementary to the diagnosis; they should be neither the first nor the most important steps when conducting a professional diagnosis. The indication of corrective or prophylactic measures necessarily involves the correct diagnosis of P deficiency (in herds), whether it be clinical or subclinical. This review discusses the main aspects related to P for cattle and buffaloes under grazing conditions in Brazil.

Este texto é a tradução inédita de um fragmento do artigo co-escrito pela gerente de projeto do Portail des Arts de la Marionnette (https://lelab.artsdelamarionnette.eu) e pelo diretor de inovação da prestadora de serviços PMB Services. O texto original (em francês) foi publicado em duas partes, uma em 2021 e outra em 2022, em Les Cahiers de la Documentation (ABD/BVD, Bruxelas). O texto apresenta a experiência sobre este projeto de valorização online de um conjunto de dados heterogêneos (catálogos de bibliotecas, objetos e documentos digitalizados e metadados relacionados, dados de pesquisa) produzidos por um consórcio atualmente composto por vinte e sete instituições e coordenado desde 2009 pelo Institut International de la Marionnette-IIM (França).Essa valorização é realizada através do software livre PMB, sobre um modelo semântico notadamente inspirado em FRBRoo e SKOS.

Objetivou-se avaliar a motilidade e o vigor de espermatozoides bovinos (in natura) quando submetidos a diferentes tipos de carboidratos. Três amostras de sêmen de cada quatro touros da raça Gir leiteiro foram utilizadas. Estas foram divididas em grupos: glicose (6mM); frutose (6mM); lactose (6mM) e sacarose (6mM), definindo assim quatro grupos e uma alíquota foi mantida sem a presença de carboidratos. Todas as amostras foram acondicionadas em tubos tipo eppendorf e mantidas a 37C em banho maria e avaliadas quanto a motilidade e vigor em intervalos de 10 mim, em microscopia de campo claro x10. Os dados foram expressos em média e desvio padrão. Análise de variância (ANOVA) foi realizada seguida pelo pós-teste de Tukey. P

OBJECTIVE The aim was to evaluate edentulous patient's willingness to accept or refuse the offer and provision of implant-retained treatment. METHODS As part of a clinical trial, edentulous subjects were offered a mandibular overdenture retained by four mini-implants opposing a conventional maxillary denture. Treatment was offered without any financial costs for the patients. Patients' level of interest in receiving treatment was assessed using a 5-point Likert scale and they were asked to respond to a list of reasons that led to their decision to accept or refuse implants. Those who refused implants received conventional prosthodontic interventions as required, and those who accepted implant treatment underwent surgical planning and implant placement. RESULTS Of 175 eligible subjects, 147 accepted the offer of treatment and were invited to take part in the study (69.4% women, mean age 67.4±10.0 years). Overall, 111 patients (75.5%) expressed a positive intention to undergo implant treatment at the initial contact. Implant treatment was performed for 56.3% (9/16) of those who answered "probably yes" about their level of interest in implant treatment on the Likert scale, and 69.6% (64/92) of "certainly yes" (p

International audience; Fast, low-cost and efficient energy storage technologies are urgently needed to balance the intermittence of sustainable energy sources. High-power capacitors using organic polymers offer a green and scalable answer. They require dielectrics with high permittivity ($\epsilon _r$) and breakdown strength ($E_B$), which bio-based poly(hydroxy urethane)s (PHUs) can provide. PHUs combine high concentrations of hydroxyl and carbamate groups, thus enhancing their $\epsilon _r$, and a highly tuneable glass transition ($T_g$), which dictates the regions of low dielectric losses. By reacting erythritol dicarbonate with bio-based diamines, fully bio-based PHUs were synthesised with $T_g$ ~ 50 °C, $\epsilon _r$ > 8, $E_B$ > 400 MV•m$^{-1}$ and low losses (tan δ < 0.03). This results in energy storage performance comparable with the flagship petrochemical materials (discharge energy density, $U_e$ > 6 J•cm$^{-3}$) combined with a remarkably high discharge efficiency, with η = 85% at $E_B$ and up to 91% at 0.5 $E_B$. These bio-based PHUs thus represent a highly promising route to green and sustainable energy-storage.

