189 results on '"Giuseppe Ricciardi"'
Search Results
2. Modal characterization and NDTs of a historical church in Noto
- Author
-
Flora Faleschini, Klajdi Toska, Filippo Andreose, Giovanni Gobbi, Gianantonio Feltrin, Mariano A. Zanini, Carlo Pellegrino, Dario De Domenico, and Giuseppe Ricciardi
- Subjects
Earth-Surface Processes - Published
- 2023
3. Full-scale experimental tests on unbonded fiber reinforced elastomeric isolators under bidirectional excitation
- Author
-
Dario De Domenico, Paolo Longo, Daniele Losanno, Natale Maugeri, Giuseppe Ricciardi, and Nicolò Vaiana
- Subjects
Earth-Surface Processes - Published
- 2023
4. Critical assessment of CO2 emission of different concretes: foamed, lightweight aggregate, recycled and ordinary concrete
- Author
-
Devid Falliano, Salvatore Quattrocchi, Dario De Domenico, Giuseppe Ricciardi, and Ernesto Gugliandolo
- Subjects
CO2 emission ,foamed concrete ,General Earth and Planetary Sciences ,lightweight concrete ,General Environmental Science - Abstract
Construction materials contribute to about 75% of the CO2 emission of all the construction processes. Concrete is one of the most widely used construction materials and is thus primarily responsible for CO2 emission. In particular, 8 − 9% of global greenhouse gas (GHG) emission are produced by concrete. CO2 emissions can be considerably reduced in the construction phase through a careful selection of materials with low environmental impact or through specific admixtures. In this study, different concretes are taken into consideration, including foamed concrete, lightweight aggregate concrete, recycled concrete and ordinary concrete. A series of mix designs of these four classes of concrete, characterized by a comparable mechanical strength or a comparable density, are taken from the relevant literature and compared to one another in terms of CO2 emission. Some guidelines or possible research lines aimed at reducing CO2 emission are finally outlined in this contribution.
- Published
- 2022
5. Low incidence of arrhythmic syncope and pacemaker implantation in older patients with bifascicular block and implantable cardiac monitor
- Author
-
Carlo Fumagalli, Martina Rafanelli, Michele Brignole, Caterina Guarducci, Niccolò Bettoni, Giulia Rivasi, Paolo Pieragnoli, Giuseppe Ricciardi, Luca Checchi, Marco Gambardella, Flavia Casolaro, Giuseppe Paolisso, Raffaele Marfella, Giuseppe Signoriello, Niccolò Marchionni, Andrea Ungar, Celestino Sardu, Fumagalli, Carlo, Rafanelli, Martina, Brignole, Michele, Guarducci, Caterina, Bettoni, Niccolò, Rivasi, Giulia, Pieragnoli, Paolo, Ricciardi, Giuseppe, Checchi, Luca, Gambardella, Marco, Casolaro, Flavia, Paolisso, Giuseppe, Marfella, Raffaele, Signoriello, Giuseppe, Marchionni, Niccolò, Ungar, Andrea, and Sardu, Celestino
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
In patients with unexplained syncope, bifascicular block (BFB) is considered associated with syncope due to either heart block or sinus arrest. Immediate or delayed pacemaker (PM) implantation after ECG documentation of syncopal recurrence by means of implantable cardiac monitors (ICM) is still debated. We aimed to assess the incidence of recurrent syncope and guideline-based PM implantation in patients with syncope and BFB implanted with ICM.Consecutive patients with syncope and BFB followed at two tertiary care syncope units and implanted with ICM from 2012 to 2020 were retrospectively reviewed. Only patients with ≥2 clinical visits and ≥ 18 years of age were included. Incidence of a Class I indication for PM implantation was the primary outcome.Of 635 syncope patients implanted with an ICM, 55 (8.7%) had a BFB and were included. Median age at implantation was 75 [interquartile range, IQR:64-81] years, and 28(49.1%) were women. At 26 [IQR:12-41] months follow-up, 20 (36.3%,16.3%/year) patients experienced syncope: in 6(10.9%) patients syncope was classified 'arrhythmic' with a higher prevalence in older individuals (p = 0.048). PM implantation (N = 14,25.5%) was more frequent in patients ≥75 years (p = 0.024). At survival analysis, patients ≥75 years were at highest risk of arrhythmic syncope and guideline directed PM implantation (Hazard Ratio: 4.5, 95% Confidence Intervals 1.5-13.3).Most older patients with syncope who received an ICM did not have events during follow-up. One-in-three experienced syncope, and an even smaller number had an arrhythmic syncope with indication for PM implantation. Older age was strongly associated with PM implantation.
- Published
- 2022
6. A generalized integro-differential theory of nonlocal elasticity of n-Helmholtz type—part II: boundary-value problems in the one-dimensional case
- Author
-
Dario De Domenico, Giuseppe Ricciardi, and Harm Askes
- Subjects
Size effects ,Enriched continua ,Constitutive equation ,02 engineering and technology ,01 natural sciences ,symbols.namesake ,0203 mechanical engineering ,Wave dispersion ,0103 physical sciences ,Helmholtz equation ,Boundary value problem ,Discrete lattice ,010301 acoustics ,Mathematics ,Internal length scale ,Series (mathematics) ,Mechanical Engineering ,Mathematical analysis ,Elasticity (physics) ,Condensed Matter Physics ,Differential operator ,Gradient elasticity ,Lattice (module) ,020303 mechanical engineering & transports ,Nonlocal elasticity ,Mechanics of Materials ,Helmholtz free energy ,symbols ,Nonlocal elasticity, Gradient elasticity, Internal length scale, Enriched continua, Helmholtz equation, Wave dispersion, Discrete lattice, Size effects ,Lattice model (physics) - Abstract
This paper is the second in a series of two that deal with a generalized theory of nonlocal elasticity of n-Helmholtz type. This terminology is motivated by the fact that the attenuation function (kernel) of the integral type nonlocal constitutive equation is the Green function associated with a generalized Helmholtz differential operator of order n. In the first paper, the governing equations have been derived and supported by suitable thermodynamic arguments. In this second paper, the proposed nonlocal model is specialized for the one-dimensional case to solve boundary-value problems. First, the relevant higher-order nonstandard boundary conditions in the differential (or, more precisely, integro-differential) version of the theory are derived. These boundary conditions are consistent with the particular family of attenuation functions adopted in the integral formulation. Then, some simple applications to statics and dynamics problems are presented. In particular, the theory is used to capture the static response and to perform free vibration analysis of a discrete lattice model with periodic microstructure (mass-and-spring chain) featured by nearest neighbor and next nearest neighbor particle interactions. In the latter case, boundary effects arise at the two lattice ends that are well captured by the proposed nonlocal continuum formulation. The nonlocal material parameters are identified a priori by matching the dispersion curve of the discrete lattice model, and a comparison in terms of attenuation function is also presented.
- Published
- 2021
7. Longevity of model 3501 subcutaneous implantable cardioverter-defibrillator leads in clinical practice
- Author
-
Stefano Viani, Federico Migliore, Luca Ottaviano, Mauro Biffi, Ernesto Ammendola, Giuseppe Ricciardi, Pietro Francia, Antonio D’Onofrio, Giovanni Bisignani, Antonio Dello Russo, Paolo De Filippo, Francesco Solimene, Antonio Scalone, Fabrizio Caravati, Roberto Rordorf, Valeria Ilia Calvi, Giovanni Luca Botto, and Maria Grazia Bongiorni
- Subjects
Physiology (medical) ,CIED malfunction ,Defibrillation lead ,Implantable cardioverter-defibrillator ,Subcutaneous ,Cardiology and Cardiovascular Medicine ,Defibrillators, Implantable - Published
- 2022
8. Appropriate and inappropriate shocks in hypertrophic cardiomyopathy patients with subcutaneous implantable cardioverter-defibrillators: An international multicenter study
- Author
-
Babak Nazer, Daniel Jacoby, Paolo Pieragnoli, Andrew Gray, Tuna Ustunkaya, Anjali T. Owens, Nikolaos Papoutsidakis, Stephen B. Heitner, Stacey J. Howell, Zack Dale, Nosheen Reza, Gianmarco Carrassa, Miriam R. Elman, David S. Frankel, Giuseppe Ricciardi, and Iacopo Olivotto
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Sinus tachycardia ,030204 cardiovascular system & hematology ,Global Health ,Risk Assessment ,Sudden death ,Article ,Sudden cardiac death ,Electrocardiography ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,business.industry ,Incidence ,Incidence (epidemiology) ,Hypertrophic cardiomyopathy ,Odds ratio ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Confidence interval ,Defibrillators, Implantable ,Primary Prevention ,Death, Sudden, Cardiac ,Cohort ,Tachycardia, Ventricular ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are attractive for preventing sudden cardiac death in hypertrophic cardiomyopathy (HCM) as they mitigate risks of transvenous leads in young patients. However, S-ICDs may be associated with increased inappropriate shock (IAS) in HCM patients. Objective The purpose of this study was to assess the incidence and predictors of appropriate shock and IAS in a contemporary HCM S-ICD cohort. Methods We collected electrocardiographic and clinical data from HCM patients who underwent S-ICD implantation at 4 centers. Etiologies of all S-ICD shocks were adjudicated. We used Firth penalized logistic regression to derive adjusted odds ratios (aORs) for predictors of IAS. Results Eighty-eight HCM patients received S-ICDs (81 for primary and 7 for secondary prevention) with a mean follow-up of 2.7 years. Five patients (5.7%) had 9 IAS episodes (3.8 IAS per 100 patient-years) most often because of sinus tachycardia and/or T-wave oversensing. Independent predictors of IAS were higher 12-lead electrocardiographic R-wave amplitude (aOR 2.55 per 1 mV; 95% confidence interval 1.15–6.38) and abnormal T-wave inversions (aOR 0.16; 95% confidence interval 0.02–0.97). There were 2 appropriate shocks in 7 secondary prevention patients and none in 81 primary prevention patients, despite 96% meeting Enhanced American College of Cardiology/American Heart Association criteria and the mean European HCM Risk-SCD score predicting 5.7% 5-year risk. No patients had sudden death or untreated sustained ventricular arrhythmias. Conclusion In this multicenter HCM S-ICD study, IAS were rare and appropriate shocks confined to secondary prevention patients. The R-wave amplitude increased IAS risk, whereas T-wave inversions were protective. HCM primary prevention implantable cardioverter-defibrillator guidelines overestimated the risk of appropriate shocks in our cohort.
