1. Expression and clinical significance of S100 family genes in patients with melanoma
- Author
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Dong Li, Ting-feng Xiong, and Fu-qiang Pan
- Subjects
Male ,0301 basic medicine ,S100A7 ,Cancer Research ,medicine.medical_specialty ,Skin Neoplasms ,Gene Expression Omnibus ,Context (language use) ,S100 family ,Dermatology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,melanoma ,medicine ,Humans ,Clinical significance ,Regulation of gene expression ,Clinical pathology ,ORIGINAL ARTICLES: Translational research ,business.industry ,Melanoma ,S100 Proteins ,mRNA expression ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Oncology ,Case-Control Studies ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Cancer research ,Female ,business ,Follow-Up Studies - Abstract
Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the Gene Expression Omnibus database to analyze how expression of these genes correlates with clinical pathology. Compared with normal skin, S100A1, S100A13, and S100B were expressed at significantly higher levels in melanoma samples. S100A2, S100A7, S100A8, S100A9, S100A10, S100A11, and S100P were all highly expressed in primary melanoma samples but were expressed at low levels in metastatic melanoma, and all of these genes were strongly correlated with each other (P
- Published
- 2019