An important advantage of optical signal processing is the possibility of performing various operations in parallel. Among the techniques proposed for parallel optical signal processing, frequency division multiplexing (FDM) is a well-known approach, in which different operations are performed in multiple sub-channels associated with different frequency bands. Here, we demonstrate the possibility of performing parallel optical signal processing by frequency division multiplexing of the edge modes of a topological photonic structure. This leads to the realization of a multiple-input-multiple-output (MIMO) topological optical signal processor that is capable of performing several analog functionalities simultaneously, enhancing the speed of computation significantly. Our theoretical and experimental findings open up the venue towards the realization of a new generation of multi-functional topological optical signal processing systems that are ultra-fast, consume little power, and enjoy strong protection against disorder.

To evaluate the test-retest reliability and validity of the Patient Generated Index (PGI) in individuals with Chronic Kidney Disease (CDK) undergoing hemodialysis. Through a non-experimental study with repeated measures, PGI was applied twice to assess internal consistency and test-retest reliability. Correlations with the Kidney Disease Quality of Life Short Form (KDQOL-SF), the Human Activity Profile (HAP) questionnaire, the Social Participation Scale, and the Glittre ADL Test were used. 91 individuals with CKD were evaluated. There was high reliability for the PGI (ICC= 0.97) PGI correlated with KQDOL – SF in Functional Capacity r = 0.38 (p < 0.001), Emotional Well-Being r = 0.31 (p = 0.003), Social Aspect r = 0.22 (p = 0.036), Emotional Function r = 0.22 (p = 0.038) and Effect of Kidney Disease r = 0.21 (p = 0.042), and Physical scores r = 0.24 (p = 0.021)), Mental r = 0.21 (p = 0.05) and General r = 0.22 (p = 0.037) summarized. There was a significant correlation between PGI and HAP r = 0.40 (p < 0.001) and the Social Participation Scale r = −0.36 (p < 0.001). There was no correlation between the PGI and Glittre ADL scores r = 0.12 (p = 0.247). In adults receiving hemodialysis, the PGI proved to be an accurate and reliable instrument for the assessment of the quality of life from the perspective of the patient.IMPLICATIONS FOR REHABILITATIONAlthough hemodialysis treatment is associated with increased survival and symptom control, there is a significant change in the patient’s lifestyle.In order to provide a more focused view of the individual, the Patient Generated Index (PGI) was created to evaluate the quality of life.PGI is reliable and correlates with KQDOL – SF and the Social Participation Scale in this population. Although hemodialysis treatment is associated with increased survival and symptom control, there is a significant change in the patient’s lifestyle. In order to provide a more focused view of the individual, the Patient Generated Index (PGI) was created to evaluate the quality of life. PGI is reliable and correlates with KQDOL – SF and the Social Participation Scale in this population.

Objetivo: O objetivo geral deste trabalho foi avaliar de que modo fatores descritivos de rivalidade se combinam de diferentes maneiras para constituir esse sentimento manifestado em diversos graus de intensidade.Métodos: Aplicou-se um questionário distribuído nas redes sociais com questões fechadas em uma Escala Likert de 7 pontos para medir seis fatores relacionados à rivalidade. Para analisar os dados utilizou-se a Coincidence Analysis (CNA) calibrados utilizando fuzzy-set em uma especificação alternativa da Totally Fuzzy and Relative.Originalidade/Relevância: O construto focal desta investigação é a rivalidade e a pretensão é contribuir com a literatura abordando a maneira na qual os fatores se combinam para constituição desse sentimento. Utilizando fatores relacionados à rivalidade e avaliando como se combinam para constituir o construto.Resultados: O resultado observado envolve os fatores estudados do conceito em uma relação de necessidade e suficiência na constituição do comportamento de rivalidade, embora não seja necessário que ocorram juntos. O resultado evidencia três caminhos alternativos para rivalidade indo desde o comportamento em que um grupo se satisfaz em vencer os rivais, passando por uma rivalidade mais visceral em que os torcedores assistem aos jogos do adversário para torcer por sua derrota, até a extrapolação do desejo de derrota para várias outros aspectos envolvidos com a equipe rival.Contribuições teóricas/metodológicas: O trabalho agrega à literatura ao evidenciar três caminhos alternativos básicos para que a rivalidade se constitua para um torcedor. É possível aplicar essas ideias na construção de teorias sobre o conceito de rivalidade e sua ligação às sensações de cada indivíduo em relação à agremiação que ele escolheu como inimigo.