- Published
- 2020
9. Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study
- Author
-
Ilaria, Casetta, Enrico, Fainardi, Giovanni, Pracucci, Valentina, Saia, Fabrizio, Sallustio, Valerio, da Ros, Sergio, Nappini, Patrizia, Nencini, Guido, Bigliardi, Sergio, Vinci, Francesco, Grillo, Sandra, Bracco, Rossana, Tassi, Mauro, Bergui, Paolo, Cerrato, Andrea, Saletti, Alessandro, De Vito, Roberto, Gasparotti, Mauro, Magoni, Luigi, Simonetti, Andrea, Zini, Maria, Ruggiero, Marco, Longoni, Lucio, Castellan, Laura, Malfatto, Paola, Castellini, Mirco, Cosottini, Alessio, Comai, Enrica, Franchini, Emilio, Lozupone, Giacomo, Della Marca, Edoardo, Puglielli, Alfonsina, Casalena, Claudio, Baracchini, Daniele, Savio, Enrica, Duc, Giuseppe, Ricciardi, Manuel, Cappellari, Luigi, Chiumarulo, Marco, Petruzzellis, Anna, Cavallini, Nicola, Cavasin, Adriana, Critelli, Nicola, Burdi, Giovanni, Boero, Andrea, Giorgianni, Maurizio, Versino, Francesco, Biraschi, Ettore, Nicolini, Simone, Comelli, Maurizio, Melis, Riccardo, Padolecchia, Tiziana, Tassinari, Nunzio, Paolo Nuzzi, Simona, Marcheselli, Simona, Sacco, Paolo, Invernizzi, Ivan, Gallesio, Delfina, Ferrandi, Maria, Fancello, Maria, Valeria Saddi, Monia, Russo, Aldo, Pischedda, Antonio, Baule, Marina, Mannino, Francesco, Florio, Vincenzo, Inchingolo, Maria, Elena Flacco, Daniele, Romano, Umberto, Silvagni, Domenico, Inzitari, Salvatore, Mangiafico, and Danilo, Toni
- Subjects
Ischemic stroke ,thrombectomy ,Original Research Articles ,sex ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,NO ,Ischemic stroke, thrombectomy, sex - Abstract
Background and purpose We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients. Methods From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke due to large vessel occlusion. We compared clinical and safety outcomes in men and women who underwent EVT alone or in combination with intravenous thrombolysis (IVT) in the total population and in a Propensity Score matched set. Results Among 3422 patients included in the study, 1801 (52.6%) were women. Despite older age at onset (mean 72.4 vs 68.7; p Conclusions Subject to the limitations of a non-randomized comparison, women with stroke due to LVO treated with mechanical thrombectomy had a better chance to achieve complete recanalization, and 3-month functional independence than men. The results could be driven by women who underwent combined treatment.
- Published
- 2022
10. Prevalence of Inherited Cardiac Diseases Among Young Patients Requiring Permanent Pacing
- Author
-
Maurizio Pieroni, Martina Berteotti, Carlo Fumagalli, Eleonora Gabrielli, Francesca Girolami, Niccolò Marchionni, Benedetta Tomberli, Giuseppe Ricciardi, Luigi Tassetti, Silvia Favilli, Francesco Cappelli, Ilaria Tanini, Luca Checchi, Iacopo Olivotto, Paolo Pieragnoli, Alessia Argirò, and Chiara Zocchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heredity ,Heart disease ,Electric Countershock ,Sick sinus syndrome ,Predictive Value of Tests ,Risk Factors ,Physiology (medical) ,Internal medicine ,Prevalence ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Age of Onset ,Retrospective Studies ,biology ,business.industry ,Cardiac Pacing, Artificial ,Syncope (genus) ,Arrhythmias, Cardiac ,Middle Aged ,medicine.disease ,biology.organism_classification ,Phenotype ,Treatment Outcome ,Italy ,Mutation ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
11. Characteristics of pulmonary vein gaps through a novel local impedance algorithm at repeat AF ablation procedures: preliminary results from the CHARISMA registry
- Author
-
A Di Cori, Maurizio Malacrida, Gennaro Izzo, M G Bongiorni, Luca Segreti, Gianluigi Bencardino, Stefano Bianchi, Patrizia Pepi, Giuseppe Ricciardi, Giulio Zucchelli, R De Lucia, Mauro Bura, Ruggero Maggio, Anna Ferraro, and Gaetano Pinnacchio
- Subjects
medicine.medical_specialty ,Sinoatrial block ,business.industry ,Radiofrequency ablation ,medicine.medical_treatment ,Left atrium ,medicine.disease ,Ablation ,Cryosurgery ,Pulmonary vein ,law.invention ,medicine.anatomical_structure ,law ,Physiology (medical) ,medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Af ablation - Abstract
Funding Acknowledgements Type of funding sources: None. Background A high incidence of pulmonary vein (PV) reconnection has been reported in patients with clinical recurrences of AF. Detailed characterization of PV gaps in terms of local impedance (LI) is still lacking. Purpose to characterize PV gaps with a novel local impedance algorithm during redo PV ablation in AF patients (pts). Methods Consecutive pts undergoing repeated AF ablation from the CHARISMA registry with complete characterization of PV gaps through local impedance at 6 Italian centers were included. A complete map of the left atrium and PVs was performed prior and after ablation through the Rhythmia mapping system. A novel RF ablation catheter with dedicated algorithm (DirectSense) was used to measure LI at the distal electrode of this catheter. Each gap was characterized in terms of LI and its variations during ablation procedure according to different ablation sites around the PVs. 7 sites around the left and right pair of PV for LI evaluation during ablation were defined: 2 for posterior sites (PS) (posterior inferior and posterior superior), 2 for anterior sites (AN) (anterior inferior and anterior superior), 1 for interior site (INF), 1 for superior site (SUP) and 1 for the carina (CAR). Ablation endpoint was PVI as assessed by entrance and exit block. Results Eighteen cases of redo AF ablation were analyzed (9 after prior RF ablation, 9 after prior cryoablation). A total of 41 PV gaps were detected (20 after RF ablation, 21 after cryoablation; mean number of gaps per pt = 2.3 ± 1.1): one gap was identified In five (27.8%) pts, 2 gaps were present in 7 (38.9%) pts, 3 gaps were detected in 2 (11.1%) pts and 4 gaps were identified in the remaining 4 (22.2%) pts. PV gaps were most common at AN sites (17, 41.5%), followed by PS sites (12, 29.3%) and CAR sites (11, 28.6%). The mean LI at gap sites was 113.9 ± 15Ω prior to ablation: it was significantly higher than LI at scar tissue closer to gap (99.7 ± 8Ω, p Conclusion In our preliminary experience, PV gaps after failed PVI were most common at anterior, followed by posterior and carina sites. LI characteristics at PV gaps significantly differ from both scar and healthy tissue and could be used to target ablation deliveries.
- Published
- 2021
12. Intraoperative neuromonitoring predicts motor recovery in a long-term hemiplegic patient with a Rolandic metastasis
- Author
-
Francesco Sala, Luigi Cattaneo, Federica Basaldella, Davide Giampiccolo, and Giuseppe Ricciardi
- Subjects
medicine.medical_specialty ,motor evoked potential ,business.industry ,hemiplegia ,Precentral gyrus ,intraoperative neuromonitoring ,medicine.disease ,Sensory Systems ,precentral gyrus ,Metastasis ,Term (time) ,motor recovery ,Physical medicine and rehabilitation ,Neurology ,Physiology (medical) ,medicine ,Motor recovery ,Neurology (clinical) ,Rolandic metastasis ,business - Published
- 2020
13. Magnetic resonance diffusion-tensor imaging metrics in High Grade Gliomas: Correlation with IDH1 gene status in WHO 2016 era
- Author
-
Antonio Nicolato, Elisa Ciceri, Alessandra Bucci, Giada Zoccatelli, Claudio Ghimenton, Giuseppe Ricciardi, Raffaele Augelli, Giampietro Pinna, and Alberto Beltramello
- Subjects
Adult ,Male ,Magnetic Resonance Spectroscopy ,IDH1 ,Multimodal Imaging ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Glioma ,Fractional anisotropy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Retrospective Studies ,business.industry ,Radial diffusivity ,General Medicine ,Middle Aged ,medicine.disease ,Isocitrate Dehydrogenase ,Diffusion Tensor Imaging ,Isocitrate dehydrogenase ,030220 oncology & carcinogenesis ,Mutation ,Anisotropy ,Immunohistochemistry ,Female ,Nuclear medicine ,business ,Diffusion MRI - Abstract
Purpose To evaluate any possible correlation between the presence of Isocitrate DeHydrogenase 1 mutation (IDH1m) and specific DTI (Diffusion Tensor Imaging) metrics, such as Fractional Anisotropy (FA), Mean Diffusivity (MD), Radial Diffusivity (RD) and Axial Diffusivity (AD). Methods We retrospectively analyzed 47 patients who underwent an advanced-MR study with DTI followed by surgical intervention with a subsequent histologic diagnosis of High-Grade Glioma (HGG) and immunohistochemical evaluation of IDH1 (Isocitrate DeHydrogenase) mutation status. For each DTI metrics we measured the ratio between tumor and normal tissue and we evaluated the correlation with IDH1 mutation. Results We observed a positive correlation with IDH1 status and RD and MD data. No correlation was demonstrated between IDH1 status and FA and AD. Discussion Our results support the hypothesis that the number of residual axonal fibers, extracellular matrix composition and the presence of colliquated tissue, may together contribute to a global RD increase in HGG, with a relatively higher increase in IDH1m tumors. Conclusions Our data are in favor of a need for multimodal advance evaluation of HGG. DTI metrics help to analyze IDH1 mutation status, in order to better characterize the lesions and to tailor treatment and follow up.
- Published
- 2019
14. Effect of PR interval and pacing mode on persistent atrial fibrillation incidence in dual chamber pacemaker patients: a sub-study of the international randomized MINERVA trial
- Author
-
Matteo Ziacchi, Raymond Tukkie, Lluís Mont, Antonis S. Manolis, Helmut Puererfellner, Giuseppe Ricciardi, Maurizio Landolina, Giuseppe Boriani, Andrea Grammatico, Mauro Biffi, Manuele Cicconelli, Paolo Pieragnoli, Giovanni Luca Botto, and Michele Massimo Gulizia
- Subjects
Male ,Tachycardia ,Pacemaker, Artificial ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,law.invention ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,law ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Interatrial Block ,030212 general & internal medicine ,PR interval ,Atrioventricular Block ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Sick Sinus Syndrome ,Atrium (architecture) ,business.industry ,Incidence ,Hazard ratio ,Cardiac Pacing, Artificial ,Arrhythmias, Cardiac ,Atrial fibrillation ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,medicine.anatomical_structure ,Ventricle ,Cardiology ,Artificial cardiac pacemaker ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Atrial anti-tachycardia pacing ,Atrioventricular interval ,Managed ventricular pacing ,Pacemaker ,Physiological pacing ,Reactive ATP™ ,Algorithms - Abstract
Aims Per standard of care, dual-chamber pacemakers are programmed in DDDR mode with fixed atrioventricular (AV) delay or with long AV delay to minimize ventricular pacing. We aimed to evaluate whether the PR interval may be a specific criterion of choice between standard DDDR, to preserve AV synchrony in long PR patients, and managed ventricular pacing (MVP), to avoid ventricular desynchronization imposed by right ventricle apical pacing, in short PR patients. Methods and results In the MINERVA trial, 1166 patients were randomized to Control DDDR, MVP, or atrial anti-tachycardia pacing plus MVP (DDDRP + MVP). We evaluated the interaction of PR interval with pacing mode by comparing the risk of atrial fibrillation (AF) longer than 7 consecutive days as a function of PR interval. Out of 906 patients with available data, the median PR interval was 180 ms. The PR interval was found to significantly (P = 0.012) interact with pacing mode for AF incidence: the risk of AF > 7 days was lower [hazard ratio (HR) 0.58, 95% confidence interval (95% CI) 0.34-0.99; P = 0.047] in patients with short PR (shorter than median PR) if programmed in MVP mode compared with DDDR mode and it was lower (HR 0.65, 95% CI 0.43-0.99; P = 0.049) in patients with long PR (equal to or longer than median PR) if programmed in DDDR mode compared with MVP. Conclusion Our data show that PR interval may be used as a selection criterion to identify the optimal physiological pacing mode. Persistent AF incidence was lower in short PR patients treated by right ventricular pacing minimization and in long PR patients treated by standard dual-chamber pacing.
