29 results on '"GUO Xiaoling"'
Search Results
2. A Missense Mutation in the SOX5 Gene (c.221C>T) Causes Mental Retardation in a Chinese Family
- Author
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Yang Xiujuan, Gan Zhongzhi, Guo Xiaoling, Huang Xiang, Liu Juan, Zheng Yingchun, Zhou Xiaoqiang, Lian Jingli, Liu Yue, Yang Tingting, Li Chao, Chen Fengying, Jiayue Du, Xiang-Min Xu, Yang Xingkun, and Xiong Fu
- Published
- 2023
3. Impact of the critical factors of customer experience on well-being: Joy and customer satisfaction as mediators
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Xie, Chunchang, Jin, Junxi, and Guo, Xiaoling
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General Psychology - Abstract
This study constructs a formation model of customer well-being (CWB) in customer experience with joy and customer satisfaction as mediating factors linking three critical factors—convenience, performance and relationship of customer experience with CWB. By collecting data from customers of retailing, the model was empirically tested. The results show that the three critical factors all have positive effects on CWB. Meanwhile, service performance has a direct effect on CWB. Joy plays a key role in the formation of CWB mediating the relationship between the three critical factors and CWB. This study is the first in the literature to explore CWB from the perspective of customer experience with joy as an antecedent of CWB. It provides important implications for managers to enhance customer experience and CWB in the service setting. It also helps managers to pay attention to the role of customer joy in customer experience and make full use of it.
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- 2022
4. Additional file 1 of Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing
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Zheng, Yuhua, Pan, Jing, Xia, Chenglai, Chen, Haiying, Zhou, Huadong, Ju, Weina, Wegiel, Jerzy, Myatt, Leslie, Roberts, James M., Guo, Xiaoling, and Zhong, Nanbert
- Abstract
Additional file 1: Figure S1. Heatmap of marker genes in cell clusters of early pregnancy loss. Heatmap of marker genes in cell clusters of different groups of early pregnancy loss. The numbers of clusters in groups A, B, C, and D were 16, 15, 16, and 18, respectively. Figure S2. Dot plot of top-10 marker genes (X axis) in trophoblast cell clusters VCT1 (upper), STB1 (middle), and EVT3 (lower), respectively, among early groups A_SM, B_SM, C_RM, and D_ET. Figure S3. Gene set variation analysis (GSVA) analysis. Figure S4. Cell cycle
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- 2022
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5. Additional file 1 of Is there an optimal inter-delivery interval in women who underwent trial of labor after cesarean delivery (TOLAC)?
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Rao, Jiaming, Fan, Dazhi, Ma, Huiting, Lin, Dongxin, Zhang, Huishan, Zhou, Zixing, Li, Pengsheng, Chen, Gengdong, Lu, Demei, Liu, Yan, Wu, Zhaoxia, He, Jieyun, Liu, Xinjuan, Peng, BingJie, Guo, Xiaoling, and Liu, Zhengping
- Abstract
Additional file 1: Table S1. Descriptive and obstetric characteristics of women who attempted TOLAC.
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- 2022
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6. Additional file 1 of Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study
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Li, Pengsheng, Wang, Haiyan, Guo, Lan, Gou, Xiaoyan, Chen, Gengdong, Lin, Dongxin, Fan, Dazhi, Guo, Xiaoling, and Liu, Zhengping
- Abstract
Additional file 1: Table S1. Instrumental variables used in MR analysis of the association between gut microbiota and PE. Table S2. Full result of MR estimates for the association between gut microbiota and PE. Table S3. The heterogeneity of gut microbiota instrumental variables. Table S4. Directional horizontal pleiotropy assessed by intercept term in MR Egger regression of the association between gut microbiota and PE. Table S5. MR-PRESSO analysis for the association between gut microbiota and PE. Table S6. Instrumental variables used in the MR analysis of the association between PE and gut microbiota. Table S7. Full result of MR estimates for the association between PE and gut microbiota. Table S8. The heterogeneity of gut microbiota instrumental variables. Table S9. Directional horizontal pleiotropy assessed by intercept term in MR Egger regression of the association between PE and gut microbiota. Table S10. MR-PRESSO analysis for the association between PE and gut microbiota.