Background: The presence of a breast nurse is recommended to advise and guide early breast cancer patients before and during chemotherapy/radiation therapy, and at the end of planned treatments. Nevertheless, some patients will need extra guidance. Little is known about the predisposing factors for additional requests. Aim and Objective: Determine time, reasons, and risk factors for breast nurse unplanned solicitations. Design and Methods: This monocentric retrospective study included all early breast cancer patients treated with chemotherapy during 1 year. Unplanned solicitations (in person, by phone, or by e-mail) were recorded in the medical file. They were extracted and stratified in four categories: treatment adverse events, medical condition, psychological support, and counselling. Results: 368 unplanned solicitations were observed for 265 patients, 140 patients (52.8%) asked for at least one unplanned solicitation and 57 (21.5%) asked for at least three. There was no significant difference between the four categories. Most of unplanned solicitations occurred significantly during chemotherapy, essentially after first docetaxel infusion (57% of calls). In univariate and multivariate analyses, anxiolytic treatment was significantly associated with more unplanned solicitations (OR = 2, p = 0.02), while a personal breast cancer history was associated with fewer unplanned solicitations (OR = 0.49, p = 0.05). Conclusion: Breast nurse unplanned solicitations during adjuvant or neoadjuvant chemotherapy in early breast cancers are frequent. Even if patients with anxiolytic treatment have a slightly higher risk of solicitation, no typical profile of a patient who will need extra support exists. Because of its known toxicity, the first cycle of docetaxel is associated with a clear increase in solicitations. Despite physicians’ consultations, breast nurses guidance, and leaflets on supportive care and treatments side effects, optimal patient management during early breast cancer remains challenging. Further randomized studies testing more customized tools are required to improve patient support.

Background: Lead is harmful for humans by having adverse effects on different biological systems. Venepuncture is the gold standard for blood lead level analysis, but this method has many flaws. The goal of this research was to develop and validate a more practical approach for blood sampling. Materials & methods: Mitra® devices based on VAMS® and inductively coupled plasma–MS/MS technologies were employed. Performance evaluation of the newly developed method was also performed by comparing it versus a commonly used method at the Centre de Toxicologie du Québec for blood lead level analysis. Results: Comparison showed no signs of significant difference between the two methods. Conclusion: VAMS may be a useful alternative sampling approach for further research on blood lead analysis and possibly for many other trace elements.

This study aimed to investigate whether hot-melt extrusion (HME) processing can promote molecular encapsulation of a multi-component natural product composed of volatile and pungent hydrophobic substances (ginger oleoresin, OR) with cyclodextrins. 6-gingerol and 6-shogaol, the biomarkers of ginger OR, were quantified by HPLC. Phase-solubility studies were performed using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) for ginger OR complexation. Solid complexes were then prepared by thermal (HME) and solvent (slurry, SL)-based methods. Morphology, thermal behavior, solubility, in vitro dissolution, and in vivo anti-inflammatory activity were evaluated. HPβCD gave rise to AL-type complexes with ginger OR, whereas βCD led to materials with limited solubility. Ginger OR was complexed with HPβCD by HME without significant change in gingerol and shogaol content. Additionally, TGA suggested higher volatile retention in HME complexes than SL ones. Shogaol and gingerol solubility and dissolution significantly increased from SL and HME complexes compared with ginger OR. In turn, 1: 2 OR/HPβCD HME complex showed higher 6-shogaol solubility than SL, associated with a gradual release. The carrageenan-induced pleurisy test showed that the anti-inflammatory activity of ginger OR was maintained after complexation with HPβCD. The complexes significantly decrease the levels of IL-1β and inhibit cell migration. HME complex showed performance equivalent to the positive control and superior to the SL material. Taken together, these results indicate that HME can be useful for promoting the molecular encapsulation of complex natural products that contain volatile and thermolabile substances. HME complexes showed better in vivo and in vitro performance than complexes prepared using the solvent-based method.