- Published
- 2019
15. Investigation on the fracture behavior of foamed concrete
- Author
-
Antonino Sciarrone, Giuseppe Ricciardi, Dario De Domenico, Jean Marc Christian Tulliani, Devid Falliano, Ernesto Gugliandolo, Luciana Restuccia, and Giuseppe Andrea Ferro
- Subjects
dry density ,Materials science ,fracture energy ,Scanning electron microscope ,foamed concrete ,Curing conditions ,Dry density ,Flexural strength ,Foamed concrete ,Fracture energy ,Lightweight concrete ,Fracture mechanics ,lightweight concrete ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Improved performance ,020303 mechanical engineering & transports ,Compressive strength ,0203 mechanical engineering ,flexural strength ,Crack mouth ,curing conditions ,Composite material ,0210 nano-technology ,Curing (chemistry) ,Earth-Surface Processes - Abstract
The fracture behavior of lightweight foamed concrete (LWFC) is significantly influenced by microstructural properties, which are ascribed to the arrangement of air bubbles and pores as well as to the presence of different hydration products. In this contribution, an experimental investigation on the fracture behavior of LWFC is performed. Notched beams made of LWFC were tested in three-point bending to determine the fracture energy based on the load-CMOD (Crack Mouth Opening Displacement) curve. The influence of the dry density is explored considering one density for non-structural purposes (equal to 800 kg/m3) and another density for structural applications (1600 kg/m3). Moreover, two curing conditions are considered (air and water). The load-CMOD curves reveal that for lower dry densities the fracture behavior of LWFC is particularly affected by the curing conditions, with better results achieved in air curing conditions, but this influence decreases with higher dry densities. The improved performance in air curing conditions for lower dry densities is also observed in terms of flexural strength, but is not particularly evident for the compressive strength. Micrographs across the crack surface determined via Scanning Electron Microscopy (SEM) are finally presented to analyze the experimental findings and justify the results in terms of microstructural configuration of the specimens.
- Published
- 2019
16. Earthquake protection of structures with nonlinear viscous dampers optimized through an energy-based stochastic approach
- Author
-
Dario De Domenico and Giuseppe Ricciardi
- Subjects
Optimal damper design ,Optimal design ,Earthquake protection ,Energy dissipation devices ,Fluid viscous dampers ,Nonlinear power-law damping ,Numerical optimization ,Stochastic linearization technique ,Civil and Structural Engineering ,Computer science ,0211 other engineering and technologies ,Linear model ,020101 civil engineering ,02 engineering and technology ,Dissipation ,0201 civil engineering ,Damper ,Nonlinear system ,Linearization ,Control theory ,021105 building & construction ,A priori and a posteriori ,Energy (signal processing) - Abstract
The earthquake protection of structures equipped with energy dissipation devices in the form of nonlinear fluid viscous dampers (FVDs) is investigated. Most of the optimal design strategies from the literature either address a simplified linear (Newtonian) idealization of the devices, or identify the characteristics of the nonlinear FVDs in a later stage, by invoking the concept of “energy-equivalent” dampers to compromise between the nonlinear power law force-velocity behavior and a simplified (equivalent, in terms of energy dissipation) linear modeling. In this paper, the nonlinear power law behavior of the devices is incorporated a priori in the optimal design process. The proposed strategy, based upon a numerical approach to a constrained optimization problem, invokes a performance criterion that is derived from the energy balance equation of the system, expressed in stochastic terms. To handle the nonlinear constitutive behavior of the FVDs, a novel equal-energy non-Gaussian stochastic linearization technique is integrated in the optimal design process. For a given power-spectral-density function of the seismic excitation, the most effective set of nonlinear FVDs that maximize the energy dissipation behavior can be identified. By stochastic dynamic analysis and by nonlinear response-history-analysis with an ensemble of ground motions, the proposed energy-based design philosophy is found to be better able to control the overall seismic response of the structure than alternative procedures that are not based on energy concepts and that minimize other performance indices.
- Published
- 2019
17. Accounting for variability in the truth-evaluation of bare epistemic possibility statement
- Author
-
Giuseppe Ricciardi and Joshua Martin
- Subjects
General Medicine - Abstract
It is hotly debated whose perspective is relevant for defining the truth-value of bare epistemic possibility statements: the utterer or the assessor. Central to this debate are findings on truth-value judgments of ‘might p’ statements in “eavesdropping” scenarios where the statement is appropriately asserted from the point of view of the speaker but does not correspond to how in reality things are. We offer findings from two studies suggesting that in these scenarios English speakers disagree on the truth-value not only of ‘might p’ but also, surprisingly, of bare ‘p’. We argue that underlying this behavior is not a disagreement on the semantic content of the statements but a disagreement on how to interpret the meaning of the adjectives ‘true’ and ‘false’ when applied to a statement uttered by another agent. Specifically, we compare two potential accounts: the first account ascribes to the adjective ‘true’ an ambiguity between a ‘coherent’ sense – a statement uttered by A is true as long as the statement coheres with A’s evidence – and a ‘correspondentist’ sense - a statement as uttered by A is true as long as the statement correspond to reality; the second account treats ‘true’ as having only the correspondentist sense but ascribes to it an inherent relative nature – to decide if a statement as uttered by A is true one has to first decide a perspective (A or the assessor). Lastly, we discuss the implications of the findings for the semantics of epistemic ‘might p’ statements.
- Published
- 2022
18. Optimum design of tuned mass damper with pinched hysteresis under nonstationary stochastic seismic ground motion
- Author
-
Dario De Domenico, Giuseppe Quaranta, Giuseppe Ricciardi, and Walter Lacarbonara
- Subjects
Control and Systems Engineering ,Mechanical Engineering ,Stochastic optimization ,Signal Processing ,Bouc–Wen hysteretic model ,Pinching ,Seismic protection ,Stochastic linearization ,Tuned mass damper ,Aerospace Engineering ,Computer Science Applications ,Civil and Structural Engineering - Published
- 2022
19. PO-618-04 LONGEVITY OF MODEL-3501 SUBCUTANEOUS IMPLANTABLE DEFIBRILLATOR LEAD IN CLINICAL PRACTICE
- Author
-
STEFANO VIANI, Luca Segreti, Luca Ottaviano, Mauro Biffi, Gerardo Nigro, Giuseppe Ricciardi, Pietro Francia, Antonio D'Onofrio, Giovanni Bisignani, Antonio Dello Russo, PAOLO DE FILIPPO, Francesco Solimene, Antonio Scalone, and Federico Migliore
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2022
20. The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association
- Author
-
Serge Boveda, Anna T. Roberts, Francesco Solimene, Stefano Fumagalli, Nicola Ramacciati, Giulia Zuo, Giuseppe Mascia, Tatjana S. Potpara, Paolo Pieragnoli, Radosław Lenarczyk, Kristina H. Haugaa, Giosuè Mascioli, Nikolaos Dagres, Laura Rasero, Niccolò Marchionni, Giuseppe Ricciardi, and Clinical sciences
- Subjects
Male ,Bradycardia ,Pacemaker, Artificial ,Aging ,medicine.medical_specialty ,media_common.quotation_subject ,Information Seeking Behavior ,Population ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,Aging/psychology ,Prospective Studies ,030212 general & internal medicine ,education ,Aged ,media_common ,Aged, 80 and over ,Heart Failure ,education.field_of_study ,Bradycardia/psychology ,business.industry ,medicine.disease ,Heart Failure/psychology ,Italian population ,Defibrillators, Implantable ,Heart Rhythm ,Defibrillators, Implantable/psychology ,Pacemaker, Artificial/psychology ,Italy ,Multicenter study ,Feeling ,Heart failure ,Ambulatory ,Quality of Life ,Physical therapy ,Female ,Geriatrics and Gerontology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND: Cardiac implantable electronic devices (CIEDs) are widely used to treat bradyarrhythmias or improve the prognosis of patients with heart failure (HF). AIMS: To evaluate age-related (≤ 75 vs. > 75 years) attitudes, worries, psychological effects and needs in an Italian CIEDs population. METHODS: Patients attending their periodical ambulatory evaluation received a questionnaire conceived by the European Heart Rhythm Association Scientific Initiatives Committee as part of a multicenter, multinational snapshot survey. Seven countries participated in the study, and 1646 replies were collected. Of these, 437 (27%) were from Italy. Present results refer to the Italian population only. CIEDs were stratified into devices to treat bradycardia or HF. RESULTS: The use of CIEDs was more common in advanced age. Older patients needed less information about CIEDs than younger ones (p = 0.044), who would prefer to be better informed about CIEDs-related consequences on psychologic profile (p = 0.045), physical (p
- Published
- 2018
21. Transnasal devascularisation of a sinonasal hypervascular tumour (glomangiopericytoma) with direct injection of liquid polymer agent (Squid®)
- Author
-
Davide Soloperto, Raffaele Augelli, Alessandra Agnello, Giuseppe Ricciardi, Mauro Plebani, Daniele Marchioni, Elisa Ciceri, and Claudio Ghimenton
- Subjects
Male ,Percutaneous ,Nose Neoplasms ,Contrast Media ,Punctures ,Injections, Intralesional ,Squid® ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,biology.animal ,Direct puncture ,Head and neck tumour ,direct puncture ,glomangiopericytoma ,intratumoral embolisation ,Animals ,Humans ,Medicine ,Squid ,biology ,business.industry ,Angiography, Digital Subtraction ,Endoscopy ,Glomus Tumor ,Magnetic Resonance Imaging ,Liquid polymer ,Polyvinyls ,Tumour ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery ,Hemangiopericytoma ,Biomedical engineering - Abstract
The technique of direct intratumoral injection of permanent liquid agents has evolved significantly over the past few decades. The percutaneous direct puncture technique is being utilised more and more for embolisation of head and neck hypervascular lesions. We describe a case treated via the direct percutaneous transnasal (TN) puncture technique for embolisation of a sinonasal hypervascular tumour, performed in a 21-year-old male patient. Due to extensive vascularisation of the tumour, preoperative embolisation was requested by our otolaryngologist team in order to minimise intraoperative bleeding and reduce surgical morbidity. A primary attempt at trans-arterial embolisation through selective ophthalmic artery catheterisation was unsuccessful due to unfavourable anatomy. An extensive devascularisation of the nasal fossa lesion was obtained using a single injection of low-density polymeric embolic agent (SQUID®). Post-operative eradication was uneventful. Final histopathology exam revealed vascular tumour consistent with a rare sinonasal glomangiopericytoma. To our knowledge, this is the first reported case of a rare sinonasal glomangiopericytoma treated by direct TN injection, utilising the liquid polymer agent SQUID®.