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- 2022
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7. Additional file 1 of Assessment of different thresholds of birthweight discordance for early neonatal outcomes: retrospective analysis of 2348 twin pregnancies
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Ye, Shaoxin, Fan, Dazhi, Li, Pengsheng, Chen, Gengdong, Rao, Jiaming, Zhang, Huishan, Zhou, Zixing, Feng, Jinping, Luo, Caihong, Guo, Xiaoling, Liu, Zhengping, and Lin, Dongxin
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Data_FILES - Abstract
Additional file 1.
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- 2022
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8. Customer motivations for sustainable consumption: Investigating the drivers of purchase behavior for a green‐luxury car
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Adnan Ali, Farhan Muhammad Muneeb, Mehkar Sherwani, Guo Xiaoling, and Afzaal Ali
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Value (ethics) ,Strategy and Management ,Geography, Planning and Development ,Collectivism ,Management, Monitoring, Policy and Law ,Structural equation modeling ,Purchasing ,Nonprobability sampling ,Individualism ,Sustainable consumption ,Business and International Management ,Marketing ,Materialism ,Psychology - Abstract
The purpose of the study is to investigate the effect of status motivation on customers' purchase intention of a green‐luxury car associated with owning a green‐luxury car, and whether materialism and horizontal–vertical individualism/collectivism moderate this relationship. The quantitative research methodology using online survey technique was used to collect cross‐cultural data from respondents (507) from China and Germany. Purposive sampling technique was used to identify and collect data from current and prospective customers of the BMW brand. Collected data were analyzed using structural equation modeling (SEM). The results demonstrated that materialism and cultural value (horizontal–vertical collectivism and vertical individualism) can serve as moderators of the effects of status motivation and purchase intention of the green‐luxury car. Although some studies have explored the factors involved in customer purchasing behaviour for green‐luxury products, our results theoretically and empirically show that materialism, vertical individualism, horizontal collectivism, and vertical collectivism enhance the positive effects of status motivation on customer purchasing behaviour for a green‐luxury car.
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- 2019
9. Additional file 2 of Anesthetic management in cesarean delivery of women with placenta previa: a retrospective cohort study
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Fan, Dazhi, Rao, Jiaming, Lin, Dongxin, Zhang, Huishan, Zhou, Zixing, Chen, Gengdong, Li, Pengsheng, Wang, Wen, Chen, Ting, Chen, Fengying, Ye, Yuping, Guo, Xiaoling, and Liu, Zhengping
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embryonic structures - Abstract
Additional file 2: Table 2. Perioperative data and maternal and neonatal outcomes (excluding placenta accreta spectrum).
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- 2021
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10. Additional file 1 of Should singleton birth weight standards be applied to identify small-for-gestational age twins?: analysis of a retrospective cohort study
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Lin, Dongxin, Rao, Jiaming, Fan, Dazhi, Huang, Zheng, Zhou, Zixing, Chen, Gengdong, Li, Pengsheng, Lu, Xiafen, Lu, Demei, Zhang, Huishan, Luo, Caihong, Guo, Xiaoling, and Liu, Zhengping
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Data_FILES - Abstract
Additional file 1.
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- 2021
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11. Additional file 1 of Anesthetic management in cesarean delivery of women with placenta previa: a retrospective cohort study
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Fan, Dazhi, Rao, Jiaming, Lin, Dongxin, Zhang, Huishan, Zhou, Zixing, Chen, Gengdong, Li, Pengsheng, Wang, Wen, Chen, Ting, Chen, Fengying, Ye, Yuping, Guo, Xiaoling, and Liu, Zhengping
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embryonic structures - Abstract
Additional file 1: Table 1. Maternal characteristics of among included patients (excluding placenta accreta spectrum).