Nesta pesquisa, de abordagem qualitativa, do tipo pesquisa-ação, buscou-se investigar quais saberes docentes podem ser identificados no pensamento complexo e transdisciplinar que possibilitam a renovação da prática pedagógica, com o objetivo de analisar junto a professores doutorandos a pertinência da construção de saberes docentes baseados no paradigma complexo e transdisciplinar, como construtos que possam subsidiar novas práticas pedagógicas. Como resultados, foi possível perceber que a abordagem da complexidade e o acolhimento da visão transdisciplinar exigem a reforma do pensamento e a necessidade emergente da religação dos saberes requeridos para o desenvolvimento de uma prática pedagógica inovadora.

Este artigo contribui para a compreensão do campo da utopia crítica contemporânea no nexo das mudanças climáticas ao consolidar teóricos, principais conceitos e abordagens metodológicas. Foi realizada uma revisão sistemática a partir das bases Web of Science e da BNU com analise VosViewer. Além da parte metodológica e resultados, há na parte da discussão um enquadramento da utopia à luz da teoria social contemporânea. Também é apresentada a análise do campo com teóricos contemporâneos como El-Ojeili, Elliott, Jameson, Levitas e Urry no nexo entre utopia e mudanças climáticas. As considerações finais apontam para novas formas de se interpretar e criticar os sistemas dominantes e para um desenvolvimento de uma sociologia do futuro capaz de mobilizar a utopia e o futuro inscritos no presente como quadros ideológico-utópicos para a emancipação e transformação socioclimática para humanos e não humanos.

Background: Vitamin D plays an important role in the prevention of many diseases. More than 1 billion people worldwide suffer from vitamin D deficiency. Vitamin D deficiency can contribute to the development of 16 types of cancer (breast, colon, prostate, etc.), cardiovascular diseases, stroke, autoimmune diseases, periodontal pathologies, transplant failure in endo-alveolar surgery, etc. There are several risk factors that would prevent the achievement of treatment objectives. The national protocol for deficiency rickets prevention privileges vitamin D2 versus vitamin D3, which creates a medical risk factor compromising oral health in both children and adults. The article provides sufficient arguments in favour of vitamin D3 vs vitamin D2 prescription for prophylactic and treatment purposes. Conclusions: Considering that vitamin D deficiency is currently a global public health problem, it can be proposed to declare vitamin D deficit/deficiency a priority public health problem at the national level. Vitamin D3 should be elective in preventing deficit. Taking into account the multitude of acute and chronic diseases related to vitamin D deficiency, in order to improve the status of vitamin D in all population categories, it is necessary to include vitamin D3 in the list of molecules fully subsidized by the state and distributed free of charge at least to children under the age of 5 years and adolescents in the period of intensive growth.

The COVID-19 pandemic led to rapid adoption of telemedicine for health-care service delivery. There are concerns that older adults, the highest users of the health-care system, would be left behind because of this shift. It remains unclear how the pandemic impacted telemedicine and other health-care service use in this group. We conducted a population-based, weekly cross-sectional study using administrative data from Ontario, Canada. Telemedicine use was measured for the overall older-adult population aged 65+ and across sociodemographic groups from January 2018 to March 2021. We also assessed the use of key health-care services between high and low patient users of telemedicine who were diagnosed with dementia. We found that telemedicine visits outnumbered in-person visits in older adults during the pandemic (average of 74 vs. 62 visits per 1000 per week). Of all specialties, psychiatrists delivered the most telemedicine visits, reaching 90% of visits in a week. Higher rates of telemedicine use during COVID-19 were found for patients who resided in urban regions (84 visits per 1000 per week), but no differences were found across income quintiles. Among dementia patients, high telemedicine users had higher health-care utilization than low telemedicine users (i.e., 21,108 vs. 3,276 outpatient visits per week) during the pandemic. Findings suggest that telemedicine was crucial in helping older adults, a group most vulnerable to COVID-19, maintain access to care during the pandemic. Telemedicine presents an important opportunity for older adults; however, future research should focus on barriers to equitable access and quality of care provided through telemedicine.