- Published
- 2018
22. Hydrology across disciplines: the experience of a Public Hydrological Service in Italy
- Author
-
Alessandro Allodi, Fabrizio Tonelli, Elisa Comune, Francesco Cogliandro, Mauro Del Longo, Giuseppe Ricciardi, Mauro Noberini, Giuseppe Nicolosi, Franca Tugnoli, Fabio Bordini, Valentina dell'Aquila, Filippo Pizzera, and Monica Branchi
- Subjects
Service (business) ,Hydrology (agriculture) ,Geography ,business.industry ,Environmental resource management ,business - Abstract
Water is very important for human consumption, production and services and also for inspiration, recreation, landscapes, ecosystems and wild life. UN and EU policies highlights the interaction of historical scientific, economic, societal and environmental factors and the linkage of water policies with biodiversity protection and Climate Change adaptation. According to the European Green Deal (2019), for a fair and prosperous society, with a modern, resource-efficient and competitive economy working across sectors and disciplines, will be needed, also involving local communities. Moreover Political and management processes may take benefits from specific participatory Tools.The Emilia-Romagna Regional Agency for Prevention, Environment and Energy (Arpae) helps sustainability developing actions for water protection, water use, flood management and education to sustainability. Arpae Hydrological Service (HS) supports flood management and water management, as also design and management of hydraulic structures, through the Flood Early Warning System FEWS and the Drought Early Warning System DEWS. Arpae HS also collect and publish hydrological time series (water, solid transport) and stage-discharge equations.Within FP7 Enhance (2017) multi risk analysis and Public Private Partnership (PPPs) experiences were supported by modeling tools combining flood /earthquake/Climate Change scenarios in a densely populated, highly developed land reclamation territory. An Application of the System for Economic and Environmental Accounting for Water (UN SEEA -Water) was developed in 2017. Within Interreg Proline-CE (2019), the FEWS and DEWS Systems, respectively supporting the Flood Forecasting Center and the Observatory on Water Uses, were proposed as Best Management Practices (BMPs) for land and water management useful for drinking water protection. BMPs where tested through workshops, questionnaires, meetings and technical visits, useful for dissemination and stakeholders involvement. H2020 Clara was useful to experience co-design/co-development approaches, to explore market segments and business models for water knowledge and climate services, and to set dedicated Policy Briefs for Water and Climate Change Adaptation; Arpae HS developed a set of modeling services (Clara PWA) related to water management, solid transport, water quality and habitat availability, useful to understand the influenced of climate change and the needs and proposal coming from market and the institutions. Interreg boDEREC-CE is a current project on pharmaceutical and personal care pollutants (PPCPs), aimed at developing tools and strategies for protection of drinking water, water ecosystems and public health from pollution, bacterial resistance, toxicity and pathogens.Arpae HS through these experiences has gained awareness of the inter linkage of hydrology with other sectors (economy, Earth sciences, ICT, health, ecology, society) and of the importance of developing specific decision support tools maximizing stakeholder participation, societal dissemination, transparency, education to sustainability and experts involvement.
- Published
- 2021
23. B-PO02-110 MIND THE GAP: ADVANCED MAPPING CAPABILITIES TO BETTER UNDERSTAND PULMONARY VEINS GAPS DURING REPEAT ATRIAL FIBRILLATION ABLATION
- Author
-
Stefano Bianchi, Mauro Bura, Raffaele De Lucia, Maurizio Malacrida, Daniele Nicolis, Ezio Soldati, Luca Segreti, Stefano Viani, Ruggero Maggio, Giuseppe Ricciardi, Gennaro Izzo, Anna Ferraro, Gianluigi Bencardino, Maria Grazia Bongiorni, and Francesco Perna
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,medicine.medical_treatment ,Internal medicine ,medicine ,Cardiology ,Atrial fibrillation ,Cardiology and Cardiovascular Medicine ,Ablation ,medicine.disease ,business - Published
- 2021
24. B-PO05-098 LOCAL IMPEDANCE CHARACTERISTICS OF PULMONARY VEIN RECONNECTIONS DURING REPEATED ATRIAL FIBRILLATION ABLATION PROCEDURES: INSIGHT FROM AN ITALIAN MULTICENTER REGISTRY
- Author
-
Maria Grazia Bongiorni, Patrizia Pepi, Giulio Zucchelli, Stefano Bianchi, Maurizio Malacrida, Gennaro Izzo, Gaetano Pinnacchio, Andrea Di Cori, Luca Segreti, Ruggero Maggio, Gianluigi Bencardino, Anna Ferraro, Mauro Bura, Giuseppe Ricciardi, and Mario Giannotti Santoro
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,Internal medicine ,medicine.medical_treatment ,Cardiology ,Medicine ,Atrial fibrillation ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Ablation ,Pulmonary vein - Published
- 2021
25. Imaging Approaches for Radiosurgical Treatment of Meningiomas
- Author
-
Giuseppe Ricciardi, Alessandra Bucci, Raffaele Augelli, and Franco Alessandrini
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Computer science ,medicine.medical_treatment ,Image registration ,Magnetic resonance imaging ,medicine.disease ,Radiosurgery ,Meningioma ,Positron emission tomography ,Cavernous sinus ,otorhinolaryngologic diseases ,medicine ,CyberKnife Radiosurgery ,Tomography ,Radiology - Abstract
Magnetic resonance imaging is the reference standard for targeting lesions in radiosurgery. Computerized tomography is mandatory in systems based on linear accelerators and a useful adjunct in selected cases in gamma beam-based systems. Image registration can help implement information from different imaging systems but must be managed with care acknowledging its intrinsic limits and dangers that may differ in different systems and software versions. Advanced magnetic resonance imaging techniques and PET are some of the tools that can provide important additional data. Meningiomas situated in specific locations pose some diagnostic challenges that must be overcome with tailored sequences. Among those, fat-suppressed sequences are very useful in the study of basicranial and intraorbital meningiomas. Heavily T2-weighted volumetric imaging is very useful to delineate margins of meningiomas in the cavernous sinus or anterior posterior fossa. Atypical meningiomas represent a challenge both from a treatment strategy and diagnostic point of view. Several advanced imaging techniques have been used to identify atypical lesions in the preoperative phase, but up to date no single technique or specific combination of techniques can provide a precise non-invasive diagnosis. Characteristics of meningiomas most commonly associated with malignant composition are summarized.
- Published
- 2021
26. Stereotactic Radiosurgery for Cavernous Sinus Meningiomas
- Author
-
Antonio Nicolato, Michele Longhi, Roberto Foroni, Jacopo Lardani, Giampietro Pinna, Emanuele Zivelonghi, Anna D’Amico, Francesco Sala, Paolo Polloniato, Giuseppe Ricciardi, and Giorgia Bulgarelli
- Subjects
Surgical resection ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,parasitic diseases ,Cavernous sinus ,Salvage treatment ,Medicine ,Radiology ,business ,Neurovascular bundle ,Radiosurgery - Abstract
Due to the close proximity of cavernous sinus meningiomas (CSMNs) to vital intracranial neurovascular structures, complete surgical resection may not always be possible. Hence, stereotactic radiosurgery (SRS) has been proposed as a primary, adjuvant and/or salvage treatment option for the management of such cases. The aims of this study were to assess the long-term outcomes of SRS on a large patient series and to identify any prognosticators significantly influencing local tumour control (LTC).
- Published
- 2021
27. Are body mass index and age independent risk factors for new-onset atrial fibrillation after cardiac surgery regardless of left atrial size and left ventricular ejection fraction value?
- Author
-
Laura Perrotta, Pierluigi Stefàno, R Rondine, Niccolò Marchionni, G Del Monaco, Giuseppe Ricciardi, Luca Checchi, Paolo Pieragnoli, Antonio Michelucci, Sergio Bevilacqua, M Bugetti, and G Popescu
- Subjects
medicine.medical_specialty ,Ejection fraction ,Left atrial ,business.industry ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Value (mathematics) ,Body mass index ,New onset atrial fibrillation ,Cardiac surgery - Abstract
Background Obesity, advanced age and left atrium dimensions have been linked to atrial fibrillation (AF). Purpose This study aimed at evidencing if the above mentioned risk factors have a role among the others in conditioning the onset of post operative AF (PoAF) in patients undergoing cardiac surgery without previous AF. Methods This study evaluated 249 consecutive patients undergoing coronary artery by-pass surgery either isolated or in combination with aortic or mitral valve repair/replacement, or isolated valve repair/replacement. Prior to surgery, in all patients the following data were collected: age (yrs), body mass index (BMI, kg/m2), left atrium (LA) diameter (cm), LA area (cm2), left ventricular ejection fraction (LVEF, %), the presence/absence of arterial hypertension (AH) and diabetes, creatinine (mg/dL). To detect the presence of PoAF, cardiac rhythm was continouosly recorded during the first seven postoperative days. Results PoAF occurred in 127 patients (51%). We compared patients with and without PoAF. Mean values (±1 SD) of continuous variables and the frequency of dicothomic ones are reported in the table. No difference was observed for sex, LA diameter, LA area, LVEF and diabetes. Instead, patients with PoAF had higher values of age, BMI, creatinine and a greater prevalence of AH. According to multivariable binary logistic analysis the independent predictors of PoAF were: age (OR = 1.05, CI 95%: 1.026–1.074, p=0.018) and BMI (OR = 1.09, CI 95%: 1.015–1.171, p=0.0001). Conclusions Results suggest that advanced age and a higher value of BMI could be strong risk factors for PoAF in patients who undergo cardiac surgery without previous AF. This considering that in the present population the values of LA diameter, LA area and LVEF showed no statistically significant difference between patients with and without PoAF. Funding Acknowledgement Type of funding source: None
- Published
- 2020
28. Hydrology across Disciplines: Organization and Application Experiences of a Public Hydrological Service in Italy
- Author
-
Alessandro Allodi, Letizia Angelo, Fabio Bordini, Monica Branchi, Elisa Comune, Mauro Del Longo, Giuseppe Nicolosi, Mauro Noberini, Filippo Pizzera, Alessio Pugliese, Giuseppe Ricciardi, Fabrizio Tonelli, Franca Tugnoli, and Enrica Zenoni
- Subjects
Atmospheric Science ,hydrological services ,water cycle modeling ,weather related risk management ,territorial knowledge ,climate change adaptation - Abstract
Water is a fundamental resource for human life and nature; flood management, water supply systems and water protection policies are a few examples of equally important disciplines across the whole hydrological cycle. The present work focuses on the creation and sharing of hydrological knowledge within public activities, with regard to materials and methods adopted for developing and supplying hydrological information, suitable to different stakeholders needs, throughout different disciplines and sectors of environment, economy, society, as well as research and analysis. The aim of this work is to better understand the market in order to increase the value of hydrological data, products and services, and to reduce potential gaps and overlapping areas. The method we developed is based on the example of the Hydrological Service of Emilia-Romagna Region, Italy. Institutional, legal and territorial frameworks as well as agency organization, materials, methods, instruments, activities, products and results are briefly described, focusing on those supporting civil and environmental protection, water management, infrastructure design, climate change adaptation and mitigation measures. We discuss the role of a public Administration in interdisciplinary activities, the links between the general background (e.g., territory, society, rules), organizations, actors, resources, tools, processes and results, by highlighting, where possible, a potential starting point for future research studies. Finally, this paper adopts a novel linguistic style, based on an informal format, in order to explore the set-up and follow-up of the Hydrological Service’s initiatives, with the final aim of sparking curiosity and building awareness, from different sectors and disciplines, which, ultimately, may benefit from the presented approaches.