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- 2021
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12. Antecedents of consumers’ Halal brand purchase intention: an integrated approach
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Guo Xiaoling, Adnan Ali, Afzaal Ali, and Mehkar Sherwani
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media_common.quotation_subject ,05 social sciences ,Questionnaire ,Advertising ,Management Science and Operations Research ,General Business, Management and Accounting ,Competitive advantage ,Purchasing ,Brand loyalty ,Originality ,0502 economics and business ,Profit margin ,050211 marketing ,Profitability index ,Quality (business) ,Business ,050203 business & management ,media_common - Abstract
PurposeThe purpose of this paper is to apply the concept of traditional branding constructs – brand image, brand satisfaction, brand trust and brand loyalty to an unexplored field of Halal products – Halal brand image, Halal brand satisfaction, Halal brand trust and Halal brand loyalty. In addition, this study seeks to elaborate the relationships among brand perceived quality, Halal brand image, Halal brand satisfaction, and Halal brand trust, Halal brand loyalty and consumer purchase intention.Design/methodology/approachA theoretical model with hypothesised relationships is developed and tested with the help of structural equation modelling procedure in AMOS. This research used the questionnaire survey method to collect data from 347 consumers in Pakistan who had the experience of purchasing Halal milk brand.FindingsThe empirical results suggest that perceived brand quality has a significant and positive influence on the Halal brand image, Halal brand satisfaction, Halal brand trust, Halal brand loyalty and purchase intention. Similarly, the Halal brand image, Halal brand satisfaction, Halal brand trust and Halal brand loyalty significantly influence consumer Halal brand purchase intention.Research limitations/implicationsThe Muslim population is growing in many parts of the world, including non-Muslim countries. Although this study’s focus is limited to Pakistani Muslims, findings related to the effects of brand perceived quality, Halal brand image, Halal brand satisfaction, and Halal brand trust and Halal brand loyalty on intentions may not be equally valid for Muslim consumers in others Muslim and non-Muslim countries and for other types of products.Practical implicationsThe findings indicate that ignoring the important quality elements of a brand could be costly to marketers who failed to realise the importance of traditional brand attributes whilst embracing Halal brand marketing initiatives. In addition, Halal branding can allow the businesses to access to new markets, to enjoy more competitive advantages and to increase their profitability by selling at higher prices with higher profit margins.Originality/valueAlthough previous research has explored the relevant issues about brand image, brand satisfaction, brand trust and brand loyalty, none highlights these traditional constructs to an unexplored field of Halal products.
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- 2018
13. AC magnetic field measurement using a small flip coil system for rapid cycling AC magnets at the China Spallation Neutron Source (CSNS)
- Author
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Shouyan Xu, Li Li, Shuai Li, Xi Wu, Jianxin Zhou, Y. M. Wu, Yiqin Liu, Changdong Deng, Yudong Liu, Sheng Wang, Guo Xiaoling, and Wen Kang
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Physics ,Nuclear and High Energy Physics ,010308 nuclear & particles physics ,01 natural sciences ,Linear particle accelerator ,Synchrotron ,law.invention ,Nuclear physics ,Dipole magnet ,Electromagnetic coil ,law ,Magnet ,0103 physical sciences ,Physics::Accelerator Physics ,010306 general physics ,Quadrupole magnet ,Instrumentation ,Spallation Neutron Source ,DC bias - Abstract
The China Spallation Neutron Source (CSNS) has two major accelerator systems, a linear accelerator and a rapid cycling synchrotron (RCS). The RCS accelerator is used to accumulate and accelerate protons from the energy of 80 MeV to the design energy of 1.6 GeV at the repetition rate of 25 Hz, and extract the high energy beam to the target. The main magnets of the RCS accelerator are excited by AC current with DC bias. The magnetic field quality is very important for the RCS accelerator operation, since it should guarantee and focus a circulating beam. In order to characterize the AC magnets, a small flip coil measurement system has been developed and one of each type of AC magnets has been studied. The measurement system and selected measurement results are presented in this paper.
