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BACKGROUND: Very young premenopausal women diagnosed with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+HER2-) early breast cancer (EBC) have higher rates of recurrence and death for reasons that remain largely unexplained. PATIENTS AND METHODS: Genomic sequencing was applied to HR+HER2- tumours from patients enrolled in the Suppression of Ovarian Function Trial (SOFT) to determine genomic drivers that are enriched in young premenopausal women. Genomic alterations were characterised using next-generation sequencing from a subset of 1276 patients (deep targeted sequencing, n = 1258; whole-exome sequencing in a young-age, case-control subsample, n = 82). We defined copy number (CN) subgroups and assessed for features suggestive of homologous recombination deficiency (HRD). Genomic alteration frequencies were compared between young premenopausal women (

It is well known that anomalies of the Indian Summer Monsoon Rainfall (ISMR) are linked to El Nino and Southern Oscillation (ENSO). We show that large anomalies of the ISMR are also linked to the Equatorial Indian Ocean Oscillation (EQUINOO) between states with enhancement/ suppression of atmospheric convection over the western part of the equatorial Indian Ocean with suppression/enhancement over the eastern part and associated changes in the anomaly of the zonal wind along the equator. EQUINOO is the atmospheric component of the coupled Indian Ocean Dipole mode. There is a strong relation between the large anomalies of ISMR and a composite index which is a linear combination of the indices for ENSO and EQUINOO with all seasons with large deficits ( excess) characterized by small ( large) values of the index.However, the variation of ISMR within one standard deviation is more complex and does not appear to be related to the composite index.