- Published
- 2022
29. Overweight and Aging Increase the Risk of Atrial Fibrillation After Cardiac Surgery Independently of Left Atrial Size and Left Ventricular Ejection Fraction
- Author
-
Pier Luigi Stefano, Marco Bugetti, Guido Del Monaco, Gloria Popescu, Paolo Pieragnoli, Giuseppe Ricciardi, Laura Perrotta, Luca Checchi, Roberto Rondine, Sergio Bevilacqua, Niccolò Marchionni, and Antonio Michelucci
- Abstract
Background: Body mass index (BMI), age, left atrium (LA) dimensions and left ventricular ejection fraction (LVEF) have been linked to post-operative atrial fibrillation (POAF) after cardiac surgery. The aim was to better define the role of these risk factors. Methods: This study evaluated 249 patients (without prior atrial dysrhythmia) undergoing cardiac or aortic surgery . Prior to surgery the following data were collected: age (yrs), BMI (kg/m2), LA diameter (cm), LA area (cm2), LVEF (%), the presence of arterial hypertension (AH) and of diabetes, tyroid stimulating hormone (TSH, mU/L) and, creatinine (mg/dL). Results: Patients with (n. 127, 51%) and without POAF (n. 122, 49%) were compared. No difference was observed for sex, LA diameter, LA area, LVEF, TSH and diabetes. Instead, patients with PoAF had higher values of age, BMI, creatinine and a greater prevalence of AH and Bentall procedures. Multivariable analysis showed that the only independent predictors of PoAF were: age (OR = 1,05, CI 95% 1,025-1,076, p= 0,0001) and BMI (OR=1,095, CI 95% 1,015-1,182, p= 0,019). Conclusions: Results suggest that advanced age and a higher value of BMI are strong risk factors for POAF in patients without previous AF. This even in the presence of comparable LA dimensions and LVEF.
- Published
- 2020
30. Myocardial Scar on Surface ECG: Selvester Score, but Not Fragmentation, Predicts Response to CRT
- Author
-
Giosuè Mascioli, Luca Checchi, Federica Michelotti, Martina Nesti, Paolo Pieragnoli, Giuseppe Ricciardi, Alessandro Paoletti Perini, Rossella Bani, Elena Cavarretta, Stella Cartei, and Luigi Sciarra
- Subjects
medicine.medical_specialty ,Article Subject ,Fragmented qrs ,ECG ,cardiac arrhythmias ,myocardial fibrosis ,left bundle branch block ,Surface ecg ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,Major adverse cardiovascular event ,Ejection fraction ,Left bundle branch block ,business.industry ,medicine.disease ,Heart failure ,RC666-701 ,Cohort ,Cardiology ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Purpose. Myocardial scar is directly related to the response to CRT after implantation. The extent of myocardial scar can be detected not only by cardiac magnetic resonance but also by two electrocardiographic scores: fragmented QRS (fQRS) and Selvester score (SSc). The aim of our study is to compare the role of baseline SSc and fQRS in predicting response to CRT in a cohort of heart failure patients with true left bundle branch block (LBBB). As a secondary endpoint, we assessed the association of both scores with overall and cardiac mortality, heart failure hospitalizations, ventricular arrhythmias requiring ICD intervention, and major adverse cardiovascular event (MACE). Methods. We evaluated fQRS and SSc of 178 consecutive HF patients with severe systolic dysfunction (LVEF ≤ 35%), NYHA class II-III despite optimal medical treatment, and true-LBBB. Response to CRT was defined as the improvement of LVEF of at least 10% or as the reduction of LVESV of at least 15% at a 6-month follow-up. Each endpoint was related to fQRS and SSc. Results. SSc ≥7 was significantly associated with the absence of echocardiographic response to CRT (OR: 0.327; 95% C.I. 0.155–0.689; p = 0.003 ), while the presence of fQRS at baseline ECG was not (OR: 1.133; 95% C.I. 0.539–2.381; p = 0.742 ). No correlation was found between SSc and overall mortality, cardiac death, ventricular arrhythmias, hospitalizations due to heart failure, or for MACE. Similar results were observed between fQRS and all secondary endpoints. Conclusion. In HF patients with true-LBBB and LVEF ≤35% eligible for CRT, myocardial scar assessed by calculating the SSc on preimplant ECG is an independent predictor of nonresponse after multiple adjustments. Neither SSc nor fQRS is associated with overall and cardiac death, ventricular arrhythmias, or hospitalization for heart failure at a 24-month follow-up.
- Published
- 2020
31. P1149Subcutaneous implantable cardioverter-defibrillator when Transvenous ICD is not a viable option
- Author
-
A Pangallo, C La Greca, Giuseppe Ricciardi, R Brambilla, Carlo Lavalle, Vincenzo Russo, Matteo Ziacchi, S De Bonis, Mariolina Lovecchio, S Molini, Anna Rago, R Ospizio, A Tordini, Federico Migliore, and Stefano Viani
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,medicine.medical_treatment ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Implantable cardioverter-defibrillator ,Intensive care medicine - Abstract
Funding Acknowledgements NO FUNDING OnBehalf RHYTHM DETECT Registry Background The class of recommendation for S-ICD implantation in patients who have inadequate vascular access is I according to AHA-ACC-HRS Guidelines and IIb according to ESC Guidelines. Data are lacking about the use of S-ICD for patients in which a transvenous ICD is not a viable option because of the inability to deploy a transvenous lead. Purpose To describe current practice and to measure outcomes associated with S-ICD use in patients in which a transvenous ICD is not a viable option. Methods 942 consecutive patients underwent S-ICD implantation at 22 Italian centers from 2014 to 2019. We identified 101 (11%) patients who received S-ICD because of the reported impossibility of deploying a transvenous lead. Results 21 patients presented with inadequate vascular access but no previous device in place. One patient had a mechanical prosthesis in tricuspid position. The remaining 79 patients received the S-ICD after removal of a prior system implanted, and venous occlusion was diagnosed after lead extraction, or partially or completely failed lead removal. In 24 of these patients a functional transvenous pacing system was left in place for persisting pacing needs. Patients were 60 ± 15 years old, 85% were male, 77% had ischemic or non-ischemic dilated cardiomyopathy, ejection fraction was 36 ± 13%. At implantation, acute conversion test was performed in 64 patients and shock energy of ≤65J was successful in 62 (96.9%) patients. During a median follow-up of 18 months, 6 patients died for non-device related reasons and 1 patient underwent heart transplantation. One patient underwent device replacement for battery depletion and one patient underwent leadless pacemaker implantation. Minor complications (hematomas not requiring system revision) were reported in 2 patients. Appropriate therapies were delivered in 4 patients and 8 patients experienced inappropriate therapies (in 3 patients due to double counting during pacing); all resolved with device reprogramming. Conclusions: In current clinical practice, a minority of S-ICD patients receive the device because of inadequate vascular access. The profile of these patients is similar to that of the typical ICD population in the context of primary sudden death prevention, but many of them present with pacing indications. Acute and mid-term efficacy of S-ICD seemed high. Few complications occurred during follow-up. Particular attention must be paid to device programming for those patients with concomitant pacing systems, in order to prevent inappropriate therapies.
- Published
- 2020
32. 67Atrial fibrillation and depressive symptoms in the elderly: an association with age, CHA2DS2-VASc score and physical performance
- Author
-
Enrico Mossello, Andrea Ungar, R Franci Montorzi, G. Pelagalli, C. Di Serio, M Lomi, Stefano Fumagalli, Marta Migliorini, Paolo Pieragnoli, Niccolò Marchionni, Giuseppe Ricciardi, and Irene Marozzi
- Subjects
Fibrillation ,Univariate analysis ,medicine.medical_specialty ,Mini–Mental State Examination ,medicine.diagnostic_test ,business.industry ,Atrial fibrillation ,medicine.disease ,Physiology (medical) ,Heart failure ,Internal medicine ,CHA2DS2–VASc score ,Heart rate ,medicine ,Geriatric Depression Scale ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background. Atrial fibrillation (AF) is the most frequent sustained arrhythmia found in clinical practice. Its prevalence significantly grows with age. The proportion of elderly individuals with depression varies between 4.2 and 10.6% according to the different criteria used for diagnosis. Interestingly, AF and depression synergistically act to increase mortality. Purpose. Aim of this study was to identify the clinical variables associated with depressive symptoms in elderly individuals with persistent AF. Methods. All patients consecutively admitted in a Day-Hospital setting to undergo electrical cardioversion of AF were enrolled in the study. No exclusion criteria were specified. Population was studied with instruments exploring neurocognitive performance (Mini-Mental State Examination - MMSE; range: 0-30; abnormal values 5). In this case, lower scores identified a healthier emotional profile. Results. Between January 2018 and August 2019, 111 patients were evaluated (age: 77 ± 9 years; women: 39.6%; weight: 78 ± 15 Kg; height: 171 ± 11 cm). Lone AF and brady- tachy- syndrome were diagnosed in 12.6% of cases. Hypertension and structural heart disease (coronary artery disease, heart failure, valvular heart disease) were responsible of the arrhythmia in 30.6% and 56.8% of patients, respectively. Left ventricular ejection fraction was 60 ± 12%, with a heart rate equal to 78 ± 17 bpm. MMSE and SPPB score were 28 ± 3 and 8.7 ± 2.9. An abnormal GDS score was observed in 19.8% of cases (mean: 3.0 ± 2.7). Interestingly, in univariate analysis, depressive symptoms increased with age (p = 0.002) and the CHA2DS2-VASc score ( =6: 4.4 ± 2.8; p Conclusions. In a population of elderly patients with persistent AF, the prevalence of depression is not negligible. Importantly, depressive symptoms are significantly associated with the CHA2DS2-VASs score, and, at multivariate analysis, with renal function, to live alone and physical performance. Paradoxically, after adjustment for these factors, GDS score decreases with age per se.