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- 2018
14. Expanding the theory of planned behaviour to predict Chinese Muslims halal meat purchase intention
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Guo Xiaoling, Sikander Hussain, Adnan Ali, Mehkar Sherwani, and Afzaal Ali
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education.field_of_study ,05 social sciences ,Population ,Theory of planned behavior ,Context (language use) ,Advertising ,language.human_language ,Acculturation ,Market segmentation ,Moral obligation ,0502 economics and business ,Food policy ,language ,Business, Management and Accounting (miscellaneous) ,050211 marketing ,Business ,education ,050203 business & management ,Consumer behaviour ,Food Science - Abstract
Purpose The purpose of this paper is to investigate the determinants of halal meat consumption within the population of Chinese Muslims in China using the theory of planned behaviour (TPB) as a conceptual framework. The role of self-identity as a Muslim, dietary acculturation in the host culture, moral obligation to purchase halal meat and trust on the authenticity of halal meat are explored. Design/methodology/approach Cross-sectional data were collected through a survey with 378 Chinese Muslims, currently living in Beijing and Xian cities. Data were analysed by means of correlations and stepwise multiple regressions to test the model and the moderating effects of self-identity, dietary acculturation, moral obligation and trust on behavioural intention. Findings A positive personal attitude towards the consumption of halal meat, personal conviction, motivation to comply, perceived control over consuming halal meat and perceived availability of halal meat predict the intention to eat halal meat among Chinese Muslims. Research limitations/implications Limitations include the focus on only four individual characteristics related to religious food consumption, namely, self-identity, dietary acculturation, moral obligation and trust. Additional individual characteristics such as individualism-collectivism and involvement or values could improve the predictive power of the model. Practical implications Practical implications extend to food marketers and food policy decision-makers who might pursue identity, acculturation, trustworthiness and moral obligation-related strategies in their distribution and communication efforts targeted at the growing halal food market segments across China and worldwide. Originality/value The current study addresses the important limitation of previous studies regarding the inclusion of additional possible individual characteristics such as moral obligation and trust in the TPB model to investigate the determinants of halal meat consumption within a food-religion context.
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- 2018
15. Overexpression of the receptor-like cytoplasmic kinase gene XCRK enhances Xoc and oxidative stress tolerance in rice
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Chiming Guo, Cui Yuchao, Yuxia Zhang, Liang Chen, and Guo Xiaoling
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0106 biological sciences ,0301 basic medicine ,Antioxidant ,Oryza sativa ,Kinase ,medicine.medical_treatment ,Transgene ,food and beverages ,Plant Science ,Biology ,medicine.disease_cause ,biology.organism_classification ,01 natural sciences ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,Xanthomonas oryzae ,Botany ,medicine ,Gene ,Oxidative stress ,Bacterial leaf streak ,010606 plant biology & botany - Abstract
In this paper, we characterized a differentially expressed receptor-like cytoplasmic kinase XCRK, which confers resistance to bacterial leaf streak (BLS). We analyzed the tissue expression of XCRK and showed that XCRK was widely expressed in multiple rice (Oryza sativa) organs, including internodes, roots, leaves and flowers. In addition, the expression of XCRK was significantly induced by ABA, salt and H2O2 treatments, suggesting its function in these pathways. The XCRK-overexpressing transgenic seedlings exhibited higher tolerance to Xanthomonas oryzae pv.oryzicola (Xoc) compared with the wild-type seedlings. Furthermore, XCRK-overexpressing seedlings showed stronger antioxidant capacity with reduced MDA and H2O2 content and higher antioxidant enzyme activities. It has been hypothesized that the enhanced Xoc tolerance was attributed to the improved expression of resistance-responsive factors positively regulated by XCRK. In accordance with this, the expression of resistance and oxidation-related genes Wrky77, Wrky13, PAL1, PR5, Fe-SOD and SodCc2 were up-regulated by the overexpression of XCRK, which might contribute collectively to the increased Xoc tolerance. Overall, overexpression of XCRK could enhance the antioxidant capacity and Xoc tolerance in rice.