Cette étude montre comment les données de conductivité mesurées par des sondes déployées sur un réseau de distribution d’eau potable peuvent être exploitées de manière automatique pour résumer et expliquer les variations spatiales de qualité d’eau. Un algorithme de classification non supervisée est utilisé pour regrouper les sondes dont les profils de conductivité se ressemblent et proposer ainsi des groupes représentant des zones de qualité d’eau homogène. La méthodologie est évaluée sur le réseau du Syndicat des eaux d’Île-de-France (Sedif), à partir des données de 215 sondes mesurant la conductivité toutes les cinq minutes. Deux types de résultats sont présentés : d’une part, l’image d’ensemble de la qualité de l’eau dans le réseau ; d’autre part, une typologie des différents phénomènes mis au jour par la méthode. Les résultats présentés montrent que les différentes zones de qualité d’eau connues par l’expertise métier sont repérées automatiquement, et que de nombreuses sous-zones jusqu’alors inconnues sont identifiées. Ainsi les conséquences des restitutions de réservoir, des interconnexions avec des distributeurs voisins, de l’âge de l’eau, des mélanges d’eaux produites par différentes usines, sont mises en évidence par la méthodologie proposée. Pour le réseau du Sedif, les résultats ont montré que 96 % des sondes pouvaient être affectées à un groupe. Cette méthodologie peut être appliquée à tout réseau équipé de capteurs de conductivité, dès lors qu’il est susceptible d’être alimenté par des eaux de qualités différentes.

International audience; Establishing an effective collaboration between augmented-reality (AR) and remote desktop users is a challenge because collaborators do not share a common physical space and equipment. Yet, such asymmetrical collaboration configurations are common today for many design tasks, due to the geographical distance of people or unusual circumstances such as a lockdown. We conducted a first study to investigate trade-offs of three remote representations of an AR workspace: a fully virtual representation, a first-person view, and an external view. Building on our findings, we designed ARgus, a multi-view video-mediated communication system that combines these representations through interactive tools for navigation, previewing, pointing, and annotation. We report on a second user study that observed how 12 participants used ARgus to provide remote instructions for an AR furniture arrangement task. Participants extensively used its view transition tools, while the system reduced their reliance on verbal instructions.

To propose a new classification system for evaluating fibrous capsules around silicone implants using magnetic resonance.We retrospectively evaluated 90 consecutive patients who underwent breast MRI scans at a single center from February to March 2022. All patients with silicone implants and contrast dynamic sequences were included. Two radiologists classified the fibrous capsules according to the proposed classification in four grades. Interobserver variability was calculated for the final score. For comparison purposes, the inter-rater agreement of background parenchymal enhancement and the amount of fibroglandular tissue were also calculated.Reader 1 classified 2 (2.2) fibrous capsules as grade 1, 7 (7.8) as grade 2, 18 (20.0) as grade 3, and 63 (70.0) as grade 4, whereas reader 2 classified 1 (1.1), 9 (10.0), 24 (26.7), and 56 (62.2) fibrous capsules, respectively, for each grade. The interobserver agreement for fibrous capsule classification was moderate (ĸ = 0.65). The inter-rater agreement of background parenchymal enhancement and amount of fibroglandular tissue were fair: ĸ = 0.50 and ĸ = 0.44, respectively.Our study proposes classifying FC by MRI in patients with SI to standardize the description and classification of the findings with good interobserver agreement.

Objective This study identified patient clinical and sociodemographic characteristics, and, more originally, service use patterns as predictors of death from physical illness or accidental/intentional causes. Methods A cohort of 19,015 patients with substance-related disorders (SRD) from 14 addiction treatment centers was investigated using Quebec (Canada) health administrative databases. Death was studied over a 3-year period (April 1, 2013, to March 31, 2016), and most predictors from 4 years to 12 months prior to the time of death, using multinomial logistic regression. Results Frequent emergency department (ED) use strongly predicted both causes of death, suggesting that outpatient care responded inadequately to patient needs. Only receipt of specialized SRD and psychiatric care significantly decreased the risk of death from physical illness, with trends toward significance for accidental/intentional death. Hospitalization, greater material deprivation and having SRD-chronic physical illnesses or alcohol-related disorders most strongly predicted risk of death from physical illness. Sociodemographic characteristics, mainly social deprivation, were more likely to predict accidental/intentional death. Conclusions Outpatient services could be improved by increasing outreach and motivational interventions and, for ED and hospital units, better screening, brief intervention, and referral to treatment, particularly for men and socially deprived patients at high risk of accidental/intentional death. Patients with more severe health conditions, notably older or materially deprived men at higher risk of death from physical illness, could benefit from programs like assertive community treatment or intensive case management that respond well to diverse and continuous patient needs. Collaborative care between SRD and health services could also be improved.