- Published
- 2020
33. Improved response-spectrum analysis of base-isolated buildings: A substructure-based response spectrum method
- Author
-
Giuseppe Ricciardi, Dario De Domenico, and Giovanni Falsone
- Subjects
Response-spectrum-method, Base-isolated buildings, Substructure approach, Spectrum-compatible artificial earthquakes, Modal superposition, Nonclassically damped structures ,Nonclassically damped structures ,021110 strategic, defence & security studies ,Superstructure ,Modal superposition ,Response-spectrum-method ,Computer science ,Modal analysis ,Monte Carlo method ,0211 other engineering and technologies ,Substructure approach ,Equations of motion ,020101 civil engineering ,02 engineering and technology ,Spectrum-compatible artificial earthquakes ,0201 civil engineering ,Nonlinear system ,Base-isolated buildings ,Substructure ,Direct integration of a beam ,Response spectrum ,Algorithm ,Civil and Structural Engineering - Abstract
Unsatisfactory numerical predictions may result from applying the classical modal analysis in conjunction with the response-spectrum-method (RSM) to nonclassically-damped systems such as base-isolated buildings. This inaccuracy is highlighted by comparing the conventional RSM outcomes with results from nonlinear time-history analyses consistent with that given spectrum. Indeed, some underlying assumptions of the conventional RSM are not really appropriate for base-isolated buildings, thus only approximate results are obtained, whereas either a complex-value modal analysis or the direct integration of the equations of motion should be undertaken to follow an exact approach to this problem. In an attempt to overcome the limitations of the conventional RSM as well as the mathematical difficulties and computational cost of the exact approach, in this paper an improved response-spectrum analysis procedure for base-isolated buildings is elaborated. Based upon the substructure approach, this procedure makes use of novel response spectra that quantify the effects of the base-isolation-system (BIS) to the superstructure while accounting for the dynamic interaction between BIS and superstructure. The developed procedure improves the conventional RSM in two aspects: (1) the seismic response of the base-isolated building is computed by applying the modal analysis to the superstructure only, which is typically considered as a classically damped system, rather than to the overall structure having nonclassical damping; (2) the BIS can potentially be modeled as a nonlinear subsystem with its actual hysteretic characteristics. The effectiveness of the proposed procedure and the improvements over the conventional RSM are scrutinized against time-history analyses with Monte Carlo simulated spectrum-compatible accelerograms.
- Published
- 2018
34. Analytical and finite element investigation on the thermo-mechanical coupled response of friction isolators under bidirectional excitation
- Author
-
Gianmario Benzoni, Fernando Fraternali, Dario De Domenico, and Giuseppe Ricciardi
- Subjects
021110 strategic, defence & security studies ,Materials science ,0211 other engineering and technologies ,Soil Science ,020101 civil engineering ,02 engineering and technology ,Mechanics ,Function (mathematics) ,Geotechnical Engineering and Engineering Geology ,Finite element method ,0201 civil engineering ,Heat flux ,Node (physics) ,Phenomenological model ,Thermal ,Coupled thermo-mechanical analysis ,Finite elements ,Friction isolators ,Frictional heating ,Multi-directional excitation ,Sliding bearings ,Civil and Structural Engineering ,Excitation ,Parametric statistics - Abstract
The hysteretic behavior of friction concave isolators is affected by the variability of the friction coefficient experienced during a seismic event. This variability is a combined function of axial load, sliding velocity and temperature rise at the sliding surface, the latter being responsible for significant friction degradation. Experimental testing and corresponding numerical models are usually focused on the monodirectional performance of the friction isolators, although multi-directional paths occur in a real earthquake scenario. In this paper, the thermo-mechanical coupled (TMC) response of friction concave isolators when subjected to bidirectional excitation is investigated in both an analytical and a numerical framework. First, a simplified phenomenological model is presented that accounts for the friction degradation due to the distance traveled via a macroscale cycling variable, based on the assumption of a uniform heat flux at the sliding interface. Then, a more sophisticated numerical investigation is performed via a TMC finite element (FE) model. A customized subroutine has been developed and implemented into the FE code to account for the local variation of the friction coefficient due to the local temperature rise and sliding velocity. The mutual interaction between mechanical and thermal response is incorporated in the proposed computational approach: the friction-induced temperature rise on the contact points and the consequent friction degradation caused by heating phenomena are analyzed as two interconnected phenomena in a recursive fashion. The friction coefficient law at the sliding interface is adjusted step-by-step and is different from node to node on the basis of the temperature distribution. Validated against experimental data, the two proposed models are used within a parametric study to scrutinize some interesting features observed in the thermo-mechanical response of friction isolators.
- Published
- 2018
35. Primary versus secondary mechanical thrombectomy for anterior circulation stroke in children: An update
- Author
-
Manuel Cappellari, Giuseppe Ricciardi, Giuseppe Moretto, Paolo Bovi, Elisa Francesca Maria Ciceri, and Andrea Grazioli
- Subjects
medicine.medical_specialty ,Anterior Cerebral Artery ,Childhood ,Endovascular ,Intra-arterial ,Pediatric ,Stroke ,Thrombectomy ,030204 cardiovascular system & hematology ,Asymptomatic ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Occlusion ,medicine ,Intra arterial ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Acute ischemic stroke ,Radiological and Ultrasound Technology ,business.industry ,medicine.disease ,Surgery ,Mechanical thrombectomy ,Middle cerebral artery ,Neurology (clinical) ,medicine.symptom ,Internal carotid artery ,business ,030217 neurology & neurosurgery - Abstract
This review of the literature on the use of mechanical thrombectomy (MT) in children with acute ischemic stroke from occlusion of the internal carotid artery and the proximal middle cerebral artery (MCA) compares the efficacy and safety of primary and secondary MT. We analyzed the data reported for 24 case reports from 20 relevant articles published up to 31 December 2016 and the data of a patient treated at our institution. Eighteen cases received primary MT and 7 received secondary MT. The proportions of complete MCA recanalization, small infarcts, and asymptomatic intracranial hemorrhage were similar in both MT groups (73% [11/15] vs. 67% [4/6], 58% [7/12] vs. 60% [3/5], and 15% [2/13] vs. 17% [1/6], respectively). The proportion of favorable neurological outcomes was higher for the primary MT group (69% [11/16] vs. 43% [3/7]). We found no substantial differences in efficacy and safety between primary and secondary MT for anterior circulation stroke in children.
- Published
- 2018
36. Earthquake Protection of Existing Structures with Limited Seismic Joint: Base Isolation with Supplemental Damping versus Rotational Inertia
- Author
-
Giuseppe Ricciardi and Dario De Domenico
- Subjects
Optimal design ,021110 strategic, defence & security studies ,Article Subject ,Computer science ,business.industry ,0211 other engineering and technologies ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Moment of inertia ,Dashpot ,0201 civil engineering ,Power (physics) ,law.invention ,lcsh:TA1-2040 ,law ,Inerter ,Joint (building) ,Isolation (database systems) ,Base isolation ,lcsh:Engineering (General). Civil engineering (General) ,business ,Civil and Structural Engineering - Abstract
Existing civil engineering structures having strategic importance, such as hospitals, fire stations, and power plants, often do not comply with seismic standards in force today, as they were designed and built based on past structural guidelines. On the other hand, due to their special importance, structural integrity of such buildings is of vital importance during and after earthquakes, which puts demands on strategies for their seismic protection. In this regard, seismic base isolation has been widely employed; however, the existing limited seismic joint between adjacent buildings may hamper this application because of the large displacements concentrated at the isolation floor. In this paper, we compare two possible remedies: the former is to provide supplemental damping in conventional base isolation systems and the latter consists in a combination of base isolation with supplemental rotational inertia. For the second strategy, a mechanical device, called inerter, is arranged in series with spring and dashpot elements to form the so-called tuned-mass-damper-inerter (TMDI) directly connected to an isolation floor. Several advantages of this second system as compared to the first one are outlined, especially with regard to the limitation of floor accelerations and interstory drifts, which may be an issue for nonstructural elements and equipment, in addition to disturbing occupants. Once the optimal design of the TMDI is established, possible implementation of this system into existing structures is discussed.