- Published
- 2017
16. Factors affecting Halal meat purchase intention
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Adnan Ali, Mehkar Sherwani, Afzaal Ali, and Guo Xiaoling
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Consumption (economics) ,education.field_of_study ,Food marketing ,05 social sciences ,Population ,Theory of planned behavior ,Questionnaire ,Context (language use) ,Advertising ,Acculturation ,Conceptual framework ,0502 economics and business ,Business, Management and Accounting (miscellaneous) ,050211 marketing ,Business ,Marketing ,education ,050203 business & management ,Food Science - Abstract
Purpose The purpose of this paper is to investigate the determinants of Halal meat consumption within international Muslim students’ population in China using the theory of planned behaviour as a conceptual framework. The role of self-identity (SI) as a Muslim, dietary acculturation (DA) in the host culture, moral obligation (MO) to purchase Halal meat and trust on the authenticity of Halal meat is explored. Design/methodology/approach Cross-sectional data were collected through a questionnaire survey with 436 international Muslim students mainly originating from Muslim countries and currently studying in China. Data were analysed by stepwise multiple regression analyses to test the model and the moderating effects of SI, DA, MO and trust on behavioural intention. Findings The results indicate that a positive personal attitude towards the consumption of Halal meat, personal conviction and the perceived control over consuming Halal meat predict the intention to eat Halal meat among Muslims. Research limitations/implications Limitations include the use of a snow-ball sampling technique and the focus on only four individual characteristics related to religious food consumption, namely, SI, DA, MO and trust. Practical implications Practical implications extend to dealing with food policymakers and food marketing managers in companies who might pursue identity-, acculturation-, MO- and trustworthiness-related strategies in their distribution and communication efforts targeted at the growing local as well as international market of Halal food. Originality/value This study is one of the first studies investigating the determinants of Halal meat consumption among international Muslim students in China and a first application of the theory of planned behaviour-related religious food consumption context by considering four individual characteristics, namely, SI, DA, MO and trust.
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- 2017
17. OsSIDP366 , a DUF1644 gene, positively regulates responses to drought and salt stresses in rice
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Liangjiang Wang, Yuxia Zhang, Liang Chen, Min Li, Chiming Guo, Lijia Guo, Guo Xiaoling, and Chengke Luo
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0106 biological sciences ,0301 basic medicine ,Abiotic stress ,fungi ,Mutant ,food and beverages ,Plant Science ,Biology ,01 natural sciences ,Biochemistry ,Genetically modified rice ,General Biochemistry, Genetics and Molecular Biology ,Cell biology ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,RNA interference ,Botany ,Gene expression ,Gene family ,Abscisic acid ,Gene ,010606 plant biology & botany - Abstract
Domain of unknown function 1644 (DUF1644) is a highly conserved amino acid sequence motif present only in plants. Analysis of expression data of the family of DUF1644-containing genes indicated that they may regulate responses to abiotic stress in rice. Here we present our discovery of the role of OsSIDP366, a member of the DUF1644 gene family, in response to drought and salinity stresses in rice. Transgenic rice plants overexpressing OsSIDP366 showed enhanced drought and salinity tolerance and reduced water loss as compared to that in the control, whereas plants with downregulated OsSIDP366 expression levels using RNA interference (RNAi) were more sensitive to salinity and drought treatments. The sensitivity to abscisic acid (ABA) treatment was not changed in OsSIDP366-overexpressing plants, and OsSIDP366 expression was not affected in ABA-deficient mutants. Subcellular localization analysis revealed that OsSIDP366 is presented in the cytoplasmic foci that colocalized with protein markers for both processing bodies (PBs) and stress granules (SGs) in rice protoplasts. Digital gene expression (DGE) profile analysis indicated that stress-related genes such as SNAC1, OsHAK5 and PRs were upregulated in OsSIDP366-overexpressing plants. These results suggest that OsSIDP366 may function as a regulator of the PBs/SGs and positively regulate salt and drought resistance in rice.
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- 2015
18. Will You Purchase Green Products? The Joint Mediating Impact of Environmental Concern and Environmental Responsibility on Consumers’ Attitude and Purchase Intention
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Afzaal Ali, Guo Xiaoling, Mehkar Sherwani, and Adnan Ali
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General Medicine - Published
- 2015
19. A Algorithm of Detectors Generating Based on Negative Selection Algorithm
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Wu Renjie, Guo Xiaoling, and Zhang Xiao
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Cover (telecommunications) ,business.industry ,Artificial immune system ,Computer science ,Detector ,A* search algorithm ,Pattern recognition ,Intrusion detection system ,law.invention ,Set (abstract data type) ,law ,Redundancy (engineering) ,Artificial intelligence ,business ,FSA-Red Algorithm - Abstract
There are a lot of redundancy and over all issues in the artificial immune system (AIS) because of using the traditional negative selection algorithm (NSA) to generate detectors. It is the main reason for the high false percentage and high missed percentage in the intrusion detection system (IDS). Therefore, an improved immune detector generation algorithm is put forward. By calculating the optimal size of mature detector set and using the twice match in the improved algorithm. The efficiency of the IDS can be guaranteed. In the last, simulation experiments show that the improved algorithm can cover the more nonself and had a higher detection rate in the IDS.
