1. Predictive factors for an increased risk of sperm aneuploidies in oligo-astheno-teratozoospermic males
- Author
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Hervé Lejeune, I. Aknin-Seifer, U. Bergues, C. Cans, Sophie Rousseaux, G. Frérot, Sylviane Hennebicq, R. Levy, R. Pelletier, N. Terrier, C. Jimenez, C. De Robertis, A.-K. Faure, ProdInra, Migration, Biologie moléculaire et cellulaire de la différenciation, Université Joseph Fourier - Grenoble 1 (UJF)-Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Joseph Fourier - Grenoble 1 (UJF), CHU Grenoble, Communications Cellulaires et Différenciation (CCD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service d'Information et d'Informatique Médicale, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), and Centre Hospitalier Universitaire de Lyon
- Subjects
Male ,CHROMOSOME ,[SDV]Life Sciences [q-bio] ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Aneuploidy ,Teratozoospermia ,Intracytoplasmic sperm injection ,0302 clinical medicine ,FSH ,OLIGOZOOSPERMIA ,DISOMY ,reproductive and urinary physiology ,media_common ,0303 health sciences ,education.field_of_study ,030219 obstetrics & reproductive medicine ,Sperm Count ,Smoking ,Middle Aged ,Spermatozoa ,[SDV] Life Sciences [q-bio] ,Asthenozoospermia ,Adult ,Urology ,media_common.quotation_subject ,GENETIC ,Population ,Fertility ,[INFO] Computer Science [cs] ,Biology ,TERATOZOOSPERMIA ,Congenital Abnormalities ,INFERTILITY ,Andrology ,03 medical and health sciences ,FISH ,Predictive Value of Tests ,medicine ,Humans ,[INFO]Computer Science [cs] ,Spermatogenesis ,education ,030304 developmental biology ,urogenital system ,Oligospermia ,medicine.disease ,Sperm ,CIGARETTE ,Reproductive Medicine ,Follicle Stimulating Hormone - Abstract
E-mail Address : sophie.rousseaux@ujf-grenoble.fr; International audience; Patients with severe spermatogenesis impairment can now successfully father a child thanks to the use of intracytoplasmic sperm injection (ICSI). In oligozoospermic patients, many studies have reported significantly higher sperm aneuploidy rates and therefore an increased risk of transmitting a chromosomal abnormality via the injection of abnormal spermatozoa. However, the frequency of aneuploidy is highly variable between patients. The aim of the present work was to identify clinical and biological factors, which, together with non-obstructive oligozoospermia, could be predictive of elevated sperm aneuploidies. The sperm aneuploidy rates for chromosomes X, Y, 13, 18 and 21 were assessed in 31 infertile men with well-characterized spermatogenesis impairment, and in a population of control men with proven fertility. The frequency of sperm aneuploidy was compared between several patient subgroups according to their clinical and biological factors. Nearly half of the oligozoospermic males (15/31) had a significantly increased disomy rate for at least one of the five chromosomes compared with that observed in the control population (mean disomy rates + 1.96 standard deviation). Factors significantly associated with higher numbers of aneuploid sperm were cigarette smoking, an elevated follicle-stimulating hormone level, a sperm concentration less than 1 M/mL, and a severe teratozoospermia. Hence, several factors predictive of an increased risk of sperm aneuploidy rates were identified in ICSI male candidates with a non-obstructive oligozoospermia.
- Published
- 2007
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