- Published
- 2018
37. An enhanced base isolation system equipped with optimal tuned mass damper inerter (TMDI)
- Author
-
Giuseppe Ricciardi and Dario De Domenico
- Subjects
Computer science ,020101 civil engineering ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,0201 civil engineering ,law.invention ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Control theory ,law ,Tuned mass damper ,Earth and Planetary Sciences (miscellaneous) ,Inerter ,Base isolation - Published
- 2017
38. 3T magnetic resonance-guided focused ultrasound thalamotomy in patients with essential tremor: Three-year clinical experience from a single center
- Author
-
Antonio Nicolato, Michele Tinazzi, Tommaso Bovi, Stefano Tamburin, Michele Longhi, Giuseppe Ricciardi, Giorgia Bulgarelli, Bruno Bonetti, Roberto Foroni, and Stefania Montemezzi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Essential tremor ,Thalamotomy ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,Single Center ,medicine.disease ,Focused ultrasound ,Neurology ,medicine ,In patient ,Neurology (clinical) ,Radiology ,business - Published
- 2021
39. CT perfusion aspects predicts final ischemia extent in patients with stroke beyond 6 h after symptoms onset
- Author
-
Bruno Bonetti, Manuel Cappellari, Giulia Sajeva, P. G. Zampieri, Nicola Micheletti, Giuseppe Ricciardi, Mauro Plebani, Niccolò Mandruzzato, Cecilia Zivelonghi, Giampaolo Tomelleri, and Raffaele Augelli
- Subjects
medicine.medical_specialty ,Neurology ,business.industry ,Internal medicine ,Cardiology ,medicine ,Ischemia ,Perfusion scanning ,In patient ,Neurology (clinical) ,medicine.disease ,business ,Stroke - Published
- 2021
40. B-PO04-060 DEVICE-RELATED DISTRESS, BODY IMAGE CONCERNS, RETURN TO FUNCTION AND POSITIVE APPRAISAL IN PATIENTS WITH SUBCUTANEOUS VERSUS TRANSVENOUS DEFIBRILLATOR
- Author
-
Antonio Scalone, Stefano Viani, Pietro Francia, Giovanni Carreras, Luca Ottaviano, Antonio D'Onofrio, G. Savarese, Silvana De Bonis, Roberto Rordorf, Eduardo Celentano, Mariolina Lovecchio, Luca Santini, Giuseppe Ricciardi, Alessandro Vicentini, and Filippo Lamberti
- Subjects
Distress ,medicine.medical_specialty ,business.industry ,Physiology (medical) ,Internal medicine ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Image (mathematics) - Published
- 2021
41. A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker
- Author
-
Anna Tamanini, Albino Eccher, Gianfranco Di Gennaro, Donatella Benati, Alessandra Bossi, Giulio Cabrini, Beatrice Gardenghi, Elisa Francesca Maria Ciceri, Francesco Sala, Giuseppe Lippi, Alessandra Santangelo, Ilaria Scambi, Pietro Imbrucè, Giampietro Pinna, Rina Agushi, Laura Belli, Giuseppe Ricciardi, Andrea Sbarbati, Raffaella Mariotti, Silvia Munari, and Maria Cristina Dechecchi
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Neurology ,Circulating biomarkers ,Exosomes ,Sensitivity and Specificity ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Glioma ,microRNA ,Biomarkers, Tumor ,medicine ,Humans ,Gliomas ,Diagnostic biomarker ,neoplasms ,Aged ,Neuroradiology ,Brain Neoplasms ,business.industry ,Middle Aged ,medicine.disease ,Microvesicles ,nervous system diseases ,MicroRNAs ,Circulating MicroRNA ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,MiRNAs ,Neurology (clinical) ,Differential diagnosis ,business - Abstract
Malignant gliomas, the most frequent primary brain tumors, are characterized by a dismal prognosis. Reliable biomarkers complementary to neuroradiology in the differential diagnosis of gliomas and monitoring for post-surgical progression are unmet needs. Altered expression of several microRNAs in tumour tissues from patients with gliomas compared to normal brain tissue have been described, thus supporting the rationale of using microRNA-based biomarkers. Although different circulating microRNAs were proposed in association with gliomas, they have not been introduced into clinical practice so far. Blood samples were collected from patients with high and low grade gliomas, both before and after surgical resection, and the expression of miR-21, miR-222 and miR-124-3p was measured in exosomes isolated from serum. The expression levels of miR-21, miR-222 and miR-124-3p in serum exosomes of patients with high grade gliomas were significantly higher than those of low grade gliomas and healthy controls and were sharply decreased in samples obtained after surgery. The analysis of miR-21, miR-222 and miR-124-3p in serum exosomes of patients affected by gliomas can provide a minimally invasive and innovative tool to help the differential diagnosis of gliomas at their onset in the brain and predict glioma grading and non glial metastases before surgery.
- Published
- 2017
42. Recurrences in the Blanking Period and 12-Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non-Paroxysmal Atrial Fibrillation
- Author
-
Luigi Padeletti, Letizia Mannucci, Alessandro Paoletti Perini, Paolo Pieragnoli, Iacopo Muraca, Andrea Giomi, Giuseppe Ricciardi, and Luca Checchi
- Subjects
medicine.medical_specialty ,Paroxysmal atrial fibrillation ,business.industry ,medicine.medical_treatment ,Cryoablation ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,Likelihood ratios in diagnostic testing ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Implantable loop recorder ,medicine ,Cardiology ,Clinical significance ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,Continuous Cardiac Monitoring ,business - Abstract
Early and Late Recurrences in AF CryoablationIntroduction Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within-blanking recurrences at 12-month follow-up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm. Methods and Results Sixty consecutive AF patients (34 paroxysmal, 56.7%) underwent their first CB-PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12-month success rate after the blanking period was 55%. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non-paroxysmal (19/26, 73.1%) than in paroxysmal AF (8/34, 23.5%; P
- Published
- 2017
43. Effectiveness of subcutaneous implantable cardioverter-defibrillator testing in patients with hypertrophic cardiomyopathy
- Author
-
Antonio Rapacciuolo, Giovanni Quarta, Giuseppe Limongelli, Maria Angela Losi, Giuseppe Allocca, Giovanni Battista Perego, Iacopo Olivotto, Giuseppe Ricciardi, Maria Grazia Bongiorni, Paolo De Filippo, Paolo Pieragnoli, Niccolò Maurizi, Stefano Viani, Ilaria Tanini, Ernesto Amendola, Paola Ferrari, Franco Cecchi, Maurizi, Niccolã³, Tanini, Ilaria, Olivotto, Iacopo, Amendola, Ernesto, Limongelli, Giuseppe, Losi, Maria Angela, Allocca, Giuseppe, Perego, Giovanni Battista, Pieragnoli, Paolo, Ricciardi, Giuseppe, De Filippo, Paolo, Ferrari, Paola, Quarta, Giovanni, Viani, Stefano, Rapacciuolo, Antonio, Bongiorni, Maria Grazia, Cecchi, Franco, and Maurizi, Niccoló
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Defibrillation ,medicine.medical_treatment ,Electric Countershock ,030204 cardiovascular system & hematology ,Sudden cardiac death ,Young Adult ,03 medical and health sciences ,S-ICD ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Sudden death prevention ,Equipment Safety ,business.industry ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Implantable cardioverter-defibrillator ,medicine.disease ,Defibrillators, Implantable ,Death, Sudden, Cardiac ,Shock (circulatory) ,Ventricular Fibrillation ,cardiovascular system ,Cardiology ,Female ,Implant ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Wall thickness ,business ,Follow-Up Studies - Abstract
Background: Subcutaneous ICD (S-ICD) is a promising option for Hypertrophic Cardiomyopathy (HCM) patients at risk of Sudden Cardiac Death (SCD). However, its effectiveness in terminating ventricular arrhythmias in HCM is yet unresolved.Methods: Consecutive HCM patients referred for S-ICD implantation were prospectively enrolled. Patients underwent one or two attempts of VF induction by the programmer. Successful conversion was defined as any 65 J shock that terminated VF (not requiring rescue shocks). Clinical and instrumental parameterswere analyzed to study predictors of conversion failure.Results: Fifty HCMpatients (34males, 40 +/- 16 years) with amean BMI of 25.2 +/- 4.4 kg/m(2) were evaluated. Mean ESC SCD risk of was 6.5 +/- 3.9% and maximal LV wall thickness (LVMWT) was 26 +/- 6 mm. In 2/50 patients no arrhythmias were inducible, while in 7 (14%) only sustained ventricular tachycardia was induced and cardioverted. In the remaining 41 (82%) patients, 73 VF episodes were induced (1 episode in 14 and > 1 in 27 patients). Of these, 4 (6%) spontaneously converted. In 68/69 (98%) the S-ICD successfully cardioverted, but failed in 1 (2%) patient, who needed rescue defibrillation. This patient was severely obese (BMI 36) and LVMWT of 25 mm. VF was re-induced and successfully converted by the 80 J reversed polarity S-ICD.Conclusions: Acute DT at 65 J at the implant showed the effectiveness of S-ICD in the recognition and termination of VT/VF in all HCM patients except one. Extreme LVH did not affect the performance of the device, whereas severe obesity was likely responsible for the single 65 J failure. (C) 2017 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2017
44. Analysis of dynamic instabilities in bridges under wind action through a simple friction-based mechanical model
- Author
-
Giuseppe Ricciardi, Dario De Domenico, and I. Failla
- Subjects
Engineering ,divergence instability ,Normal force ,business.industry ,Traction (engineering) ,02 engineering and technology ,General Medicine ,Structural engineering ,follower force ,021001 nanoscience & nanotechnology ,Coulomb friction ,Flutter instability ,Engineering (all) ,01 natural sciences ,Centripetal force ,Contact force ,Central force ,0103 physical sciences ,Fictitious force ,0210 nano-technology ,business ,010301 acoustics ,Conservative force ,Friction torque - Abstract
In the field of stability of structures under nonconservative loads, the concept of follower force has long been debated by scientists due to the lack of actual experimental evidence. Bigoni and Noselli’s work [2] aimed to investigate flutter and divergence instability phenomena through a purely mechanical model with Coulomb friction represents a praiseworthy attempt to shed light on this issue. A two-degree-of-freedom (DOF) system, conceived as a variant of the Ziegler column, was set up experimentally. The follower load was induced by a frictional force acting on a wheel mounted at the column end, so that the rolling friction vanishes and the sliding frictional force keeps always coaxial to the column, thus representing a tangential follower force. Along this research line, in this contribution a model is elaborated that stems from the analysis of an elastically supported rigid plate that represents the behaviour of a bridge deck suspended on springs and subjected to a wind-induced force. The wind force has been simulated by a Coulomb friction force acting on a wheel mounted on the plate aerodynamic centre, so that the sliding friction force keeps perpendicular to the plate axis throughout the system motion, thus representing a follower force. To properly reproduce the wind force, the friction force is applied to the wheel by a lever mechanism wherein one of the two lever arms involves the plate rotation via a particular circular guide. The corresponding equations of motion of the bridge deck are derived in a completely dimensionless form. Depending on the mechanical characteristics of the plate and the magnitude of the friction force, stability, flutter or divergence phenomena may occur. The occurrence of these phenomena is numerically investigated by integration of the equations of motion. The development of an experimental framework of the model to corroborate these intuitions is the object of an ongoing research.