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- 2016
20. An Algorithm for Image Denoising Based on Adaptive Total Variation
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Guo Xiaoling, Zhang Xiao, and Yang Jie
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Basis (linear algebra) ,Computer science ,Tv model ,Enhanced Data Rates for GSM Evolution ,Variation (game tree) ,Total variation denoising ,Image denoising ,Non-local means ,Algorithm ,Image (mathematics) - Abstract
Although the traditional TV (Total Variation) model owns excellent image denoising ability, there are staircase effect problems for TV model. In this article, two detection operators for staircase effect problem are proposed. The staircase effect problem can be solved effectively by introducing two operators into traditional TV model. On the basis, it proposes an adaptive total variation model for image denoising. When dealing with image edge, it can still use the traditional TV model. Its purpose is to maintain the advantages in edge protection for TV model. When it is in the smooth area of image, linear diffusion is used to avoid the staircase effect.
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- 2016
21. Prediction of Crop Yield Using Big Data
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Wang Juyun, Guo Xiaoling, Wu Fan, Yu Hua, and Chen Chong
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Structure (mathematical logic) ,Data processing ,Food security ,Computer science ,business.industry ,Crop yield ,Yield (finance) ,Big data ,Volume (computing) ,Data mining ,business ,computer.software_genre ,computer - Abstract
Quantifying the yield is essential to optimize policies to ensure food security. This paper aims at providing a new method to predict the crop yield based on big-data analysis technology, which differs with traditional methods in the structure of handling data and in the means of modeling. Firstly, the method can make full use of the existing massive agriculturerelevant datasets and can be still utilized with the volume of data growing rapidly, due to big-data friendly processing structure. Secondly, the "nearest neighbors" modeling, which employs results gained from the former data processing structure, provides a well-balanced result on the account of accuracy and prediction time in advance. Numerical examples on actual crop dataset in China from 1995-2014 have showed a better performance and an improved prediction accuracy of the proposed method compared with traditional ones.
- Published
- 2015
22. Quantitative investigation of two metallohydrolases by X-ray absorption spectroscopy near-edge spectroscopy
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Liwen Niu, Maikun Teng, Wangsheng Chu, Maurizio Benfatto, Ziyu Wu, N. Shi, Meijuan Yu, Deng-Yi Chen, Weimin Gong, Weichang Zhao, D.W. Zhou, Feifei Yang, Augusto Marcelli, and Guo Xiaoling
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Physics ,Nuclear and High Energy Physics ,Crystallography ,X-ray absorption spectroscopy ,Molecular geometry ,Extended X-ray absorption fine structure ,Absorption spectroscopy ,Synchrotron radiation ,Spectroscopy ,Absorption (electromagnetic radiation) ,Instrumentation ,XANES - Abstract
The last several years have witnessed a tremendous increase in biological applications using X-ray absorption spectroscopy (BioXAS), thanks to continuous advancements in synchrotron radiation (SR) sources and detector technology. However, XAS applications in many biological systems have been limited by the intrinsic limitations of the Extended X-ray Absorption Fine Structure (EXAFS) technique e.g., the lack of sensitivity to bond angles. As a consequence, the application of the X-ray absorption near-edge structure (XANES) spectroscopy changed this scenario that is now continuously changing with the introduction of the first quantitative XANES packages such as Minut XANES (MXAN). Here we present and discuss the XANES code MXAN, a novel XANES-fitting package that allows a quantitative analysis of experimental data applied to Zn K-edge spectra of two metalloproteins: Leptospira interrogans Peptide deformylase (LiPDF) and acutolysin-C, a representative of snake venom metalloproteinases (SVMPs) from Agkistrodon acutus venom. The analysis on these two metallohydrolases reveals that proteolytic activities are correlated to subtle conformation changes around the zinc ion. In particular, this quantitative study clarifies the occurrence of the LiPDF catalytic mechanism via a two-water-molecules model, whereas in the acutolysin-C we have observed a different proteolytic activity correlated to structural changes around the zinc ion induced by pH variations.
- Published
- 2007
23. Induction of anti B-cell malignance CTL response by subfamily-shared peptides derived from variable domain of immunoglobulin heavy chain
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Li Huifang, Liu Ying, Zhu Xia, Fan Qingqing, Guo Xiaoling, Zhu Ping, and Liu Jing
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Cytotoxicity, Immunologic ,Cancer Research ,Subfamily ,Immunology ,Immunoglobulin Variable Region ,Epitopes, T-Lymphocyte ,Biology ,Epitope ,Cell Line, Tumor ,medicine ,Humans ,Immunology and Allergy ,Gene ,B cell ,Gene Rearrangement ,Genetics ,HLA-A Antigens ,Gene rearrangement ,Burkitt Lymphoma ,Molecular biology ,Peptide Fragments ,medicine.anatomical_structure ,Oncology ,Genes, T-Cell Receptor beta ,biology.protein ,Immunoglobulin heavy chain ,Antibody ,Immunoglobulin Heavy Chains ,IGHV@ ,T-Lymphocytes, Cytotoxic - Abstract
The variable domain of immunoglobulin heavy chain (Ig HV) is well-characterized tumor associated antigen expressed in B-cell malignancies, which may function as a T-cell target. However, T-cell epitopes derived from shared framework regions (FRs) of each IgHV subfamily capable of inducing cytotoxic T lymphocytes (CTLs) against the B-cell malignancy, have not been identified. Using the specific PCR primers of seven IgHV gene subfamilies, we amplified the IgHV gene rearrangement for 108 cases of B-cell acute lymphoblastic leukemia (B-ALL) patients. The IgHV gene rearrangement fragments of B-ALL patients were directly sequenced then classified into seven different subfamilies. The T-cell epitopes encoded by the IgHV gene in the B-ALL patients were predicted by SYFPEITHI and BIMAS programs and compared with those from 56 representative germline IgHV sequences in the genebank. For the HLA-A*0201 locus, we found 1 or 2 top score shared epitopes from each subfamily and got 12 epitopes altogether. Results showed that ten of them were in the FRs. Using an antigen-specific T-cell expansion system, we generated the peptide-special CTLs in vitro, which were capable of killing B lymphoma cell lines that belonged to the same IgHV subfamily in a peptide-specific and HLA-restricted manner. Furthermore, we proved that the cytotoxicity of CTLs was IgHV subfamily-specific. These data indicate possible immunotherapy approaches for B-cell malignances patients based on IgHV gene subfamilies.
- Published
- 2005
24. Experience in retroperitoneal laparoscopic radical nephrectomy: A report of 30 cases
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Zhang Xu, Zhu Qingguo, Li Longcheng, Ye Zhangqun, Guo Xiaoling, and Ma Xin
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medicine.medical_specialty ,business.industry ,Modified technique ,Surgery ,Oncology ,Blood loss ,Anesthesia ,Ambulatory ,Operative time ,Medicine ,Laparoscopic radical nephrectomy ,Function recovery ,Clinical efficacy ,business ,Hospital stay - Abstract
Objective: To evaluate the clinical efficacy of the modified retroperitoneal laparoscopic radical nephrectomy.Methods: Thirty cases who had received retroperitoneal laparoscopic radical nephrectomy (RLRN) were retrospectively compared in terms of blood loss, operative time and followed up.Results: The modified retroperitoneal laparoscopic radical nephrectomy could substantially shorten operation time and reduce blood loss and result in no obvious complications. The mean operative time was 101±41.4 min, with the mean time of 166 min being in initial 5 cases being reduced to 74 min in the final 5 cases. The mean operative blood loss was 51±44 ml, with the mean blood loss of 104 ml in the initial 5 cases being reduced to 26 ml in the final 5 cases. The postoperative bowl function recovery time was 32±18 h on average; the operative ambulatory time was 30.4±12 h; postoperative hospital stay was 5.6±1.5 days. The follow-up study revealed no local relapse of tumor and implantation metastasis of puncture channel.Conclusion: Compared with traditional retroperitoneal laparoscopic radical nephrectomy, the modified technique has the merits of shorten operation time, reduced blood loss and less complications.