- Published
- 2017
45. P6556Prevention of long-lasting atrial fibrillation through device therapy in dual-chamber pacemakers: analysis on 1384 patients of the role of Reactive ATP and atrial preventive pacing
- Author
-
J. Comisso, Matteo Ziacchi, G. Zanotto, M. Landolina, Michele Massimo Gulizia, Andrea Grammatico, Giuseppe Ricciardi, D. Facchin, Mauro Biffi, Renato Pietro Ricci, Alessandro Proclemer, G.L. Botto, Paolo Pieragnoli, and G Boriani
- Subjects
Dual Chamber Pacemaker ,medicine.medical_specialty ,Sinoatrial node ,business.industry ,Atrial fibrillation ,medicine.disease ,law.invention ,medicine.anatomical_structure ,law ,Internal medicine ,Heart failure ,medicine ,Cardiology ,Artificial cardiac pacemaker ,Atrium (heart) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Atrial flutter ,Atrial tachycardia - Abstract
Background Atrial fibrillation (AF) is the most prevalent heart rhythm disorder in clinical practice and it is associated with poor quality of life and increased risks of heart failure, dementia, stroke, and death. Moreover AF management is a huge cost for healthcare systems. AF is irregular, typically originates from the pulmonary veins, and as such, requires cardioversion to terminate persistent episodes. AF is not susceptible to pace-termination, however, the MINERVA trial has shown that AF may transform in slower organized rhythms such as atrial flutter or atrial tachycardia, which can often be terminated by atrial anticahycardia pacing (ATP); in particular by Reactive ATP, a specific ATP feature which can be re-armed when atrial arrhythmias get slower or more regular. The MINERVA trial showed that the combination of ATP, preventive atrial pacing algorithms and minimal ventricular pacing (MVP) was associated with lower progression to persistent and permanent AF, compared with standard DDD pacing mode and to MVP mode, in pacemaker patients with clinical history of AF. Purpose We aimed to confirm MINERVA trial results in real-world clinical practice and to evaluate whether AF prevention was associated with preventive atrial pacing or solely with ATP. Indeed in our project atrial preventive pacing algorithms were not enabled and the pacing mode (DDD or MVP) was chosen according to patients' AV conduction characteristics. Methods Consecutive dual-chamber pacemaker patients with sinus node disease and device detected AT/AF were prospectively followed by 30 Italian cardiologic centers in an observational research. Clinical and device data were collected and reviewed by expert cardiologists to assess AT/AF occurrence through in clinic visit and/or remote transmissions of device data. Results A total of 239 patients (73 years old, 56% male) wearing a dual-chamber pacemaker with Reactive ATP were included in the project, followed for a median observation period of 13 months and compared with 1145 patients included in the MINERVA trial followed for a median observation period of 34 months and programmed with DDD pacing mode (383 patients), MVP (389 patients) and MVP+Reactive ATP+preventive algorithms (373 patients). As shown in the following figure incidence of 7 consecutive days of AF in the patients treated by DDD/MVP+Reactive ATP in real-world clinical practice was very similar to that found in the MINERVA trial arm programmed with MVP+Reactive ATP+preventive algorithms. Incidence of AF longer than 7 days Conclusions Our analysis performed in a population of sinus node disease patients with dual-chamber pacemakers confirmed MINERVA trial results in terms of prevention of long-lasting AF episodes. In particular these results confirm the benefit associated with the use of Reactive ATP, rather than preventive atrial pacing algorithms.
- Published
- 2019
46. P5688Is renal dysfunction associated with the outcome of CRT patients?
- Author
-
Albino Reggiani, Massimiliano Marini, Giuseppe Arena, Giampiero Maglia, Pietro Palmisano, Emanuele Bertaglia, Antonio Rapacciuolo, Giuseppe Stabile, Si. Caico, Antonio D'Onofrio, Quintino Parisi, Domenico Pecora, Giuseppe Ricciardi, A De Simone, and Maurizio Malacrida
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Outcome (game theory) - Abstract
Background The benefit of cardiac resynchronization therapy (CRT) in patients (pts) with chronic kidney disease (CKD) remains controversial despite frequent use. Pts with impaired renal function have systematically been excluded from randomized clinical trials and therefore specific recommendations for the use of CRT in these pts are still lacking. Purpose Study objectives were to assess long-term outcomes and clinical/echocardiographic response in a large population of patients with moderate-to-severe impaired renal function implanted with a CRT device in accordance with the current standard of care. Methods We prospectively analyzed clinical, instrumental data and survival of pts with CKD who received a CRT device in the CRT-MORE registry from 2011 to 2014. Adverse events for the analysis of clinical outcome comprised death from any cause and nonfatal HF events requiring hospitalization after CRT implantation. LV reverse remodeling and Clinical Response (CR) were also evaluated at 12-month follow-up. Patients were stratified according to current definition of CKD stage: low-moderate CKD with a GFR = 45–59 mL/min (stage 3A); moderate CKD with a GFR = 30–44 mL/min (stage 3B) and severe CKD with a GFR = 15–29 mL/min (stage 4). Results Of the 922 consecutive patients enrolled in the registry, 416 (45%) pts had a moderate-to-severe impaired renal function (43% Stage 3A, 43% Stage 3B and 14% Stage 4). The mean follow-up was 935±506 days. By the end of the study, 85 pts had died and 47 pts had been hospitalized for HF. The combined end-point of death or HF hospitalization was reached by 121 (29%) pts. After 12 months the absolute LVEF improvement was greater than 10% in 37% of pts and 58% of pts displayed a positive clinical response. The percentage of pts who died was higher in the group of pts with severe CKD (32.8% vs 18.4%; p=0.012, compared to the group of pts with moderate CKD). On the contrary the percentage of pts who had at least one HF hospitalization was lower in the group with more severe CKD (2% vs 13%; p=0.011). According to CKD stage both LV remodeling (LVEF improvement ranging from 43.7% - 3A - to 30.8% - 4) and CR (positive response ranging from 63.9% - 3A - to 50% - 4) were higher in low-moderate stage and decreased with CKD severity. At multivariate Cox regression analysis adjusted for baseline confounders, CKD class at implantation [HR=1.5; 95% CI: 1.06–2.14; p=0.0219], chronic obstructive pulmonary disease [HR=1.89; 1.18–3.01; p=0.0077], persistent/permanent AF [HR=1.86; 1.15–3.01; p=0.0115] and male gender [HR=1.92; 1.07–3.46; p=0.0301] remained associated with death. Conclusions Among CKD patients in the CRT-MORE registry, severity of renal dysfunction at the time of CRT implantation was associated with worse prognosis, lower clinical response and LV reverse remodeling. Acknowledgement/Funding None
- Published
- 2019
47. P3746Temporal patterns of premature atrial contractions predict atrial fibrillation occurrence in bradycardia patients continuously monitored through pacemaker diagnostics
- Author
-
Matteo Ziacchi, Carlo Pignalberi, Mauro Gasparini, E Tartaglione, Antonio Sagone, Renato Pietro Ricci, Paolo Pieragnoli, Mauro Biffi, G.L. Botto, Giuseppe Ricciardi, Andrea Grammatico, G Boriani, A Avella, and Massimiliano Marini
- Subjects
Bradycardia ,Atrial Premature Complexes ,medicine.medical_specialty ,endocrine system diseases ,Premature atrial contraction ,business.industry ,education ,food and beverages ,Atrial fibrillation ,medicine.disease ,humanities ,law.invention ,medicine.anatomical_structure ,law ,health services administration ,Internal medicine ,medicine ,Cardiology ,Artificial cardiac pacemaker ,Sinus rhythm ,medicine.symptom ,Atrium (heart) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The frequency of premature atrial complexes (PACs) has been indirectly related with atrial fibrillation (AF) occurrence and adverse outcomes. Objective To evaluate whether temporal patterns of PACs are directly associated with AF onset in pacemaker patients with continuous monitoring of the atrial rhythm. Methods Overall, 193 pacemaker patients (49% female, 72±9 years old), enrolled in a national registry, were analyzed. Frequency of daily PACs was measured in a 14-day initial observation period, during which patients were in sinus rhythm. In the following period, temporal occurrence and frequency of daily PACs and eventual onset of AF were derived by pacemaker diagnostics. Results In the run-in period, median PACs frequency was 614 PACs/day (interquartile range=70–3056). Subsequently, in a median follow-up of 6 months, AF occurred in 109 patients, in particular in 37/96 (38.5%) patients with a PAC rate PACs changes daily trend before AF Conclusion PACs frequency increases in the 5–6 days preceding AF onset. A relative increase of the daily PACs is significantly associated with the risk of AF occurrence.
- Published
- 2019
48. IMPROVED SEISMIC BASE ISOLATION COMBINED WITH FLUID INERTER AND TUNED MASS DAMPER
- Author
-
Giuseppe Ricciardi, Neil D. Sims, David J. Wagg, Predaricka Deastra, and Dario De Domenico
- Subjects
law ,business.industry ,Tuned mass damper ,Inerter ,Structural engineering ,Base isolation ,business ,Geology ,law.invention - Published
- 2019
49. EXPERIMENTAL INVESTIGATION ON THE TEMPERATURE RISE OF DOUBLE CURVED SURFACE SLIDERS AND ITS IMPLICATIONS ON THE HYSTERETIC BEHAVIOR
- Author
-
Antonino Quattrocchi, Samuele Infanti, Roberto Montanini, Giuseppe Ricciardi, Gianmario Benzoni, Dario De Domenico, and C. Borsellino
- Subjects
Surface (mathematics) ,Materials science ,Mechanics - Published
- 2019
50. Diffuse gliomas in patients aged 55 years or over: A suggestion for IDH mutation testing
- Author
-
Giampietro Pinna, Francesco Sala, Aldo Scarpa, Bruno Bonetti, Francesca Calabria, Giuseppe Ricciardi, Rekha Cappellini, Albino Eccher, Claudio Ghimenton, Valeria Barresi, Michele Simbolo, Renzo Mazzarotto, and Marco Cancedda
- Subjects
IDH ,Male ,Methyltransferase ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Glioma ,medicine ,Biomarkers, Tumor ,Humans ,In patient ,Genetic Testing ,glioma ,immunohistochemistry ,prognosis ,neoplasms ,Aged ,business.industry ,Brain Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Isocitrate Dehydrogenase ,nervous system diseases ,Idh mutation ,Isocitrate dehydrogenase ,030220 oncology & carcinogenesis ,Mutation ,Cancer research ,Immunohistochemistry ,Female ,Neurology (clinical) ,Oligodendroglioma ,business ,030217 neurology & neurosurgery ,Anaplastic astrocytoma - Abstract
Diffuse gliomas are defined on the isocitrate dehydrogenase (IDH) gene (IDH) mutational mutational status. The most frequent IDH mutation is IDH1 R132H, which is detectable by immunohistochemistry; other IDH mutations are rare (10%). IDH mutant gliomas have better prognosis. Further, IDH wild-type low-grade (II/III) gliomas have clinical behaviors similar to those of glioblastoma (GBM) and it was suggested that they are submitted to similar post-surgical treatment. The incidence of IDH mutant gliomas (2%) and that of GBMs with non-canonical IDH mutations (< 1%) are very low in patients ≥ 55 years. For this reason, it was suggested that immunohistochemistry against IDH1 R132H is sufficient to classify GBM as IDH wild-type in this age group. However, no indication was provided for IDH mutational testing in low-grade diffuse gliomas. To address this issue, 273 diffuse gliomas were tested for IDH1 R132H immunohistochemistry. 2/4 diffuse astrocytomas (DAs), 4/9 anaplastic astrocytomas (AAs), 2/256 GBMs, and 4/4 oligodendrogliomas had positive staining. No other IDH mutations were found in immuno-negative low-grade cases by DNA sequencing. To validate our findings, we considered 311 diffuse gliomas in patients ≥ 55 years in The Cancer Genome Atlas database. Fifty-five out of 311 gliomas had IDH R132H mutations (9/16 DAs; 8/48 AAs; 3/211 GBMs; 35/36 oligodendrogliomas), one DA, and one oligodendroglioma had other IDH mutations. IDH mutant gliomas had significantly higher frequency of O-6-methylguanine-DNA methyltransferase promoter methylation (P = 0.0008) and longer overall survival (P
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.