- Published
- 2003
25. Design and Development of Tele-Diagnosis System of Medical Image Based on Mobile Terminal
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Guo Xiaoling, Peng Wei, Zhang Xiao, and Sun Xing-Hua
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Hypertext Transfer Protocol ,Multimedia ,business.industry ,computer.internet_protocol ,Computer science ,Mobile computing ,eMix ,Cloud computing ,computer.software_genre ,World Wide Web ,Server ,Remote diagnostics ,Mobile telephony ,business ,computer ,Cloud storage - Abstract
A mobile telediagnosis system of medical images has been developed, doctors can diagnose patients with the help of Mobile Terminal anytime and anywhere. System uses the "cloud + client" application development model for development and design. The cloud platform, as the system servers, saves remote diagnostics data. Android-based mobile terminal, as a client, exchange information with cloud platform by HTTP protocol. Through this application, users can achieve appointment registration, electronic medical records, medical image processing and viewing, remote diagnosis, the doctor-patient interaction, medical certificate issued, diagnostics and management functions etc.
- Published
- 2014
26. Study of High Density Multi-Wave Zero-Offset VSP
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Guo Xiaoling, Chen Yuanzhong, Zhao Haiying, Tang Donglei, and Liu Congwei
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Offset (computer science) ,Seismic vibrator ,S-wave ,High density ,Geology ,Seismology - Abstract
In general, sample interval for zero-offset VSP (ZVSP) is 5-10m in depth domain. We got ZVSP date of Well X that located in western China with P wave and S wave vibroseis source respectively, the depth sample interval is 1m. In view of the high density multi-wave ZVSP data, a series of processing approaches different from conventional ZVSP were taken. The results show high density ZVSP could get accurate S-wave velocity and various wave corridor stack sections. The high density multi-wave ZVSP could play a positive role in stage of fine exploration and development.
- Published
- 2014
27. Notice of Retraction: Advertising adapation strategy of global companies from developing countries: evidence from an exploratory study in China and in Thailand
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Wang Yonggui and Guo Xiaoling
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Globalization ,Notice ,Content analysis ,Multinational corporation ,Cultural diversity ,Exploratory research ,Developing country ,Advertising ,Business ,Marketing ,China - Abstract
This article explores the adaptation/standardization choice of advertising messages for global companies from developing countries. With verbal data collected from China and Thailand, content analysis is conducted. It is inferred from the results that contrary to what the literature suggests, adaptation strategy is preferred, implying its compatibility with global brand building mission.
- Published
- 2011
28. Wavefield separation of large array 3D3C VSP data in time domain
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Xu Zhengshun, Chen Yuanzhong, and Guo Xiaoling
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Acoustics ,Separation (aeronautics) ,Large array ,Time domain ,Geology - Published
- 2009
29. Application of wavelet-based active power filter in accelerator magnet power supply
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Guo Xiaoling and Cheng Jian
- Subjects
Accelerator Physics (physics.acc-ph) ,Physics ,Nuclear and High Energy Physics ,business.industry ,Electrical engineering ,FOS: Physical sciences ,Astronomy and Astrophysics ,law.invention ,Power (physics) ,Quality (physics) ,Wavelet ,Transformation (function) ,law ,Magnet ,Harmonic ,Physics - Accelerator Physics ,Current (fluid) ,Collider ,business ,Instrumentation - Abstract
As modern accelerators demand excellent stability to magnet power supply (PS), it is necessary to decrease harmonic currents passing magnets. Aim at depressing rappel current from PS in Beijing electron-positron collider II, a wavelet-based active power filter (APF) is proposed in this paper. APF is an effective device to improve the quality of currents. As a countermeasure to these harmonic currents, the APF circuit generates a harmonic current, countervailing harmonic current from PS. An active power filter based on wavelet transform is proposed in this paper. Discrete wavelet transform is used to analyze the harmonic components in supply current, and active power filter circuit works according to the analysis results. At end of this paper, the simulation and experiment results are given to prove the effect of the mentioned Active power filter., Comment: 4 pages, 10 figures
- Published
- 2014
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